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Diagnostic performance of the current risk-stratified approach with computed tomography for suspected choledocholithiasis and its options when negative finding

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 366-372页

作者： Hyun Woo Lee Tae Jun song Do Hyun Park Sang Soo Lee Dong-Wan Seo Sung Koo Lee Myung-Hwan Kim Jae Hyuck Jun Ji Eun Moon yeon han song Digestive Disease Center and Research Institute Department of Internal MedicineSoonchunhyang University School of MedicineBucheonKorea Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoulKorea Division of Gastroenterology Department of Internal MedicineUniversity of Eulji College of MedicineEulji Medical CenterDaejeonKorea Department of Biostatistics Clinical trial centerSoonchunhyang University Bucheon HospitalBucheonKorea

Background:Several studies evaluated the current guideline of the American Society for Gastrointestinal Endoscopy(ASGE)and reported only suboptimal *** study evaluated the diagnostic performance of the ASGE guideline based on computed tomography(CT)and role of endoscopic ultrasonography(EUS)and magnetic resonance cholangiopancreatography(MRCP)in patients with suspected choledocholithiasis but negative CT ***:Patients with suspected choledocholithiasis undergoing ERCP between January 2016 and January 2017 were retrospectively *** patients underwent CT to detect *** or MRCP was performed when the CT scan showed negative *** were classified into the high and intermediate-risk groups,based on predictors from the ASGE ***:Of 583 patients with suspected choledocholithiasis,340(58.3%)had stones on ERCP(65.9%in the high-risk group and 40.6%in the intermediate-risk group).The accuracy of ASGE guideline for CT was 63.98%(79.12%sensitivity,42.80%specificity)and 36.02%(20.88%sensitivity,57.20%specificity)in the high-risk and intermediate-risk groups,*** 103 patients in the high-risk group underwent both CT and US,the accuracy of CT was higher than that of US for detecting choledocholithiasis(78.64%vs.53.40%),with a significant difference in area under the curve(AUC)(0.78 vs.0.59,Phan that of MRCP(90.91%vs.82.76%),but with no significant difference in AUC(0.91 vs.0.83,P=0.347).Conclusions:CT-based ASGE guideline showed superior diagnostic performance than US for predicting *** diagnostic options,EUS or MRCP,with negative CT finding showed comparable ***,the diagnostic modality should be selected based on availability,experience,cost,and contraindications.

关键词： Choledocholithiasis ASGE guideline Accuracy Endoscopic ultrasound Magnetic resonance cholangiopancreatography

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian Hu Siying Kang song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang song Xie Zi-Meng han Hao-Cheng Liu Chong-han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-han Li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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A novel high-order scheme for numerical simulation of wake flow over helicopter rotors in hover

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Chinese Journal of Aeronautics 2022年第5期35卷 260-274页

作者： Shaoqiang han Wenping song Zhonghua han Institute of Aerodynamic and Multidisciplinary Design Optimization National Key Laboratory of Science and Technology on Aerodynamic Design and ResearchSchool of AeronauticsNorthwestern Polytechnical UniversityXi’an 710072China

Accurate prediction of tip vortices is crucial for predicting the hovering performance of a helicopter rotor.A new high-order scheme(we call it WENO-K)proposed by our research group is employed to minimize numerical dissipation and extended to numerical simulation of unsteady compressible viscous flows dominated by tip vortices over hovering ***-K is referred to as an adaptively optimized WENO scheme with Gauss-Kriging reconstruction,and its advantage is to reduce dissipation in smooth regions of flow while preserving high-resolution around *** WENO-K scheme is adopted to reconstruct left and right state values within the Roe Riemann solver updating the inviscid fluxes on a structured dynamic overset *** minimize the accuracy loss for high-order reconstruction on artificial boundaries of overset grid,a method of multilayer fringes is proposed to carry out interpolation between background grid and blade *** parallel computing considering automatic load balance on averagely partitioned overset grid is developed to reduce the wall-clock time of an unsteady *** results for Caradonna-Tung(C-T)rotor in hover at the conditions of subsonic and transonic tip Mach numbers show that the thrust coefficient error for the result of WENO-K scheme is no more than 3%.Compared with WENO-JS scheme,WENO-K scheme achieves about 40%improvement on accuracy of predicting rotor thrust with only 4.1%extra computational *** importantly,WENO-K scheme can capture more sophisticated unsteady flow structures and resolve tip vortices to a larger wake age with an increment of about 270°compared to WENO-JS scheme.

关键词： Dynamic overset grid Helicopter rotors High-order scheme Unsteady flow Vortex flow WENO scheme

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Dual membership SVM method based on spectral clustering

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Journal of Systems Engineering and Electronics 2012年第2期23卷 225-232页

作者： Xiaodong song Liyan han School of Economics and Management Beihang UniversityBeijing 100191P.R.China

A new fuzzy support vector machine algorithm with dual membership values based on spectral clustering method is pro- posed to overcome the shortcoming of the normal support vector machine algorithm, which divides the training datasets into two absolutely exclusive classes in the binary classification, ignoring the possibility of ＂overlapping＂ region between the two training classes. The proposed method handles sample ＂overlap＂ effi- ciently with spectral clustering, overcoming the disadvantages of over-fitting well, and improving the data mining efficiency greatly. Simulation provides clear evidences to the new method.

关键词： dual membership model fuzzy support vector ma- chine (FSVM) spectral clustering sample "overlap".

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran song Qian-Qian Wan Yu-Ming Wang han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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雨课堂结合CBL教学模式在中医骨伤科的应用

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中国中医药现代远程教育 2025年第2期23卷 36-38页

作者：宋春霖韩杰广西中医药大学瑞康临床医学院广西南宁530001 广西中医药大学附属瑞康医院关节科广西南宁530011

目的探索中医骨科临床教学运用雨课堂结合基于案例的学习(CBL)教学模式的效果。方法选取广西中医药大学中医骨伤科2021级108名本科生,以随机编号的方式分为实验组和对照组,每组54人。实验组应用雨课堂结合CBL教学法,对照组应用传统教学... 详细信息

目的探索中医骨科临床教学运用雨课堂结合基于案例的学习(CBL)教学模式的效果。方法选取广西中医药大学中医骨伤科2021级108名本科生,以随机编号的方式分为实验组和对照组,每组54人。实验组应用雨课堂结合CBL教学法,对照组应用传统教学模式,两组授课教师和教材均相同。教学结束后,比较两组考核成绩及教学满意度。结果实验组考核成绩及满意度调查评分均高于对照组,差异均有统计学意义(P<0.05)。结论雨课堂结合CBL教学模式是一种能够有效提高中医骨伤科课堂参与度,激发学生学习兴趣,提升学生综合能力的方法。

关键词：雨课堂案例教学法中医骨伤科临床教学远程网络教学

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Attenuation of boundary-layer instabilities for natural laminar flow design on supersonic highly swept wings

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Chinese Journal of Aeronautics 2024年第11期37卷 118-137页

作者： han NIE Wenping song Zhonghua han Kefeng ZHENG School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China National Key Laboratory of Aircraft Configuration Design Xi’an 710072China

To meet the challenge of drag reduction for next-generation supersonic transport aircraft,increasing attention has been focused on Natural Laminar Flow(NLF)***,the highly swept wings and high-Reynolds-number conditions of such aircraft dramatically amplify Crossflow(CF)instabilities inside boundary layers,making it difficult to maintain a large laminar flow *** explore novel NLF designs on supersonic wings,this article investigates the mechanisms underlying the attenuation of Tollmien-Schlichting(TS)and CF instabilities by modifying pressure *** evolution of TS and CF instabilities are evaluated under typical pressure distributions with different leading-edge flow acceleration region lengths,pressure coefficient slopes and pressure coefficient *** results show that shortening the leading-edge flow acceleration region and using a flat pressure distribution are favorable for suppressing CF instabilities,and keeping a balance of disturbance growth between positive and negative wave angles is favorable for attenuating TS *** on the uncovered mechanisms,a strategy of supersonic NLF design is *** of the proposed strategy at a 60°sweep angle and Ma=2 presents potential to exceed the conventional NLF limit and achieve a transition Reynolds number of 17.6million,which can provide guidance for NLF design on supersonic highly swept wings.

关键词： Supersonic transport aircraft Natural laminar flow design Supersonic flow Highly-swept wings Transition delay Linear stability theory

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Green chemistry: a tool for the sustainable development of the chemical industry

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National Science Review 2015年第3期2卷 255-256页

作者： Jinliang song Buxing han Institute of Chemistry Chinese Academy of Sciences

Most manufactured products involve one or more chemical *** cannot imagine what our life will be like without the products produced by the chemical ***,on average,only a small proportion of the resources we take from the Earth is converted into the desired products in current chemical processes,and large amounts of wastes and hazardous materials are *** to supply humanity with enough food,

关键词： a tool for the sustainable development of the chemical industry Green chemistry

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A high-resolution numerical investigation of unsteady wake vortices for coaxial rotors in hover

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Chinese Journal of Aeronautics 2024年第11期37卷 278-299页

作者： Shaoqiang han Wenping song Zhonghua han Jianhua XU Tianfu Engineering-oriented Numerical&Software Innovation Center College of Computer ScienceSichuan UniversityChengdu 610065China National Key Laboratory of Science and Technology on Aerodynamic Design and Research School of AeronauticsNorthwestern Polytechnical UniversityXi’an 710072China

High-resolution numerical simulations for wake vortical flows have long been a challenge in rotor aerodynamics.A novel spectrum-optimized sixth-order Weighted Essentially NonOscillatory(WENO)scheme is proposed to discretize inviscid fluxes on moving overset grids,and the Improved Delayed Detached Eddy Simulation(IDDES)is employed to resolve turbulent *** integration of these methods facilitates a comprehensive numerical investigation into the unsteady vortical flows over coaxial rotors in *** results highlight the substantial improvement in numerical resolution,in terms of both spatial structure and temporal evolution of unsteady multiscale wake *** rotors in hover manifest three primary scales of wake vortex structures:(A)the helical evolution of primary blade tip vortices and the periodic occurrence of strong Blade-Vortex Interactions(BVI);(B)the continuous shedding of small-scale horseshoeshaped vortices from the trailing edges of rotor blades,forming the vortex sheets;(C)the emergence of small-scale secondary vortex braids induced by interactions between rotor tip vortices and the vortex *** vortex structures and their interactions cause high-frequency oscillations in rotor disk loads and induce unsteady perturbations in the local flow *** among these primary vortices,coupled with the generation of secondary vortices,result in the dissipation,distortion,and breakup of the rotor tip vortices,ultimately forming a vortex ***,a substantial quantity of seemingly weak small-scale secondary vortex braids significantly contribute to energy dissipation during the evolution of wake vortices for coaxial rotors in hover.ó2024 Chinese Society of Aeronautics and *** and hosting by Elsevier *** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Coaxial rotor Blade tip vortex Secondary vortex High-order scheme IDDES Moving overset grid

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