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A study on the treatment of chloasma with moxibustion based on the theory of“Yang transforming Qi,and Yin shaping”

Clinical Research Communications 2024年第3期7卷 23-28页

作者： Mi Yang Hong-Yi Lan Hong wu Xu Wang Xin-ju Li Baokang Hospital Affiliated to Tianjin University of Traditional Chinese Medicine Tianjin 300193China. Cardiology Dept Wuxi Traditional Chinese Medicine HospitalWuxi 214071China. Acupuncture&Moxibustion Dept Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300131China. College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China.

Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human *** of the strengths of TCM in treating diseases is holistic *** theory of“Yang transforming Qi,and Yin shaping”implies a strong holistic ***,one of the common skin diseases,seriously affects the physical and mental health of patients due to its unclear etiology,difficult treatment and easy *** occurrence and development of chloasma are closely related to internal *** paper is based on the theory of internal meridian,“Yang transforming Qi,and Yin shaping”which attaches importance to the concept of“Yang Qi”,from a new understanding of the pathogenesis etiology of ***:The author believes that the incidence of the disease is the deficiency of Yang Qi,which can’t promote the movement of Qi and blood to nourish the face,resulting in tangible material condensation,so proposes that this disease needs to be promoted by Yang transforming Qi and warm to *** belongs to the fire,and its warming effect can dissipate the tangible ***:Combined with clinical practice and the theory of internal meridian,the author elaborated that moxibustion is one of the effective methods for treating chloasma,which provides a new way of thinking for the treatment of ***:“Yang Transforming Qi and Yin shaping”can be used to guide the treatment of chloasma.

关键词： Yang Transforming Qi and Yin shaping moxibustion chloasma

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Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases

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World Journal of Clinical Cases 2024年第1期12卷 188-195页

作者： Shi-Yuan Liu Hao Chen Li-Jia He Chun-Kai Huang Pu Wang Zhang-Ru Rui jue wu Yang Yuan Yue Zhang Wen-ju Wang Xiao-Dan Wang Central Laboratory Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan ProvinceYan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Department of Nephropathy Yan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina

BACKGROUND In this study,we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis(LN)who un-derwent repeated renal *** SUMMARY Clinical data of three diffuse proliferative LN patients with different pathological characteristics(case 1 was LN IV-G(A),case 2 was LN IV-G(A)+V,and case 3 was LN IV-G(A)+thrombotic microangiopathy)were *** patients underwent repeated renal biopsies 6 mo later,and renal biopsy specimens were *** infiltration was assessed by CD68 expression detected by immunohistochemical staining,and an immunofluorescence assay was used to detect podocin expression to assess podocyte *** treatment,Case 1 changed to LN III-(A),Case 2 remained as type V LN lesions,and Case 3,which changed to LN IV-S(A),had the worst *** observed reduced macro-phage infiltration after ***,two of the patients with active lesions after treatment still showed macrophage infiltration in the renal *** treatment,the three patients showed discontinuous expression of ***,the integrity of podocin was restored after treatment in Case *** It may be possible to reverse podocyte damage and decrease the infiltrating ma-crophages in LN patients through effective treatment.

关键词： Lupus nephritis Macrophage Podocyte Repeat renal biopsy Thrombotic microangiopathy Case report

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m^(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

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Frontiers of Medicine 2024年第3期18卷 499-515页

作者： Han wu Weitao Jiang Ping Pang Wei Si Xue Kong Xinyue Zhang Yuting Xiong Chunlei Wang Feng Zhang Jinglun Song Yang Yang Linghua Zeng Kuiwu Liu Yingqiong Jia Zhuo Wang Jiaming ju Hongtao Diao Yu Bian Baofeng Yang Department of Pharmacology(National Key Laboratory of Frigid Zone Cardiovascular Diseases the State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin150081China

Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction(MI)can lead to heart *** N6-methyladenosine(m^(6)A)methylation has been shown to play a pivotal role in the occurrence and development of many *** investigating the biological function of the m^(6)A reader YTHDF1 in cardiac fibrosis,adeno-associated virus 9 was used to knock down or overexpress the YTHDF1 gene in mouse hearts,and MI surgery in vivo and transforming growth factor-β(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosis *** results demonstrated that silencing YTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosis,whereas YTHDF1 overexpression could further enhance cardiac dysfunction and aggravate the occurrence of ventricular pathological remodeling and fibrotic ***,zinc finger BED-type containing 6 mediated the transcriptional function of the YTHDF1 gene ***1 augmented AXL translation and activated the TGF-β-Smad2/3 signaling pathway,thereby aggravating the occurrence and development of cardiac dysfunction and myocardial ***,our data indicated that YTHDF1 was involved in activation,proliferation,and migration to participate in cardiac fibrosis in *** results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis.

关键词： cardiac fibrosis YTHDF1 AXL ZBED6 heart failure

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Fermi Surface Nesting with Heavy Quasiparticles in the Locally Noncentrosymmetric Superconductor CeRh2As2

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Chinese Physics Letters 2024年第9期41卷 107-121页

作者： Yi wu Yongjun Zhang Sailong ju Yong Hu Yanen Huang Yanan Zhang Huali Zhang Hao Zheng Guowei Yang Evrard-Ouicem Eljaouhari Baopeng Song Nicholas C.Plumb Frank Steglich Ming Shi Gertrud Zwicknagl Chao Cao Huiqiu Yuan Yang Liu Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China Institute for Advanced Materials Hubei Normal UniversityHuangshi 435002China Swiss Light Source Paul Scherrer InstitutCH-5232 Villigen PSISwitzerland Institut for Mathematische Physik 38106 BraunschweigGermany Max Planck Institute for Chemical Physics of Solids 01187 DresdenGermany Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China State Key Laboratory of Silicon Materials Zhejiang UniversityHangzhou 310058China

The locally noncentrosymmetric heavy fermion superconductor CeRh2As2 has attracted considerable interests due to its rich superconducting phases,accompanied by possible quadrupole density wave and pronounced antiferromagnetic *** understand the underlying physics,here we report measurements from highresolution angle-resolved *** results reveal fine splittings of the conduction bands related to the locally noncentrosymmetric structure,as well as a quasi-two-dimensional Fermi surface(FS)with strong 4𝑓*** FS shows signs of nesting with an in-plane vector q1=(π/α,π/α),which is facilitated by the heavy bands nearˉ𝑋arising from the characteristic conduction-X *** FS nesting provides a natural explanation for the observed antiferromagnetic spin fluctuations at(π/α,π/α),which might be the driving force for its unconventional *** experimental results can be reasonably explained by density functional theory plus dynamical mean field theory calculations,which can capture the strong correlation *** study not only provides spectroscopic signature of the key factors underlying the field-induced superconducting transition,but also uncovers the critical role of FS nesting and lattice Kondo effect in the underlying magnetic fluctuations.

关键词： symmetric Fermi conduction

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振幅整合脑电图评估孕妇产前糖皮质激素治疗对早产儿脑发育的影响

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中国当代儿科杂志 2024年第3期26卷 244-249页

作者：吴迪鞠俊常贺生首都医科大学附属北京朝阳医院儿科北京100020

目的通过振幅整合脑电图(amplitude-integrated electroencephalography,aEEG)探讨孕妇产前糖皮质激素(antenatal corticosteroid,ACS)治疗对早产儿脑发育的影响。方法回顾性纳入胎龄28^(+0)~34^(+6)周早产儿211例,根据产前是否使用地塞米松进行促胎肺成熟治疗分为ACS组(131例)和对照组(80例)。在生后24 h内进行首次aEEG监测(记为aEEG1),生后5~7 d进行第2次aEEG监测(记为aEEG2),对aEEG结果进行分析比较。结果胎龄28^(+0)~31^(+6)周早产儿中,ACS组相较于对照组,aEEG1周期性更成熟、振幅下边界更高(P<0.05);胎龄32^(+0)~33^(+6)周及胎龄34^(+0)~34^(+6)周早产儿中,ACS组相较于对照组,连续模式比例更高、周期性更成熟且Burdjalov评分更高(P<0.05)。胎龄32^(+0)~33^(+6)周及胎龄34^(+0)~34^(+6)周早产儿中,ACS组相较于对照组,aEEG2连续模式比例更高、周期性更成熟、振幅下边界更高、波谱带宽更窄且Burdjalov评分更高(P<0.05)。结论ACS治疗早产儿比未行ACS早产儿aEEG图形更成熟,ACS对早产儿脑发育有一定促进作用。

关键词：脑发育产前糖皮质激素振幅整合脑电图早产儿

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Efficacy of graphene nanocomposites for air disinfection in dental clinics: A randomized controlled study

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World Journal of Clinical Cases 2024年第28期12卷 6173-6179页

作者： Ya-Qiong ju Xiang-Hua Yu Jing wu Ying-Hui Hu Xiang-Yong Han Dan Fang Department of Nursing Minhang District Dental ClinicShanghai 201107China Department of Medical Sciences Minhang District Dental ClinicShanghai 201107China Department of Orthopedics Center for Spinal Minimally Invasive ResearchShanghai Jiao Tong UniversityShanghai 201107China

BACKGROUND Aerosols containing disease-causing microorganisms are produced during oral diagnosis and treatment can cause secondary *** To investigate the use of graphene material for air disinfection in dental clinics by leveraging its adsorption and antibacterial *** Patients who received ultrasonic cleaning at our hospital from April 2023 to April *** were randomly assigned to three groups(n=20 each):Graphene nanocomposite material suction group(Group A),ordinary filter suction group(Group B),and no air suction device group(Group C).The air quality and air colony count in the clinic rooms were assessed before,during,and after the ***,bacterial colony counts were obtained from the air outlets of the suction devices and the filter screens in Groups A and *** Before ultrasonic cleaning,no significant differences in air quality PM2.5 and colony counts were observed among the three ***,significant differences in air quality PM2.5 and colony counts were noted among the three groups during ultrasonic cleaning and after ultrasonic ***,the number of colonies on the exhaust port of the suction device and the surface of the filter were significantly lower in Group A than in Group B(P=0.000 and P=0.000,respectively).CONCLUSION Graphene nanocomposites can effectively sterilize the air in dental clinics by exerting their antimicrobial effects and may be used to reduce secondary pollution.

关键词： Graphene Nanocomposites Oral clinic Air disinfection Secondary contamination

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基于诊断观测器的最优事件触发故障检测

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控制与决策 2024年第2期39卷 559-567页

作者：吴劲松邱爱兵顾菊平姜旭南通大学电气工程学院江苏南通226019

提出一种基于诊断观测器的最优事件触发故障检测方法.首先,针对自适应混合事件触发下的远程监控系统,发展一种数值代数结合型的低阶诊断观测器参数矩阵计算方法,以满足残差生成中的Luenberger条件;然后,通过评估事件触发传输误差、干扰... 详细信息

提出一种基于诊断观测器的最优事件触发故障检测方法.首先,针对自适应混合事件触发下的远程监控系统,发展一种数值代数结合型的低阶诊断观测器参数矩阵计算方法,以满足残差生成中的Luenberger条件;然后,通过评估事件触发传输误差、干扰和故障对残差信号的影响,构建H∞/H∞型性能指标,并利用互内外分解技术设计最优后置滤波器,以实现对故障灵敏度和对干扰鲁棒性的最优权衡;进一步,为降低传统的预设残差阈值方法的保守性,依据系统初始状态和干扰的有界性,采用基于中心对称多胞体的方法设计残差评价函数及相应的故障决策逻辑来实现故障检测;最后,通过多车跟踪系统的仿真,验证所提方法的有效性.

关键词：诊断观测器事件传输误差故障检测鲁棒性灵敏度权衡

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A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F

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Journal of biomedical research 2024年第5期38卷 1-14页

作者： Jing Xue Linwei Zhang Jingxian Tao Xuexue Xie Xi Wang Linlin wu Shuhu Du Ninghua Tan Yang Jin Jianming ju junting Fan jun Wang Fei Huan Rong Gao Key Laboratory of Modern Toxicology Ministry of Education Department of Toxicology School of Public Health Nanjing Medical University Nanjing Jiangsu 211166 China. Taizhou Center for Disease Control and Prevention Taizhou Jiangsu 225300 China. wuxi Center for Disease Control and Prevention Wuxi Jiangsu 214023 China. School of Pharmacy Jiangsu Province Engineering Research Center of Antibody Drug Nanjing Medical University Nanjing Jiangsu 211166 China. School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China. Department of Pharmaceutical Analysis School of Pharmacy Nanjing Medical University Nanjing Jiangsu 211166 China. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu 210028 China. Department of Hygienic Analysis and Detection Key Laboratory of Modern Toxicology Ministry of Education School of Public Health Nanjing Medical University Nanjing Jiangsu 211166 China.

As a potential endocrine-disrupting chemical, bisphenol F (BPF) may cause nonalcoholic fatty liver disease (NAFLD)-like changes, but the mechanisms underpinning its pathogenesis as well as the intervention strategies remain poorly understood. Using the electron microscopy technology, along with LipidTOX Deep Red neutral and Bodipy 493/503 staining assays, we observed that BPF treatment elicited a striking accumulation of lipid droplets in HepG2 cells, accompanied by an increased total level of triglycerides. At the molecular level, the lipogenesis-associated mRNAs and proteins, including acetyl-CoA carboxylase, fatty acid synthase, stearoyl-CoA desaturase-1, peroxisome proliferator-activated receptor gamma, and CCAAT-enhancer-binding proteins, increased significantly the AMP-activated protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling regulation in both and studies. Furthermore, the immunofluorescence results also showed the robust lipogenesis induced by BPF, evident in its ability to promote the translocation of sterol regulatory element-binding protein-1c from the cytoplasm to the nuclei. To investigate the intervention strategies for BPF-induced NAFLD-like changes, we demonstrated that bellidifolin, isolated and purified from , significantly attenuated BPF-induced lipid droplet deposition in HepG2 cell and NAFLD-like changes in mice by blocking the expression of lipogenesis-associated proteins. Therefore, the present study elucidates the mechanisms underlying BPF-induced lipid accumulation in HepG2 cells, while also highlighting the potential of bellidifolin to mitigate BPF-induced NAFLD-like changes.

关键词： bellidifolin bisphenol F lipogenesis non-alcoholic fatty liver disease

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A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F

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The Journal of Biomedical Research 2024年第05期 451-463页

作者： Jing Xue Linwei Zhang Jingxian Tao Xuexue Xie Xi Wang Linlin wu Shuhu Du Ninghua Tan Yang Jin Jianming ju junting Fan jun Wang Fei Huan Rong Gao Key Laboratory of Modern Toxicology Ministry of Education Department of Toxicology School of Public HealthNanjing Medical University Taizhou Center for Disease Control and Prevention wuxi Center for Disease Control and Prevention School of Pharmacy Jiangsu Province Engineering Research Center of Antibody Drug Nanjing Medical University School of Traditional Chinese Pharmacy China Pharmaceutical University Department of Pharmaceutical Analysis School of Pharmacy Nanjing Medical University Laboratory of Quality and Metabolomics of Traditional Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Department of Hygienic Analysis and Detection Key Laboratory of Modern Toxicology Ministry of Education School of Public Health Nanjing Medical University

As a potential endocrine-disrupting chemical, bisphenol F(BPF) may cause nonalcoholic fatty liver disease(NAFLD)-like changes, but the mechanisms under its pathogenesis as well as the intervention strategies remain unclear. Using the electron microscopy technology, along with Lipid TOX Deep Red neutral and Bodipy 493/503staining assays, we observed that BPF treatment elicited a striking accumulation of lipid droplets in HepG2 cells,accompanied by an increased total level of triglycerides. At the molecular level, the lipogenesis-associated m RNAs and proteins, including acetyl-CoA carboxylase, fatty acid synthase, stearoyl-CoA desaturase-1,peroxisome proliferator-activated receptor gamma, and CCAAT-enhancer-binding proteins, increased significantly via the AMP-activated protein kinase(AMPK)-mammalian target of rapamycin(m TOR) signaling regulation in both in vitro and in vivo studies. Furthermore, the immunofluorescence results also showed the robust lipogenesis induced by BPF, evident in its ability to promote the translocation of sterol regulatory elementbinding protein-1c from the cytoplasm to the nuclei. To investigate the intervention strategies for BPF-induced NAFLD-like changes, we demonstrated that bellidifolin, isolated and purified from Swertia chirayita,significantly attenuated BPF-induced lipid droplet deposition in HepG2 cells and NAFLD-like changes in mice by blocking the expression of lipogenesis-associated proteins. Therefore, the present study elucidates the mechanisms underlying the BPF-induced lipid accumulation in HepG2 cells, while also highlighting the potential of bellidifolin to mitigate BPF-induced NAFLD-like changes.

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电化学法深度处理电厂脱硫废水

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电化学（中英文） 2024年第4期30卷 49-57页

作者：韦聚才易娟吴旭华中科技大学环境科学与工程学院湖北武汉430074 湖北华德莱节能减排科技有限公司湖北武汉430223

本文介绍了一种用于处理电厂脱硫废水的电聚浮+电解联合工艺深度,实现废水中SS、COD和氯离子的有效去除。通过线性伏安扫描法探究了电厂脱硫废水中亚硫酸根和氯离子在β-PbO_(2)电极表面的反应机理和相关动力学参数,以此验证了β-PbO_(2... 详细信息

本文介绍了一种用于处理电厂脱硫废水的电聚浮+电解联合工艺深度,实现废水中SS、COD和氯离子的有效去除。通过线性伏安扫描法探究了电厂脱硫废水中亚硫酸根和氯离子在β-PbO_(2)电极表面的反应机理和相关动力学参数,以此验证了β-PbO_(2)是良好的亚硫酸盐电催化氧化和电产活性氯的材料。实验室自制方形连续推流式电解槽,分为电聚浮段和电解段。电沉积法自制钛基β-PbO_(2)网状电极为电解阳极。若以《火电厂石灰石-石膏湿法脱硫废水水质控制指标》(DL/T 997-20006)COD排放标准为处理终点,3.5 V电解电压下某电厂脱硫废水处理能耗仅为10.78 kWh·m^(–3)。电解电压为4.0 V时,电解槽运行300 min可去除废水中的绝大多数的COD和氯离子,二者去除率分别为91.43%和92.98%。验证了工艺路线的技术可行性和经济可行性。

关键词：脱硫废水二氧化铅电催化 COD 亚硫酸脱氯

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