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survival Rate and Factors Influencing It in Triptorelin-Castrated Metastatic Prostate Cancer Patients

Open Journal of Urology 2024年第3期14卷 160-172页

作者： sossa Jean Vissoh Gilvias yevi dodji magloire inès Hodonou Fred Avakoudjo Déjinnin Josué Georges Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Bénin

Background: Most newly diagnosed prostate cancers in Benin are metastatic diseases and patients are reluctant to undergo orchiectomy. still, chemical androgen deprivation therapy is not always available and not every patient can afford it. Thus, it will be interesting to evaluate the results of that therapy in the country. Objective: To analyze the survival rate and factors influencing it in metastatic prostate cancer patients who underwent triptorelin-based androgen deprivation therapy at the former Military Teaching Hospital of Cotonou from January 1, 2012, to December 31, 2022. Patients and Method: Metastatic prostate cancer patients received intragluteal injections of triptorelin 11.25 mg every 3 months. We retrospectively collected follow-up data from the patients’ medical records. By means of the software stataTM version 15, we performed a descriptive analysis of qualitative data. We used Kaplan-Meir method to estimate the overall survival rate in the whole cohort and in specific subgroups of patients. We compared survival rates by using the log-rank test. Results: 68 metastatic prostate cancer patients aged 47-86 years (mean = 69.9) with initial PsA ranging from 24.25 to 6334 ng/mL (mean = 666.1) started triptorelin-based castration. The tumor grade in 21 (33.3%), 14 (22.2%), 15 (23.8), 8 (12.7%), and 5 (7.9%) patients was respectively IsUP grade groups 5, 4, 3, 2, and 1. 15 (22.1%), 4 (5.9%), 2 (2.9%), 1 (1.5%), 11 (16.2%), and 7 (10.3%) patients respectively had hypertension, diabetes mellitus, peptic ulcer, asthma, unilateral or bilateral hydronephrosis, and paralysis. The mean nadir PsA level was 22.5 ng/mL (range: 0.01-220.25). The mean time to nadir PsA level was 8.9 months (range: 3-57). The overall survival rate was 42.6%. There was no significant survival difference between age groups (p = 0.475), relating to the presence of diabetes or hypertension (p = 0.757) or to the presence of paralysis or hydronephrosis (p = 0.090). The initial PsA level exert

关键词： Metastatic Prostate Cancer Androgen Deprivation Therapy Overall survival PsA Nadir

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Results of an Eight Year Long Practice of saline Bipolar Transurethral Resection of Prostate

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Open Journal of Urology 2024年第4期14卷 189-196页

作者： sossa Jean Mangoue Moube Ariane Landry yevi dodji Inès magloire Hodonou Fred Avakoudjo Déjinnin Josué Georges Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Benin

Background: Open prostatectomy has long been the only prostatic bladder outlet obstruction’s surgery available in Benin. It is prone to postoperative bleeding and infections and is not suitable for prostate cancer-induced bladder outlet obstruction. Objective: To evaluate the first results of endoscopic surgery of prostatic bladder outlet obstruction in our environment. Patients and Method: We conducted an observational study of saline bipolar transurethral resection of prostate (B-TURP) at the former Military Teaching Hospital of Cotonou. We retrospectively collected the data from patients’ medical records from November 17, 2014, to september 7, 2022. We used Excel 2019 to make a descriptive analysis of the data. Results: saline B-TURP was performed in 60 consecutive patients. Their mean age was 69.1 years (range: 48-85). The procedure was indicated in 22 (36.7%), 32 (53.3%), 3 (5%), and 3 (5%) patients, respectively for acute urinary retention, chronic urinary retention, obstructive renal failure, and unresponsiveness to alpha-blockers. 35 patients (58.3%) had prostate cancer (PCa). 25 patients (41.7) had benign prostate hyperplasia (BPH). No patient got a blood transfusion. The duration of postoperative hospitalization was 3 days (88.3%) to 5 days (11.7%). 5 patients (8.3%), i.e., 3 BPH and 2 prostate cancer patients got preoperative urinary tract infection. The causative bacteria were Escherichia coli in 3 patients (60%), Klebsiella pneumoniae in 2 patients (40%), and multi-resistant Acinetobacter as a metachronous infection to Escherichia coli in 1 patient (20%). All the infections were associated with indwelling Foley catheter. 7 patients (11.7%), i.e., 3 BPH and 4 prostate cancer patients, got a second resection to recover full spontaneous micturition. Prostate size was available in the medical record of 21 BPH patients and 15 prostate cancer patients. Prostate size ranged from 22 to 123 g with a mean value of 61.1 g in BPH patients, and from 34 to 180 g with

关键词： saline B-TURP BPH Prostate Cancer

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Klingsor syndrome: An Observation in a Patient with schizophrenia

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Open Journal of Urology 2024年第5期14卷 346-351页

作者： Mbuya Musapudi Eric Ouake Hadidjatou Michel Agounkpe yevi dodji magloire inès Hodonou Fred Martin Avakoudjo Josué Georges Dejinnin Department of Urology and Andrology Hubert Koutoukou Maga National Teaching Hospital Cotonou Benin Department of surgery University Clinics of Lubumbashi Lubumbashi Democratic Republic of the Congo

Background: Klingsor syndrome refers to genital self-mutilation in man following delusional religious beliefs. Later, schweitzer proposed expanding the term to include all psychotic disorders, drug and alcohol abuse. Apart from the noted hemorrhagic emergency and difficult surgical operation, there is a psychosocial impact, sexual and urinary complications (stenosis, urethral fistula) which make this pathology complex. Aim: The Aim of this study is to describe the clinical case of Klingsor syndrome and evaluate its management in light of the literature. Case Presentation: We report a rare case of genital self-mutilation in a 35-year-old man, non-compliant schizophrenic, received 04 days after the trauma and whose treatment consisted of remodeling of the penis stump and follow-up by psychiatrists. Conclusion: Klingsor syndrome is a rare but serious phenomenon. Its management remains complex, but it must be early and multidisciplinary.

关键词： Klingsor syndrome Génital self-Mutilation schizophrenia

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survival Rate and Factors Influencing It in Triptorelin-Castrated Metastatic Prostate Cancer Patients

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Open Journal of Urology（泌尿学期刊） 2024年第3期 160页

作者： sossa Jean Vissoh Gilvias yevi dodji magloire inès Hodonou Fred Avakoudjo Déjinnin Josué Georges

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Results of an Eight Year Long Practice of saline Bipolar Transurethral Resection of Prostate

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Open Journal of Urology（泌尿学期刊） 2024年第4期 189页

作者： sossa Jean Mangoue Moube Ariane Landry yevi dodji Inès magloire Hodonou Fred Avakoudjo Déjinnin Josué Georges

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Klingsor syndrome: An Observation in a Patient with schizophrenia

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Open Journal of Urology（泌尿学期刊） 2024年第5期 346页

作者： Mbuya Musapudi Eric Ouake Hadidjatou Michel Agounkpe yevi dodji magloire inès Hodonou Fred Martin Avakoudjo Josué Georges Dejinnin

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The Impact of Body Mass on Male Fertility in a Cohort of 127 Patients

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Open Journal of Urology 2023年第11期13卷 469-475页

作者： sossa Jean Fanou Lionelle Kikpadé Joachim Hounto Yao Félicien yevi dodji magloire inès Hodonou Fred Martin Avakoudjo Déjinnin Josué Georges Clinique Universitaire d’Urologie-Andrologie Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Benin

Background: Aromatase and leptin are two adipose tissue cytokines. The former converts androgens into estrogens and stimulates adipogenesis. The latter cannot fully stimulate GnRH release as its hypothalamic receptors are reduced in obese men. Thus, obesity which is associated with an adipose tissue increment can interfere with male fertility. Objective: We aim to study the correlation between the body mass index (BMI) of an individual and the quality of semen he produces. Patients and Method: By means of the software R 4.2.1 we performed a retrospective analysis of the relationship between the BMI and the semen alterations in the patients managed at the former Military Teaching Hospital of Cotonou from October 1, 2017, to september 30, 2022: a bi-varied analysis and Fischer’s exact test (significance threshold 5%, confidence interval 95%) followed by a logistic regression when a non-significant p-value is below 0.20. Results: 127 males managed for infertility (mean age = 36.2 years) were recorded, including 11.1% obese (BMI > 30 kg/msup>2sup>) and 36.5% overweighted (25 kg/msup>2sup> sup>2sup>). The most frequent semen alterations were: oligoasthenospermia (27.8%), asthenospermia (22.2%), oligoasthenoteratospermia (14.3%), azoospermia (13.5%) and asthenoteratospermia (9.5%). Bi-varied analysis showed no correlation between the BMI and the semen alterations (p-value ranged from 0.086 to 0.9) and no difference in semen alterations between patients with BMI below and above 25 kg/msup>2sup> (p-value ranged from 0.12 to 0.9). Logistic regression demonstrated that asthenoteratospermia were correlated with BMI ≥ 25 kg/msup>2sup> [OR = 2.1, 95% CI (1.50 - 2.70), p = 0.021]. Conclusion: Male obesity and overweight can trigger asthenoteratospermia.

关键词： Body Mass Index Male Infertility semen Alterations

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Prevalence of Comorbidities in the Urological Patients at the Former Military Teaching Hospital of Cotonou

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Open Journal of Urology 2023年第11期13卷 476-483页

作者： sossa Jean Fanou Lionelle Hounto Yao Félicien yevi dodji magloire inès Hodonou Fred Martin Avakoudjo Déjinnin Josué Georges Clinique Universitaire d’Urologie-Andrologie Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Benin

Background: Comorbidities are additive diseases and care burdens in urological patients. Determining the epidemiologic profile of comorbidities in urological patients in our setting may help us to better the management of urological disease. Objective: To evaluate the prevalence of comorbidities in urological patients. Patient and Method: We collected comorbidity, urological disease and demographic data in all urological patients managed at the former Military Teaching Hospital of Cotonou from January 1, 2012, to December 31, 2020. We used the software R 4.2.2 to perform descriptive and bi-varied data analysis. student’s t test was used to compare means. Results: The prevalence of comorbidities was 14.2%, i.e., 601 comorbidity-affected among 4242 patients. The comorbidities predominantly affected men: the sex ratio was 13:1. The presence of comorbidity was correlated with patients’ age (p s observed in the 601 affected patients were hypertension (84.5%), diabetes (26.5%), asthma (2%), and heart failure (1.2%). Hypertension (p = 0.001) and asthma (p = 0.030) were correlated with age. No comorbidity was associated with gender. The comorbidities’ prevalence was highest in patients aged 40 - 80 years who presented urological diseases such as BPH (68.9%), Erectile dysfunction (ED) and ejaculatory disorders, overactive bladder (OAB) and neurogenic lower urinary tract dysfunction (LUTD), renal cyst (5%), inguinal hernia (4.2%), urinary stones (2.8%), and prostate cancer (2.3%). Conclusion: The comorbidities’ prevalence was 14.2% in the urological patients. The main comorbidities were hypertension (84.5%) and diabetes mellitus (26.5%).

关键词： Comorbidity Urological Patients Prevalence

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Prevalence of Comorbidities in the Urological Patients at the Former Military Teaching Hospital of Cotonou

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Open Journal of Urology（泌尿学期刊） 2023年第11期

作者： sossa Jean Fanou Lionelle Hounto Yao Félicien yevi dodji magloire inès Hodonou Fred Martin Avakoudjo Déjinnin Josué Georges

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The Impact of Body Mass on Male Fertility in a Cohort of 127 Patients

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Open Journal of Urology（泌尿学期刊） 2023年第11期

作者： sossa Jean Fanou Lionelle Kikpadé Joachim Hounto Yao Félicien yevi dodji magloire inès Hodonou Fred Martin Avakoudjo Déjinnin Josué Georges

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