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Numerical modeling of the failure process of the heterogeneous karst rock mass using the DDA-SPH method

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Underground Space 2023年第6期13卷 1-22页

作者： Jingyao Gao Guangqi Chen Zhijie Wang Liping Li yasuhiro Mitani Changze Li Hongyun Fan Xinyan Peng Yifan Jiang Department of Civil and Structural Engineering Kyushu UniversityFukuoka 819-0395Japan School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610065China School of Qilu Transportation Shandong UniversityJinanShandong 250000China MOE Key Laboratory of Deep Earth Science and Engineering Institute for Disaster Management and ReconstructionSichuan UniversityChengdu 610031China

The sanding process caused by karstification in dolomite creates a special sandy dolomite stratum,where the frequent catastrophic instability of the surrounding rock occurred during tunnel *** this study,the micro-origin and macro-performance of the sandy dolomite stratum are first ***,a numerical model based on the coupling method between the discontinuous deformation analysis and smoothed particle hydrodynamics is proposed to depict the heterogeneous dolomite formation with different sanding ***,the mechanical behaviors of the heterogeneous dolomite samples under uniaxial compression are studied after calibrating the numerical parameters with the two single materials sampled from the tunnel site ***,the instability disasters of the dolomite surrounding rock with different sanding degrees are reproduced,and the failure behaviors of tunnels are explained with respect to the stress distribution and plastic *** obtained results show that the rotation and dislocation of the remained dolomite block contribute to the unsmooth stress–strain curve and deterioration in uniaxial compressive ***,the block serves as the skeleton in the transmission of field stress in underground space,which improves the stability of the formation.

关键词： Karst sanding effect DDA-SPH method Uniaxial compressive test Tunnel excavation Failure process

Climate and land-use interactively shape butterfly diversity in tropical rainforest and savanna ecosystems of southwestern China

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Insect Science 2021年第4期28卷 1109-1120页

作者： Bai-Ge Miao Yan-Qiong Peng Da-Rong Yang yasuhiro Kubota Evan P.Economo Cong Liu CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnanChina Plant Ecology Core Botanical GardensChinese Academy of SciencesMenglaYunnanChina Faculty of Science University of the RyukyusNishiharaOkinawaJapan Biodiversity and Biocomplexity Unit Okinawa Institute of Science and Technology Graduate UniversityOnna-sonOkinawaJapan Department of Organismic and Evolutionary Biology Museum of Comparative ZoologyHarvard UniversityCambridgeMAUnited States

Human-induced habitat conversion and degradation,along with accelerating climatic change,have resulted in considerable global biodiversity ***,how local ecological assemblages respond to the interplay between climate and land-use change remains poorly ***,we examined the effects of climate and land-use interactions on butterfly diversity in different ecosystems of southwestern ***,we investigated variation in the alpha and beta diversities of butterflies in different landscapes along human-modified and climate *** found that increasing land-use intensity not only caused a dramatic decrease in butterfly alpha diversity but also significantly simplified butterfly species composition in tropical rainforest and savanna *** findings suggest that habitat modification by agricultural activities increases the importance of deterministic processes and leads to biotic *** land-use intensity model best explained species richness variation in the tropical rainforest,whereas the climate and land-use intensity interaction model best explained species richness variation in the *** results indicate that climate modulates the effects of land-use intensity on butterfly alpha diversity in the savanna *** also found that the response of species composition to climate varied between sites:specifically,species composition was strongly correlated with climatic distance in the tropical rainforest but not in the *** together,our long-term butterfly monitoring data reveal that interactions between human-modified habitat change and climate change have shaped butterfly diversity in tropical rainforest and *** findings also have important implications for biodiversity conservation under the current era of rapid human-induced habitat loss and climate change.

关键词： butterfly diversity climate change conservation habitat conversion savanna tropical rainforest

Isolated pancreatic metastasis from a malignant pleural mesothelioma diagnosed using endoscopic ultrasonography-guided fne needle aspiration biopsy

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 196-198页

作者： Yuki Ishikawa-Kakiya Hirotsugu Maruyama Kojiro Tanoue Shusei Fukunaga Yasuaki Nagami yasuhiro Fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine1-4-3AsahimachiAbeno-kuOsaka 545-8585Japan

To the Editor:Malignant pleural mesothelioma is a rare and aggressive form of cancer with a poor prognosis [1].Its progression is mainly a direct invasion from the primary lesion,and metastasis to distant regions rarely *** was found that metastasis of malignant pleural mesothelioma may occur in the liver,adrenal glands,and kidneys in autopsy cases [2].

关键词： metastasis pleural needle

Morphomics via next-generation electron microscopy

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Journal of Molecular Cell Biology 2023年第12期15卷 12-27页

作者： Raku Son Kenji Yamazawa Akiko Oguchi Mitsuo Suga Masaru Tamura Motoko Yanagita yasuhiro Murakawa Satoshi Kume RIKEN-IFOM Joint Laboratory for Cancer Genomics RIKEN Center for Integrative Medical SciencesYokohama 230-0045Japan Department of Nephrology Graduate School of MedicineKyoto UniversityKyoto 606-8507Japan Advanced Manufacturing Support Team RIKEN Center for Advanced PhotonicsWako 351-0198Japan Multimodal Microstructure Analysis Unit RIKEN–JEOL Collaboration CenterKobe 650-0047Japan Technology and Development Team for Mouse Phenotype Analysis RIKEN BioResource Research CenterTsukuba 305-0074Japan Institute for the Advanced Study of Human Biology(ASHBi) Kyoto UniversityKyoto 606-8501Japan IFOM—The FIRC Institute of Molecular Oncology Milan 20139Italy Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchKobe 650-0047Japan Center for Health Science Innovation Osaka City UniversityOsaka 530-0011Japan Osaka Electro-Communication University Neyagawa 572-8530Japan

The living body is composed of innumerable fine and complex *** these structures have been studied in the past,a vast amount of information pertaining to them still remains *** attempting to observe these ultra-structures,the use of electron microscopy(EM)has become ***,conventional EM settings are limited to a narrow tissue area,which can bias ***,new trends in EM research have emerged,enabling coverage of far broader,nano-scale fields of view for two-dimensional wide areas and three-dimensional large ***,cutting-edge bioimage informatics conducted via deep learning has accelerated the quantification of complex morphological *** together,these technological and analytical advances have led to the comprehensive acquisition and quantification of cellular morphology,which now arises as a new omics science termed‘morphomics’.

关键词： comprehensive morphological analysis next-generation electron microscopy 3D bioimaging imaging database deep learning

High harmonic exploring on different materials in dynamic atomic force microscopy

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Science China(Technological Sciences) 2018年第3期61卷 446-452页

作者： ZHENG ZhiYue XU Rui YE ShiLi HUSSAIN Sabir JI Wei CHENG Peng LI YanJun SUGAWARA yasuhiro CHENG ZhiHai CAS Center for Excellence in Nanoscience and Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and Technology Beijing 100190 China Department of Physics Renmin University of China Beijing 100872 China The State Key Laboratory of Digital Manufacturing Equipment and Technology Department of Instrument Science and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China University of Chinese Academy of Sciences Belting 100049 China Asylum Research Santa Barbara 93117 USA Department of Applied Physics Graduate School of Engineering Osaka University Osaka 565-0871 Japan

In atomic force microscopy(AFM), high-frequency components consisted in dynamic tip-sample interaction have been recently demonstrated as a promising technique for exploring more extensive material properties. Here we present an exploratory study of high harmonic atomic force microscopy by force-spectroscopy and high harmonic imaging. Since these components are very weak compared to the fundamental response, we firstly designed a high harmonic cantilever by tuning the second order flexural resonance frequency to an integer 6 times of its fundamental mode(i.e. ω_2=6ω_1). Moreover, it is verified that high harmonic can discern extra features than topographies on different samples with amplitude/frequency modulation(AM/FM) dynamic AFM mode. In AM mode, the first resonance amplitude and 6 th harmonic amplitude were discussed. The 6 th harmonic is more sensitive than the first order response. In FM mode, it is noted that the decaying rate of the 6 th harmonic frequency is approximately 6 multiples to the slope of the fundamental frequency shift when the tip approaches to the surface of sample. This non-destructive method was also adopted to investigate the local interlayer coupling and intercalation in the two-dimensional graphene films tentatively.

关键词： high harmonic AFM high harmonic cantilever dynamic AFM

Improvement of a Real Gas-Sensor for the Origin of Methane Selectivity Degradation by l-XAFS Investigation

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Nano-Micro Letters 2015年第3期7卷 255-260页

作者： Takahiro Wada Naoyoshi Murata Takuya Suzuki Hiromitsu Uehara Hiroaki Nitani yasuhiro Niwa Motohiro Uo Kiyotaka Asakura Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Corporate R&D Headquarters Fuji Electric Co. Ltd Catalysis Research Center Hokkaido University Photon Factory Institute of Materials Structure Science

We have directly investigated the chemical state of the Pd species in a real l-gas sensor device by examining the l-fluorescence X-ray absorption fine structure. The l-gas sensor device was heavily damaged by a heating process in which the temperature was ill-controlled, resulting in decrease of methane selectivity. We found that the Pd O in the fresh l-gas sensor was reduced to Pd metal particles as the methane selectivity decreased. Based on the investigation results, we modified the device structure so as to heat up homogeneously. The lifetime of the sensor was then successfully increased by more than 5 years.

关键词： Micro gas sensor Micro-XAFS Pd/Al2O3 Deactivation

Oncological problems in pancreatic cancer surgery

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World Journal of Gastroenterology 2006年第28期12卷 4466-4472页

作者： Akimasa Nakao Tsutomu Fujii Hiroyuki Sugimoto Naohito Kanazumi Shuji Nomoto yasuhiro Kodera Soichiro Inoue Shin Takeda Department of Surgery Ⅱ Nagoya University Graduate School of MedicineNagoyaJapan

Despite the development of more sophisticated diagnostic techniques, pancreatic carcinoma has not yet been detected in the early stage. Surgical resection provides the only chance for cure or long-term survival. The resection rate has increased due to recent advances in surgical techniques and the application of extensive surgery. However, the postoperative prognosis has been poor due to commonly occurring liver metastasis, local recurrence and peritoneal dissemination. Recent molecular-biological studies have clarified occult metastasis, micrometastasis and systemic disease in pancreatic cancer. Several oncological problems in pancreatic cancer surgery are discussed in the present review.

关键词： Pancreatic cancer Extended resection Molecular diagnosis Micrometastasis Adjuvant therapy

Growth and luminescence properties of Eu-doped HfO2/α-Al2O3 eutectic scintillator

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Journal of Rare Earths 2016年第8期34卷 796-801页

作者： Kei Kamada Kosuke Hishinuma Shunsuke Kurosawa Akihiro Yamaji yasuhiro Shoji Jan Pejchal Yuji Ohashi Yuui Yokota Akira Yoshikawa New Industry Creation Hatchery Center Tohoku University6-6-10 AobaAramakiAoba-kuSendaiMiyagi980-8579Japan C&A Corporation T-Biz 6-6-40 AobaAramakiAoba-kuSendaiMiyagi 980-8579Japan Institute for Material Reseach Tohoku University2-1-1 Katahira Aoba-kuSendal Miyagi980-8577Japan Institute of Physics AS CR Cukrovarnicka 1016253 PragueCzech Republic

HfO2/a-A12O3 eutectics were grown by the micro-pulling down （μ-PD） method at the composition of 63.2 mol.% of-A1203, 35.512 mol.% HfO2, 0.92 mol.% Eu203 and 0.368 tool.% Y2O3. Rod phases with around 3-4 μm diameter were observed on the transverse cross-section. The phase-separated scintillator fibers （PSSFs） structure with fibers of around 3-4 μm diameter and 10-20 μm length was observed. The electron back scattering patterns indicated crystal orientation of [101] for monoclinic HfO2 rod phase and [0001] for μt-A1203 matrix in the transverse cross-section. Eu3＋ 4f-4f emission was observed at 550-750 nm.

关键词： eutectic scintillator micro-pulling down method rare earths

Cryptogenic cirrhosis in the region where obesity is not prevalent

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World Journal of Gastroenterology 2006年第13期12卷 2080-2085页

作者： Hideyuki Kojima Shinya Sakurai Masahiko Matsumura Norie Umemoto Masahito Uemura Hiroyo Morimoto yasuhiro Tamagawa Hiroshi Fukui Third Department of Internal Medicine Nara Medical University 840 Shijo-cho Kashihara-shiNara 634-8522Japan Department of General Medicine and Clinical Investigation Nara Medical University 840 Shijo-cho Kashihara-shiNara 634-8522Japan Department of Internal Medicine Kokuho Central Hospital 404-1 Miyako TawaramotochoNara 636-0302Japan

AIM： Recent studies have demonstrated that obesity is the common feature of cryptogenic cirrhosis （CC） and non-alcoholic steatohepatitis. However, there is little information on CC in the region where obesity is not prevalent, METHODS： The clinical features, and the liver-related morbidity and mortality of CC were analyzed in Japan where the prevalence of obesity is low. Among 652 cirrhotic patients, we identified 29 patients （4.4%） with CC. Of these, 24 CC patients who were followed up for more than 6 months were compared in a case-control study with age-, sex-, and Child-Pugh score-matched controls having cirrhosis of viral etiology. RESULTS： Obesity （BMI≥25 kg/m^2）, diabetes mellitus, and hypertriglyceridemia were more frequent, and the visceral fat area was larger in the CC patients than in the controls. The indices of insulin resistance were higher and the serum aminotransferase levels were lower in the CC patients than in the controls. Logistic regression analysis identified the elevated hemoglobin A1c, BMI ≥ 25 kg/m^2, and normal aminotransferase levels as independent predictors of CC. Kaplan-Meier analysis demonstrated lower occurrence of hepatocellular carcinoma and higher survival rate in the CC than in the controls in contrast to the similar cumulatlve probability of liverrelated morbidity between those ***： CC more frequently presents with the clinical features suggestive of non-alcoholic steatohepatitis compared with controls even in the region where obesity is not prevalent. The lower occurrence of hepatocellular carcinoma and higher survival rate may indicate an indolent clinical course in CC as compared with viral cirrhosis.

关键词： Ke Cryptogenic cirrhosis Viral cirrhosis Nonalcoholic steatohepatitis Hepatocellular carcinoma Case-control study