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Switch mode capacitive pressure sensors

第五届亚洲儿科研究大会

作者： Hidetoshi Takada Hirosuke Inoue Masataka Ishimura Takeshi Kusuda Takako Goto Masayuki Ochiai Tadamune Kinjo Jun Muneuchi yasushi takahata Kenjiro Kosaki Toshiro Hara Department of Pediatrics Graduate School of Medical SciencesKyushu University

＜正＞Charge syndrome is a distinctive syndrome of multiple congenital anomalies including coloboma,congenital heart defects,choanal atresia,retarding of growth,developmental delay,genital abnormalities,ear anomalies,...

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Microsystems & Nanoengineering 2022年第6期8卷 47-60页

作者： Nabil Shalabi Kyle Searles Kenichi takahata Department of Electrical and Computer Engineering University of British ColumbiaVancouverBC V6T 1Z4Canada School of Biomedical Engineering University of British ColumbiaVancouverBC V6T 1Z3Canada

Switch mode capacitive pressure sensors are proposed as a new class of microfabricated devices that transform pressure into a mechanically switching capacitance to form an analog-to-digital signal with zero power,high sensitivity,and a high signal-to-noise ratio.A pressure-sensitive gold membrane suspended over a capacitive cavity makes ohmic contact with patterned gold leads on the substrate,closing circuits to fixed on-chip capacitors outside the cavity and leading to significant step *** function is achieved by allocating the switch leads on the part of the counter electrode area,while the remaining area is used for touch mode analog capacitive *** sensor microchip is prototyped through a novel design approach to surface micromachining that integrates micro-Tesla valves for vacuum sealing the sensor cavity,showing an unprecedented response to applied *** a gauge pressure range of 0–120 mmHg,the sensor exhibits an increase of 13.21 pF with resultant switch events,each of which ranges from 2.53–3.96 pF every 12–38 mmHg,in addition to the touch mode linear capacitive increase between *** equivalent sensitivity is 80–240 fF/mmHg,which is 11–600×more than commercial and reported touch mode sensors operating in similar pressure *** sensor is further demonstrated for wireless pressure tracking by creating a resonant tank with the sensor,showing a 32.5–101.6 kHz/mmHg sensitivity with frequency jumps led by the switch *** developed sensor,with its promising performance,offers new application opportunities in a variety of device areas,including health care,robotics,industrial control,and environmental monitoring.

关键词： mode cavity sealing

Crustal Signature of δ^(13)C and Nitrogen Content in Microdiamonds from Erzgebirge, Germany: Ion Microprobe Studies

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Journal of Earth Science 2010年第5期21卷 623-634页

作者： Larissa F Dobrzhinetskaya Harry W Green II Naoto takahata Yuji Sano Korato Shirai Department of Earth Sciences University of California at Riverside Riverside 92521 USA Division of Ocean-Earth Systems Atmosphere and Ocean Research Institute University of Tokyo Kashiwanoha Chiba 277-8564 Japan

The study of δ13CCpDB （Pee Dee Belemnite） and nitrogen contents in 1 to 5-pm-diameter microdinmonds included in garnets from the qnartz-feldspathic gneisses （Erzgehirge, Germany） was performed in situ with the Nano-scale Secondary Ion Mass Spectrometer. The results revealed that there were two stages of diamond crystallization from a C-O-H supeeritical fluid rich in biogenic carbon and diverse minor elements of crustal origin. The δ13CCpDB Of the Erzgebirge diamond of the first stage falls in the range -17‰ to 19‰, with an average value of -17.8‰; the average content of nitrogen is 820 ppm. Diamonds of the second stage are characterized by δ13CPDB=-21.5‰ to -25.5‰, with an average value of -23.24‰; the average nitrogen content is non-homogeneously scattered from 740 ppm to 3 370 ppm among 6 diamonds situated in garnets within the same polished rock slide. Both diamond of the first stage and diamond of the second stage carbon reservoirs belong to biogenic matter, therefore confirming deep subduction of the continental crust sediments and their subsequent exhumation during the Variscan orogeny.

关键词： metamorphic diamond carbon isotope nitrogen content geochemistry.

Degassing of deep-sourced CO_(2) from Xianshuihe-Anninghe fault zones in the eastern Tibetan Plateau

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Science China Earth Sciences 2022年第1期65卷 139-155页

作者： Sheng XU Lufeng GUAN Maoliang ZHANG Jun ZHONG Wei LIU Xian'gang XIE Congqiang LIU Naoto takahata Yuji SANO Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China Atmosphere and Ocean Research Institute The University of TokyoKashiwaChiba 277-8564Japan

A large number of gases are releasing from the medium-high temperature geothermal fields distributed along the large-scale strike-slip fault zones in the southeastern margin of the Tibetan *** this study,11 hot spring water and the associated bubbling gas samples were collected along the Xianshuihe-Anninghe fault zones(XSH-ANHFZ)and analyzed for chemical and isotopic *** δ^(18)_(H_(2)O) and δD_(H_(2)O) values indicate that hot spring waters are predominantly meteoric origin recharged from different *** water samples are significantly enriched in Na^(+) and HCO_(3) due to the dissolution of regional evaporites,carbonates and Na-silicates.^(3)He/^(4)He ratios of the gas samples are 0.025-2.73 times the atmospheric *** ^(3)He/^(4)He ratios are high in the Kangding region where the dense faults are distributed,and gradually decrease with increasing distance from Kangding towards both sides along the Xianshuihe fault zones(XSHFZ).Hydrothermal fluids have dissolved inorganic carbon(DIC)concentrations from 2 to 42 mmol L^(-1),δ^(13)C_(DIC) from -6.9‰ to 1.3‰,δ^(13)C_(CO_(2)) from -7.2‰ to -3.6‰ and Δ^(14)C from -997‰ to -909‰.Combining regional geochemical and geological information,the CO_(2)sources can be attributed to deep-sourced CO_(2)from mantle and metamorphism of marine carbonate,and shallow-sourced CO_(2)from the dissolution of marine carbonate and biogenic CO_(2).The mass balance model shows that 11±6% of the DIC is sourced from the dissolution of shallow carbonate minerals,9±8% formed by pyrolysis of sedimentary organic matter,80±9% derived from deep metamorphic origin and mantle-derived CO_(2).Among them,the deep-sourced CO_(2)in Anninghe fault zones(ANHFZ)is merely metamorphic carbon,whereas ca.12% and ca.88% of the deep-sourced CO_(2)in the XSHFZ are derived from the mantle and metamorphic carbon,*** average deep-sourced CO_(2)flux in the Kangding geothermal field is estimated to be 160 ta^(-1).If all the hot

关键词： Hot spring Fluid geochemistry Deep-sourced carbon Xianshuihe-Anninghe fault zones Tibetan Plateau

利用ISSR分子标记进行不同来源大豆品种的分类

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大豆科学 2005年第3期24卷 161-165页

作者：谢甫绨 Yoshihito takahata 沈阳农业大学农学院沈阳110161 日本岩手大学农学部

采用ISSR分子标记技术对不同来源大豆品种(系)进行了分类研究,对UBC ISSR801—850 引物进行筛选,发现有11个引物没有产物,选出39个引物具有扩增产物,一般每个引物可以扩增出1—6条带,产物片段大小多在831—3530b之间。39个引物共扩增出... 详细信息

采用ISSR分子标记技术对不同来源大豆品种(系)进行了分类研究,对UBC ISSR801—850 引物进行筛选,发现有11个引物没有产物,选出39个引物具有扩增产物,一般每个引物可以扩增出1—6条带,产物片段大小多在831—3530b之间。39个引物共扩增出121条带,其中多肽性带47条,占38.84%。每个引物平均可扩增出带数为3.1条;其中多肽性带数为1.21条。ISSR引物扩增的结果表明,ISSR分子标记技术能很好地用来区分不同来源的大豆品种(系)。不同大豆品种(系)因其遗传背景不同,经ISSR引物扩增出来的谱带数也不一样,而且不同品种(系)还具有特异性的标记谱带。另外,对沈农系列大豆品种(系)的生产力与本试验采用的日本大豆品种的比较分析可以看出,沈农系列大豆品种(系)的生产力要高于日本大豆品种的生产力。

关键词：大豆 ISSR 分子标记

利用ISSR标记进行菜用大豆和普通大豆的分类

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大豆科学 2008年第5期27卷 732-739页

作者：谢甫绨 takahata Yoshihito Ohno Yasuo 沈阳农业大学农学院辽宁沈阳110161 Faculty of Agriculture lwate University020-8550Japan Sato Masayuki Seed Co. Yahabacho 02-0891Japan

ISSR标记技术因具有很高的多肽性而被广泛应用于遗传多样性研究。进行菜用大豆品种多样性研究将有助于育种家进行杂交亲本的合理选配。采用ISSR标记技术对37个菜用大豆品种（系）和13个普通大豆品种（系）进行了分类研究。结果表明：50... 详细信息

ISSR标记技术因具有很高的多肽性而被广泛应用于遗传多样性研究。进行菜用大豆品种多样性研究将有助于育种家进行杂交亲本的合理选配。采用ISSR标记技术对37个菜用大豆品种（系）和13个普通大豆品种（系）进行了分类研究。结果表明：50个ISSR引物中有11个引物没有多肽性，其他39个引物共产生132条谱带，其中81条多肽性谱带，占61．4％。引物扩增的谱带数在1—7条之间，大小为830—3530bp．每个引物平均扩增的谱带数和多肽性带数分别为3．3和2．1。聚类分析结果表明，可将供试的50个品种划分为3个类组，扁茎大豆Taikadaizu单独一组，7个普通大豆（多数为中国选育）划归为B组，C组由日本菜用大豆和4个普通大豆组成。C组还可以划分成若干亚组，同一亚组的品种具有相似的性状，比如有一亚组的品种均是褐脐、茶色种皮、白花、不易炸荚。系选的品种和原始品种在分类图中也显示出其密切的亲缘关系。基于ISSR标记的分类可以反映菜用大豆的遗传关系，菜用大豆和普通大豆之间存在遗传多样性，合理保存菜用大豆种质将有助于未来大豆品质改良计划。

关键词：大豆 ISSR标记多样性

在被旧日军毒气武器的有机砷化合物污染的日本某些地区使用地下水资源(英文)

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中国地质 2010年第3期37卷 741-746页

作者： Hisashi NIREI Tomoyo HIYAMA Hideyo takahata Hidefumi IKEDA Ibakaki University. Chairperson：(NPO)The Geo-pollution Control Agency Japan. Rose hights-1 5-24-1 Makuharihongoh Hanamigawa-ku Chiba-city Chiba prefecture 262-0003 Japan Techno Earth Corporation. 33-1 Shinden-cho Chuo-ku Chiba-city Chiba prefecture 260-0027 Japan

从医学地质学角度看,在日本地质污染的地方如何使用地下水资源,我们面临许多问题。本文讨论了地质污染学(geo-pollution science)作为医学地质学中一门学科的概念以及在受二苯亚砷酸污染的地方成功使用农业地下水的案例。

关键词：地质污染医学地质学有机砷化合物毒气武器地层污染地下水污染地下空气污染

Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice

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Bone Research 2017年第2期5卷 95-108页

作者： Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester NY USA Department of Environmental and Occupational Medicine Rutgers University Piscataway NJ USA and Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry Rochester NY USA

Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in ***, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone.

关键词： Sclerostin prenatal negative

青藏高原东缘鲜水河-安宁河断裂带深源气体释放

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中国科学：地球科学 2022年第2期52卷 291-308页

作者：徐胜管芦峰张茂亮钟君刘伟谢显刚刘丛强 Naoto takahata Yuji SANO 天津大学地球系统科学学院天津300072 Atmosphere and Ocean Research Institute The University of TokyoKashiwaChiba 277-8564Japan

青藏高原东南缘分布的大规模超壳走滑断裂带和中-高温地热区释放大量深源气体.鲜水河-安宁河断裂带温泉水和逸出气体的化学和同位素组成分析结果显示,该断裂带的水-岩相互作用显著,深源含碳流体强烈释放,是研究大陆碰撞造山带巨型走滑... 详细信息

青藏高原东南缘分布的大规模超壳走滑断裂带和中-高温地热区释放大量深源气体.鲜水河-安宁河断裂带温泉水和逸出气体的化学和同位素组成分析结果显示,该断裂带的水-岩相互作用显著,深源含碳流体强烈释放,是研究大陆碰撞造山带巨型走滑断裂系统深源CO_(2)释放的重要地区.δ^(18)O_(H_(2)O)和δD_(H_(2)O)值显示温泉水主要来源于不同补给高度的大气降水循环;水-岩相互作用过程中,区域蒸发盐、碳酸盐和钠硅酸盐矿物的溶解作用导致温泉水显著富集Na^(+)和HCO_(3).温泉逸出气体^(3)He/^(4)He比值为大气的0.025~2.73倍,局部地区显示强烈的幔源He释放:^(3)He/^(4)He比值在断裂密集分布的康定地区最高,并以此为中心向断裂带延伸和垂直方向递减.溶解无机碳(Dissolved inorganic carbon,DIC)浓度变化范围为2~42mmol L^(-1),δ^(13)CDIC值为-4.0∼1.3‰,13C CO_(2)值为-7.2∼-3.6‰,Δ14CDIC值为-997∼-909‰.结合地球化学与区域地质资料,认为CO_(2)来源主要包括深部的上地幔和变质碳酸盐岩,以及近地表的海相碳酸盐岩和有机质.质量平衡混合模型计算结果显示,平均11±6%的溶解碳来源于浅层碳酸盐矿物的溶解作用,9±8%为沉积有机质热解成因,80±9%来自深部变质成因和幔源CO_(2).其中,安宁河断裂带深源CO_(2)主要为单一的变质成因碳;而在鲜水河断裂带深源CO_(2)中,约12%和88%分别源自地幔和变质成因碳.康定地热田平均深源CO_(2)通量为160t a^(-1),如果推算至青藏高原东南缘各类断裂带内的所有温泉,区域深源CO_(2)通量将达到10^(5)t a^(-1)量级.这一初步结果表明,非火山区深源CO_(2)释放量在全球范围深源碳释放总量中占有相当的份额,需要引起重视和深入研究.

关键词：温泉流体地球化学深源碳释放鲜水河-安宁河断裂带青藏高原

Impact of ABO Blood Types on Survival after Pancreatectomy for Pancreatic Cancer

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Journal of Cancer Therapy 2013年第10期4卷 7-12页

作者： Tadashi Kayashima Masafumi Nakamura Kenoki Ohuchida Syunichi takahata Kohei Nakata Naoki Ikenaga Lin Cui Shingo Kozono Kazuhiro Mizumoto Masao Tanaka Department of Surgery and Oncology Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Background/Purpose: A recent genome-wide association study (PanScan) identified significant association between the ABO gene locus and the risk of pancreatic cancer. The aim of this study was to analyze survival of pancreatic cancer patients who underwent surgical resection based on serotype-defined ABO blood types. Methods: In terms of ABO blood types and gemcitabine-based adjuvant therapy, we investigated the survival of 153 patients who underwent pancreatectomy for pancreatic cancer at the Department of Surgery and Oncology,KyushuUniversity(Fukuoka,Japan). Results: Among the four blood type groups, the O serotype group (median survival time (MST): 47.9 months) showed the best prognostic outcome. The A serotype group (MST: 22.5 months) showed the second best prognostic outcome, followed by the AB serotype group (MST: 20.4 months). The B serotype group (MST: 15 months) showed the worst prognostic outcome when considering the MST after the surgical resection. Next, we examined the effect of adjuvant chemotherapy with gemcitabine based on the ABO blood types. The A serotype group showed the greatest improvement in prognosis by adjuvant therapy with gemcitabine after the surgical resection. The other three serotype groups showed no significant differences in the prognostic outcomes between subgroups with and without gemcitabine therapy. Conclusions: The present data suggest the possibility that ABO blood types are prognostic factors for pancreatic cancer patients after surgical treatment and are also predictive factors for the chemosensitivity to gemcitabine of pancreatic cancer patients after pancreatectomy.

关键词： Pancreatic Cancer ABO Blood Type Survival Gemcitabine Adjuvant Chemotherapy