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Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

Nano Research 2022年第5期15卷 4201-4211页

作者： Tsukasa Akasaka Miho Tamai Yoshitaka Yoshimura Natsumi Ushijima Shinichiro Numamoto Atsuro Yokoyama Hirofumi Miyaji Ryo Takata Shuichi Yamagata Yoshiaki Sato Ko Nakanishi yasuhiro yoshida Department of Biomaterials and Bioengineering Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Immune Signal Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan Department of Pharmacology Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Support Section for Education and Research Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Oral Functional Prosthodontics Division of Oral Functional ScienceFaculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Periodontology and Endodontology Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Orthodontics Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan

The surface topography of a material can influence osteoclast ***,the surface structural factors that promote osteoclast activity have not yet been investigated in ***,we investigated osteoclastogenesis by testing various defined patterns with different dimensions and *** systematic patterns,made of a cyclo-olefin polymer,were prepared at a micron-,submicron-,and nano-scale with a groove,hole,or pillar shape with a 1:1 pitch ***264.7 cells were cultured on these patterns in the presence of the receptor activator of NF-κB ligand(RANKL).Osteoclast formation was induced in the order:pillar>groove≥*** two-dimensional factors also indicated that submicron-sized patterns strongly induced osteoclast *** optimal pillar dimension for osteoclast formation was 500 nm in diameter and 2μm in ***,we observed two types of characteristic actin structure,i.e.,belt-like structures with small hollow circles and isolated ring-like structures,which formed on or around the pillars depending on size and ***,resorption pits were observed mainly on the top of calcium phosphate-coated ***,osteoclasts prefer convex shapes,such as pillars for differentiation and *** results indicate that osteoclastogenesis can be controlled by designing surfaces with specific morphologies.

关键词： micro/nano-pattern pillar RAW264.7 osteoclast actin structure resorption pit

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Erratum to: Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

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Nano Research 2022年第5期15卷 4773-4773页

The article“Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure”,written by Tsukasa Akasaka,Miho Tamai,Yoshitaka Yoshimura,Natsumi Ushijima,Shinichiro Numamoto,Atsuro Yokoyama,Hirofumi Miyaji,Ryo Takata,Shuichi Yamagata,Yoshiaki Sato,Ko Nakanishi,and yasuhiro yoshida,was originally published electronically on the publisher’s internet portal on January 17,2022 without open access.

关键词： internet portal Nat

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Evaluation of interfacial strength by an instrumented indentation method and its application to an actual TBC vane

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 109-117页

作者： yasuhiro YAMAZAKI Shin-ichiro KUGA Toshihiko yoshida Department of Mechanical and Control Engineering Department of Advanced Production Systems Engineering Niigata Institute of Technology Graduate School Ryodensya Co.

The thermal fatigue behaviour of an air plasma sprayed thermal barrier coating was investigated. And also the interfacial strengths of thermal barrier coated specimens subjected to thermal fatigue, as well as a retired TBC vane were also evaluated by means of an instrumented indentation machine. The results indicated that, （1） the TGO grew at the interface during thermal fatigue cycle as a function of the exposure time at elevated temperature; （2） the microcracks were initiated in the top coating and at the interface after thermal cycle tests; （3） the interfacial strength of TBC, which was evaluated by the indentation method, increased with the thermal cycles; （4） the interfacial strength of the retired TBC vane was almost equal with that of the as-sprayed TBC specimen.

关键词： Thermal barrier coating Interfacial fracture toughness Indentation method

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Improvement of die life in high speed injection die casting

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China Foundry 2008年第4期5卷 280-285页

作者： yasuhiro Arisuda Akihito Hasuno Junji yoshida Kazunari Tanii RYOBI Limited Nippon Kosyuha Steel Co. Ltd.

High-speed injection die casting is an efficient manufacturing technology for upgrading aluminum die-cast ***,deficiencies(such as die damage in early period)due to larger load on the molding die compared with conventional technology have brought new *** this study,the cause of damage generated in super high-speed injection was investigated by the combination of experimental observation of the dies and CAE simulation(*** temperature analysis,flow analysis and thermal stress analysis).The potential countermeasures to solve the above problems were also proposed.

关键词： CAE simulation die casting heat check thermal stress

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New methods for the management of gastric varices

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World Journal of Gastroenterology 2006年第37期12卷 5926-5931页

作者： Hiroshi yoshida yasuhiro Mamada Nobuhiko Taniai Takashi Tajiri Department of Surgery Nippon Medical SchoolTokyo 113-8603 Japan

Bleeding from gastric varices has been successfully treated by endoscopic modalities. Once the bleeding from the gastric varices is stabilized, endoscopic treatment and/or interventional radiology should be performed to eradicate varices completely. Partial splenic artery embolization is a supplemental treatment to prolong the obliteration of the veins feeding and/or draining the varices. The overall incidence of bleeding from gastric varices is lower than that from esophageal varices. No studies to date have defi nitively characterized the causal factors behind bleeding from gastric varices. The initial episodes of bleeding from esophageal varices or gastric varices without prior treatment may be at least partly triggered by a violation of the mucosal barrier overlying varices. This is especially likely in the case of varices of the fundus. In view of the high rate of hemostasis achieved among bleeding gastric varices, treatment should be administered in selective cases. Among untreated cases, steps to prevent gastric mucosal injury confer very important protection against gastric variceal bleeding.

关键词： Gastric varices Esophageal varices Bleeding

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New methods for the management of esophageal varices

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World Journal of Gastroenterology 2007年第11期13卷 1641-1645页

作者： Hiroshi yoshida yasuhiro Mamada Nobuhiko Taniai Takashi Tajiri Department of Surgery Nippon Medical School Tokyo 1138603 Japan

Bleeding from esophageal varices (EVs) is a catastrophic complication of chronic liver disease. Many years ago, surgical procedures such as esophageal transection or distal splenorenal shunting were the only treatments for EVs. In the 1970s, interventional radiology procedures such as transportal obliteration, left gastric artery embolization, and partial splenic artery embolization were introduced, improving the survival of patients with bleeding EVs. In the 1980s, endoscopic treatment, endoscopic injection sclerotherapy (EIS), and endoscopic variceal ligation (EVL), further contributed to improved survival. We combined IVR with endoscopic treatment or EIS with EVL. Most patients with EVs treated endoscopically required follow- up treatment for recurrent varices. Proper management of recurrent EVs can significantly improve patients’ quality of life. Recently, we have performed EVL at 2-mo (bimonthly) intervals for the management of EVs. Longer intervals between treatment sessions resulted in a higher rate of total eradication and lower rates of recurrence and additional treatment.

关键词： Esophageal varices Surgery Interventional radiology Embolization Endoscopic treatment Bi-rnonthly

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Diagnosis and initial management of cholangiocarcinoma with obstructive jaundice

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World Journal of Gastroenterology 2008年第19期14卷 3000-3005页

作者： Takashi Tajiri Hiroshi yoshida yasuhiro Mamada NobuhikoTaniai Shigeki Yokomuro Yoshiaki Mizuguchi Departmentof Surgery Nippon Medical School1-1-5 SendagiBunkyo-ku

Cholangiocarcinoma is the second most common primary hepatic cancer. Despite advances in diagnostic techniques during the past decade, cholangiocarcinoma is usually encountered at an advanced stage. In this review, we... 详细信息

关键词： Cholangiocarcinoma Obstructive jaundice Diagnosis Treatment Initial management

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Relating brain structure images to personality characteristics using 3D convolution neural network

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CAAI Transactions on Intelligence Technology 2021年第3期6卷 338-346页

作者： Lixian Cao Yanchun Liang Wei Lv Kaechang Park yasuhiro Miura Yuki Shinomiya Shinichi yoshida Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education Zhuhai College of Jilin UniversityZhuhaiChina Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education College of Computer Science and TechnologyJilin UniversityChangchunChina School of Information&Research Institute Kochi University of TechnologyKochiJapan

The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural *** results obtained are matched with the content of personality *** Big Five personality traits provide easy differentiation for dividing personalities into different *** now,the highest accuracy obtained from the results of personality prediction from the analysis of brain structure is about 70%.Although there is still no effective evidence to prove a clear relationship between brain structure and personality,the obtained results could prove helpful in understanding the basic relationship between brain structure and personality characteristics.

关键词： convolution structure dividing

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Quality of life after total vs distal gastrectomy with Rouxen-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45

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World Journal of Gastroenterology 2017年第11期23卷 2068-2076页

作者： Masazumi Takahashi Masanori Terashima Hiroshi Kawahira Eishi Nagai Yoshikazu Uenosono Shinichi Kinami yasuhiro Nagata Masashi yoshida Keishiro Aoyagi yasuhiro Kodera Koji Nakada Division of Gastroenterological Surgery Yokohama Municipal Citizen’s Hospital Division of Gastric Surgery Shizuoka Cancer Center Center for Frontier Medical Engineering Chiba University Department of Surgery and Science Graduate school of medicine Kyushu University Department of Digestive Surgery Kagoshima University Graduate School of Medicine Department of Surgical Oncology Kanazawa Medical School Center for Comprehensive Community Care Education Graduate School of Biomedical Sciences Nagasaki University Department of Surgery International University of Health and Welfare Hospital Department of Surgery Kurume University School of Medicine Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine Department of Laboratory Medicine The Jikei University School of Medicine

AIM To investigate the detrimental impact of loss of reservoir capacity by comparing total gastrectomy(TGRY) and distal gastrectomy with the same Rouxen-Y(DGRY) reconstruction. The study was conducted using an integrated questionnaire, the Postgastrectomy Syndrome Assessment Scale(PGSAS)-45, recently developed by the Japan Postgastrectomy Syndrome Working *** The PGSAS-45 comprises 8 items from the Short Form-8, 15 from the Gastrointestinal Symptom Rating Scale, and 22 newly selected items. Uni-and multivariate analysis was performed on 868 questionnaires completed by patients who underwent either TGRY(n = 393) or DGRY(n = 475) for stage I gastric cancer(52 institutions). Multivariate analysis weighed of six explanatory variables, including the type of gastrectomy(TGRY/DGRY), interval after surgery, age, gender, surgical approach(laparoscopic/open), and whether the celiac branch of the vagus nerve was preserved/divided on the quality of life(QOL).RESULTS The patients who underwent TGRY experienced the poorer QOL compared to DGRY in the 15 of 19 main outcome measures of PGSAS-45. Moreover, multiple regression analysis indicated that the type of gastrectomy, TGRY, most strongly and broadly impaired the postoperative QOL among six explanatory variables. CONCLUSION The results of the present study suggested that TGRY had a certain detrimental impact on the postoperative QOL, and the loss of reservoir capacity could be a major cause.

关键词： Postgastrectomy syndrome Quality of life Gastric cancer Gastrectomy Patient-reported outcome

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Effect of transforming growth factor-β1 on human intrahepatic cholangiocarcinoma cell growth

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World Journal of Gastroenterology 2006年第39期12卷 6316-6324页

作者： Tetsuya Shimizu Shigeki Yokomuro Yoshiaki Mizuguchi Yutaka Kawahigashi Yasuo Arima Nobuhiko Taniai yasuhiro Mamada Hiroshi yoshida Koho Akimaru Takashi Tajiri Surgery for Organ Function and Biological Regulation Graduate School of Medicine Nippon Medical School Tokyo 113-8603 Japan

AIM： To elucidate the biological effects of transforming growth factor-β1 （TGF-β1） on intrahepatic cholangiocarcinoma （ICC）.METHODS： We investigated the effects of TGF-β1 on human ICC cell lines （HuCCT1, MEC, and HUH-28） by monitoring the influence of TGF-β1 on tumor growth and interleukin-6 （IL-6） expression in ICC cells.RESULTS： All three human ICC cell lines produced TGF-β1 and demonstrated accelerated growth in the presence of TGF-β1 with no apoptotic effect. Studies on HuCCT1 revealed a TGF-β1-induced stimulation of the expression of TGF-β1, as well as a decrease in TGF-β1 mRNA expression induced by neutralizing anti-TGF-β1 antibody. These results indicate that TGF-β1 stimulates the production and function of TGF-β1 in an autocrine fashion. Further, IL-6 secretion was observed in all three cell lines and exhibited an inhibitory response to neutralizing anti-TGF-β1 antibody. Experiments using HuCCT1 revealed a TGF-β1-induced acceleration of IL-6 protein expression and mRNA levels. These findings demonstrate a functional interaction between TGF-β1 and IL-6. All three cell lines proliferated in the presence of IL-6. In contrast, TGF-β1 induced no growth effect in HuCCT1 in the presence of small interfering RNA against a specific cell surface receptor of IL-6 and signal transducer and activator of transcription-3.CONCLUSION： ICC cells produce TGF-β1 and confer a TGF-β1-induced growth effect in an autocrine ***-β1 activates ILo6 production, and the functional interaction between TGF-β1 and IL-6 contributes to ICC cell growth by TGF-β1.

关键词： Transforming growth factor-β1 Interleukin-6 Intrahepatic cholangiocarcinoma

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