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Stream-power incision model in non-steady-state mountain ranges: An empirical approach

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Chinese Science Bulletin 2006年第22期51卷 2789-2794页

作者： chen yen-Chieh SUNG Quocheng chen Chao-Nan Center of Environmental Education and Safety Health NationalKaohsiung Normal University Kaohsiung 802 Taiwan China Institute of Civil Engineering and Disaster Reduction Technology Chin Yun University Jung-Li 320 Taiwan China Department of Leisure and Recreation Toko University Chia-YiCounty 613 Taiwan China

溪流力量切口模型总是被用于检测范围的 thesteady 状态状况。在引起台湾山的时期 ofPenglai 造山运动期间发生的倾斜的弧大陆碰撞系上带子开发三个进化阶段的风景，也就是上演 pre 不变(在南部的台湾的成长范围) ，不变(在中央台湾的范... 详细信息

溪流力量切口模型总是被用于检测范围的 thesteady 状态状况。在引起台湾山的时期 ofPenglai 造山运动期间发生的倾斜的弧大陆碰撞系上带子开发三个进化阶段的风景，也就是上演 pre 不变(在南部的台湾的成长范围) ，不变(在中央台湾的范围) 并且 steady-state 以后(在北台湾的腐烂的范围) 。在探索在基岩隧道(S) 和集水区域(A) 的斜坡之间的关系做的台湾山带的分析开工，在这三个阶段的范围的地志的特征被获得。不变的范围的 S-A 阴谋在一种线性形式，表明基岩隧道的河床高度不随着时间的过去变化(dz/dt = 0 ) 。斜坡并且直线 S-A 拦截与不变的地形学的进化时间有关并且构造高举分别地评价。台湾山带的南部、北的范围的 S-A 阴谋看起来分别地在凸、凹面的形式，暗示在二个范围的基岩隧道的河床高度升起(dz/tit> 0 ) 并且下降(dz/dt < 0 ) 随着时间的过去分别地。他们的正切拦截罐头仍然思考构造高举率。这研究开发一个实验 stream-powererosion 模型 pre 不变并且 steady-state 以后地形学。

关键词：台湾区域稳定态值域水流侵蚀模型地形学

Effects of the number of neoadjuvant therapy cycles on clinical outcomes, safety, and survival in patients with metastatic colorectal cancer undergoing metastasectomy

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Oncology Research 2022年第2期30卷 65-76页

作者： YUNG-SUNG YEH hsiang-LIN TSAI yen-chenG chen WEI-CHIH SU PO-JUNG chen TSUNG-KUN CHANG CHING-CHUN LI CHING-WEN HUANG JAW-YUAN WANG Division of Trauma and Surgical Critical Care Department of SurgeryKaohsiungMedical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Emergency Medicine Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipeiTaiwanChina Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Center for Cancer Research Kaohsiung Medical UniversityKaohsiungTaiwanChina Pingtung Hospital Ministry of Health and WelfarePingtungTaiwanChina

The controversial outcomes in patients with metastatic colorectal cancer(mCRC)highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical *** optimal treatment cycles in patients with mCRC for metastasectomy remain undeﬁ*** retrospective study compared the efﬁcacy,safety,and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such ***-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April ***-eight patients received 6 cycles of chemotherapy/targeted therapy,whereas 36 patients received≥7 cycles(median,13;range,7–20).Clinical outcomes,including response,progression-free survival(PFS),overall survival(OS),and adverse events,were compared between these two *** the 64 patients,47(73.4%)were included in the response group,and 17(26.6%)were included in the nonresponse *** analysis revealed chemotherapy/targeted therapy cycle and pretreatment serum carcinoembryonic antigen(CEA)level as independent predictors of the response as well as overall survival and chemotherapy/targeted therapy cycle as an independent predictor of progression(all p0.05).The median OS and PFS were 48 months(95%CI,40.855–55.145)and 28 months(95%CI,18.952–37.48)in the≥7-cycle group and 24 months(95%CI,22.038–25.962)and 13 months(95%CI,11.674–14.326)in the 6-cycle group,respectively(both p<0.001).The oncological outcomes in the≥7-cycle group were signiﬁcantly better than those in the 6-cycle group,without signiﬁcant increases in adverse ***,prospective randomized trials are mand

关键词： Metastatic colorectal cancer Neoadjuvant chemotherapy/targeted therapy Treatment cycles Metastasectomy

Current status of endoscopic sleeve gastroplasty: An opinion review

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World Journal of Gastroenterology 2020年第11期26卷 1107-1112页

作者： Jiunn-Wei Wang Chih-yen chen Division of Gastroenterology Department of Internal medicineKaohsiung Medical University HospitalKaohsiung 80756Taiwan Department of Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 80756Taiwan Graduate Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 80756Taiwan Division of Gastroenterology and Hepatology Department of MedicineTaipei Veterans General HospitalTaipei 11217Taiwan Endoscopy Center for Diagnosis and Treatment Taipei Veterans General HospitalTaipei 11217Taiwan Faculty of Medicine and Institute of Emergency and Critical Medicine National Yang-Ming University School of MedicineTaipei 11217Taiwan Institutional Review Board Taipei Veterans General HospitalTaipei 11217Taiwan Chinese Taipei Society for the Study of Obesity Taipei 11031Taiwan

Bariatric surgeries have been demonstrated to be safe and effective treatment options for morbid obesity patients, but operative risks and high health care costs limit their clinical application. Endoscopic bariatric therapies are emerging as valuable alternatives for patients with doubts about bariatric surgery or ineligible for it. Endoscopic sleeve gastroplasty(ESG), a relatively novel technique of endoscopic bariatric therapies, has gained standing in the past few years. The safety, feasibility, repeatability, and potential for reversibility of ESG have been proven by multicenter studies. Compared to other weight loss strategies, current evidence demonstrates that ESG offers satisfactory efficacy in weight loss. Even though it is inferior to laparoscopic sleeve gastrectomy, it has lower risks of adverse events than surgical interventions and intragastric balloon within oneyear follow-up. Furthermore, ESG may be the ideal weight control strategy for patients who have poor adherence to behavioral interventions. Even so, trends in decreased weight loss effect over time, post-procedure weight regain, postprocedure gut hormone alteration, and possible effects of race and ethnicity on ESG still remain undetermined due to very limited reports and very short followups. Further clinical trials are required to validate and answer these questions.

关键词： Obesity Endoscopic bariatric therapy Endoscopic sleeve gastroplasty Laparoscopic sleeve gastrectomy Intragastric balloon Behavioral weight loss intervention

Effects of solution treatment and cold rolling on structure and tensile properties of hot-rolled Ti-7.5Mo alloy

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Journal of Iron and Steel Research International 2019年第12期26卷 1366-1375页

作者： yen-chun chen Chien-ping Ju Jiin-huey Chern Lin Department of Materials Science and Engineering ChengKung UniversityTaiwan 70101China

The effects of solution treatment(ST)and cold rolling(CR)on structure and tensile properties of a heavily hot-rolled(HR)Ti–7.5Mo alloy were *** results indicated that,after HR with a one-pass 65%reduction in thickness,the pores in as-received samples substantially disappeared,the misorientation angle distribution became broader,and grain texture shifted toward.Post-HR ST produced an orthorhombicα''-phase with fine needle-type morphology and caused misorientation to narrow down to 55°–65°with substantially random texture;post-ST CR caused misorientation shift toward high-angle side and texture towardand.With an increase in reduction in thickness,α'(102)intensity increased at the expense of two adjacent(112)/(022)α''-*** X-ray diffraction,metallography and electron backscattered diffraction on scanning electron microscope results indicated that pre-ST HR did not affect the formation of the desired low-modulusα''-phase when the alloy was subsequently *** a practical point of view,the most optimal tensile properties may be found in the sample solution-treated at 900°C for 30 min and cold-rolled by a 20%reduction in thickness,which demonstrated a yield strength of 924 MPa,an ultimate tensile strength of 933 MPa,a tensile modulus of 73 GPa,and an elongation of 26%.

关键词： Titanium alloy Ti–Mo alloy Electron backscattered diffraction Microstructure Mechanical property

PTX-symmetric metasurfaces for sensing applications

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Frontiers of Optoelectronics 2021年第2期14卷 211-220页

作者： Zhilu YE Minye YANG Liang ZHU Pai-yen chen Department of Electrical and Computer Engineering University of Illinois at ChicagoChicagoIL 60607USA

In this paper,we introduce an ultra-sensitive optical sensing platform based on the parity-time-reciprocal scaling(PT^-symmetric non-Hermitian metasurfaces,which leverage exotic singularities,such as the exceptional point(EP)and the coherent perfect absorber-laser(CPAL)point,to significantly enhance the sensitivity and detectability of photonic *** theoretically studied scattering properties and physical limitations of the PTX-symmetric metasurface sensing systems with an asymmetric,unbalanced gain-loss *** PTLY-symmetric metasurfaces can exhibit similar scattering properties as their Pr-symmetric counterparts at singular points,while achieving a higher sensitivity and a larger modulation depth,possible with the reciprocal-scaling factor(i.e.,X transformation).Specifically,with the optimal reciprocalscaling factor or near-zero phase offset,the proposed PTX-symmetric metasurface sensors operating around the EP or CPAL point may achieve an over 100 dB modulation depth,thus paving a promising route toward the detection of small-scale perturbations caused by,for example,molecular,gaseous,and biochemical surface adsorbates.

关键词： parity-time symmetry exceptional point(EP) laser oscillator coherent perfect absorber electromagnetic sensor radio frequency(RF)and microwave sensing optical sensing

Current Evidence of the Monoaminergic Regulation of Romantic Love and Relationship

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Advances in Sexual Medicine 2017年第3期7卷 139-152页

作者： Wei-Hsi chen Mei-yen Chu Yuan-hsiang Chu yen-Chin Lin Kuo-yen chen Graduate School of Human Sexuality Shu-Te University Taiwan Department of Neurology Kaohsiung Chang Gung Memorial Hospital and College of Medicine Chang Gung University Taiwan Life Education Center Chang Jung Senior High School Taiwan

Introduction: Sexual response cycle is modulated by a variety of biological factors, especially antidepressants and antipsychotics. Although the circuit of romantic love has recently been delineated, the biological impact on romantic love is barely mentioned in human, however. Methods: In thus study, a comprehensive literature review was completed to elucidate the role of central monoamines, including dopamine, serotonin, norepinephrine, epinephrine, melatonin and histamine, for the romantic love and relationship in human. Results: The central circuit of romantic love includes the mesolimbic and mesocortical tract and their extensions widely distributed in cortical, subcortical and brainstem structures. The activation of brain foci progressively decreases along with the romantic relationship in many areas, including the bilateral caudate and ventral tegmentum area without change of passionate love. Hyperactivity of dopamine and serotonin is suggested at the synaptic level for romantic love in lovers, probably through an inhibition of transporters or increase of terminal release. Romantic love can be modulated by antidepressants or recreational drugs. Polymorphism of dopamine and serotonin receptor relates to the romantic relationship. The effect of other monoamines is barely mentioned. Conclusions: Romantic love is vulnerable for secondary effect, such as drugs which modulate the dopamine and serotonin, in human. Romantic relationship is also impacted by the polymorphism of monoamine receptors. Therefore, the biological effect is not limited to sexual response cycle but also the romantic love and relationship. Further investigation is warranted for understanding the secondary effect in romantic love for romantic dissolution or divorce.

关键词： Romantic Love Passionate Love Love Dopamine Serotonin

Esophageal squamous cell carcinoma with dural and bone marrow metastases

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World Journal of Gastroenterology 2014年第35期20卷 12691-12695页

作者： yen-Hao chen cheng-Hua Huang Department of Hematology-Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Patients with esophageal squamous cell carcinoma generally present at an advanced stage at the time of *** most common sites of visceral metastasis are the lung,liver and bone,but brain and bone marrow involvement is exceedingly ***,we report a 62-year-old man with a 4-wk history of progressive low back pain with radiation to bilateral lower legs,dysphagia and body weight *** squamous cell carcinoma with regional lymph node,liver and bone metastases was *** underwent concurrent chemoradiotherapy and got a partial *** months later,he complained of headache,diplopia and severe hearing impairment in the left *** was no evidence for bacterial,fungal,tuberculous infection or neoplastic *** resonance imaging of the brain demonstrated thickening and enhancement of bilateral pachymeninges and multiple enhancing masses in bilateral *** metastasis was diagnosed and he received whole brain *** addition,laboratory examination revealed severe thrombocytopenia and leucopenia,and bone marrow study confirmed the diagnosis of metastatic squamous cell *** is the first described case of esophageal squamous cell carcinoma with dural and bone marrow *** also discuss the pathogenesis of unusual metastatic diseases and differential diagnosis of pachymeningeal thickening.

关键词： Esophageal cancer Squamous cell carcinoma Dural metastasis Bone marrow metastasis

Synergistic effect of fatty liver and smoking on metabolic syndrome

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World Journal of Gastroenterology 2009年第42期15卷 5334-5339页

作者： Po-Hsin Chiang Tsui-yen Chang Jong-Dar chen Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital#95 Wen Chang RoadShih LinTaipei 111TaiwanChina School of Medicine Fu Jen Catholic University#510 Chung Cheng RoadHsinchuangTaipei 242TaiwanChina

AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its ***:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005.A total of 3455(1981 men and 1474 women) subjects were included in final *** liver was diagnosed using abdominal ultrasonography by trained *** modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic *** associations between smoking,fatty liver and metabolic syndrome were analyzed using multiple logistic ***:Subjects with fatty liver,and who smoked tobacco,had the highest odds ratios(ORs) for high waist circumference [OR,4.5(95% CI:3.3-6.1) ,P < 0.05],hypertriglyceridemia [OR,8.1(95% CI:6.0-10.9) ,P < 0.05],low serum high-density lipoprotein cholesterol(HDL-C) [OR,8.3(95% CI:6.1-11.3) ,P < 0.05],and metabolic syndrome [OR,9.5(95% CI:6.7-13.4) ,P < 0.05] compared to subjects without fatty liver who did not smoke *** also found that the ORs for hypertriglyceridemia,low serum HDL-C,and metabolic syndrome for subjects with fatty liver who smoked tobacco had greater than the sum of the ORs for subjects with fatty liver who did not smokeplus those who did not have fatty liver and who did ***:Fatty liver and smoking had a synergistic effect on metabolic syndrome and its components,especially for hypertriglyceridemia and low serum HDL-C.

关键词： Smoking Fatty liver Synergistic effect Metabolic syndrome

Numerical Simulation of the Motion of A Floating Body with Partially Filled Tanks by A Pressure-Convection Particle Method

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China Ocean Engineering 2010年第3期24卷 401-416页

作者： Hung-Pin CHIEN Jen-Shiang KOUH yen-Jen chen Institute of Engineering Science and Ocean Engineering National Taiwan University Department of Multimedia and Game Science Lunghwa University of Science Technology

The moving particle semi-implicit（MPS）method has demonstrated its usefulness in practical engineering *** it has wide applicability,it is still hard to predict the pressure precisely using the MPS method.A pressure-convection particle method based on the MPS method is proposed to overcome this *** improved performance of this new method is validated with computational and measured *** approach is also applied to compute the problem of sloshing associated with floating body motion in *** pressure-convection MPS method demonstrated its capability to improve the prediction of pressure.

关键词： pressure-convection particle method impact pressure heaving motion rolling motion