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Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer

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World Journal of Gastroenterology 2007年第28期13卷 3829-3835页

作者： iwao Kaneko Shinji Tanaka Shiro Oka Shigeto Yoshida Toru Hiyama Koji Arihiro Fumio Shimamoto Kazuaki Chayama Department of Medicine and Molecular Science Hiroshima University Graduate School of Biomedical ScienceHiroshimaJapan Department of Endoscopy Hiroshima University HospitalHiroshimaJapan Health Service Center Hiroshima UniversityHiroshimaJapan Department of Pathology Hiroshima University HospitalHiroshimaJapan Department of Health Science Prefectural University of HiroshimaFaculty of Human Culture and SocietyHiroshimaJapan

AIM: To clarify the usefulness of immunohistochemical molecular markers in predicting lymph node metastasis of submucosal colorectal cancer. METHODS: We examined microvessel density, lymphatic vessel density, the Ki-67 labeling index, expression of MUC1 and Matrix metalloproteinase-7 (MMP-7) in tumor cells, and expression of cathepsin D in stromal cells at the invasive front by immunostaining of samples resected from 214 patients with submucosal colorectal cancer. Pathologic features were assessed on hematoxylin-eosin- stained samples. We evaluated the relations between clinicopathologic/immunohistochemical features and lymph node metastasis. RESULTS: Lesions of the superficial type, with an unfavorable histologic grade, budding, lymphatic involvement, high microvessel density (≥ 40), high lymphatic vessel density (≥ 9), high Ki-67 labeling index (≥ 42), and positivity of MUC1, cathepsin D, and MMP-7 showed a significantly high incidence of lymph node metastasis. Multivariate analysis revealed that high microvessel density, unfavorable histologic grade, cathepsin D positivity, high lymphatic vessel density, superficial type, budding, and MUC1 positivity were independent risk factors for lymph node metastasis.A combined examination with four independent immunohistochemical markers (microvessel density, cathepsin D, lymphatic vessel density, and MUC1) revealed that all lesions that were negative for all markers or positive for only one marker were negative for lymph node metastasis. CONCLUSION: Analysis of a combination of immuno- histochemical molecular markers in endoscopically resected specimens of submucosal colorectal cancer allows prediction of curability regardless of the pathologic features visible of hematoxylin-eosin-stained sections.

关键词： Submucosal colorectal cancer Microvessel density Lymphatic vessel density Mucin 1 Ki-67 Cathepsin D Matrix metalloproteinase-7 Lymph node metastasis Immunohistochemistry

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Chiral Electrodeposition by the Rotation in a Vertical Magnetic Field

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Journal of Iron and Steel Research International 2012年第S2期19卷 1158-1161页

作者： AOGAKI Ryoichi TAKAGI Satoshi MORIMOTO Ryoichi SUGIYAMA Atsushi MOGI iwao ASANUMA Miki MIURA Makoto OSHIKIRI Yoshinobu YAMAUCHI Yusuke Polytechnic University Ryogoku Sumida-kuTokyo130-0026Japan National Institute for Materials Science(NIMS) Tsukuba Ibaraki305-0044Japan Saitama Prefectural Okubo Water Filtration Plant Saitama 338-0814Japan Graduate School of Advanced Science and Engineering Waseda University Institute for Materials Research Tohoku University Yokohama Harbour Polytechnic College Polytechnic College Akita Yamagata College of Industry and Technology National Institute for Materials Science(NIMS)

The roles of the rotations in the process of chirality appearance in magnetoelectrodeposition were theoretically *** in a vertical magnetic field induces a macroscopic fluid rotation called vertical MHD flow(VMHDF) over the electrode *** the rotation,minute numerous micro-vortexes called micro-MHD flow(MMHDF) arise from 2D and 3D nucleation,which interact with the mass flux of metallic ion,yielding chiral deposits with the characteristic features called micro- and nano-mystery ***,numerous vortexes always keep chiral symmetry,forming four types of vortexes,i.e.,with the combination of upward or downward and clockwise or ***,ionic vacancy acting as an atomic scale lubricant is created in electrodeposition,which gives a restriction to the vortexes;the bottom of an upward vortex covered with ionic vacancies becomes a free surface without friction,whereas the bottom of a downward vortex exposed without ionic vacancies remains rigid with *** rotation of VMHDF donates a precession to the upward vortexes to rotate in the same direction,which finally yield a chiral *** similar effect to that of VMHDF can be expected for the system rotation(SR),where an electrolytic cell rotates in a vertical magnetic *** this case,the SR gives the reverse rotation to the upward vortexes,so that a deposit with reverse chirality is obtained.

关键词： chirality chiral electrodeposition magnetoelectrodeposition rotation magnetic field ionic vacancy

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Double Nucleophilic Addition of Ketene Silyl (THIO)Acetals and Trimethylsilyl Cyanide to N-Allylideneamine

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复旦学报（自然科学版） 2007年第5期46卷 586-页

作者： Isao Mizoia iwao Hachiya Makoto Shimizu Department of Chemistry for Materials Mie University

1 Results We have already published a double nucleophilic addition reaction of α,β-unsaturated imines with several nucleophiles such as ketene silyl acetals, trimethylsilyl cyanides, trimethylsilyl azides and thiols[1]. However, it was not easy to use N-allylideneamine 2 derived from acrolein for such reactions. Since there is no substituent at the β-position, imine 2 has high reactivity and are prone to be polymerization. We report the first synthesis of N-allylideneamines 2 using the isomerization of ...

关键词： double nucleophilic addition reaction regioselectivity N-allylideneamine silica gel ketene silyl acetal

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Characterization of CD133^+ parenchymal cells in the liver:Histology and culture

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World Journal of Gastroenterology 2009年第39期15卷 4896-4906页

作者： Seiichi Yoshikawa Yoh Zen Takahiko Fujii yasunori Sato Tetsuo Ohta Yutaka Aoyagi Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine Division of Gastro-enterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences Division of Pathology Kanazawa University Hospital Department of Gastrointestinal Surgery Kanazawa University Graduate School of Medicine

AIM： To reveal the characteristics of CD133^＋ cells in the liver, METHODS： This study examined the histological characteristics of CD133^＋ cells in non-neoplastic and neoplastic liver tissues by immunostaining, and also analyzed the biological characteristics of CD133^＋ cells derived from human hepatocellular carcinoma （HCC） or cholangiocarcinoma cell lines. RESULTS： Immunostaining reveated constant expression of CD133 in non-neoplastic and neoplastic biliary epithelium, and these cells had the immunophenotype CD133^＋/CK19^＋/HepPar-1. A small number of CD133^＋/CK19/HepPar-1^＋ cells were also identified in HCC and combined hepatocellular and cholangiocarcinoma. In addition, small ductal structures, resembling the canal of Hering, partly surrounded by hepatocytes were positive for CD133. CD133 expression was observed in three HCC （HUH7, PLC5 and HepG2） and two cholangiocarcinoma cell lines （HuCCT1 and CCKS1）. Fluorescence-activated cell sorting （FACS） revealed that CD133^＋ and CD133 cells derived from HuH7 and HuCCT1 cells similarly produced CD133^＋ and CD133 cells during subculture. To examine the relationship between CD133^＋ cells and the side population （SP） phenotype, FACS was performed using Hoechst 33342 and a monoclonal antibody against CD133. The ratios of CD133^＋/CD133 cells were almost identical in the SP and non-SP in HUH7. In addition, four different cellular populations （SP/CD133^＋, SP/CD133, nonP/CD133^＋, and non- SP/CD133） could similarly produce CD133^＋ and CD133- cells during subculture. CONCLUSION： This study revealed that CD133 could be a biliary and progenitor cell marker in vivo. However, CD133 alone is not sufficient to detect tumor-initiating cells in cell lines.

关键词： Cholangiocarcinoma Hepatocellular carcinoma Keratins Stem cells

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Coefficient Diagram Method Based Load Frequency Control for a Modern Power System

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Journal of Electronic Science and Technology 2014年第3期12卷 270-276页

作者： Princess Garasi Yaser Qudaih Raheel Ali Masayuki Watanabe yasunori Mitani Department of Electrical and Electronic Engineering Kyushu Institute of Technology

increasing penetration of renewable energy sources with a wide range of operating conditions causing power system uncertainties, conventional controllers are incapable of providing proper performance to keep the system stable. However, controllable or dispatchable loads such as electric vehicles （EVs） and heat pumps （HPs） can be utilized for supplementary frequency control. This paper shows the ability of plug-in hybrid EVs, HPs, and batteries （BTs） to contribute in the frequency control of an isolated power system. Moreover, we propose a new online intelligent approach by using a coefficient diagram method （CDM） to enhance the system performance and robustness against uncertainties. The performance of the proposed intelligent CDM control has been compared with the proportional-integral （PI） controller and the superiority of the proposed scheme has been verified in Matiab/Simulink programs.

关键词： Battery coefficient diagram method electric vehicles heat pump load frequency control renewable energy sources.

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Application of the Modified Force-Coupling Method of Tracing the Trajectories of Spherical Bubbles with Solid-Like and Slip Surfaces

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Open Journal of Fluid Dynamics 2017年第4期7卷 657-672页

作者： Chao Guan Shinichiro Yanase Koji Matsuura Toshinori Kouchi yasunori Nagata Graduate School of Natural Science and Technology Okayama University Okayama Japan Department of Biomedical Engineering Faculty of Engineering Okayama University of Science Okayama Japan

The force-coupling method (FCM) developed by Maxey and Patel (2001) was modified and applied to trace the trajectories of spherical bubbles with solid-like and slip surfaces. Careful comparison was made to the experimental results of Takemura et al. (2000, 2002a, 2002b). First, the result obtained by use of the original version of the FCM was compared to the experimental results. It was found that the original FCM was not feasible for tracing spherical bubble trajectories. Then, a correction was made to the FCM calculation of the bubble velocity by renormalization in terms of the bubble Reynolds number, which could very well trace the trajectory of the bubble with a solid-like, no-slip surface, but not that of a bubble with a slip surface. Finally, a substantial correction was made to the monopole term of the FCM, which could trace the trajectory of a bubble with a solid-like or slip surface very well even for the Reynolds number up to 20.

关键词： Force-Coupling Method Vertical Wall Spherical Bubble Multiphase Flow

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How Dose Future Look for Steel Bridges： Based on State of the Art of Corrosions

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材料科学与工程（中英文A版） 2013年第12期3卷 793-805页

作者： Tetsuya Yabuki Tetsuhiro Shimozato yasunori Arizumi Hiroaki Matsusita Shuhei Yamasita Emeritus Professor Faculty of Engineering University of Ryukyu Nishihara 903-0213 Japan Hitachi Zosen Corp. Osaka 550-0002 Japanand Miyaji Engineering Corp. Chiba 290-8580 Japan

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Lansoprazole-associated collagenous colitis:Diffuse mucosal cloudiness mimicking ulcerative colitis

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World Journal of Gastroenterology 2009年第17期15卷 2166-2169页

作者： Mitsuro Chiba Takeshi Sugawara Haruhiko Tozawa Hidehiko Tsuda Toru Abe Takuo Tokairin iwao Ono Eriko Ushiyama Division of Gastroenterology Nakadori General Hospital Akita 010-8577 Japan Department of Pathology Nakadori General Hospital Akita 010-8577 Japan Department of Internal Medicine Nakadori Rehabilitation Hospital Akita 010-8577 Japan

There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient's diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infi ltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis.

关键词： Collagenous colitis Microscopic colitis,Lansoprazole Ulcerative colitis Sulfasalazine

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Numerical Study of the Lift Force, Velocities and Pressure Distribution of a Single Air Bubble and Two Interacting Air Bubbles Rising in Quiescent Liquid

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Open Journal of Fluid Dynamics 2020年第1期10卷 31-51页

The study of multiphase flow consisting of liquid and air bubbles has been attracting the interest of many researchers. Numerical methods for such a system are, however, facing difficulty in numerical accuracy and a heavy computational load. In this paper, we made corrections to the modified force-coupling method in our previous papers and applied it to the numerical studies of a single air bubble rising near a vertical wall and two interacting air bubbles rising in line in quiescent liquid. Corrections were made to the effective ranges of the force-coupling method. The calculation results showed that the lift force acting on an air bubble obtained by the experimental data was more accurately reproduced than those by our previous method. We accurately calculated the time evolution of the velocities of interacting two air bubbles rising in line obtained in the previous experiments and resolved the physical mechanism of the relative movement of two bubbles. We also found the present method is much quicker and needs much smaller memory capacity than other methods, such as the volume of fluid method.

关键词： Force-Coupling Method Multiphase Flow Bubble Motion Two Bubble Interaction

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Endoscopic occlusion with silicone spigots for the closure of refractory esophago-bronchiole fistula after esophagectomy

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World Journal of Gastroenterology 2017年第28期23卷 5253-5256页

作者： Masaya Uesato Tsuguaki Kono yasunori Akutsu Kentarou Murakami Akiko Kagaya Yorihiko Muto Akira Nakano Mizuho Aikawa Tomohide Tamachi Hiroyuki Amagai Takahiro Arasawa Yasuhide Muto Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine

A 65-year-old man with cT1bN0M0 stage I middle thoracic esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the posterior mediastinal route after preoperative carbon-ion radiotherapy and chemotherapy in a clinical trial. Anastomotic leakage occurred, but it spontaneously improved. At six months after the operation, he was rehospitalized with a cough and dysphagia. An esophago-bronchiole fistula and stenosis of the gastric tube were observed. He first underwent stent placement in the gastric tube. Two weeks later, the syringeal epithelium was burned by argon plasma coagulation after stent removal. Endoscopic occlusion was then performed for the fistula with two guidewire-assisted silicone spigots. Two weeks later, he was discharged on an oral diet, and he has not developed recurrence of the fistula or cancer for three years. This is the first report of endoscopic occlusion with a guidewire-assisted silicone spigot through the esophagus.

关键词： Endobronchial Watanabe spigot Guidewire Fistula Leakage Esophagectomy Esophageal cancer Endoscopic occlusion

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