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心脑血管病患者CT增强检查中非离子型碘对比剂相关急性不良反应预测模型的构建

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中国CT和MRI杂志 2024年第4期22卷 13-16页

作者：宋卉曾超廖凯叶佳雨四川大学华西医院放射科/四川大学华西护理学院四川成都610041 自贡市第四人民医院急诊科四川自贡643000

目的探究心脑血管病患者CT增强检查中非离子型碘对比剂相关急性不良反应(ICM-AARs)预测模型构建的价值。方法选取2023年1月~2023年5月期间于四川大学华西医院进行CT增强检查的心脑血管病患者2031例,统计ICM注射后1h内AARs的发生情况,从2... 详细信息

目的探究心脑血管病患者CT增强检查中非离子型碘对比剂相关急性不良反应(ICM-AARs)预测模型构建的价值。方法选取2023年1月~2023年5月期间于四川大学华西医院进行CT增强检查的心脑血管病患者2031例,统计ICM注射后1h内AARs的发生情况,从2031例患者中选取符合纳入标准的未发生AARs的患者174例,纳入未发生ICM-AARs组,发生AARs的患者58例纳入ICM-AARs组,收集并比较两组患者临床资料,采用Logistic回归分析明确导致心脑血管病患者CT增强检查中发生AARs的危险因素。应用独立危险因素构建列线图预测模型,并采用受试者工作特征曲线(ROC)、Bootstrap法验及Calibration曲线对模型进行评价。结果2031例心脑血管病患者进行CT增强检查中发生ICM-AARs 58例,ICM-AARs发生率为2.86%;ICM-AARs组有过敏史、检查前未水化、未外预热、注射速率≥3.5mL/s、静脉注射及使用碘普罗胺的人数占比均高于未发生ICM-AARs组(P<0.05);Logistic回归分析结果显示,有过敏史、检查前未水化、未外预热、注射速率≥3.5mL/s、静脉注射及使用碘普罗胺是影响CT增强检查发生ICM-AARs的独立危险因素(P<0.05);ROC曲线显示,预测模型曲线下面积(AUC)为0.765(95%CI:0.706~818),灵敏度89.66%、特异度81.03%、约登指数0.706;Bootstrap法验证结果显示,C-index值为0.779(95%CI:0.713~0.861);Calibration曲线结果显示,Hosmer-Lemeshowχ^(2)=0.708,P=0.295。结论有过敏史、检查前未水化、未外预热、注射速率≥3.5mL/s、静脉注射及碘普罗胺均为心脑血管病患者CT增强检查中发生ICMAARs的独立危险因素,上述因素构建的列线图预测模型对ICM-AARs具有较高的预测效能。

关键词：心脑血管病 CT增强检查非离子型碘对比剂对比剂相关急性不良反应预测列线图

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风电场功率预测的研究进展及发展趋势

排灌机械工程学报 2024年第8期42卷 778-784,817页

作者：李根银郁冶王异成何嘉桦王强罗坤樊建人浙江浙能国电投嵊泗海上风力发电有限公司浙江舟山202450 国家电投集团浙江新能源有限公司浙江杭州310016 杭州意能电力技术有限公司浙江杭州310027 浙江大学能源高效清洁利用全国重点实验室浙江杭州310027 浙江省清洁能源与碳中和重点实验室浙江杭州310027

风电场功率预测可以有效地帮助平衡系统电力供应和负荷需求,从而降低风电功率波动性和不确定性对电力系统稳定性的影响.随着风电接入电力系统比例的增加,如何准确地预测风电场发电功率成为一大难点,将影响风电场并网运行.由此,系统总结... 详细信息

风电场功率预测可以有效地帮助平衡系统电力供应和负荷需求,从而降低风电功率波动性和不确定性对电力系统稳定性的影响.随着风电接入电力系统比例的增加,如何准确地预测风电场发电功率成为一大难点,将影响风电场并网运行.由此,系统总结了近些年来国内外学者在风电场功率预测方面的研究进展.首先,以预测时间尺度、预测物理量、预测原理、预测特点为分类标准,对多种风电场功率预测方法进行了分类梳理,总结了各类预测方法的研究情况,阐述了其特点及应用场景,为预测模型的选择提供了参考.之后,从单点预测、概率预测、预测曲线的角度总结了预测效果的评价指标,并就评价指标的选择给出建议.最后,总结了当前风电场功率预测全过程遇到的影响预测准确性、实用性的关键因素,提出了未来风电场功率预测可能的发展趋势,为准确预测风电场功率及电网的稳定并网运行提供了参考.

关键词：风电场功率预测评价指标研究进展发展趋势

A biomimetic adipocyte mesenchymal stem cell membrane-encapsulated drug delivery system for the treatment of rheumatoid arthritis

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Nano Research 2023年第8期16卷 11401-11410页

作者： Chaoyu Gu Shaoying Yang Xuesong Liu Yi Jin ye yu Liangjing Lu Department of Rheumatology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001China

Rheumatoid arthritis(RA)is a chronic,progressive,and inflammatory systemic autoimmune *** drug therapy for RA is hindered by severe side effects due to inefficient delivery to the disease site and broad drug *** by biomimetic biology,this study developed a drug delivery system of adipose-derived mesenchymal stem cell membrane-encapsulated nanoparticles for the treatment of *** intact adipose-derived mesenchymal stem cell(ADSC)membrane was coated on poly(lactic-co-glycolic acid)(PLGA)nanoparticles and loaded with tacrolimus(FK506),a T cell *** ADSC membrane encapsulated on nanoparticles retains the original homing properties of ADSC,targeting the inflamed joints and enhancing tacrolimus anti-inflammatory *** in vitro and in vivo experiments proved that the synergistic effect of the ADSC-membrane and tacrolimus effectively inhibited inflammation in vivo and reduced the expression of pro-inflammatory factors(IL-1β,IL-6,tumor necrosis factor-α(TNF-α)),and increased the expression of anti-inflammatory factors(IL-10).In addition,collagen-induced arthritis(CIA)model results also showed that the drug delivery system could effectively reduce the destruction of articular cartilage and bone in mice without causing any adverse *** study provided a new biomimetic targeting strategy to reshape the inflammatory microenvironment by modulating T cell subsets,providing new inspiration for RA treatment.

关键词： adipose mesenchymal stem cell tacrolimus drug delivery system rheumatoid arthritis

High cycle fatigue behavior of titanium microalloyed high-strength beam steels

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Journal of Iron and Steel Research(International) 2023年第11期30卷 2267-2279页

作者： Zhi-jun Gao Guang-fei Pan yu Song Shui-ze Wang Xiao-yu ye Xin-ping Mao Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing100083China Pangang Group Research Institute Co. Ltd.State Key Laboratory of Vanadium and Titanium Resources Comprehensive UtilizationPanzhihua617000SichuanChina Guangdong Laboratory for Materials Science and Technology Yangjiang Branch(Yangjiang Advanced Alloys Laboratory)Yangjiang529500GuangdongChina

The realization of an ideal combination of mechanical and fatigue properties is prerequisites for practical application of titanium(Ti)microalloyed steel in automotive *** fatigue behavior of four Ti microalloyed high-strength beam steels with different Ti contents was systematically *** results show that the content of microalloying element Ti has a significant effect on the fatigue properties,especially in the steel with a high Ti *** the experimental Ti microalloyed steel,inclusion-induced crack initiation is the main fatigue failure *** from general fatigue fracture mechanism in Ti-contained steel,no TiN,which is the most detrimental to fatigue behavior,was found in fatigue crack initiation ***,the large-sized TiN and oxide complex inclusion with a core-shell structure is the dominant cause of fatigue *** of the intense-localized deformation at the interface between complex inclusion and matrix,the angular TiN in the outer shell has a serious deteriorating effect on the fatigue properties,which is consistent with the result of the Kernel average misorientation ***,the modification effect of a small amount of MnS on large-sized inclusion is not obvious and has little effect on the fatigue *** more practical guidance,the critical inclusion sizes of the experimental steels were also investigated by experimental extrapolation *** the increasing tensile strength,the inclusion sensitivity of the experimental steels increases,leading to the small critical inclusion size.

关键词： Titanium microalloyed steel High cycle fatigue Fatigue fracture Critical inclusion size

人民城市理念下的数字化城市体检探索——基于多源时空数据

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西部人居环境学刊 2024年第3期39卷 35-42页

作者：叶宇黄成成陈昶宇韩赟陈志洋孙拓同济大学建筑与城市规划学院香港大学中国香港腾讯云计算(北京)有限责任公司

随着城市体检在城市更新与治理中的重要性日益凸显,既有城市体检的不足也日益明确。既有工作框架一方面存在人本化考量不足的问题,多为自上而下的分析视角且数据时空精度受限;另一方面缺乏数字化的通用性架构,难以适应新时期精细化的分... 详细信息

随着城市体检在城市更新与治理中的重要性日益凸显,既有城市体检的不足也日益明确。既有工作框架一方面存在人本化考量不足的问题,多为自上而下的分析视角且数据时空精度受限;另一方面缺乏数字化的通用性架构,难以适应新时期精细化的分析需求。本研究一方面基于2022版住建部城市体检指标体系,探索在多源时空大数据支持下,融入人民城市理念,拓展和优化人本化体检指标体系;另一方面探索数字化城市体检云平台建构,满足动态监测、标准口径和实时交互需求,从而实现城市体检的理论创新、技术创新和治理创新。最后以徐汇滨江某片区为例,展示该平台的应用。本研究为人民城市理念下的数字化城市体检提供了新思路,是数字技术促进城市体检范式创新的有益尝试。

关键词：城市体检人民城市人本化数字化多源时空数据

基于谱效关系的续断盐制前后对肾阳虚大鼠的物质基础研究

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中国中药杂志 2024年第12期49卷 3220-3228页

作者：方可儿张海瑞竹炳叶宇陈磊杜伟锋葛卫红浙江中医药大学药学院浙江杭州311402 浙江中医药大学中药炮制技术研究中心浙江杭州311401 浙江中医药大学中药饮片有限公司浙江杭州311401

研究续断盐制前后指纹图谱与温补肾阳药效之间的谱效关系,寻找续断盐制前后抗肾阳虚的主要活性成分,为明确盐制对肾阳虚药效的影响提供依据。采用HPLC-DAD建立了续断盐制前后HPLC指纹图谱,得到15个共有峰,并指认了11个成分。检测大鼠血... 详细信息

研究续断盐制前后指纹图谱与温补肾阳药效之间的谱效关系,寻找续断盐制前后抗肾阳虚的主要活性成分,为明确盐制对肾阳虚药效的影响提供依据。采用HPLC-DAD建立了续断盐制前后HPLC指纹图谱,得到15个共有峰,并指认了11个成分。检测大鼠血清中多种成分含量的含量变化,比较续断盐制前后的药效差异。药理实验结果表明续断盐制后能够增强肾指数,同一剂量下,生续断和盐续断组间有显著差异;与模型组相比,给药组的大鼠血清中促肾上腺皮质激素(ACTH)、环磷酸腺苷(cAMP)、皮质酮(CORT)、雌二醇(E_2)、生长激素(GH)、Na^(+)-K^(+)-ATP酶(Na^(+)-K^(+)-ATPase)、睾酮(T)、甲状腺素(T4)含量均有一定程度上升,环磷酸鸟苷(cGMP)、肿瘤坏死因子(TNF-α)含量均有一定程度下降,其中生续断高剂量组、盐续断中剂量组、盐续断高剂量组和阳性药组大鼠血清中以上指标均有显著性差异,整体结果表明盐续断抗肾阳虚药效强于生续断。采用灰色关联分析、熵值法和皮尔逊相关性分析法对续断药效进行评价,筛选出盐制续断抗肾阳虚药效的成分。根据关联度排序变化结果得,续断盐制前后排名上升的成分为马钱苷、绿原酸、续断苷A、川续断皂苷Ⅵ、咖啡酸、异绿原酸B,初步推测这些化合物可能是续断盐制前后治疗肾阳虚的潜在药效成分。确定了续断盐制前后变化的成分,证明了盐续断在治疗肾阳虚方面优于续断,建立了续断盐制前后与治疗肾阳虚的药效之间的谱效关系,为后续对盐制续断的药效成分及分子机制研究奠定了基础。

关键词：续断盐制谱效关系指纹图谱肾阳虚灰色关联度

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Global precipitation change during the Holocene:a combination of records and simulations

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Frontiers of Earth Science 2024年第1期18卷 112-126页

作者： Wangting ye yu LI Key Laboratory of Western China᾽s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesCenter for Hydrologic Cycle and Water Resources in Arid RegionLanzhou UniversityLanzhou 730000China

Precipitation can shape our climate both in the present and the *** though we have made significant advances in studying the mechanisms of millennial-scale climate changes through high-resolution records,we still cannot quantitatively characterize the global spatiotemporal precipitation variations within the ***,we developed a new approach to integrating data from 349 globally distributed records and climate models to reconstruct regional and global precipitation patterns over the last 12000 *** results reveal that precipitation reconstructions can be divided into monsoon-driven and westerly driven *** results suggest that an arid climate was experienced in the late glacial and early Holocene epoch(~12−7.4 cal ka BP),attaining a middle Holocene optimum(~7.4−3.5 cal ka BP),and drier after the middle *** to our reconstructions,the global precipitation reconstruction increased from the early Holocene until 3.8 cal ka BP and then subsequently *** addition,our reconstructions better reproduce the low-frequency events and extreme precipitation at the millennial scale in the hemispheres,but the performance of the reconstructions in the equatorial Pacific and the Southern Hemisphere of Africa and the Americas is *** resolution of the record and the simulation capability of the climate model remain important means to improve our understanding of past climate change.

关键词： Holocene equatorial glacial

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介入治疗纵隔型支气管动脉瘤破裂1例

中国临床医学影像杂志 2024年第1期35卷 67-68页

作者：王一焯周方程潘建军肖叶玉广州市中西医结合医院广东广州510000

病例男,62岁,主诉:反复咳嗽1年,加重伴胸痛1天。患者1年前无明显诱因出现咳嗽,咳少量白色痰,1天前咳嗽加重,出现阵发性胸痛,呼吸时疼痛加重,无咯血、咽痛、鼻塞、流涕。入院查体:双肺呼吸音粗,左下肺闻及湿罗音。急诊胸部CT平扫提示左... 详细信息

病例男,62岁,主诉:反复咳嗽1年,加重伴胸痛1天。患者1年前无明显诱因出现咳嗽,咳少量白色痰,1天前咳嗽加重,出现阵发性胸痛,呼吸时疼痛加重,无咯血、咽痛、鼻塞、流涕。入院查体:双肺呼吸音粗,左下肺闻及湿罗音。急诊胸部CT平扫提示左肺下叶支气管扩张并感染,中纵隔迂曲血管影伴纵隔、左侧胸腔积血;胸部CTA检查提示左侧支气管动脉瘤(Bronchial artery aneurysm,BAA)破裂伴纵隔血肿(图1~3)。

关键词：支气管肿瘤动脉瘤放射摄影术,介入性

A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-Qi yu Tao yu Jian-Hua ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)