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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Enhancement of Sensitivity for Determination of Phenols in Environmental Water Samples by Single-drop Liquid Phase Microextraction Using Ionic Liquid prior to HPLC

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Chinese Chemical Letters 2006年第8期17卷 1073-1076页

作者： Qing xiang ZHOU Jun Ping xiao Cun Ling ye Xin Ming WANG School of Chemistry and Environmental Sciences Henan Key Laboratory for Environmental Pollution Control Henan Normal University Xinxiang 453007 Department of Chemistry University of Science and Technology Beijing Beijing 100083 State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640

A single-drop liquid phase micro-extraction procedure using 1-butyl-3-methylimidazolium hexafluorophosphate （[C4MIM][PF6]） was demonstrated for the sensitive determination of four phenols in water samples. Under the optimized conditions, the linear range of proposed method was excellent in the range of 0.5-100 μg·L^-1, the reproducibility （RSD, n=6） were in the range 5.4%-8.9% and detection limits （S/N=3） were 0.3, 0.3, 0.5 and 0.5 μg·L^-1 for 2, 4-dichlorophenol, 2-naphthol, 2-nitrophenol and 4-chlorophenol, respectively. The experimental results indicated that the effect of complex matrices natural water samples could be resolved with addition of sodium ethylene diamine tetracetate （EDTA） into the samples. Excellent spiked recoveries were achieved for these four phenols ranged from 86.2%-114.9 %. All these facts demonstrated that the proposed method with merits of low cost, simplicity and easy operating would be a competitive alternative procedure for the determination of such compounds at trace level.

关键词： 1-Butyl-3-methylimidazolium hexafluorophosphate single-drop liquid phase microextraction phenols.

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Proton antagonist membrane towards exclusive CO_(2)reduction

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Nano Research 2023年第4期16卷 4589-4595页

作者： Taishi xiao Yao Ma Shicheng Zeng xiang Yao Tong ye Hongbin Li Wei Li Zhengzong Sun Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200433China School of Microelectronics and State Key Laboratory of ASIC and System Fudan UniversityShanghai 200433China

Membrane electrode assembly reactor offers great promise toward practical CO_(2)***,traditional proton exchange membrane possesses strong acidic chemical environment,which facilitates undesired hydrogen evolution *** we report a proton antagonist strategy,through which the proton diffusion pathways have been severely impeded by Na+cation to produce an alkaline-rich *** this new membrane electrode assembly,we can significantly suppress the hydrogen evolution and achieve a Faradaic efficiency of 95.7%for CO with 51.5%energy *** addition,our proton antagonist membrane outperforms the commercial anion exchange membrane in both conductivity and oxidation resistance lifetime,which are crucial for large scale electrolysis of carbon neutral chemicals.

关键词： CO_(2)reduction proton antagonist membrane electrode assembly

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Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

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Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu xiaomin Xu xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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Properties of Fe-Mn-Al alloys with different Mn contents using density functional theory

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Rare Metals 2023年第4期42卷 1387-1397页

作者： xiang Luo Jing Feng Ya-Hui Liu Ming-Yu Hu xiao-Yu Chong ye-Hua Jiang Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China

The chemical stability,electronic structures,mechanical properties and Debye temperature of Fe-MnAl alloys were investigated using first-principles *** formation enthalpy and cohesive energy are negative for Fe-Mn-Al alloys,showing that they are thermodynamically *** has the lowest formation enthalpy,indicating that FeAl is the most stable alloy in the Fe-Mn-Al *** partial density of states,total density of states and electron density distribution maps were used to analyze the physical properties of the Fe-MnAl alloys.A combination of mainly covalent and metallic bonds exists in these Fe-Mn-Al alloys,resulting in good electronic conductivity,high melting points,and high *** alloys display disparate anisotropy due to the calculated different shapes of the 3D curved surface of the Young's modulus and anisotropic *** has the highest bulk modulus,shear modulus and Yong's modulus of 187.1,119.8 and 296.2 GPa,***,the Debye temperatures and sound velocity of these Fe-Mn-Al compounds were explored.

关键词： Fe-Mn-Al alloys Electronic structures Stability Mechanical properties Debye temperature First-principles calculation

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Geometric effects of cross sections on equilibrium of helical and twisted ribbon

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Applied Mathematics and Mechanics(English Edition) 2017年第4期38卷 495-504页

作者： ye xiao Zaixing HUANG State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

In the framework of elastic rod model, the Euler-Lagrange equations characterizing the equilibrium configuration of the polymer chain are derived from a free energy functional associated with the curvature, torsion, twisting angle, and its derivative with respect to the arc-length. The configurations of the helical ribbons with different cross-sectional shapes are given. The effects of the elastic properties, the cross-sectional shapes, and the intrinsic twisting on the helical ribbons are discussed. The results show that the pitch angle of the helical ribbon decreases with the increase in the ratio of the twisting rigidity to the bending rigidity and approaches the intrinsic twisting. If the bending rigidity is much greater than the twisting rigidity, the bending and twisting of the helical ribbon always appear simultaneously.

关键词： Euler-Lagrange equation twisting angle pitch angle elastic rod model helical and twisted ribbon

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Closed Strong Spacelike Curves, Fenchel Theorem and Plateau Problem in the 3-Dimensional Minkowski Space

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Chinese Annals of Mathematics,Series B 2019年第2期40卷 217-226页

作者： Nan ye xiang MA College of Mathematics and Econometrics Hunan University LMAM School of Mathematical Sciences Peking University

The authors generalize the Fenchel theorem for strong spacelike closed curves of index 1 in the 3-dimensional Minkowski space, showing that the total curvature must be less than or equal to 2π. Here the strong spacelike condition means that the tangent vector and the curvature vector span a spacelike 2-plane at each point of the curve γ under consideration. The assumption of index 1 is equivalent to saying that γ winds around some timelike axis with winding number 1. This reversed Fenchel-type inequality is proved by constructing a ruled spacelike surface with the given curve as boundary and applying the Gauss-Bonnet formula. As a by-product, this shows the existence of a maximal surface with γ as the boundary.

关键词： Fenchel theorem Spacelike curves Total curvature Maximal surface

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Transport of phosphorus in runoff and sediment with surface runoff from bare purple soil during indoor simulated rainfall

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Journal of Mountain Science 2022年第8期19卷 2333-2345页

作者： MA xiao YANG Jie ZHOU xiang-jun WU Hong-tao XIONG Qiao LI ye College of Urban and Environmental Sciences Hubei Normal UniversityHuangshi 435002China Hubei Key Laboratory of Pollutant Analysis&Reuse Technology Hubei Key Research Institute of Humanities&Social ScienceHuangshi 435002China School of Resource and Environmental Engineering Wuhan University of TechnologyWuhan 430070China

Phosphorus(P)in surface runoff from purple soil is a critical element of agricultural nonpoint source pollution,leading to eutrophication of surface waters in the Three Gorges Reservoir Area(TGRA)of *** work aimed to understand the processes and mechanisms of P losses from bare purple *** on an indoor rainfall simulation experiment,we focused on the processes of surface runoff and P losses via different hydrological *** treatments included three simulated rainfall intensities,four slope gradients,and three fertilizer treatments.P loss from sediment was the main pathway in the purple soil,and bioavailable P was mainly transferred in dissolved P(DP)of runoff *** P loss loads tend to grow with the increase of the slope until 25°for the maximum load of runoff water and 20°for the maximum load of *** of DP in the surface runoff after fertilizer application can exceed the estimates of those required for accelerated *** P control might be an essential way for reducing P loss in purple soil for the local government and farmers of TGRA.

关键词： Surface runoff Sediment yield Phosphorus loss Purple soil Simulated rainfall

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负载纳米钽的液晶显示光固化聚乳酸支架制备及促成骨性能

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中国组织工程研究 2025年第4期29卷 670-677页

作者：李明哲叶翔凌王冰余翔南阳医学高等专科学校针灸骨伤系河南省南阳市473000 广州中医药大学东莞医院广东省东莞市523888 广州中医药大学第一附属医院广东省广州市510405 广东省中医临床研究院广东省广州市510405

背景:聚乳酸因具有良好的生物相容性和可控的降解速率在生物医学工程中得到了广泛应用,然而存在机械强度低和生物活性不足等缺陷,限制了其在骨组织工程中的进一步应用。目的:构建聚乳酸/聚多巴胺/钽(PLA/PDA/Ta)骨组织工程支架,探究其... 详细信息

背景:聚乳酸因具有良好的生物相容性和可控的降解速率在生物医学工程中得到了广泛应用,然而存在机械强度低和生物活性不足等缺陷,限制了其在骨组织工程中的进一步应用。目的:构建聚乳酸/聚多巴胺/钽(PLA/PDA/Ta)骨组织工程支架,探究其生物安全性和体外促成骨性能。方法:利用液晶显示光固化技术制备具有多孔结构的聚乳酸(PLA)支架,将PLA支架分别浸泡在多巴胺溶液与多巴胺-纳米钽混合溶液中分别制备聚乳酸/聚多巴胺(PLA/PDA)支架、PLA/PDA/Ta支架,表征支架的微观形貌与水接触角。将MC3T3-E1细胞分别与PLA、PLA/PDA、PLA/PDA/Ta支架共培养,进行CCK-8检测与活/死细胞染色;成骨诱导分化后,进行碱性磷酸酶、茜素红染色及成骨基因检测。结果与结论:①扫描电镜下可见3种支架均具有互连的多孔三维结构,平均孔径为200μm;PLA/PDA/Ta支架的水接触角低于PLA、PLA/PDA支架(P<0.05);②CCK-8检测显示,相较于PLA、PLA/PDA支架,PLA/PDA/Ta支架可促进细胞的增殖(P<0.05);活/死细胞染色显示3组细胞增殖良好;③碱性磷酸酶与茜素红染色显示,相较于PLA、PLA/PDA支架,PLA/PDA/Ta支架可促进细胞碱性磷酸酶的表达与矿化结节形成;RT-qPCR检测显示,相较于PLA、PLA/PDA支架,PLA/PDA/Ta支架可促进细胞骨形态发生蛋白、Runx-2及Ⅰ型胶原mRNA的表达(P<0.05,P<0.01);④结果表明,PLA/PDA/Ta支架具有优异的促细胞增殖与成骨活性。

关键词：液晶显示光固化打印聚乳酸聚多巴胺纳米钽 MC3T3-E1细胞骨组织工程支架

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