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Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis

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Journal of Integrative Medicine 2022年第2期20卷 173-181页

作者： ye-juan jia Tian-yu Li Peng Han Yu Chen Li-jia Pan Chun-sheng jia School of Acupuncture Moxibustion and TuinaHebei University of Chinese MedicineShijiazhuang 050200Hebei ProvinceChina

Objective:This study was done to determine the effects of different courses of moxibustion on a rat knee osteoarthritis(KOA)model,and explore the dose–effect relationship of moxibustion on KOA from the perspectives of intestinal flora and inflammatory ***:Wistar rats were randomly divided into five groups:normal,model,moxibustion for 2 weeks,moxibustion for 4 weeks and moxibustion for 6 weeks groups(n=5 each group).A KOA rat model was induced by monosodium iodoacetate,and moxibustion intervention was performed at the acupoints“Dubi”(ST35)and“Zusanli”(ST36),once every other *** changes in the cartilage of rat knee joints were assessed after intervention,and fecal samples were subjected to 16 S r RNA high-throughput sequencing for microbial diversity ***:Damage to the knee articular cartilage was obvious in the model group,which also had increased levels of pro-inflammatory factors,decreased levels of anti-inflammatory factors,and intestinal flora disorders with decreased *** degree of cartilage damage in the 4 and 6 weeks of moxibustion groups was significantly improved compared with the model *** 4 and 6 weeks of moxibustion groups also demonstrated reduced levels of interleukin-1βand tumor necrosis factor-a and increased levels of interleukin-10(P<0.05).Both the abundance and diversity of the intestinal flora were increased,approaching those of the normal *** of probiotics Eubacterium coprostanoligenes group and Ruminococcaceae UCG-014 increased,while that of the pathogenic bacteria Lachnospiraceae NK4 A136 group decreased(P<0.05).Although the abundance of Lachnospiraceae NK4 A136 group decreased in the 2 weeks of moxibustion group compared with the model group(P<0.05),there was no statistically significant difference in serum inflammatory factors,flora species diversity or degree of pathological damage compared with the model ***:Moxibustion treatment led to significant improvements in t

关键词： Knee osteoarthritis Different courses Moxibustion treatment Intestinal flora Inflammatory cytokines

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei ye Tao Song Shuai Huang jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-ye Hu Meng-Can Li Zi-jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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Heuristic algorithm based on the principle of minimum total potential energy(HAPE):a new algorithm for nesting problems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第11期12卷 860-872页

作者： Xiao LIU jia-wei ye School of Civil and Transportation Engineering South China University of Technology Guangzhou 510640 China

We present a new algorithm for nesting *** equally spaced points are set on a sheet,and a piece is moved to one of the points and rotated by an *** the point and the rotation angle constitute the packing attitude of the *** propose a new algorithm named HAPE(Heuristic Algorithm based on the principle of minimum total Potential Energy) to find the optimal packing attitude at which the piece has the lowest center of *** addition,a new technique for polygon overlap testing is proposed which avoids the time-consuming calculation of no-fit-polygon(NFP).The detailed implementation of HAPE is presented and two computational experiments are *** first experiment is based on a real industrial problem and the second on 11 published benchmark *** a hill-climbing(HC) search method,the proposed algorithm performs well in comparison with other published solutions.

关键词： Packing Cutting Nesting Irregular Heuristic algorithm Minimum total potential energy

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A more precise method to evaluate kinetic leakage of anion exchange resin used in condensate polishing of power plant

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Chinese Journal of Chemical Engineering 2021年第12期34卷 160-166页

作者： Tianping Wang Xuxiang jia Chunsong ye Department of Water Quality Engineering School of Power&Mechanical EngineeringWuhan UniversityWuhan 430072China

Sulfate mass transfer coefficient(MTC) is a sensitive parameter to evaluate the kinetic leakage of anion exchange resin used in condensate polishing system of thermal and nuclear power ***,a sufficiently precise determination method has not been well *** this paper,the final expression of sulfate MTC derived based on plug flow reactor model is the same as Harries' model,which is widely acknowledged in this *** the determining system we constructed,in-situ calibration of the concentration of sulfate and its cation conductivity was conducted and sulfate MTCs of four typical strongly basic anion exchange resin samples were *** systematic error is 8.26% and the calibrated curve used for quantifying sulfate is *** repeatability and reproducibility standard deviation are 0.05×10^(-4) m·s^(-1) and 0.07×10^(-4) m·s^(-1) respectively,which are lower than previous *** controlling test condition accurately,this study has developed a more precise sulfate MTC determining *** method provides a basis for further research.

关键词： Sulfate mass transfer coefficient(MTC) Anion exchange resin Kinetic leakage Condensate polishing Power plant

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A description of ophthalmic management of late recovered facial paralysis with patient-tailored procedures:a case report

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 668-670页

作者： Hui-Na Zhang jia-Jun Xie Qi Gao juan ye Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang UniversityZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhou 310003Zhejiang ProvinceChina

Dear Editor,We reported a case of a multidisciplinary therapy for late recovered facial paralysis 2y after the initial *** paralysis has an incidence of 20-30 people out of 100000 per year,and up to 1 in 60 people wil... 详细信息

关键词： has paralysis recovered

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Changes of crystallinity and spherulite morphology in isotactic polypropylene after rolling and heat treatment

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Journal of University of Science and Technology Beijing 2008年第4期15卷 514-520页

作者： juan jia Weimin Mao Dierk Raabe School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Max-Planck-Institut fur Eisenforschung Max-Planck-Str. 1 Düsseldorf 40237 Germany

The spherulite morphology of the rolled and subsequent heat-treated isotactic polypropylene （iPP） was observed by polarized microscopy, and the crystallinity evolution of materials was also measured by the wide angle X-ray scattering （WAXS）. Rolling led to the oblate spherulites in the deformed iPP samples. The sheared crystalline lamellae broke apart into sets of crystalline blocks during rolling. As a result, the crystallinity of the iPP samples was greatly reduced during deformation, which induced the unclear spherulites and spherulite boundaries. Subsequent heat treatment resulted in the strong reerystallization of the rolled iPP samples. But the recrystaUizatinn in this work only meant the rearrangement of the macromolecule along the unbroken crystalline lamellae and the existing small crystalline blocks in the deformed spherulites. Heat treatment did not change the shape of the spherulites formed during deformation. The recrystallization also resulted in very clear spherulites and spherulite boundaries.

关键词： isotaetic polypropylene (iPP) rolling heat treatment X-ray diffraction crystallinity spherulites

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Minimal Representations of Cuntz Algebras

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Acta Mathematica Sinica,English Series 2020年第7期36卷 749-764页

作者： Ling juan ye Li Ning jiaNG School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081P.R.China

Suppose that O_n(2 ≤ n ≤∞) is a Cuntz algebra. There exists a number 1 ≤ k(π, Ω) ≤∞such that if the cyclic representations(H, π, Ω) and(H, π, Ω) of the Cuntz algebra O_n are unitary equivalent, k(π, Ω) = k(π, Ω). Applying the number, one can define a minimal representation of O_n and give a sufficient condition of the minimality for a representation of O_n. Moreover, the relations between minimal states and minimal representations of Cuntz algebras and the relations between the minimality and the irreducibility of the representation of O_n are investigated, respectively.

关键词： algebra. O_n representation

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Boundedness and liveness enforcement for labeled Petri nets using transition priority

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Journal of Electronic Science and Technology 2023年第4期21卷 75-90页

作者： ye-jia Liu Xun-Bo Li School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu611731China

This paper deals with the supervisory control problem of discrete event systems modeled by labeled Petri nets. The system is originally unbounded. First, the solvability of the problem is confirmed. A necessary condition is given and proven for the existence of a feasible priority-based controller based on the notions of liveness and transition invariants. Next, a cyclic behavior graph is constructed, which shows the reachable markings that guarantee the maximum liveness of the system within a given bound vector. Finally, an on-line control strategy is proposed to enforce boundedness and liveness to the given system by appending priority relations to transitions. The dynamic priority relation changes flexibly according to the current state of the system and enforces the system evolving in a bounded and live manner. In addition, numerical examples are studied to verify the validity of the proposed approach that remains the structure of the plant net and is efficient for on-line control.

关键词： Boundedness Control strategy Liveness Petri nets Priority Transition invariant

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Correlation between blepharospasm and psychological diseases:the anxiety,depression and sleep disorder study

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International Journal of Ophthalmology(English edition) 2024年第11期17卷 2007-2013页

作者： Hui-Na Zhang Qi Gao jia-Jun Xie juan ye Eye Center of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

AIM:To investigate the relationship between benign essential blepharospasm(BEB)symptoms and depression/anxiety/sleep disorder in a prospective manner and to determine whether treatment the BEB with botulinum toxin type A(BoNT/A)can impact psychological ***:This prospective interventional case series recruited 61 adults with evidence of *** were administered the Jankovic Rating Scale(JRS),the Blepharospasm Disability Index(BSDI),Personal Health Questionnaire Depression Scale(PHQ-8),Generalized Anxiety Disorder 7-item scale(GAD-7)and the Athens insomnia scale(AIS)to evaluate the severity of BEB symptoms,depression,anxiety and sleep disorder before and 1wk,1,3mo after the BoNTA *** analysis was performed to assess the relationships between changes in the survey ***:The mean score for JRS,BSDI,PHQ-8,and GAD-7 improved significantly(P<0.0001),respectively,compared to the initial visit at *** baseline,worse BSDI scores were correlated with worse GAD-7 and PHQ-8,but not with worse *** 1mo follow-up visit,there was no correlation between change in BSDI and PHQ-8/AIS,the change in GAD-7 showed a mild association with change in *** change in BSDI was correlated with the change in both PHQ-8 and GAD-7 in the subgroup of patients without a prior diagnosis of depression or *** satisfaction with BoNT/A treatment reached the highest at 1mo of follow-up(83.6%,51/61).CONCLUSION:BEB may lead to psychological ***/A can significantly improve motor and non-motor symptoms of BEB,which emphasize the effectiveness of BoNT/A and therefore pave the way for its use in the field of ***,further research is needed to confirm these findings and understand the underlying mechanisms.

关键词： blepharospasm psychological diseases sleep disorder botulinum toxin type A

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