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Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer:theory-to-practice

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Cancer Biology & Medicine 2023年第2期20卷 98-103页

作者： Hang Zhang Fan Yang yi Xiao yi-Zhou jiang Zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer Center、Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Ferroptosis,a type of regulated cell death named one decade ago,is a unique type driven by lipid peroxidation in an iron-dependent *** differs radically from apoptosis and other regulated forms of cell death in both morphology and molecular *** can be triggered by a variety of physiologic conditions and pathologic *** has been growing interest in ferroptosis in recent years,and research on ferroptosis is productive.

关键词： peroxidation death breast

Parameter Design for Time-Domain Optimization of the Fourth-Order Carrier Loop in a BDS Receiver

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Chinese Journal of Electronics 2021年第3期30卷 584-594页

作者： LI Na ZHANG Shufang ZHANG Jingbo HUAI Shuaiheng jiang yi Information Science and Technology College Dalian Maritime University Physics and Electronic Information College Hulunbuir University

In the design of a Bei Dou navigation satellite system(BDS) receiver, the carrier loop is largely influenced by the loop filter, and the selection of loop filter parameters is crucial to the performance of the carrier loop. In this paper, by analyzing the relationship between the parameters of the loop filter transfer function of the BDS receiver’s fourth-order carrier loop system and the time-domain index of the system, the loop filter transfer function parameters of the fourth-order system are obtained when the dynamic performance is best optimized under the condition that the maximum steady-state error is limited. The relationship between the phase margin,magnitude margin of the system and the parameters of the system transfer function is obtained through simulation experiment and theoretical derivation. The simultaneous equations of deriving the loop system transfer function parameters are given under the following conditions:the optimal phase margin and magnitude margin of the system are settled. These research results have important reference significance for the design of a high-performance BDS receiver.

关键词： optimisation high-performance BDS receiver loop filter transfer function parameters satellite navigation optimal phase margin fourth-order carrier loop time-domain analysis time-domain optimization phase locked loops transfer functions time-domain index fourth-order system loop system transfer function parameters loop filter parameters magnitude margin parameter design

Challenges and opportunities for carbon neutrality in China’s building sector—Modelling and data

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Building Simulation 2022年第11期15卷 1899-1921页

作者： Shan Hu Yang Zhang Ziyi Yang Da Yan yi jiang Building Energy Research Center School of ArchitectureTsinghua UniversityBeijing 100084China

The building sector is one of the largest energy user and carbon emitter *** achieve China’s national carbon target,the building sector in China needs to achieve carbon peaking and neutrality targets by 2030 and 2060,***,data deficiency on building energy and emissions become barriers for tracking the status of building energy and emissions,and identify potential opportunities for achieving dual carbon *** address these shortcomings,this study established an integrated China Building Energy and Emission Model(CBEEM).With CBEEM,this study evaluated the building-construction and building-operation energy and emissions in China,and revealed the status quo and potential challenge and *** to modelling results,building operation energy use of China was 1.06 billion tce in 2020,accounting for 21%of China’s total primary energy *** construction energy consumption was 0.52 billion tce in 2020,accounting for another 10%of total primary energy *** messages found on building carbon emissions are:building construction embodied emissions were 1.5 billion tCO_(2) in 2020 and are declining slowly,building operational carbon emissions were 2.2 billion tCO_(2) in 2020 and are still *** comparisons between China and other countries on building stock,energy use intensity and carbon emission intensity were conducted as well,and help shed a light on the challenges for decarbonization of China’s building ***,technology perspectives to achieve carbon neutrality target were discussed and related policy suggestions were provided.

关键词： climate change building sector carbon neutrality global comparison China building energy and emission

What Is Philosophical Education？

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Frontiers of Philosophy in China 2013年第2期8卷 273-277页

作者： jiang yi Departmeni of Philosophy and Sociology Beijing Normal University Beijing 100875 China

1 Clarification in VocabularyBy ＂education,＂ we generally mean education in schools and colleges. Education in schools, as we know, focuses on teaching knowledge and training capacities in science, technology and other fields in which students will need to grow well. There is, however, another implication of education on which I concentrate here, that we have to consider seriously in our discussion on education. The implication I am thinking of is education in a philosophical sense. But before I present my main ideas on education in such a sense, I have to clarify some terms. First of all, there are terms such as ＂philosophical education,＂＂education in philosophy＂ and ＂philosophy of education.＂ It seems that there would be no sharp difference between those terms. We often have philosophical education in mind when we talk about the education in philosophy, and those two terms have similar meaning as the philosophy of education. But in my understanding of those terms there are slight differences between them.

关键词： Educational philosophies Eastern philosophy Humans Socratic philosophy Academic education Rationality Death Modern philosophy Meditation

Solid state self-assembly of triptycene-based catechol derivatives by multiple O-H…O hydrogen bonds

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Chinese Chemical Letters 2013年第6期24卷 475-478页

作者： ying Han yi jiang Chuan-Feng Chen Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

Single crystals of two triptycene-based catechol derivatives 1 and 2 were obtained,and their X-ray crystal structural studies showed that the two tecton molecules had different conformations in the solid state,and they could self-assemble into interesting 3D networks with solvent molecules included inside, in which multiple O-H…O hydrogen bonds played important roles.

关键词： Triptycene Catechol derivative Hydrogen bond Self-assemble

The behavior of a lithospheric magnetization and magnetic field model

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Earth and Planetary Physics 2023年第1期7卷 66-73页

作者： PengFei Liu yi jiang Qing Yan Ann MHirt State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacaoChina CNSA Macao Center for Space Exploration and Science MacaoChina Institute of Geophysics ETH ZürichSonneggstrasse 5CH-8095 ZürichSwitzerland

The Earth’s“lithosphere”is its outer shell,made up of the Earth’s crust and outermost *** part of the Earth’s magnetic field that originates in the lithosphere consists of a superposition of magnetic anomalies with a broad spectrum of sizes and intensities,which arise from geological and tectonic *** lithospheric magnetic field is known from surface observations,and on larger scales from above-surface *** increase in recent decades of satellites dedicated to measuring the Earth’s magnetic field has improved significantly our models of the Earth’s magnetic *** on these increasing observations,a number of comprehensive field models have been constructed,some of which focus solely on the lithosphere,such as the MF model *** present a map of lithospheric magnetic anomalies at 400 km altitude,based on a vertically integrated magnetization *** height was chosen because it is the expected orbital altitude of the Macao Science Satellite-1(MSS-1)*** model presented herein indicates that the amplitude of the lithospheric anomalies at 400 km altitude is between-14.8 n T and 18.2 n *** information is useful because it provides a reference for the lithospheric source of the Earth’s magnetic field that contributes to the magnetic measurements made from satellite *** low inclination orbit of the MSS-1 mission will provide information that is sensitive to lateral variation within the lithosphere;these variations arise from plate tectonic features with longitudinal *** conclusion,the new MSS-1mission will provide valuable information in detecting compositional variations in the lithosphere,and in delineating large-scale geological structures.

关键词： vertically integrated magnetization lithospheric magnetic field field model MSS-1

Unsteady heat-moisture transfer of wet airway in deep mining

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Journal of Central South University 2013年第7期20卷 1971-1977页

作者： WANG yi-jiang ZHOU Guo-qing WU Lei State Key Laboratory for Geomechanics and Deep Underground Engineering (China University of Mining and Technology) Xuzhou 221116 China School of Mechanics and Civil Engineering China University of Mining and Technology Xuzhou 221116 China

To study the mechanism of unsteady heat-moisture transfer of wet surrounding rock in deep mining, a series of experiments with different initial and boundary conditions were carried out. Test results show that rock temperature decreases quickly at the initial stage, and reduces slowly to be a constant value finally for transient heat-moisture transfer. The quasi-steady surface temperature of wet airway is lower than that of dry airway due to the moisture transfer. The diffusion radius is less than the cooling radius owing to the large diffusion resistance. The outlet airflow enthalpy of wet airway is much larger than that of dry airway. Latent heat caused by the moisture transfer plays a significant role in a deep thermal environment. For periodic heat-moisture transfer, temperature, humidity and enthalpy of outlet airflow and rock temperature also change periodically. The wave amplitude of rock temperature decreases gradually with increasing distance away from the airway surface, and the wave phase of rock temperature is also behind that of airflow. Moreover, direction of the heat-moisture transfer between airway and airflow is bidirectional, which is different from results of transient transfer.

关键词： unsteady heat-moisture transfer wet airway deep mining moisture content airflow enthalpy

A Hybrid Mathematical Model of Tumor-Induced Angiogenesis with Blood Perfusion

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Tsinghua Science and Technology 2014年第6期19卷 648-657页

作者： Junping Meng Shoubin Dong Liqun Tang yi jiang School of Electronic & Information Engineering South China University of Technology School of Computer Science & Engineering South China University of Technology School of Civil Engineering & Transportation South China University of Technology Department of Mathematics & Statistics Georgia State University Atlanta GA 30303 USA

Angiogenesis, the growth of new blood vessel from existing ones, is a pivotal stage in cancer development,and is an important target for cancer therapy. We develop a hybrid mathematical model to understand the mechanisms behind tumor-induced angiogenesis. This model describes uptake of Tumor Angiogenic Factor（TAF）at extracellular level, uses partial differential equation to describe the evolution of endothelial cell density including TAF induced proliferation, chemotaxis to TAF, and haptotaxis to extracellular matrix. In addition we also consider the phenomenon of blood perfusion in the micro-vessels. The model produces sprout formation with realistic morphological and dynamical features, including the so-called brush border effect, the dendritic branching and fusing of the capillary sprouts forming a vessel network. The model also demonstrates the effects of individual mechanisms in tumor angiogenesis： Chemotaxis to TAF is the key driving mechanisms for the extension of sprout cell; endothelial proliferation is not absolutely necessary for sprout extension; haptotaxis to Extra Cellular Matrix（ECM） gradient provides additional guidance to sprout extension, suggesting potential targets for anti-angiogenic therapies.

关键词： tumor angiogenesis Extra Cellular Matrix(ECM) capillary network partial differential equation

BIOMECHANICAL MODELING OF SURFACE WRINKLING OF SOFT TISSUES WITH GROWTH-DEPENDENT MECHANICAL PROPERTIES

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Acta Mechanica Solida Sinica 2012年第5期25卷 483-492页

作者： Yanping Cao yi jiang Bo Li Xiqiao Feng Institute of Biomechanics and Medical Engineering Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

This paper explores growth induced morphological instabilities in biological soft materials. In view of that the growth of a living tissue not only changes its geometry but also can alter its mechanical properties, we suggest a refined volumetric growth model incorporating the effects of growth on the mechanical properties of materials. Analogy between this volumetric growth model and the conventional thermal stress model is addressed for both small and finite de- formation problems, which brings great ease for the finite element analysis based on the suggested model. Examples of growth induced surface wrinkling behavior in soft composites, including core- shell soft cylinders and three-layered soft tissues, are explored. The results and discussions foresee possible applications of the model in understanding the correlation between the morphogenesis and growth of soft biological tissues （e.g. skins and tumors）, as well as in evaluating the defor- mation and surface instability behavior of soft artificial materials induced by swelling/shrinkage.

关键词： volumetric growth soft tissues surface instability morphogenesis