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A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning

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International Journal of Oral Science 2024年第3期16卷 425-435页

作者： Kai Sun Miao Yu Jiayu Wang Hu Zhao Haochen liu hailan Feng Yang liu Dong Han Department of Prosthodontics Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Chinese Institute for Brain Research BeijingChina

Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted teeth,known as taurodontism;thus,indicating the critical role of Wnt10a in tooth root ***,the endogenous mechanism by which epithelial Wnt10a regulates Hertwig’s epithelial root sheath(HERS)cellular behaviors and contributes to root furcation patterning remains *** this study,we found that HERS in the presumptive root furcating region failed to elongate at an appropriate horizontal level in K14-Cre;Wnt10a^(fl/fl)mice from post-natal day 0.5(PN0.5)to *** assays and immunofluorescent staining of cyclin D1 revealed significantly decreased proliferation activity of inner enamel epithelial(IEE)cells of HERS in K14-Cre;Wnt10a^(fl/fl)mice at PN2.5 and *** staining of E-Cadherin and acetyl-α-Tubulin demonstrated that the IEE cells of HERS tended to divide perpendicularly to the horizontal plane,which impaired the horizontal extension of HERS in the presumptive root furcating region of K14-Cre;Wnt10a^(fl/fl)***-seq and immunofluorescence showed that the expressions of Jag1 and Notch2 were downregulated in IEE cells of HERS in K14-Cre;Wnt10a^(fl/fl)***,after activation of Notch signaling in K14-Cre;Wnt10a^(fl/fl)molars by Notch2 adenovirus and kidney capsule grafts,the root furcation defect was partially *** together,our study demonstrates that an epithelial Wnt10a-Notch signaling axis is crucial for modulating HERS cell proper proliferation and horizontal-oriented division during tooth root furcation morphogenesis.

关键词： Wnt10a Notch impaired

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The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication

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Molecular Plant 2020年第2期13卷 309-320页

作者： Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo yawenyang-hailan liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou State Key Laboratory of Exploration and Utilization of Crop Gene Resources in Southwest China Key Laboratory of Biology and Genetic Improvement of Maize in Southwest RegionMinistry of AgricultureMaize Research Institute of Sichuan Agricultural UniversityChengdu 611130China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesState Key Laboratory Breeding Base of Dao-di HerbsBeijing 100700China Tobacco Research Institute of Chinese Academy of Agricultural Sciences Qingdao 266101China Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610064China College of Agronomy Liaocheng UniversityLiaocheng 252000China Biomarker Technologies Corporation Beijing 101300China

Coix is a grass crop domesticated as early as the Neolithic *** is still widely cultivated for both highly nutritional food and medicinal ***,the genetic study and breeding of this crop are hindered by the lack of a sequenced ***,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding *** genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in *** further constructed a genetic map and mapped several important traits,especially the strength of *** of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix *** papery hull makes seed easier to process and *** and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall *** also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,*** two QTLs were further fine mapped within intervals of 250 kb and 146 kb,*** resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop.

关键词： Coix genome Comparative genomics Panicoideae evolution hull domestication QTL mapping

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Recent Developments of Photodeformable Polymers:From Materials to Applications

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Research 2024年第2期2023卷 729-752页

作者： Shuting Kong hailan Wang Eethamukkala Ubba Yuxin Xiao Tao Yu Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)Northwestern Polytechnical University127 West Youyi RoadXian 710072China OMC Research Laboratory.Department of Chemistry School of Advanced SciencesVITVelloreTamilnaduIndia Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China

Photodeformable polymer materials have a far influence in the fields of flexibility and *** stimulation energy is converted into mechanical energy through molecular *** kinds of photodeformable polymer materials,liquid crystalline polymer(LCP)photodeformable materials have been a hot topic in recent *** such as azobenzene,a-cyanostilbene,and 9,10-dithiopheneanthracene have been widely used in LCP,which are helpful for designing functional molecules to increase the penetration depth of light to change physical *** to the various applications of photodeformable polymer materials,there are many excellent reports in intelligent *** this review,we have systematized LCP containing azobenzene into 3 categories depending on the degree of crosslinking liquid crystalline elastomers,liquid crystalline networks,and linear *** structural,typical polymer materials and their applications are *** issues faced and future directions to be developed for photodeformable polymer materials are also summarized.

关键词： properties. field. crystalline

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Dual-channel mechano-phosphorescence:a combined locking effect with twisted molecular structures and robust interactions

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Light(Science & Applications) 2024年第4期13卷 738-746页

作者： Zongliang Xie Zhu Mao hailan Wang Yuxin Xiao Xiayu Zhang Tao Yu Zhongfu An Wei Huang Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics&Xi’an Institute of Biomedical Materials and EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’an 710072China. Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518100China. Shenzhen Institutes of Advanced Electronic Materials Shenzhen 518100China. Key Laboratory of Flexible Electronics&Institute of Advanced Materials Nanjing Tech University30 South Puzhu RoadNanjing 211816China

Organic mechanoluminescence materials,featuring dual emission and ultralong phosphorescence characteristics,exhibit significant potential for applications in real-time stress sensing,pressure-sensitive lighting,advanced security marking techniques,and material breakage ***,due to immature molecular design strategies and unclear luminescence mechanisms,these materials remain rarely *** this study,we propose a valuable molecular design strategy to achieve dual-channel *** introducing the arylphosphine oxide group into a highly twisted molecular framework,enhanced intra-and intermolecular interactions could be achieved within rigid structures,leading to dual-channel mechanoluminescence with greatly promoted ultralong *** investigations reveal the substantial boosting effect of intra-and intermolecular interactions on mechanoluminescence and ultralong phosphorescence properties by locking the highly twisted molecular *** work provides a concise and guiding route to develop novel smart responsive luminescence materials for widespread applications in material science.

关键词： channel luminescence locking

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Effect of mutations on acetohydroxyacid synthase(AHAS)function in Cyperus difformis L.

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Journal of Integrative Agriculture 2024年第1期23卷 177-186页

作者： Xiaotong Guo Xiangju Li Zheng Li Licun Peng Jingchao Chen Haiyan Yu hailan Cui State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China

Cyperus difformis *** a troublesome weed in paddy fields and has attracted attention due to its resistance to acetohydroxyacid synthase(AHAS)*** was found that the amino acid mutation in AHAS was the primary cause for the resistance of Cyperus ***,the effect of different mutations on AHAS function is not clear in Cyperus *** confirm the effect of mutations on AHAS function,six biotypes were collected,including Pro197Arg,Pro197Ser,Pro197Leu,Asp376Glu,Trp574Leu and wild type,from Hunan,Anhui,Jiangxi and Jiangsu provinces,China and the function of AHAS was *** AHAS in vitro inhibition assay results indicated that the mutations decreased the sensitivity of AHAS to pyrazosulfuron-ethyl,in which the I_(50)(the half maximal inhibitory concentration)of wild type AHAS was 0.04μmol L^(-1)and Asp376Glu,Pro197Leu,Pro197Arg,Pro197Ser and Trp574Leu mutations were 3.98,11.50,40.38,38.19 and 311.43μmol L^(-1),*** the determination of enzyme kinetics parameters,the Km and the maximum reaction velocity(Vmax)of the wild type were 5.18 mmol L^(-1)and 0.12 nmol mg^(-1)min^(-1),respectively,and the Km values of AHAS with Asp376Glu,Trp574Leu,Pro197Leu and Pro197Ser mutations were 0.38-0.93 times of the wild *** Km value of the Pro197Arg mutation was 1.14times of the wild type,and the Vmax values of the five mutations were 1.17-3.33-fold compared to the wild *** was found that the mutations increased the affinity of AHAS to the substrate,except for the Pro197Arg *** a concentration of 0.0032-100 mmol L^(-1)branched-chain amino acids(BCAAs),the sensitivity of the other four mutant AHAS biotypes to feedback inhibition decreased,except for the Pro197Arg *** study elucidated the effect of different mutations on AHAS function in Cyperus difformis and provided ideas for further study of resistance development.

关键词： acetohydroxyacid synthase(AHAS) mutation enzyme function Cyperus difformis

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Fuzzy C-Means Algorithm Based on Density Canopy and Manifold Learning

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Computer Systems Science & Engineering 2024年第3期48卷 645-663页

作者： Jili Chen hailan Wang Xiaolan Xie Guangxi Key Laboratory of Embedded Technology and Intelligent System Guilin541006China College of Information Science and Engineering Guilin University of TechnologyGuilin541004China

Fuzzy C-Means(FCM)is an effective and widely used clustering algorithm,but there are still some *** the number of clusters must be determined manually,the local optimal solutions is easily influenced by the random selection of initial cluster centers,and the performance of Euclid distance in complex high-dimensional data is *** solve the above problems,the improved FCM clustering algorithm based on density Canopy and Manifold learning(DM-FCM)is ***,a density Canopy algorithm based on improved local density is proposed to automatically deter-mine the number of clusters and initial cluster centers,which improves the self-adaptability and stability of the ***,considering that high-dimensional data often present a nonlinear structure,the manifold learning method is applied to construct a manifold spatial structure,which preserves the global geometric properties of complex high-dimensional data and improves the clustering effect of the algorithm on complex high-dimensional ***-Mallows Index(FMI),the weighted average of homogeneity and completeness(V-measure),Adjusted Mutual Information(AMI),and Adjusted Rand Index(ARI)are used as performance measures of clustering *** experimental results show that the manifold learning method is the superior distance measure,and the algorithm improves the clustering accuracy and performs superiorly in the clustering of low-dimensional and complex high-dimensional data.

关键词： Fuzzy C-Means(FCM) cluster center density canopy ISOMAP clustering

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基于YOLOv8n改进的蚕虫检测与计数方法

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农业工程学报 2024年第15期40卷 143-151页

作者：马小林王梦麟旷海兰唐亮刘新华武汉理工大学信息工程学院武汉430070 广西壮族自治区蚕业技术推广站南宁530007

为解决桑蚕养殖过程中对蚕虫计数的难题,特别是针对蚕虫目标小、分布密集且易被遮挡的问题。改研究提出了一种基于YOLOv8模型改进的蚕虫检测与计数新方法(SDM-YOLO)。该方法的核心创新包括:1)引入RCS-OSA模块作为残差模块,替代原YOLOv8... 详细信息

为解决桑蚕养殖过程中对蚕虫计数的难题,特别是针对蚕虫目标小、分布密集且易被遮挡的问题。改研究提出了一种基于YOLOv8模型改进的蚕虫检测与计数新方法(SDM-YOLO)。该方法的核心创新包括:1)引入RCS-OSA模块作为残差模块,替代原YOLOv8中的C2f模块,以增强网络的多尺度特征提取能力并融合不同感受野的信息,提升对密集分布蚕虫的识别能力;2)改造检测头为动态预测头(dynamic prediction head),结合尺寸、空间和通道三个维度的特征信息,提高蚕虫识别的精确度,减少误检;3)优化损失函数,采用EIOU LOSS作为边界框回归的损失函数,以改善密集场景下蚕虫目标的漏检问题。经过试验验证,SDM-YOLO方法在多个评估指标上均表现出色。具体而言,该方法在精确度上达到了88.2%,召回率为87.2%,平均准确度mAP@0.5为93.2%,而mAP@0.5:0.95也达到了74.7%。这些结果充分证明了与一阶段检测模型YOLO系列相比,SDM-YOLO在蚕虫检测与计数方面具有比较明显的优势。

关键词：目标检测通道混洗深度学习注意力机制损失函数

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《经典释文》异读字又音成因探析

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黑河学院学报 2024年第4期15卷 135-138页

作者：刘海兰长沙医学院湖南长沙410219

《经典释文》丰富的异读材料,不仅是音韵研究的重要语料载体,同时也反映了复杂的字际关系问题。书中的“又音”,除了语音演变导致的又音,还有诸多又音是在用字过程中产生的,对因假借、训读和同形而造成的又读现象进行了辨析。

关键词：《经典释文》异读字又音

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双氮源共掺杂木素碳量子点/有机溶剂水份探针的构建及性能

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光子学报 2024年第9期53卷 116-129页

作者：刘凯张培培胡妙言高诗雨连海兰徐长妍南京林业大学材料科学与工程学院南京210037

以木素为碳源,以盐酸为解聚剂,以邻苯二胺和尿素为氮掺杂剂,通过一锅水热法获得了碳量子点。该碳量子点的荧光量子产率为2.05%,其水溶液在紫外区具有明显的吸收,并表现出较强的溶剂依赖性。将其用于检测实验室常用的三种有机溶剂(乙醇、... 详细信息

以木素为碳源,以盐酸为解聚剂,以邻苯二胺和尿素为氮掺杂剂,通过一锅水热法获得了碳量子点。该碳量子点的荧光量子产率为2.05%,其水溶液在紫外区具有明显的吸收,并表现出较强的溶剂依赖性。将其用于检测实验室常用的三种有机溶剂(乙醇、N,N-二甲基甲酰胺和四氢呋喃)时,随着有机溶剂中水份含量的增加,发射光谱出现红移,且其荧光强度下降。在所构建的双氮源共掺杂木素碳量子点/有机溶剂水份荧光探针中,碳量子点的荧光强度与有机溶剂的水份含量存在良好的线性关系,对乙醇、N,N-二甲基甲酰胺和四氢呋喃中水份的检出下限分别为0.079%、0.075%和0.080%,并实现了可视化的水份检测。该研究结果可为有机溶剂中微量水份的检测提供理论和实验参考。

关键词：木质素碳量子点氮掺杂荧光探针可视化有机溶剂水份检测

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重点国有林区治理碎片化困境及破解对策——基于整体性治理理论的分析

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中国农村观察 2024年第5期 116-137页

作者：纪元赵海兰柯水发中国人民大学农业与农村发展学院国家林业和草原局发展研究中心中国社会科学院数量经济与技术经济研究所

在国家推动治理结构调整的过程中,重点国有林区实施的政企分开改革取得了一定成效,但也产生了治理碎片化问题,制约了林区的高质量发展。基于整体性治理理论,本文结合龙江森工集团有限公司和相关属地政府的林区治理实践,从主体、理念、... 详细信息

在国家推动治理结构调整的过程中,重点国有林区实施的政企分开改革取得了一定成效,但也产生了治理碎片化问题,制约了林区的高质量发展。基于整体性治理理论,本文结合龙江森工集团有限公司和相关属地政府的林区治理实践,从主体、理念、权责、机制、数据五个维度深入探究林区治理碎片化的表现形式,以及林区面临的公共服务裂解、管理成本提高、工作衔接不畅、治理效率下降等问题。研究发现,重点国有林区原政企合一管理体制的制度路径依赖效应与快速变化治理需求间的矛盾、传统官僚体制的刚性边界与林区治理系统内在张力的冲突、林区数字治理技术应用滞后和数字技术藩篱的存在等都是导致治理碎片化的原因。为了破解多元主体参与下的治理碎片化困境,推动林区治理现代化,重点国有林区的治理体系调整可以采取以下措施:通过重构行动主体间的协调机制和信任机制破除制度的路径依赖,重塑行动者网络;通过完善治理责任机制和整合机制,突破传统行政边界,构建治理主体双向互动机制;通过增强数字技术应用以提升协同治理效能。这些措施的采用可以促使林区建设更好地融入东北高质量发展大局,并为推进国家治理现代化改革提供林区方案。

关键词：整体性治理治理碎片化多元治理主体重点国有林区政企分开改革

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