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辅助生殖技术助孕双胎妊娠临床管理建议

中国实用妇科与产科杂志 2021年第7期37卷 724-730页

作者： “生殖健康及重大出生缺陷防控研究”重点专项——高龄产妇妊娘期并发症防治策略研究项目组赵扬玉乔杰不详北京大学第三医院妇产科北京100191

双胎妊娠为高危妊娠,多种不良产科结局高于单胎妊娠。辅助生殖技术(assisted reproductive technology,ART)助孕双胎妊娠由于其特殊性,不良妊娠结局发生风险可能更高。三孩生育政策实施后,预计高龄、多产次和ART助孕的孕产妇将有所增加... 详细信息

双胎妊娠为高危妊娠,多种不良产科结局高于单胎妊娠。辅助生殖技术(assisted reproductive technology,ART)助孕双胎妊娠由于其特殊性,不良妊娠结局发生风险可能更高。三孩生育政策实施后,预计高龄、多产次和ART助孕的孕产妇将有所增加,发生妊娠期并发症、合并症和出生缺陷的风险可能上升。针对ART助孕双胎妊娠,我国目前尚缺乏如何实施规范化围产期管理体系的临床管理建议。为提高ART助孕双胎妊娠围产保健质量,降低相关并发症发生率,国家重点研发计划"生殖健康及重大出生缺陷防控研究"重点专项——高龄产妇妊娠期并发症防治策略研究项目组探索并制定了适宜基层医院推广应用的ART助孕双胎妊娠临床管理建议。

关键词：辅助生殖技术双胎妊娠临床管理

白假丝酵母菌25SrDNA基因分型与粘附力的相关性

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华中科技大学学报（医学版） 2010年第2期39卷 243-245页

作者：刘刚卢光琇中南大学生殖与干细胞工程研究所长沙410078

目的调查白假丝酵母菌25SrDNA基因型分布,并分析白假丝酵母菌各基因型与粘附力之间的相关性。方法收集76株白假丝酵母菌,转沙保罗氏培养液纯培养24 h,裂解法提取基因组DNA,用特异性引物扩增白假丝酵母菌25SrDNA基因,根据PCR产物电泳图... 详细信息

目的调查白假丝酵母菌25SrDNA基因型分布,并分析白假丝酵母菌各基因型与粘附力之间的相关性。方法收集76株白假丝酵母菌,转沙保罗氏培养液纯培养24 h,裂解法提取基因组DNA,用特异性引物扩增白假丝酵母菌25SrDNA基因,根据PCR产物电泳图谱进行基因分型;分别测定各基因型粘附力。结果PCR产物电泳结果显示76例白假丝酵母菌可分为A、B、C 3种基因型(其中A型48例,B型8例,C型20例)。测序结果显示,B型和C型产物比A型产物多出1个379 bp的序列(Ⅰ类内含子)。根据有无内含子将菌株分为无内含子组(A型)和有内含子组(B型+C型),无内含子组粘附力明显强于有内含子组,两组比较差异有统计学意义(P<0.05)。结论白假丝酵母菌25SrDNA基因型与粘附力之间可能存在相关性,内含子的插入可能影响白假丝酵母菌的粘附力。

关键词：白假丝酵母菌基因分型粘附力内含子

不同类型宫内避孕器对子宫内膜微血管影响的形态测量研究

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同济医科大学学报 1992年第2期21卷 100-102页

作者：刘运国熊承良郑清平吴熙瑞同济医科大学计划生育研究所生殖医学中心卫生部妇幼卫生司100725 同济医科大学实验医学研究中心超微病理研究室

采用ERNST-LEITZ-WETZLAR ASM形态测量系统,测定4种不同类型宫内避孕器(IUDs)对兔子宫内膜微血管总面积(TABV)、微血管面积在内膜中所占百分比(PBV)和微血管密度(DBV)的影响。结果表明,与空白自身对照子宫比较,凡接触IUDs 30d后的兔子宫... 详细信息

采用ERNST-LEITZ-WETZLAR ASM形态测量系统,测定4种不同类型宫内避孕器(IUDs)对兔子宫内膜微血管总面积(TABV)、微血管面积在内膜中所占百分比(PBV)和微血管密度(DBV)的影响。结果表明,与空白自身对照子宫比较,凡接触IUDs 30d后的兔子宫,内膜中TABV、PBV和DBV均有所增加,TABV与PBV增加程度在不锈钢避孕器组(SS-IUD)和孕激素避孕器组(LNG-IUD)差异有显著性意义(PLNG-IUD、含孕激素与钢避孕器>含铜避孕器。

关键词：宫内避孕器微血管子宫内膜

Comparison of the Effects and Safety of Mild Ovarian Stimulation and Conventional Ovarian Stimulation with A Long GnRH Agonist Protocol on IVF Outcomes

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Journal of Reproduction and Contraception 2013年第3期24卷 159-172页

作者： Rong-rong TAN Dan-hua PU Jia-yin LIU Jie WU State Key Laboratory of reproductive Medicine Department of Obstetrics and Gynecologythe First Affiliated Hospital of Nanjing Medical University

Objective To conduct a Meta-analysis of studies that compared the efficacies of mild ovarian stimulation and conventional long GnRH agonist protocol in patients under- going IVF or intracytoplasmic sperm injection （ICSI）. Methods Meta-analysis was performed. All studies were published by July 2012 with data related to outcomes following mild ovarian stimulation compared with the conventional protocol. Odds ratios （ORs） and weighted/standardized mean difference （WMD/SMD） from individual study were pooled in fixed and random effect models. Main outcome measure was the efficacy of mild ovarian stimulation. Results Six articles were included in this Meta-analysis. The number of oocytes retrieved was lower, the cycle cancellation rate was higher and the incidence of ovarian hyperstimulation syndrome （OHSS） was lower in the mild stimulation group than in conventional ovarian stimulation group. Clinical pregnancy rates were similar in both mild and conventional stimulation groups. Conclusions The level of evidence supporting the use of mild stimulation protocols in IVF is low, considering the fewer oocytes retrieved and the higher rates of cycle cancellation.

关键词： mild ovarian stimulation long GnRH agonist ovarian stimulation in vitro fertilization (IVF)

Physiological Roles of Endogenous Opioid System during Preimplantation Embryo Development and Blastocyst Implantation in Mice

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Physiological Roles of Endogenous Opioid System during Preim...

Circulating Antisperm Antibody (ASA) in Women is not Associated with Missed Abortions at the First-trimester Pregnancy

2012全国发育生物学大会

作者： Yongjie Chen,Yayuan Fu,Bingyan Wang,Weixiang Wang,Haibin Wang State key laboratory of reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,PR China

Previous epidemiology survey has demonstrated that an endogenous opioid system via opioid receptors is implicated in the regulation of female reproductive ***,its pathophysiological significance of this system in the reproductive events remained to be further *** receptors belong to the superfamily of seven transmembrane-spanning(7TM) G protein coupled receptors(GPCRs),which were discovered in 1970s and first cloned in *** far,four opioid receptor subtypes have been characterized including u-opioid receptor(MOR),δ-opioid receptor (DOR),K-opioid receptor(KOR) and oprl-1(nociceptin/ orphanin FQ receptor).In the present study,we have applied immunofluorescence,q-RT-PCR,Southern and in situ hybridization to identify the expression levels of MOR,DOR and KOR,as well as the endogenous opioid peptide precursors proopiomelanocortin(POMC),proenkephalin(PENK) and prodynorphin(PDYN) in the preimplantation embryos and the pregnant mouse *** analysis revealed that opioid receptors were spatiotemporally expressed in the preimplantation embryos(1-cell,2-cell,4-cell,8-cell, morale and blastocyst).Moreover,opioid receptors and opioid peptide precursor mRNAs were also spatiotemporally expressed in Day 1-4 uteri and Day 5-8 implantation *** interestingly,we observed that opioid peptide precursors mRNA levels were significantly decreased in the implantation sites compared to those in the inter-implantation tissues. Then we administrated morphine to the pregnant WT and opioid receptor knockout mouse(oprm,and oprd/Voprk) at D2 and *** results showed that morphine could decrease the blastocyst ratio on D4 1000 in morphine-injected group,but not the control groups in WT mice,and this effect could be rescued by naloxone;The blastocyst ratio on D4 1000 in oprm mouse was not significantly different between morphine and saline groups,but morphine could significantly decreased the blastocyst ratio in the oprd/oprk mouse. Conclusons:Thes

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Journal of Reproduction and Contraception 2011年第3期22卷 139-143页

作者： Yu-xia WANG Wei-jie ZHU Department of Obstetrics and Gynecology the First Affiliated Hospital Jinan University Guangzhou 510630 China Institute of reproductive Immunology Jinan University Guangzhou 510632 China

Objective To determine the role of the circulating antisperm antibody （ASA） in the pathogenesis of missed abortion at the first-trimester pregnancy. Methods Sixty-two patients with a history of missed abortion at the first-trimester pregnancy were enrolled into this study. Indirect immunobead test （IBT） was used to measure the circulating ASA levels. Fifty healthy women with the first-trimester pregnancy set as the control. Results No case had the positive level of ASA according to the World health Organization criteria （50% or more of the motile sperm with immunobead binding）. Only 1 case in patient group and 1 case in the control had 10%-20% of the motile spermatozoa with ASA-IgG bead binding. In both patient and control groups, ASA-IgA was found to be completely negative binding. Conclusion The circulating ASA is not associated with the pathogenesis of missed abortions at the first-trimester pregnancy.

关键词： antisperm antibody (ASA) missed abortion sperm woman

关于准备妊娠和辅助生殖技术助孕人群新型冠状病毒疫苗接种的专家建议

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中华生殖与避孕杂志 2021年第4期41卷 296-299页

作者：北京市人类辅助生殖技术质量控制和改进中心专家组乔杰马彩虹梁靓任昀不详北京大学第三医院国家妇产疾病临床医学研究中心北京市人类辅助生殖技术质量控制和改进中心专家组办公室

新型冠状病毒疫情暴发以来,世界各国加快新型冠病毒疫苗(简称新冠疫苗)的研发。已有多个候选疫苗进入Ⅲ期临床试验或附条件上市及紧急使用。虽然所有年龄段人群均对新型冠状病毒易感,但孕妇仍被排除在新冠疫苗Ⅲ期临床试验之外,因此无... 详细信息

新型冠状病毒疫情暴发以来,世界各国加快新型冠病毒疫苗(简称新冠疫苗)的研发。已有多个候选疫苗进入Ⅲ期临床试验或附条件上市及紧急使用。虽然所有年龄段人群均对新型冠状病毒易感,但孕妇仍被排除在新冠疫苗Ⅲ期临床试验之外,因此无法确定新冠疫苗对妊娠期妇女及其子代的安全性,也缺乏孕期及准备妊娠人群新冠疫苗有效性和安全性的数据。本专家建议参考国内外最新研究进展、相关机构推荐和我国相关政策规范,经过北京市人类辅助生殖技术质量控制和改进中心专家组讨论,为我国准备妊娠和接受辅助生殖技术助孕人群新冠疫苗接种提供指导性意见。

关键词：生殖技术,辅助新型冠状病毒新型冠状病毒疾病新型冠状病毒疫苗

新型冠状病毒肺炎疫情对辅助生殖技术服务的影响:一项全国性横断面调查

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中华生殖与避孕杂志 2021年第1期41卷 7-11页

作者：国家辅助生殖技术质量管理专家组乔杰王媛媛郝永秀陈立雪吴红萍李蓉刘平不详北京大学第三医院国家辅助生殖技术质量管理专家组办公室

目的了解新型冠状病毒肺炎疫情对全国不孕不育症诊疗技术——辅助生殖技术服务的影响情况,为生殖医学中心和精子库的复工复产工作提供指导性意见,以便更好地保障育龄夫妇获得生殖健康相关医疗服务。方法2020年5月,采用线上问卷调查的方... 详细信息

目的了解新型冠状病毒肺炎疫情对全国不孕不育症诊疗技术——辅助生殖技术服务的影响情况,为生殖医学中心和精子库的复工复产工作提供指导性意见,以便更好地保障育龄夫妇获得生殖健康相关医疗服务。方法2020年5月,采用线上问卷调查的方式向中国内地31个省(自治区、直辖市)已批准开展人类辅助生殖技术的517家生殖医学中心和27家人类精子库的机构负责人进行调查。主要调查内容包括:2019年及2020年1~4月各机构的辅助生殖技术服务量、开展的疫情防控措施、医患感染情况、疫情期间业务暂停及复工复产情况等。结果本次调查共获得475家生殖医学中心和22家精子库的有效反馈,分别占全国总机构数的91.9%和81.5%。在新型冠状病毒肺炎疫情期间,63.6%(302/475)的生殖医学中心和95.5%(21/22)的精子库都受疫情影响而暂停对外业务。与2019年同期相比,2020年1~4月份生殖医学中心的门诊量、夫精人工授精周期数、供精人工授精周期数、取卵周期数、新鲜移植周期数和解冻移植周期数的下降比例分别为45.0%、46.5%、52.8%、49.2%、52.3%和37.1%(疫情最严重的湖北省下降比例在70%~90%),精子库的捐精人数和自精保存人数下降比例分别为60.7%和51.1%。全国生殖医学中心共上报了5例工作人员新型冠状病毒感染病例(均在湖北省),精子库未出现工作人员感染病例。结论针对目前新型冠状病毒肺炎疫情防控常态化的形势,应制定专门针对生殖医学中心和精子库的疫情防控流程和新型冠状病毒筛查指南,有必要建立一个患者分层分级动态评估及管理体系,从而帮助机构在疫情防控期间迅速鉴别出来哪些患者需要向其优先提供生育治疗服务。

关键词：生殖技术,辅助新型冠状病毒肺炎卫生质量管理

Study on the Clinical and Endocrine Characteristics of Polycystic Ovary Syndrome with Different Ovarian Morphology

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Journal of Reproduction and Contraception 2014年第3期25卷 133-145页

作者： Zhi-ping HU Tian-shu PANG Ying WANG Jie QIAO Mei-zhi LI reproductive Medical Center Peking University Third Hospital

Objective To evaluate the differences of the clinical manifestation and endocrine situation in patients with different ovarian morphology of polycystic ovary syndrome （PCOS）. Methods A total of 234 PCOS patients were enrolled according to the ovary morphology and divided into three groups： 112 patients with B-polycystic ovary mor- phology （both two ovaries were PCOM, B-PCOM）, 50 with U-PCOM （only one ovary was PCOM） and 72 with N-PCOM （none was PCOM）. There were 39 infertile women without PCOS as control group. Data were analyzed by using SPSS 15.0 software. ResuIts There was no statistical difference in body mass index （BM1） among the three groups of PCOS. The endometrial thickness increased in patients with B-PCOM and decreased with N-PCOM. The levels of testosterone, androstenedione and luteinizing hormone increased in PCOS groups, especially in N-PCOM patients. HOMA-IR increased, HOMA-fl, disposition index （DI） and △160/AG60 decreased in patients with N- PCOM compared with in B-PCOM and U-PCOM groups. Higher level of total choles- terol （TC） and lower level of high-density lipoprotein （HDL）-C existed in PCOS patients, especially in N-PCOM. There were positive correlations between oligo-anovulation, endometrial thickness, LH/FSH ratio, fasting insulin （FINS）, the area under curve of glucose（A UCcLu） and PCOM, while there was a negative correlation between HOMA- IR and PCOM. Conclusion There are relationships among hyperandrogenism, hyperinsulinemia, insulin resistance （IR） and ovary morphology in PCOS patients. PCOS patients with- out PCOM have more serious IR and hyperandrogenism.

关键词： polycystic ovary syndrome (PCOS) polycystic ovary morphology (PCOM) hyperandrogenism (HA) insulin resistance (IR)