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Particle Simulation of Skin Basal Layer Formation

Journal of Biosciences and Medicines 2016年第3期4卷 33-37页

作者： Katsuya Nagayama Takeshi Kurihara yasuko amano Masanori Tanahashi Kyushu Institute of Technology Fukuoka Japan Kao Corporation Tokyo Japan

There has been increasing concern regarding the cosmetic aspects of skin in recent years. Computational simulation can be useful in understanding the mechanism underlying skin formation. The bottom of the epidermis is called the basal layer and is very undulation. In this study, we focus on the basal layer formation. We created a particle model, which forms an undulation basal layer and regenerates the basal layer formation by numerical simulation. At first, two-dimensional basal layer formation without epidermal turnover was simulated. The results showed film shape changes and the stability, as a layer in the process of long-time with an increase and decrease of basal cells. Next, the model was applied to three-dimensional basal layer formation with epidermal turnover. As the structure of the basal layer was deformed, the upper structure of the epidermis comprising the cells divided from the basal layer also became irregular. The simulation results accurately represented and reproduced the three-dimensional basal layer formation and epidermis turnover process.

关键词： Numerical Simulation Skin Formation Particle Model Basal Layer

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3D Numerical Simulation of Epidermal Skin Turnover Process Using a Particle Model

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Journal of Biosciences and Medicines 2015年第3期3卷 45-49页

作者： Katsuya Nagayama Takahiro Uehara yasuko amano Masanori Tanahashi Kyushu Institute of Technology Fukuoka Japan Kao Corporation Tokyo Japan

Skin is the largest organ of the human body. In recent years, concern regarding the cosmetics area has increased, and research studies on anti-aging therapy or cosmetics have been rapidly conducted. Skin cells are not only changing its shape but also its physical properties during the epidermal skin turnover process. Computational simulation can be useful in further understanding the mechanisms of skin formation. We propose a particle model that can handle complex biological phenomena, including cell interactions and is a suitable method for simulating skin formation. The particle model was applied to simulate three-dimensional skin formation accompanied by proliferation and cornification of skin cells. The simulation results represented and reproduced the epidermal skin turnover phenomenon.

关键词： Numerical Simulation Skin Formation Particle Model

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By using either endogenous or transplanted stem cells,which could you prefer for neural regeneration？

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Neural Regeneration Research 2018年第10期13卷 1731-1732页

作者： satoru matsuda yukie nakagawa kumi amano yuka ikeda ai tsuji yasuko kitagishi department of food science and nutrition nara women's University，Kita—Uoya，Nishimachi，Nara，Iapa

Neural regeneration by stem cells transplantation：Tissue regeneration and homeostasis are principally dependent on tissue stem cells which possess abilities of self-renewal and differentiation into multidirectional specialized cell *** general,stem cells are critical for normal tissue renewal as well as repair after tissue *** example,mesenchymal stromal cells and endothelial progenitor cells identified in bone marrow could.

关键词： SPINAL-CORD-INJURY ISCHEMIA

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