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Recent trends in the prevalence and distribution of colonic diverticula in Japan evaluated using computed tomography colonography

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World Journal of Gastroenterology 2021年第27期27卷 4441-4452页

作者： Noriyuki Isohata Koichi Nagata Kenichi Utano Ryoichi Nozaki Satoshi Nozu Takashi Kato Shigeyoshi Kijima Hiroshi Matsumoto Kenichiro Majima yasuji ryu Michiaki Hirayama Shungo Endo Department of Coloproctology Fukushima Medical UniversityAizu Medical CenterAizuwakamatsu 969-3492FukushimaJapan Department of Gastroenterology Fukushima Medical UniversityFukushima 960-1295FukushimaJapan Department of Radiology Fukushima Medical UniversityAizu Medical CenterAizuwakamatsu 969-3492FukushimaJapan Department of Gastroenterology Takano HospitalColoproctology CenterKumamoto 862-0971KumamotoJapan Department of Radiology Saitama Cancer CenterIna 362-0806SaitamaJapan Department of Gastroenterology National Hospital Organization Hokkaido Medical CenterSapporo 063-0005HokkaidoJapan Department of Radiology Jichi Medical UniversityShimotsuke 329-0498TochigiJapan Division of Gastroenterology Kawasaki Medical School HospitalKurashiki 701-0192OkayamaJapan Department of Health Management Kameda Medical CenterKamogawa 296-8602ChibaJapan Department of Radiology Tonami General HospitalTonami 939-1395ToyamaJapan Department of Gastroenterology Tonan HospitalSapporo 060-0004HokkaidoJapan

BACKGROUND Computed tomography colonography(CTC)may be superior to colonoscopy and barium enema for detecting ***,few studies have used CTC to diagnose *** To evaluate the current prevalence and distribution of colonic diverticula in Japan using *** This study was conducted as part of the Japanese National Computed Tomographic Colonography Trial,which included 1181 participants from 14 hospitals in *** analyzed the prevalence and distribution of colonic diverticula and their relationships with age and *** relationship between the diverticula and the length of the large intestine was also *** Diverticulosis was present in 48.1%of the *** prevalence of diverticulosis was higher in the older participants(P<0.001 for trend).The diverticula seen in younger participants were predominantly located in the right-sided *** participants had a higher frequency of bilateral type(located in the rightand left-sided colon)diverticulosis(P<0.001 for trend).The length of the large intestine with multiple diverticula in the sigmoid colon was significantly shorter in those without diverticula(P<0.001).CONCLUSION The prevalence of colonic diverticulosis in Japan is higher than that previously *** prevalence was higher,and the distribution tended to be bilateral in older participants.

关键词： Computed tomography colonography Diverticulosis Diverticular disease Colon

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning Xuan Yuan Hyun Sung Kim Gye Ryeol Park Jae Eun ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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Cellulose Elementary Fibrils as Deagglomerated Binder for High-Mass-Loading Lithium Battery Electrodes

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Nano-Micro Letters 2025年第5期17卷 281-296页

作者： Young-Kuk Hong Jung-Hui Kim Nag-Young Kim Kyeong-Seok Oh Hong-I Kim Seokhyeon ryu Yumi Ko Ji-Young Kim Kwon-Hyung Lee Sang-Young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Advanced Analysis and Data Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Ulsan Advanced Energy Technology R&D Center Korea Institute of Energy Research(KIER)Ulsan 44776Republic of Korea Department of Battery Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea

Amidst the ever-growing interest in high-mass-loading Li battery electrodes,a persistent challenge has been the insufficient continuity of their ion/electron conduction ***,we propose cellulose elementary fibrils(CEFs)as a class of deagglomerated binder for high-mass-loading *** from natural wood,CEF represents the most fundamental unit of cellulose with nanoscale *** preparation of the CEFs involves the modulation of intermolecular hydrogen bonding by the treatment with a proton acceptor and a hydrotropic *** elementary deagglomeration of the cellulose fibers increases surface area and anionic charge density,thus promoting uniform dispersion with carbon conductive additives and suppressing interfacial side reactions at ***,a homogeneous redox reaction is achieved throughout the *** resulting CEF-based cathode(overlithiated layered oxide(OLO)is chosen as a benchmark electrode active material)exhibits a high areal-mass-loading(50 mg cm^(-2),equivalent to an areal capacity of 12.5 mAh cm^(-2))and a high specific energy density(445.4 Wh kg–1)of a cell,which far exceeds those of previously reported OLO *** study highlights the viability of the deagglomerated binder in enabling sustainable high-mass-loading electrodes that are difficult to achieve with conventional synthetic polymer binders.

关键词： Cellulose elementary fibrils Deagglomeration Electrode binders Lithium batteries High-mass-loading

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Expression rates of p16,p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity

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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： Ha-Jong Nam Heongrae ryu Da-Woon Lee Je Yeon Byeon Jun Hyuk Kim Ji Hye Lee Soomin Lim Hwan Jun Choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea Bachelor of Medicine and Bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong ***-related tumors exhibit unique mechanisms that target p16 and p53 ***,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains *** retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian *** All patients underwent wide excision and *** staining for HPV,p16,and p53 yielded positive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关键词： Squamous cell carcinoma Oropharyngeal Non-oropharyngeal Human papillomavirus The p16 The p53

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Relationship between the zonal displacement of the western Pacific subtropical high and the dominant modes of low-tropospheric circulation in summer

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Progress in Natural Science:Materials International 2008年第2期18卷 161-165页

作者： Chan-Su ryu Center for Asian Monsoon and Climate Environment Research Chosun University Gwangju Republic of Korea

The zonal displacement of the western Pacific subtropical high remarkably influences the climate anomalies in China. In this paper,a new zonal index of the subtropical high is defined by modifying previous indices,and is used to investigate the relationship between the zonal displacement of the subtropical high and the dominant modes of 850-hPa circulations. It is found that the zonal displacement of the subtropical high is significantly correlated with the first two leading modes of circulations. In particular,the correlation coefficient between the index and the time series associated with the second mode is as high as 0.78 in 1958-2003 (46 years). Since the second mode is not associated with significant anomalies of sea surface temperatures,the above results imply the diffculty in seasonal forecasting of the zonal displacement of the subtropical high. In addition,the interannual variability in the zonal displacement of the subtropical high has been considerably enhanced since 1978,due to the effects of both dominant modes,especially the second mode. This is likely to account for the frequent occurrence of anomalous climate in China during the recent two decades.

关键词： Western Pacific subtropical high General circulation Dominant mode Interannual variability Interdecadal variation

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Ubiquitin homeostasis: from neural stem cell differentiation to neuronal development

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Neural Regeneration Research 2015年第8期10卷 1209-1210页

作者： Han-Wook ryu Kwon-Yul ryu Department of Life Science University of Seoul

Ubiquitin（Ub）is a well-known eukaryotic protein that exerts diverse signaling functions inside the cells,including targeting its substrates for proteasomal degradation（Hershko and Ciechanover,1998）.

关键词： Ubiquitin neuronal homeostasis eukaryotic sequential targeting diverse suppression maintain impaired

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Applying machine learning techniques to predict detonation initiation fromhot spots

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Energy and AI 2022年第3期9卷 121-127页

作者： Je Ir ryu Department of Mechanical Engineering University of California-BerkeleyBerkeleyCA 94720USA

As hot spots can be a source of detonation initiation by autoignition in a reactive mixture, understanding hotspot initiated detonation is significantly important for energy-related applications of detonation. Although theZel’dovich reactivity gradient theory is extremely useful to predict reaction propagation modes from hot spots,the prediction is limited due to the changes in the unburnt mixture during the induction time. In the currentstudy, machine learning based estimation methods by training the numerical simulation result data set aresuggested to avoid the extensive and empirical effort to find initial conditions of hot spot initiated detonationin inhomogeneous mixtures. The data set was obtained from the detailed numerical simulations with variousconditions of hot spots and divided into training and test data sets. Some variables were normalized withothers to avoid multicollinearity. Three different machine learning techniques, logistic regression, classificationand regression trees, and artificial neural network, were utilized to develop prediction models. Using thedeveloped models by machine learning approaches, the modes of hot spot initiated reaction front propagationcan be predicted without computationally expensive numerical simulations. The accuracies of the machinelearning based prediction models were significantly improved compared to the baseline model simply usingthe Zel’dovich reactivity gradient theory. These models can be utilized as preliminary prediction methods ofhot spot induced detonation initiation conditions for further detailed numerical simulations and dominantinput variables.

关键词： Detonation Deflagration Hydrogen Syngas Logistic regression CART Artificial neural network

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Organic solar cells for indoor power generation

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Science China Chemistry 2020年第1期63卷 1-2页

作者： Hwa Sook ryu Han Young Woo Department of Chemistry College of Science Korea University

During last decades,organic solar cells(OSCs)have achieved remarkable advancements via extensive studies on the optimization of photovoltaic donor/acceptor(D/A)materials,device fabrication,and the D/A bulk heterojunction *** conversion efficiencies(PCEs)up to〜16%for single junction cells and over 17%PCEs were successfully demonstrated for tandem OSC devices[1,2].OSCs may find real industrial applications soon,including building integrated photovoltaics,portable power sources and indoor power generation for low power consumption electronic devices(i.e.,internet of things(IOT)sensors).Among them,indoor applications have great potentials because OSCs can convert indoor lights into electricity more efficiently compared to inorganic counterparts[3].

关键词： D/A power portable

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A Hybrid Instance Selection Using Nearest-Neighbor for Cross-Project Defect Prediction

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Journal of Computer Science & Technology 2015年第5期30卷 969-980页

作者： Duksan ryu Jong-In Jang Jongmoon Baik School of Computinq Korea Advanced Institute of Science and Technology Yuseong-gu Daejeon 305-701 Korea

Software defect prediction （SDP） is an active research field in software engineering to identify defect-prone modules. Thanks to SDP, limited testing resources can be effectively allocated to defect-prone modules. Although SDP requires sufficient local data within a company, there are cases where local data are not available, e.g., pilot projects. Companies without local data can employ cross-project defect prediction （CPDP） using external data to build classifiers. The major challenge of CPDP is different distributions between training and test data. To tackle this, instances of source data similar to target data are selected to build classifiers. Software datasets have a class imbalance problem meaning the ratio of defective class to clean class is far low. It usually lowers the performance of classifiers. We propose a Hybrid Instance Selection Using Nearest-Neighbor （HISNN） method that performs a hybrid classification selectively learning local knowledge （via k-nearest neighbor） and global knowledge （via na/ve Bayes）. Instances having strong local knowledge are identified via nearest-neighbors with the same class label. Previous studies showed low PD （probability of detection） or high PF （probability of false alarm） which is impractical to overall performance as well as high PD and low PF. use. The experimental results show that HISNN produces high overall performance as well as high PD and low PF.

关键词： software defect analysis instance-based learning nearest-neighbor algorithm data cleaning

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Connolly Surface on an Atomic Structure via Voronoi Diagram of Atoms

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Journal of Computer Science & Technology 2006年第2期21卷 255-260页

作者： Joonghyun ryu Rhohun Park Deok-Soo Kim Voronoi Diagram Research Center Hanyang University Seoul Korea Department of Industrial Engineering Hanyang University Seoul Korea

One of the most important geometric structures of a protein is the Connolly surface of protein since a Connolly surface plays an important role in protein folding, docking, interactions between proteins, amongst other things. This paper presents an algorithm for precisely and efficiently computing the Connolly surface of a protein using a proposed geometric construct called β-shape based on the Voronoi diagram of atoms in the protein. Given the Voronoi diagram of atoms based on the Euclidean distance from the atom surfaces, the proposed algorithm first computes a β-shape with an appropriate probe. Then, the Connolly surface is computed by employing the blending operation on the atomic complex of the protein by the given probe.

关键词： protein Connolly/molecular surface β-shape Voronoi diagram of atoms blending surface

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