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Principle for obtaining high joint quality in dissimilar friction welding of Ti-6Al-4V alloy and SUS316L stainless steel

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Journal of Materials Science & Technology 2020年第11期42卷 211-224页

作者： Huihong Liu Yo Aoki yasuhiro Aoki Kohsaku Ushioda Hidetoshi Fujii Joining and Welding Research Institute Osaka UniversityIbarakiOsaka 567-0047Japan

Ti-6Al-4V alloy(Ti64)and SUS316 L stainless steel rods were dissimilarly friction *** focusing on the detailed observation of interface microstructural evolution during the friction welding(FW),the relationship between the processing conditions,weld interface microstructure,and mechanical properties of the obtained joints were systematically investigated to elucidate the principle for obtaining a high joint quality in the FW of Ti64 and SUS316L.A higher friction pressure produced a lower welding temperature in the FW,hence suppressing the thick intermetallic compound layer ***,hard and brittle Ti64/SUS316L mechanically mixed layers generally formed especially at the weld interface periphery due to the high temperature increasing rate,high rotation linear velocity and high outward flow velocity of the *** harmful layers tended to induce the cracks/voids formation at the weld interfaces hence deteriorating the joints’mechanical *** rotation speed reduction and liquid CO2 cooling during the entire processing decreased the temperature increasing rate,rotation linear velocity and outward flow velocity of the Ti64 at the weld interface ***,they suppressed the formation of the harmful mechanically mixed layers,facilitated the homogeneous and sound interface microstructure generation,and finally produced a high-quality dissimilar joint in the FW of Ti64 and SUS316L.

关键词： Friction welding Titanium alloy Stainless steel Microstructure formation mechanism Mechanically mixed layers

Infinite Family of Imaginary Cyclic Fields of Degree p-1 with the p-Rank of the Ideal Class Groups of at Least Two

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Tsinghua Science and Technology 2007年第4期12卷 475-478页

作者： Shin-ichi Katayama yasuhiro Kishi Department of Mathematical Sciences Tokushima University 1-1 Minamijosanjima-cho Tokushima-shi Tokushima 770-8502 Japan Department of Mathematics Fukuoka University of Education 1-1 Bunkyoumachi Akama Munakata-shi Fukuoka 811-4192 Japan

Imaginary cyclic fields of degree p-1 which have two distinct unramified cyclic extensions of degree p are produced using elementary properties of the Lucas sequences. An infinite family of imaginary cyclic fields of ... 详细信息

关键词： ideal class group imaginary cyclic field Lucas sequence

Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer

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World Journal of Gastroenterology 2019年第22期25卷 2743-2751页

作者： Koki Nakanishi Mitsuro Kanda yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of Medicine

Gastrectomy with radical lymph node dissection is the most promising treatment avenue for patients with gastric cancer. However, this procedure sometimes induces excessive intraoperative blood loss and requires perioperative allogeneic blood transfusion. There are lasting discussions and controversies about whether intraoperative blood loss or perioperative blood transfusion has adverse effects on the prognosis in patients with gastric cancer. We reviewed laboratory and clinical evidence of these associations in patients with gastric cancer. A large amount of clinical evidence supports the correlation between excessive intraoperative blood loss and adverse effects on the prognosis. The laboratory evidence revealed three possible causes of such adverse effects: anti-tumor immunosuppression, unfavorable postoperative conditions, and peritoneal recurrence by spillage of cancer cells into the pelvis. Several systematic reviews and meta-analyses have suggested the adverse effects of perioperative blood transfusions on prognostic parameters such as all-cause mortality, recurrence, and postoperative complications. There are two possible causes of adverse effects of blood transfusions on the prognosis: Anti-tumor immunosuppression and patient-related confounding factors (e.g., preoperative anemia). These factors are associated with a worse prognosis and higher requirement for perioperative blood transfusions. Surgeons should make efforts to minimize intraoperative blood loss and transfusions during gastric cancer surgery to improve patients’ prognosis.

关键词： Gastric cancer Blood loss Prognosis Transfusion Adverse effect Immunosuppression Mortality Recurrence Complication

Emerging evidence of the molecular landscape specific for hematogenous metastasis from gastric cancer

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World Journal of Gastrointestinal Oncology 2018年第6期10卷 124-136页

作者： Dai Shimizu Mitsuro Kanda yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of MedicineNagoya 466-8550Japan

Gastric cancer(GC) is one of the most frequentlydiagnosed cancers in the world. Most GC patients are diagnosed when the cancer is in an advanced stage, and consequently, some develop metastatic lesions that generally cause cancer-related death. Metastasis establishment is affected by various conditions, such as tumor location, hemodynamics and organotropism. While digestive cancers may share a primary site, certain cases develop hematogenous metastasis with the absence of peritoneal metastasis, and vice versa. Numerous studies have revealed the clinicopathological risk factors for hematogenous metastasis from GC, such as vascular invasion, advanced age, differentiation, Borrmann type 1 or 2 and expansive growth. Recently, molecular mechanisms that contribute to metastatic site determination have been elucidated by advanced molecular biological techniques. Investigating the molecules that specifically participate in metastasis establishment in distinct secondary organs will lead to the development of novel biomarkers for patient stratification according to their metastatic risk and strategies for preventing and treating distinct metastases. We reviewed articles related to the molecular landscape of hematogenous metastasis from GC.

关键词： Gastric cancer Hematogenous metastasis Hepatic metastasis Molecular mechanism Biomarker Premetastatic niche

A MULTI-GROUP SVEIR EPIDEMIC MODEL WITH DISTRIBUTED DELAY AND VACCINATION

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International Journal of Biomathematics 2012年第3期5卷 1-18页

作者： JINLIANG WANG yasuhiro TAKEUCHI SHENGQIANG LIU School of Mathematical Science Heilongjiang University Harbin 150080 P. R. China Graduate School of Science and Technology Shizuoka University Hamamatsu 432-8561 Japan The Academy of Fundamental and Interdisciplinary Science Harbin Institute of Technology 3041# 2 Yi-Kuang Street Harbin 150080 P. R. China

In this paper, based on a class of multi-group epidemic models of SEIR type with bilinear incidences, we introduce a vaccination compartment, leading to multi-group SVEIR model. We establish that the global dynamics are completely determined by the basic reproduction number R0V which is defined by the spectral radius of the next generation matrix. Our proofs of global stability of the equilibria utilize a graph-theoretical approach to the method of Lyapunov functionals. Mathematical results suggest that vaccination is helpful for disease control by decreasing the basic reproduction number. However, there is a necessary condition for successful elimination of disease. If the time for the vaccines to obtain immunity or the possibility for them to be infected before acquiring immunity is neglected in each group, this condition will be satisfied and the disease can always be eradicated by suitable vaccination strategies. This may lead to over evaluation for the effect of vaccination.

关键词： Multi-group SVEIR model vaccination strategy global stability Lyapunovfunctionals graph theory.

Transcatheter arterial chemoembolization with a fine-powder formulation of cisplatin for hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第27期16卷 3437-3444页

作者： Kazuhiro Kasai Akira Ushio Kei Sawara yasuhiro Miyamoto Yukiho Kasai Kanta Oikawa Hidekatsu Kuroda yasuhiro Takikawa Kazuyuki Suzuki Division of Gastroenterology and Hepatology Department of Internal MedicineIwate Medical University

AIM:To evaluate the efficacy of transcatheter arterial chemoembolization(TACE) using a suspension of a fine-powder formulation of cisplatin(DDPH) for hepatocellular carcinoma(HCC).METHODS:The study population was comprised of 164 patients who were treated by TACE *** these patients,76 underwent TACE using a suspension of DDPH in lipiodol(LPD)(DDPH group),and the remaining 88 underwent TACE with an emulsion of doxorubicin(ADM) with LPD(ADM group).We compared the DDPH group with the ADM group in terms of the objective early response rate,progression free survival(PFS) and overall survival(OS).RESULTS:The objective early response rate in the DDPH group was significantly higher than that in the ADM group(54% vs 24%,P < 0.001).The PFS rate in the DDPH group was also significantly higher than that in the ADM group(P < 0.001).Moreover,the OS in the DDPH group was significantly longer than that in the ADM group(P = 0.002).Although the incidence rate of nausea or vomiting in the DDPH group was higher than that in the ADM group,the ADM group showed a higher incidence rate of the adverse events of hepatic arterial damage and *** other serious complications were observed in either ***:We conclude that TACE using a suspension of DDPH in LPD could be a useful treatment for HCC.

关键词： Hepatocellular carcinoma DDPH Transcatheter arterial chemoembolization Cisplatin Doxorubicin

Heparin/Growth Factors‑Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin‑Based Nerve Guidance Conduits

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Advanced Fiber Materials 2023年第2期5卷 554-573页

作者： yasuhiro Ikegami Muhammad Shafiq Shinichi Aishima Hiroyuki Ijima Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu University744 MotookaNishi‑KuFukuoka 819‑0395Japan Department of Biotechnology Faculty of Science and TechnologyUniversity of Central Punjab(UCP)Lahore 54000Pakistan Department of Pathology and Microbiology Faculty of MedicineSaga UniversityNabeshima 5‑1‑1Saga 849‑8501Japan

Injuries to the nervous system account for the widespread morbidity,mortality,and discomfort *** nerve guidance conduits(NGCs)offer a promising platform for nerve reconstruction,however,they require extracellular matrix(ECM)-like features to better mimic the in vivo ***,this research was aimed to fabricate heparin/growth factors(GFs)-immobilized artificial *** was covalently immobilized onto aligned electrospun polycapro-lactone/gelatin(PCL/Gel)***,basic fibroblast growth factor(bFGF)and nerve growth factor(NGF)were preferentially immobilized on heparinized nanofibers;the immobilization efficiency of GFs was found to be 50%with respect to(w.r.t.)their initial loaded *** in vivo implantation of NGCs in a sciatic nerve defect model revealed the successful retention(~10%w.r.t the initial loaded amount)and bioactivity of NGF for up to 5 *** permeability of bovine serum albumin(BSA)from nanofibrous membranes was further assessed and found to be comparable with the commercialized cel-lulose acetate *** bioactivity of NGCs was assessed in a sciatic nerve defect model in rats for short-term(1 week)and long-term(1-month).The NGCs displayed good structural stability and biocompatibility in *** in vivo evaluation revealed the accumulation of host cells into the transplanted *** together;these heparin/GFs-immobilized artificial NGCs may have broad implications for nerve regeneration and related tissue engineering disciplines.

关键词： Heparin Growth factor-immobilized scaffolds Aligned nanofibers Core/shell nanofibers Nerve tissue engineering Scaffolds Co-axial electrospinning

Expression and significance of ICAM-1 and its counter receptors LFA-1 and Mac-1 in experimental acute pancreatitis of rats

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World Journal of Gastroenterology 2006年第31期12卷 5005-5009页

作者： Wei Sun yasuhiro Watanabe Zhong-Qiu Wang Department of Pediatric Surgery of Kagawa Medical University Japan now in the Department of General Surgery 2^nd Affiliated Hospital China Medical University Shenyang 110004 Liaoning Province China Zhong-Qiu Wang Department of Pediatric Surgery Faculty of Medicine Kagawa University Japan

AIM： To investigate the role of intercellular adhesion molecule-1 （ICAM-1） and its counter receptors LFA-1 and Mac-1 in acute pancreatitis （AP）. METHODS： SD rats were allocated to AP group and control group randomly （25 rats each）. AP was induced by infusion of 5% chenodeoxycholic acid into the pancreatic duct, followed by ligation of pancreatic duct. The rats were sacrificed at 1, 3, 6, 12 and 24 h after induction of pancreatitis. Five rats were sacrificed at one time point in the two groups before the blood and specimens from pancreas and lung were obtained. Serum amylase and ascitic fluid were measured at each time point. Expression of ICAM-1 at different time points was assessed by immunohistochemistry in pancreas and lung, and the expression of LAF-1 and Mac-1 on neutrophils at different time points was detected by flow cytometer. RESULTS： Induction of AP was confirmed by the serum levels of amylase and histological studies. The expression of ICAM-1 in pancreas increased significantly than that in the control group at all time points （P 〈 0.05 orP 〈 0.01）, as well as the expression in lung except at 1 h. The expression of LFA-1 and Mac-1 on neutrophil in blood increased significantly in AP group than that in control group at several time points （P 〈 0.05 or P 〈 0.01）. The amount of ascitic fluid and serum amylase level of AP group increased significantly than that of control group at all time points （P 〈 0.05 or P 〈 0.01）. Parallel to these results, a significant neutrophil infiltration was found in pancreas and lung tissues of AP group rats. CONCLUSION： Our findings suggest the important role for ICAM-1, LFA-1 and Mac-1 in mediating the development of AP from a local disease to a systemic illness. Upregulation of ICAM-1, LFA-1, Mac-1 and subsequent leukocyte infiltration appear to be significant events of pancreatic and pulmonary injuries in AP.

关键词： Acute pancreatitis ICAM-1 LAF-1, Mac-1

Non-genetic contributions of the sperm nucleus to embryonic development

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Asian Journal of Andrology 2011年第1期13卷 31-35页

作者： yasuhiro Yamauchi Jeffrey A Shaman W Steven Ward Department Anatomy and Reproductive Biology Institute for Biogenesis Research John A. Burns School of Medicine University of Hawaii at Manoa Honolulu HI USA GLP Services GENEWlZ Inc. 115 Corporate Blvd. South Plainfield NJ 07080 USA

Recent data from several laboratories have provided evidence that the newly fertilized oocyte inherits epigenetic signals from the sperm chromatin that are required for proper embryonic development. For the purposes of this review, the term epigenetic is used to describe all types of molecular information that are transmitted from the sperm cell to the embryo. There are at least six different forms of epigenetic information that have already been established as being required for proper embryogenesis in mammals or for which there is evidence that it may do so. These are （i） DNA methylation; （ii） sperm-specific histones, （iii） other chromatin-associated proteins; （iv） the perinuclear theca proteins; （v） sperm-born RNAs and, the focus of this review; and （vi） the DNA loop domain organization by the sperm nuclear matrix. These epigenetic signals should he considered when designing protocols for the manipulation and cryopreservation of spermatozoa for assisted reproductive technology as necessary components for effective fertilization and subsequent embryo development.

关键词： embryogenesis epigenetics sperm DNA sperm nuclear matrix DNA loop domain organization