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By using either endogenous or transplanted stem cells,which could you prefer for neural regeneration？

Neural Regeneration Research 2018年第10期13卷 1731-1732页

作者： satoru matsuda yukie nakagawa kumi amano yuka ikeda ai tsuji yasuko kitagishi department of food science and nutrition nara women's University，Kita—Uoya，Nishimachi，Nara，Iapa

Neural regeneration by stem cells transplantation：Tissue regeneration and homeostasis are principally dependent on tissue stem cells which possess abilities of self-renewal and differentiation into multidirectional specialized cell *** general,stem cells are critical for normal tissue renewal as well as repair after tissue *** example,mesenchymal stromal cells and endothelial progenitor cells identified in bone marrow could.

关键词： SPINAL-CORD-INJURY ISCHEMIA

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Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy

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World Journal of Diabetes 2022年第3期13卷 150-160页

作者： Nozomi Nagase Yuka Ikeda Ai Tsuji yasuko kitagishi Satoru Matsuda Department of Food Science and Nutrition Nara Women's UniversityNara 630-8506Japan

Diabetic nephropathy(DN)is a major cause of end-stage renal disease,and therapeutic options for preventing its progression are *** number of patients with DN has been increasing in Asian countries because of westernization of dietary lifestyle,which may be associated with the following changes in gut *** in the gut microbiota composition can lead to an imbalanced gastrointestinal environment that promotes abnormal production of metabolites and/or inflammatory *** microenvironments of the gut could be changed in the different stages of *** particular,altered levels of short chain fatty acids,D-amino acids,and reactive oxygen species biosynthesis in the gut have been shown to be relevant to the pathogenesis of the *** far,evidence suggests that the gut microbiota may play a key role in determining networks in the development of *** directing the gut microbiota deserve further investigation as a new protective therapy in *** this review,we discuss the potential roles of the gut microbiota and future perspectives in the protection and/or treatment of kidneys.

关键词： Diabetic nephropathy Short chain fatty acids Superoxide dismutase Reactive oxygen species D-amino acids Gut microbiota Diabetes mellitus Renal disease

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Secretome-microRNA and anti-proliferative APRO family proteins as cancer prevention and stem cell research strategies

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BIOCELL 2022年第5期46卷 1163-1167页

作者： YUKA IKEDA NOZOMI NAGASE AI TSUJI KURUMI TANIGUCHI yasuko kitagishi SATORU MATSUDA Department of Food Science and Nutrition Nara Women’s UniversityNara630-8506Japan

Stemness of cancer cells contains limitless self-renewal *** the purpose of proliferation,secretome might exert its effects via the paracrine *** microRNAs enclosed in the secretome of cancer stem cells could regulate the expression of anti-proliferative APRO family *** biological functions of APRO family proteins seems to be quite intricate,however,which might be a key modulator of microRNAs,then could regulate the proliferation of cancer *** addition to affecting proliferation/differentiation during cellular development,APRO family proteins might also play an imperious role on keeping homeostasis in healthy stem cells under a physiological ***,relationship between the microRNAs and the APRO family proteins has attracted much attention in the field of cancer research and regenerative ***,we have described the molecular mechanism behind this interplay that have a potential role in the future promising tools with targeting APRO family proteins for the medical applications.

关键词： Cancer Stem cell Secretome Proliferation APRO family microRNA

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Neuroprotection by dipeptidyl-peptidase-4 inhibitors and glucagonlike peptide-1 analogs via the modulation of AKT-signaling pathway in Alzheimer’s disease

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World Journal of Biological Chemistry 2021年第6期12卷 104-113页

作者： Yuka Ikeda Nozomi Nagase Ai Tsuji yasuko kitagishi Satoru Matsuda Satoru Matsuda Food Science and NutritionNara Women’s UniversityNara 630-8506Japan

Alzheimer’s disease(AD)is the most common reason for progressive dementia in the *** has been shown that disorders of the mammalian/mechanistic target of rapamycin(mTOR)signaling pathways are related to the *** the other hand,diabetes mellitus(DM)is a risk factor for the cognitive *** pathogenesis of the neuronal impairment caused by diabetic hyperglycemia is intricate,which contains neuro-inflammation and/or neurodegeneration and ***-like peptide-1(GLP1)is interesting as a possible link between metabolism and brain *** of GLP1 activity can influence amyloid-beta peptide aggregation via the phosphoinositide-3 kinase/AKT/mTOR signaling pathway in *** GLP1 receptor agonists have been shown to have favorable actions on the brain such as the improvement of neurological *** might also exert a beneficial effect with refining learning and memory on the cognitive impairment induced by *** experimental and clinical evidence indicates that dipeptidyl-peptidase-4(DPP4)inhibitors,being currently used for DM therapy,may also be effective for AD *** DPP-4 inhibitors have demonstrated neuroprotection and cognitive improvements in animal *** further studies for mTOR,GLP1,and DPP4 signaling pathways in humans would be intensively required,they seem to be a promising approach for innovative *** would like to review the characteristics of AD pathogenesis,the key roles of mTOR in AD and the preventive and/or therapeutic suggestions of directing the mTOR signaling pathway.

关键词： Alzheimer’s disease Cognitive disorder Dementia Glucagon-like peptide-1 Dipeptidyl peptidase-4 Mammalian/mechanistic target of rapamycin

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