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Predictive factors and unfavourable prognostic factors of interstitial lung disease in patients with polymyositis or dermatomyositis： a retrospective study

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Chinese Medical Journal 2010年第5期123卷 517-522页

作者： JI Su-yun ZENG Fan-qin GUO Qing TAN Guo-zhen tang Hong-feng LUO yi-jin tang Zeng-qi HAN Yan-fang Department of Dermatology Second Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510120 China

Background Interstitial lung disease （ILD） is a serious lung complication in polymyositis （PM） and dermatomyositis （DM） which affects prognosis and requires a more aggressive approach in therapy. This study investigated the prevalence, characteristics, predictive factors and unfavourable prognostic factors of ILD in newly diagnosed PM, DM and amyopathic DM （ADM）. Methods From January 2000 to December 2008, the medical records of 197 consecutive PM and DM patients at the Second Affiliated Hospital of Sun Yat-Sen University were reviewed excluding overlapping, juvenile, and malignancy-associated cases. The patients were assigned to an ILD （69 patients） and a non-lLD group （128 patients）. The clinical features, laboratory findings, and prognosis were compared. Results The multivariate analysis indicated that older age at onset （OR 1.033, 95%C/1.009-1.058, P=0.007）, fever （OR 4.109, 95%CI 1.926-8.767, P 〈0.001） and arthritis/arthralgia （OR 2.274, 95%C/1.101-4.695, P=0.026） were the independent predictive factors for developing ILD in PM/DM after excluding anti-Jo-1. Regarding anti-Jo-1, fever （OR 4.912, 95%CI 2.121-11.376, P 〈0.001） was associated with ILD. Poor survival in ILD patients was associated with ILD clinical subset （RR 0.122, 95%CI 0.049-0.399, P 〈0.001）, ADM/DM/PM-ILD （RR 0.140, 95%C/0.031-0.476, P=0.002）, cardiac involvement （RR 4.654, 95%CI 1.391-15.577, P=-0.013） and serum albumin level （RR 0.910, 95%CI 0.831-0.997, P=-0.042）. Conclusions Patients who presented with fever tended to have a higher frequency of PM/DM-associated ILD. A Hamman-Rich-like presentation, ADM-ILD, cardiac involvement and hypoalbuminemia were poor prognostic factors in ILD-PM/DM.

关键词： dermatomyositis polymyositis lung diseases, interstitial

三硫代-α-过萘甲酸基吡啶合铜的二聚体的合成和结构

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化学学报 1986年第6期44卷 580-583页

作者：金祥林金奕彦唐有祺北京大学物理化学研究所北京大学物理化学研究所北京

标题化合物由α-萘荒酸和CuCl2在吡啶溶剂中反应或由Cu4(a-C10H7CSS2)4·（1/2）CS2在吡啶和甲醇的混合溶剂中结晶合成得到.此化合的结构由单晶X射线衍射分析测定.晶体属三斜晶系,C1-PI空间群,晶胞参数α=7.085（2）,b=8.672（3）,c=13.... 详细信息

标题化合物由α-萘荒酸和CuCl2在吡啶溶剂中反应或由Cu4(a-C10H7CSS2)4·（1/2）CS2在吡啶和甲醇的混合溶剂中结晶合成得到.此化合的结构由单晶X射线衍射分析测定.晶体属三斜晶系,C1-PI空间群,晶胞参数α=7.085（2）,b=8.672（3）,c=13.598（5）A,α=92.40（3）,β=102.59（4）,γ=105.67（4）°,V=780.6A3,Z=1.对于2390个衍射点结构修正后,R=0.058.化合物的分子处在对称中心上,Cu—Ca键长（2.616A）表明铜原子之间有一定的相互作用.如果不考虑Cu—Cu的相互作用,周围的S和N原子以变形的四面体构型与Cu配位.

关键词：键长化学键变形四面体配位原子分子吡啶氮杂苯氮杂环化合物二聚体

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui Chen Zuo-tang Liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： jin-Fang Wu yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Distinct MLT asymmetry of auroral kilometric radiation observed by the FAST satellite

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Earth and Planetary Physics 2025年第1期9卷 188-193页

作者： JiaWen tang Sai Zhang FuLiang Xiao HongMing Yang Si Liu yiHua He Chang Yang YuYue jin ZhouKun Deng Ping Li Archie James Johnston School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hunan Province Higher Education Key Laboratory of Modeling and Monitoring on the Near-Earth Electromagnetic Environments Changsha University of Science and TechnologyChangsha 410114China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha 410114China

Auroral Kilometric Radiation(AKR)is a common radio emission,which can contribute to the magnetosphere−ionosphere−atmosphere *** emissions have been observed in all magnetic planet magnetospheres of the solar *** this study,using observations from the FAST satellite from 30 August 1996 to 9 September 2001,the distribution of AKR in altitude=500−4500 km and invariant latitude(|ILAT|)=60°−80°has been analyzed.63045 AKR samples have been identified with~48%(52%)samples on the dayside(nightside).Of considerable interest,there is a distinct MLT asymmetry with the high occurrence rate in MLT=05−08 and 18−22(02−05 and 12−17)in the northern(southern)*** distinct MLT asymmetry is associated with the direction of Bxof the interplanetary magnetic *** addition,the occurrence rate on the nightside clearly increases as the index *** study further enriches *** and understanding of AKR in the magnetosphere as well as other similar radio emissions.

关键词： asymmetry auroral kilometric radiation interplanetary magnetic field

A method for neutron-induced gamma spectra decomposition analysis based on Geant4 simulation

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Nuclear Science and Techniques 2022年第12期33卷 36-48页

作者： Wei tang jin-Gang Liang yi Ge Qiong Zhang University of Electronic Science and Technology of China Chengdu 610000China Tsinghua University Beijing 10000China

In various monitoring and detection tools that use pulsed neutron generators as radiation sources,the gamma rays induced by the interaction with various nuclei at different stages of neutron transport can reflect information about the *** gamma rays are generated in two major interactions:inelastic scattering of fast neutrons and radiative capture of thermal neutrons,corresponding to the inelastic and capture gamma rays,***,the two types of gamma rays that reflect different properties of the medium are difficult to collect by normal detectors *** proportion of the two gamma rays needs to be solved for the separation of inelastic and capture ***,this study proposes an optimized spectra decomposition method to calculate the inelastic-to-capture ratio in the measured total gamma spectra based on the net inelastic and capture spectra obtained using the Geant4 *** the simulated data cannot reflect the energy resolution of the measured spectra,we introduce the Gaussian broadening function of the gamma detector while calculating the proportion of the spectra components,and achieve optimization of the proportion values and resolution parameters *** on the results,the total simulated spectra obtained by superimposing the broadened net inelastic and capture gamma spectra according to the calculated inelastic-to-capture ratio are in good agreement with their measured counterpart.

关键词： Neutron-induced gamma Geant4 Spectra analysis

Photo-induced Alignment Behavior of Azobenzene-containing Polymer Films with Different Cross-linking Degree

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Chinese Journal of Chemical Physics 2008年第5期21卷 493-499页

作者： jing Shena jin-tang Huang Yan-hua Luoa Qi-jin Zhang Ke-yi Wang CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering Key Laboratory of Optoelectronic Science and Technology Anhui Province University of Science and Technology of China Hefei 230025 China Department of Precision Machinery and Precision Instrumentation University of Science and Tech- nology of China Hefei 230025 China

Three series of amorphous copolymers containing azobenzene groups with various substituents and certain amounts of crosslinkable acrylic groups were prepared. The cross-linked polymer films were obtained by thermal polymerization of the acrylic groups in the copolymers, during which, by controlling the time of cross-linking reaction, the films can be made with different cross-linking degree （from 0 to 32%, which was monitored by FT-IR spectra measurement）. Photo-induced alignment process of the films was performed under irradiation with linearly polarized light at 442 nm, and the effect of cross-linking degree on the photo-induced alignment rate was investigated. The dynamics of the photo-induced alignment was analyzed with biexponential curve fitting. The photo-induced alignment rate and the maximum transmittance of the films decreased because of the cross-linking. Furthermore, for the cross-linked samples, it was found that their saturated value of transmittances keep constant after repeated ＂writing＂ and ＂erasing＂ cycles. The findings reveal that the cross-linking of the film can effectively restrain the phototactic mass transport of azopolymer during irradiation by polarized light. The relationship between the cross-linking degree and the photo-induced alignment behavior of azopolymer is discussed in detail.

关键词： Azo polymer Cross-linking Photo-induced alignment Mass transport

Preparation of AlN thin films for film bulk acoustic resonator application by radio frequency sputtering

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第3期10卷 464-470页

作者： Kan LI Hao jin De-miao WANG yi-fei tang Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

Aluminum nitride （AlN） thin films with high c-axis orientation have been prepared on a glass substrate with an Al bottom electrode by radio frequency （RF） reactive magnetron sputtering. Based on the analysis of Berg＇s hysteresis model, the improved sputtering system is realized without a hysteresis effect. A new control method for rapidly depositing highly c-axis oriented AlN thin films is proposed. The N2 concentration could be controlled by observing the changes in cathode voltage, to realize the optimum processing condition where the target could be fixed stably in the transition region, and both stoichiometric film composition and a high deposition rate could be obtained. Under a 500 W RF power of a target with a 6 cm diameter, a substrate temperature of 450 ℃, a target-substrate distance of 60 mm and a N2 concentration of 25%, AlN thin film with preferential （002） orientation was deposited at 2.3 μm/h which is a much higher rate than previously achieved. Through X-ray diffraction （XRD） analysis, the full width at half maximum （FWHM） of AlN （002） was shown to be about 0.28°, which shows the good crystallinity and crystal orientation of AlN thin film. With other parameters held constant, any increase or decrease in N2 concentration results in an increase in the FWHM of AlN.

关键词： Aluminum nitride (A1N) Piezoelectric thin film Radio frequency (RF) reactive sputtering Preferred orientation,Film bulk acoustic resonator (FBAR)

Structural Evolution During Mechanical Milling of Bimodal-Sized Al_2O_3 Particles Reinforced Aluminum Matrix Composite

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Acta Metallurgica Sinica(English Letters) 2018年第4期31卷 423-430页

作者： Ke Zhao Dan tang jin-Ling Liu yi-Guang Wang Science and Technology on Thermostructural Composite Materials Laboratory Northwestern Polytechnical University State Key Laboratory of Traction Power School of Mechanics and Engineering Southwest Jiaotong University Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province Southwest Jiaotong University

Hybrid aluminum matrix composite powders reinforced with bimodal-sized Al2O3 particles were synthesized by mechanical *** different approaches were investigated for the addition of submicron-and nano-sized Al2O3 particles to the aluminum powders,It was observed that the simultaneous addition of bimodal-sized Al2O3 particles to the aluminum powders resulted in an equiaxed morphology of the composite powders and the average particle size stabilized after 5 h of milling,indicating that the presence of bimodal-sized particles has greater effect on accelerating milling process as compared to nano-sized particles;the grain size of the aluminum matrix in composite powders was reduced to under 40 nm,approximate to the value obtained in the separate addition case,while a lower rate of refining was observed due to hindrance of submicron-sized particles on the interactions between nano-sized particles and the aluminum matrix.

关键词： Bimodal-sized Aluminum matrix composite Mechanical milling Grain refinement