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Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly:A case report

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世界临床病例杂志 2023年第26期11卷 6262-6267页

作者： Mari Mori Satoru Takeshita Nami Nakamura Yuki Mizuno Akiko Tomita Mineyoshi Aoyama Hiroki Kakita yasumasa yamada Department of Perinatal and Neonatal Medicine Aichi Medical UniversityNagakute 480-1195Japan Department of Pathobiology Nagoya City University Graduate School of Pharmaceutical SciencesNagoya 467-8603Japan Department of Pediatrics Aichi Medical UniversityNagakute 480-1195Japan Department of Pharmacy Aichi Medical UniversityNagakute 480-1195Japan

BACKGROUND Holoprosencephaly(HPE)is a congenital malformation with various degrees of incomplete separation of the cerebral hemispheres due to differentiation disorders of the *** HPE with diabetes insipidus due to associated pituitary dysfunction has been reported,HPE with the syndrome of inappropriate antidiuretic hormone secretion(SIADH)is very ***,a vasopressin V2 receptor antagonist,is effective in adults with ***,there is no report of its efficacy in infants with *** purpose of this report is to demonstrate that tolvaptan is effective for SIADH in infants and that administration of tolvaptan eliminates the need for restriction of water intake and sodium *** SUMMARY A 2414-g female infant was born at 38 wk by normal vaginal *** anomalies and head magnetic resonance imaging indicated semilobar *** birth,she had hyponatremia due to SIADH and was treated using water and sodium ***,she developed an exaggerated response to the fluid restrictions,resulting in large fluctuations in serum sodium *** administration of tolvaptan improved the fluctuations in serum sodium levels without the need for adjustment of water or sodium *** sodium was maintained within the normal range after discontinuation of tolvaptan at 80 d of *** were no side effects,such as hypernatremia or liver dysfunction,during the administration of *** This is the first report on the safety and efficacy of tolvaptan in an infant with SIADH associated with HPE.

关键词： Tolvaptan Holoprosencephaly Antidiuretic hormone Syndrome of inappropriate secretion of antidiuretic hormone Hyponatremia Case report

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Pulmonary artery diameter ratio as a prognostic indicator of congenital diaphragmatic hernia

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World Journal of Pediatric Surgery 2024年第1期7卷 20-25页

作者： Yuichiro Miyake Hiroyuki Koga Shuko Nojiri Shunsuke yamada Takanori Ochi Go Miyano Geoffrey J Lane Atsuyuki Yamataka Tadaharu Okazaki Department of Pediatric General and Urogenital Surgery Juntendo University School of MedicineBunkyo-kuTokyoJapan Department of Medical Technology Innovation Center Juntendo UniversityBunkyo-ku TokyoJapan Department of Pediatric Surgery Juntendo University Urayasu HospitalUrayasuChibaJapan

Background Following on from an earlier study published in 2008 about left pulmonary artery(LPA)flow measured on serial echocardiography being strongly prognostic in left-sided congenital diaphragmatic hernia(CDH)and the ratio of LPA to right pulmonary artery(RPA)diameters being a simple and reliable indicator for commencing nitric oxide(NO)therapy,the ratio of LPA:RPA diameters(PA ratio orPAR)was hypothesized to possibly reflect cardiopulmonary stresses accompanying CDH *** Subjects with isolated left-sided CDH treated between 2007 and 2020 at a single pediatric surgical center were recruited and classified according to *** obtained retrospectively for subject demographics,clinical course,LPA/RPA diameters,and PAR were compared between survivors and *** value of PAR for optimizing the prognostic value of PA diameter data in CDH were analyzed with receiver operating characteristic(ROC)curve *** Of 65 subjects,there were 54 survivors(82.3%)and 11 non-survivors(17.7%);7 of 11 non-survivors died before surgical repair could be *** PAR for survivors(0.851±0.152)was significantly higher than for non-survivors(0.672±0.108)(p=0.0003).Mean PAR for non-survivors was not affected by surgical *** of survivors were:LPA≥2 mm(n=52 of 54;mean PAR=0.866±0.146)and RPA≥3mm(n=46 of 54;mean PAR=0.857±0.152).Non-survivors with similar LPA and RPA diameters to survivors had significantly lower mean *** curve cut-off for PAR was *** with high PAR(≥0.762)required high-frequency oscillatory ventilation/NO less than subjects with low PAR(<0.762)(p=0.0244 and p=0.0485,respectively)and subjects with high PAR stabilized significantly earlier than subjects with low PAR(1.71±0.68 days vs 3.20±0.87 days)(p<0.0001).Conclusions PAR would appear to be strongly correlated with clinical outcome in CDH and be useful for planning management of cardiopulmonary instability in CDH.

关键词： hernia congenital diameters

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Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第2期12卷 399-404页

作者： Saeko Kohara Yoshito Kamijo Ryoko Kyan Ichiro Okada Eiju Hasegawa Soichiro yamada Koichi Imai Asuka Kaizaki-Mitsumoto Satoshi Numazawa Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical CenterTokyo 1900014Japan Department of Clinical Toxicology Saitama Medical UniversitySaitama 3500495Japan Saitama Prefectural Institute of Public Health Saitama Prefectural Institute of Public HealthSaitama 3550133Japan Division of Toxicology Department of PharmacologyToxicology and TherapeuticsShowa University School of PharmacyTokyo 1428555Japan

BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular *** describe a case of severe aconite poisoning that was successfully treated through venoarterial extracorporeal membrane oxygenation(VA-ECMO)and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).CASE SUMMARY A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled,“Aconitum japonicum Thunb”.Two hours after arrival,VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and *** hours after arrival,an electrocardiogram revealed a return to sinus *** patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5,*** hospital day 15,he was transferred to a psychiatric *** other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS,revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the *** on admission contained 1.50 ng/mL of *** hospital day 2,neither were *** on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine,but these rapidly decreased after hospital day *** The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.

关键词： Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation Aconitine Mesaconitine Case report

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Excellentπ-Bowl Semiconductors Based on C_(70)Subunit

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CCS Chemistry 2024年第2期6卷 353-364页

作者： Meng Chen Yuxiao Duan Xinyue Liu Qian Zhan Hironobu Hayashi Kyohei Matsuo Hiroko yamada Guangpeng Gao Yonghao Zheng Lei Zhang Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029 School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 610054 Division of Materials Science Nara Institute of Science and Technology(NAIST)IkomaNara 630-0192 Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081

As open substructures of fullerenes,aromaticπ-bowls are promising candidates as new organic semiconductors,as well as attractive hosts for *** demonstrate herein the synthesis and characterization of a novel C_(2v)symmetricπ-bowl,pyracyleno[6,5,4,3,2,1-pqrstuv]pentaphene(3).Bowl 3 was equipped with two distinctive reactive sites,allowing for bromination and cross-coupling reactions to readily yield functionalized bowls with two 2,4,6-trimethylphenyl(5)and triethylsilyl(TES)-ethynyl(6)substituents,***-temperature 1H NMR analysis and density functional theory(DFT)calculations indicated bowl-to-bowl inversions of 3,5,and 6 at room *** alternating the substituents,the crystal structures of the threeπ-bowls 3,5,and 6 could be controlled from 1D linear to 1D slipped to 2D herringbone packing motifs,providing insight into the packing behavior ofπ-bowls.1H NMR titration study indicated that the TES-ethynyl substituent enhanced the ability ofπ-bowl to bind C_(70)with an association constant of 2485 M−*** C_(70)molecules withπ-bowls 3 and 6 formed 1:1 complexes,in which C_(70)molecules aggregated into zig-zag and 1D linear arrays,*** hole mobility of 2.3 cm^(2)V^(−1)^s(−1)and electron mobility of 0.16 cm^(2)V^(−1)^s(−1)ofπ-bowl 3 and its complex with C_(70)were demonstrated,respectively,which proved a great value for the development of aromaticπ-bowl semiconductors with tunable properties for organic electronic devices.

关键词： organic semiconductor π-bowl fullerene crystal engineering mobility

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Study of the Effect of Acetic Acid and Phosphate on Copper Corrosion by Immersion Tests

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Materials Sciences and Applications 2024年第1期15卷 15-23页

作者： Yuna Yamaguchi Kaho Sugiura Toyohiro Arima Fuka Takahashi Itaru Ikeda Yutaka yamada Osamu Sakurada Department of Chemistry and Biomolecular Science Faculty of Engineering Gifu University Gifu Japan Dai-Dan Co. Ltd. Saitama Japan Daiwa Techno Co. Ltd. Gifu Japan

It was reported that hemispheric corrosion occurred in copper tubes in an acetic acid environment. When hemispheric corrosion occurred, corrosion could easily progress if water then flowed into the copper pipe, and countermeasures were needed. Therefore, we studied the copper corrosion caused by acetic acid. The present work investigated the relationship between the corrosion form of copper and acetic acid concentration using phosphorous-deoxidized copper, and reported that hemispherical corrosion was observed at acetic acid concentrations of 0.01 to 1 vol.% (0.002 to 0.2 mol·L-1) in the immersion test. In this study, the effects of acetic acid and phosphate on copper corrosion were examined using oxygen-free copper in immersion tests. The results suggested that different concentrations of phosphate in acetic acid solutions and the presence or absence of acetic acid and phosphate affected the corrosion of copper, resulting in different corrosion forms and corrosion progress.

关键词： Acetic Acid Phosphate Oxygen-Free Copper Hemispherical Corrosion Ant-Nest Corrosion

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Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats

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Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro Yokoyama Takako yamada Tetsuo Iida Susumu Mochizuki Akihide Yoshihara Kazuya Akimitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warran

关键词： Rare Sugar d-Allulose Medium-Chain Triglycerides Body Fat Rat

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Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

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Energy & Environmental Materials 2024年第3期7卷 133-142页

作者： Hiroki yamada Koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda Takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki Hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano Takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara Koji Amezawa Yoshitaka Tateyama Shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Faculty of Materials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Institute of Materials Structure Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Centre for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary International Research Organisation of Advanced Science and Technology(IROAST) Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Faculty of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Faculty of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li_(3)PS_(4)glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li^(+)cation mobility and the PS_(4)^(3-)anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect(i.e.,a cation-cation interaction),which is regarded as the essence of high Li ion ***,the correlation between the Li^(+)ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li_(3)PS_(4)glass,and that the more mobile Li ions(i.e.,the Li3-type ions)exhibit a characteristic correlation at relatively long distances of ***,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics

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The stay coefficient: a novel quantification of the relationship between stay time and travel time for urban shopping behavior analysis

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Geo-Spatial Information Science 2023年第1期26卷 44-57页

作者： Takashi yamada Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityWakayamaJapan

Shoppers typically want to spend an amount of time at a destination that is proportional to the travel time required to arrive there;thus,the travel time can be considered the cost of their *** is likely to be the case across regions with different urban structures and *** purpose of this study was therefore to analyze the shopping behaviors contained in travel survey data from three metropolitan areas in Japan to identify common patterns and indicators based on travel time and stay time,thereby obtaining an understanding to inform future trade area *** the travel time and stay time associated with shopping behavior were found to be log-normally distributed regardless of metropolitan area,and four shopping behavior patterns common among the metropolitan areas were ***“stay coeffi-cient”was then defined to express the elasticity of stay time according to travel time,and its values were similar according to shopping behavior pattern regardless of metropolitan *** stay coefficient proposed in this study can therefore be applied to identify shopping behavior patterns in any urban area based on the relationship between travel time and stay time,realizing a novel approach to the analysis of and marketing for trade areas when planning the construction or renovation of commercial *** approach can help inform the decisions of urban policy makers,marketing advisors,and commercial facility operators,and should be of interest to researchers and practitioners working with geospatial,shopping,and other human behavioral characteristics.

关键词： Travel survey shopping behavior travel time stay time stay coefficient trade area analysis

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Storylines of family medicine Ⅱ:foundational building blocks—context,community and health

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Family Medicine and Community Health 2024年第S3期12卷 12-22页

作者： William B Ventres Leslie A Stone Rupal Shah Tamala Carter Geoffrey M Gusoff Winston Liaw Bich-May Nguyen Joanna V Rachelson Mary Alice Scott Teresa L Schiff-Elfalan Seiji yamada Robert C Like Kathleen Zoppi A Peter Catinella Richard M Frankel Shailendra Prasad Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge Lane Group Practice LondonUK Penn Center for Community Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National Clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health Systems and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New Mexico Family Medicine Residency Program Las CrucesNew MexicoUSA New Mexico Primary Care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Family Medicine and Community Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Family Medicine and Community Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Family Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine–Transmountain Texas Tech University Health Sciences CenterEl PasoTexasUSA Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine and Community Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,community and health’,authors address the following themes:‘Context—grounding family medicine in time,place and being’,‘Recentring community’,‘Community-oriented primary care’,‘Embeddedness in practice’,‘The meaning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial model’,‘The biopsychosocial approach’and‘Family medicine as social medicine.’May readers grasp new implications for medical education and practice in these essays.

关键词： thematic illustration dimensions

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An Inverse Laplace Transform on Lattice Spacing

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Chinese Physics Letters 2013年第3期30卷 32-35页

作者： Hirofumi yamada Division of Mathematics and Science Chiba Institute of TechnologyShibazono 2-1-1NarashinoChiba 275-0023Japan

An inverse Laplace transform on lattice spacing is introduced as a computational framework of the extrapolation of the strong coupling expansion to the scaling *** apply the transform to the two-dimensional nonlinear O(N)model at N≥3 and show that the approximation of the continuum limit of the susceptibility agrees with the existing theoretical and Monte Carlo data.

关键词： apply spacing susceptibility

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