检索结果-南通市图书馆

Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第22期25卷 2743-2751页

作者： Koki Nakanishi Mitsuro Kanda yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of Medicine

Gastrectomy with radical lymph node dissection is the most promising treatment avenue for patients with gastric cancer. However, this procedure sometimes induces excessive intraoperative blood loss and requires perioperative allogeneic blood transfusion. There are lasting discussions and controversies about whether intraoperative blood loss or perioperative blood transfusion has adverse effects on the prognosis in patients with gastric cancer. We reviewed laboratory and clinical evidence of these associations in patients with gastric cancer. A large amount of clinical evidence supports the correlation between excessive intraoperative blood loss and adverse effects on the prognosis. The laboratory evidence revealed three possible causes of such adverse effects: anti-tumor immunosuppression, unfavorable postoperative conditions, and peritoneal recurrence by spillage of cancer cells into the pelvis. Several systematic reviews and meta-analyses have suggested the adverse effects of perioperative blood transfusions on prognostic parameters such as all-cause mortality, recurrence, and postoperative complications. There are two possible causes of adverse effects of blood transfusions on the prognosis: Anti-tumor immunosuppression and patient-related confounding factors (e.g., preoperative anemia). These factors are associated with a worse prognosis and higher requirement for perioperative blood transfusions. Surgeons should make efforts to minimize intraoperative blood loss and transfusions during gastric cancer surgery to improve patients’ prognosis.

关键词： Gastric cancer Blood loss Prognosis Transfusion Adverse effect Immunosuppression Mortality Recurrence Complication

Emerging evidence of the molecular landscape specific for hematogenous metastasis from gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2018年第6期10卷 124-136页

作者： Dai Shimizu Mitsuro Kanda yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of MedicineNagoya 466-8550Japan

Gastric cancer(GC) is one of the most frequentlydiagnosed cancers in the world. Most GC patients are diagnosed when the cancer is in an advanced stage, and consequently, some develop metastatic lesions that generally cause cancer-related death. Metastasis establishment is affected by various conditions, such as tumor location, hemodynamics and organotropism. While digestive cancers may share a primary site, certain cases develop hematogenous metastasis with the absence of peritoneal metastasis, and vice versa. Numerous studies have revealed the clinicopathological risk factors for hematogenous metastasis from GC, such as vascular invasion, advanced age, differentiation, Borrmann type 1 or 2 and expansive growth. Recently, molecular mechanisms that contribute to metastatic site determination have been elucidated by advanced molecular biological techniques. Investigating the molecules that specifically participate in metastasis establishment in distinct secondary organs will lead to the development of novel biomarkers for patient stratification according to their metastatic risk and strategies for preventing and treating distinct metastases. We reviewed articles related to the molecular landscape of hematogenous metastasis from GC.

关键词： Gastric cancer Hematogenous metastasis Hepatic metastasis Molecular mechanism Biomarker Premetastatic niche

Transcatheter arterial chemoembolization with a fine-powder formulation of cisplatin for hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第27期16卷 3437-3444页

作者： Kazuhiro Kasai Akira Ushio Kei Sawara yasuhiro Miyamoto Yukiho Kasai Kanta Oikawa Hidekatsu Kuroda yasuhiro Takikawa Kazuyuki Suzuki Division of Gastroenterology and Hepatology Department of Internal MedicineIwate Medical University

AIM:To evaluate the efficacy of transcatheter arterial chemoembolization(TACE) using a suspension of a fine-powder formulation of cisplatin(DDPH) for hepatocellular carcinoma(HCC).METHODS:The study population was comprised of 164 patients who were treated by TACE *** these patients,76 underwent TACE using a suspension of DDPH in lipiodol(LPD)(DDPH group),and the remaining 88 underwent TACE with an emulsion of doxorubicin(ADM) with LPD(ADM group).We compared the DDPH group with the ADM group in terms of the objective early response rate,progression free survival(PFS) and overall survival(OS).RESULTS:The objective early response rate in the DDPH group was significantly higher than that in the ADM group(54% vs 24%,P < 0.001).The PFS rate in the DDPH group was also significantly higher than that in the ADM group(P < 0.001).Moreover,the OS in the DDPH group was significantly longer than that in the ADM group(P = 0.002).Although the incidence rate of nausea or vomiting in the DDPH group was higher than that in the ADM group,the ADM group showed a higher incidence rate of the adverse events of hepatic arterial damage and *** other serious complications were observed in either ***:We conclude that TACE using a suspension of DDPH in LPD could be a useful treatment for HCC.

关键词： Hepatocellular carcinoma DDPH Transcatheter arterial chemoembolization Cisplatin Doxorubicin

A MULTI-GROUP SVEIR EPIDEMIC MODEL WITH DISTRIBUTED DELAY AND VACCINATION

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2012年第3期5卷 1-18页

作者： JINLIANG WANG yasuhiro TAKEUCHI SHENGQIANG LIU School of Mathematical Science Heilongjiang University Harbin 150080 P. R. China Graduate School of Science and Technology Shizuoka University Hamamatsu 432-8561 Japan The Academy of Fundamental and Interdisciplinary Science Harbin Institute of Technology 3041# 2 Yi-Kuang Street Harbin 150080 P. R. China

In this paper, based on a class of multi-group epidemic models of SEIR type with bilinear incidences, we introduce a vaccination compartment, leading to multi-group SVEIR model. We establish that the global dynamics are completely determined by the basic reproduction number R0V which is defined by the spectral radius of the next generation matrix. Our proofs of global stability of the equilibria utilize a graph-theoretical approach to the method of Lyapunov functionals. Mathematical results suggest that vaccination is helpful for disease control by decreasing the basic reproduction number. However, there is a necessary condition for successful elimination of disease. If the time for the vaccines to obtain immunity or the possibility for them to be infected before acquiring immunity is neglected in each group, this condition will be satisfied and the disease can always be eradicated by suitable vaccination strategies. This may lead to over evaluation for the effect of vaccination.

关键词： Multi-group SVEIR model vaccination strategy global stability Lyapunovfunctionals graph theory.

Heparin/Growth Factors‑Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin‑Based Nerve Guidance Conduits

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Fiber Materials 2023年第2期5卷 554-573页

作者： yasuhiro Ikegami Muhammad Shafiq Shinichi Aishima Hiroyuki Ijima Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu University744 MotookaNishi‑KuFukuoka 819‑0395Japan Department of Biotechnology Faculty of Science and TechnologyUniversity of Central Punjab(UCP)Lahore 54000Pakistan Department of Pathology and Microbiology Faculty of MedicineSaga UniversityNabeshima 5‑1‑1Saga 849‑8501Japan

Injuries to the nervous system account for the widespread morbidity,mortality,and discomfort *** nerve guidance conduits(NGCs)offer a promising platform for nerve reconstruction,however,they require extracellular matrix(ECM)-like features to better mimic the in vivo ***,this research was aimed to fabricate heparin/growth factors(GFs)-immobilized artificial *** was covalently immobilized onto aligned electrospun polycapro-lactone/gelatin(PCL/Gel)***,basic fibroblast growth factor(bFGF)and nerve growth factor(NGF)were preferentially immobilized on heparinized nanofibers;the immobilization efficiency of GFs was found to be 50%with respect to(w.r.t.)their initial loaded *** in vivo implantation of NGCs in a sciatic nerve defect model revealed the successful retention(~10%w.r.t the initial loaded amount)and bioactivity of NGF for up to 5 *** permeability of bovine serum albumin(BSA)from nanofibrous membranes was further assessed and found to be comparable with the commercialized cel-lulose acetate *** bioactivity of NGCs was assessed in a sciatic nerve defect model in rats for short-term(1 week)and long-term(1-month).The NGCs displayed good structural stability and biocompatibility in *** in vivo evaluation revealed the accumulation of host cells into the transplanted *** together;these heparin/GFs-immobilized artificial NGCs may have broad implications for nerve regeneration and related tissue engineering disciplines.

关键词： Heparin Growth factor-immobilized scaffolds Aligned nanofibers Core/shell nanofibers Nerve tissue engineering Scaffolds Co-axial electrospinning

Non-genetic contributions of the sperm nucleus to embryonic development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2011年第1期13卷 31-35页

作者： yasuhiro Yamauchi Jeffrey A Shaman W Steven Ward Department Anatomy and Reproductive Biology Institute for Biogenesis Research John A. Burns School of Medicine University of Hawaii at Manoa Honolulu HI USA GLP Services GENEWlZ Inc. 115 Corporate Blvd. South Plainfield NJ 07080 USA

Recent data from several laboratories have provided evidence that the newly fertilized oocyte inherits epigenetic signals from the sperm chromatin that are required for proper embryonic development. For the purposes of this review, the term epigenetic is used to describe all types of molecular information that are transmitted from the sperm cell to the embryo. There are at least six different forms of epigenetic information that have already been established as being required for proper embryogenesis in mammals or for which there is evidence that it may do so. These are （i） DNA methylation; （ii） sperm-specific histones, （iii） other chromatin-associated proteins; （iv） the perinuclear theca proteins; （v） sperm-born RNAs and, the focus of this review; and （vi） the DNA loop domain organization by the sperm nuclear matrix. These epigenetic signals should he considered when designing protocols for the manipulation and cryopreservation of spermatozoa for assisted reproductive technology as necessary components for effective fertilization and subsequent embryo development.

关键词： embryogenesis epigenetics sperm DNA sperm nuclear matrix DNA loop domain organization

Microstructure and Electrochemical Corrosion Behavior of Fe-Cr System Alloys as Substitutes for Ni-Based Brazing Filler Metal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2016年第8期29卷 697-706页

作者： kangdao shi takahiro tsunoda ikuo shohji kotaro matsu yasuhiro taguchi Graduate School of Engineering Gunma UniversityKiryuGunma 376-8515Japan Graduate School of Science and Technology Gunma UniversityKiryuGunma 376-8515Japan Tokyo Braze Co LtdShikiSaitarma 353-0001Japan

Two new Fe-Cr system alloys,Fe-20Cr-43Ni-10P（mass%）and Fe-20Cr-20Ni-8P-5Si-2Mo（mass%）,have been developed as substitutes for the expensive Ni-based brazing filler metal used in brazing exhaust gas recirculation *** microstructures and melting properties of the alloys were analyzed by electron probe X-ray microanalyzer and differential scanning *** electrochemical characteristics of the alloys were investigated by potentiodynamic polarization testing in an electrolyte solution made in accordance with the standards of the Automobile Manufacturers Association of ***,the corrosion behaviors of the alloys were investigated by constant-potential polarization testing and surface *** is found that both alloys are composed of solid-solution phases and phosphide *** solid-solution phases serve as the anode,and the phosphide phases serve as the cathode in the corrosion reaction for both ***-20Cr-43Ni-10 P exhibits galvanic corrosion on the entire *** contrast,Fe-20Cr-20Ni-8P-5Si-2Mo is attacked at a few localized areas so that the cavities form on the *** corrosion potential（E_（corr）） is lower than that of Ni-29Cr-6P-4Si（mass%）for both *** means that the Fe-Cr system alloys are more easily corroded than *** corrosion rate and corrosion resistance cannot be investigated by the corrosion current density（i_（corr）） and polarization resistance（R_p）,respectively,because of localized corrosion of the two alloys.

关键词： Iron-chromium system alloy Microstructure Electrochemical corrosion Brazing

Effects of Vertical Angle of Conical Punch on Stretch Flangeability of High Strength Steel

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1503-1509页

作者： yasuhiro Ito Yoshiaki Nakazawa Yukihisa Kuriyama Katsuyuki Suzuk Noriyuki Suzuki Nippon Steel and Sumitomo Metal Corporation The University of Tokyo

To clarify the effects of the vertical angle of a conical punch on stretch flangeability, hole expansion forming tests were conducted. Test results showed that the hole expansion ratio becomes larger as the vertical angle *** also showed that the fracture strain at the fracture location on the hole edge was constant and independent of the vertical angle. This is because the hole expansion ratio was controlled not only by the fracture strain, which is independent of the vertical angle, but also by deformation uniformity along the hole edge. From the result of numerical analyses, it was determined that deformation uniformity depends on the gradient of circumferential stress along the radius direction. When the vertical angle is sharp, the circumferential stress showed a steep decline and the deformation localization was suppressed. Consequently, the hole edge deformed more uniformly and the hole expansion ratio became larger. It is concluded that in order to improve stretch flangeability of high strength steel, it is important to uniformly deform the hole edge by applying a conical punch with a sharp vertical angle.

关键词： Formability Ductile fracture Finite element analysis Hole expansion test

Comparison of luminescent properties of helicene-like bibenzothiophenes with o-carborane and 5,6-dicarba-nidodecaborane

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2018年第8期61卷 940-946页

作者： Kenta Nishino Kazushi Hashimoto Kazuo Tanaka yasuhiro Morisaki Yoshiki Chujo Department of Polymer Chemistry Graduate School of Engineering Kyoto University Department of Applied Chemistry for Environment School of Science and Technology Kwansei Gakuin University

This article describes comparison of the anchoring effect on electronic properties of the helicene-like bibenzothiophene between o-carborane and 5,6-dicarba-nido-decaborane. The o-carborane and nido-decaborane-fused bibenzothiophenes were simultaneously obtained in the same reaction and successfully isolated. Initially, the X-ray single crystal analysis revealed that the helicene-like distorted structure was realized in the nido-decaborane-fused bibenzothiophene. From optical measurements in the solution state, distinct different characteristics depending on the type of anchors were observed. It was summarized that the absorption and luminescent properties originated from weak π-conjugation at the bibenzothiophene moiety in the o-carboranefused compound were obtained, whereas robust π-conjugation and significant emission from the intramolecular charge transfer state were detected from the nido-decaborane-fused compound. These data can be explained by the theoretical results that π-conjugation was restrictedly developed within the bibenzothiophene moiety in frontier orbitals of the o-carborane-fused compound. In contrast, π-conjugation can be constructed even through the distorted bibenzothiophene because of the nido-decaborane unit. Moreover, the intramolecular charge transfer state should be realized because of electronic interaction involving the nido-decaborane unit in the excited state. Furthermore, it was demonstrated that the nido-decaborane-fused compound possessed solid-state emission and mechanochromic luminescent properties. The π-conjugation on the distorted structure supported by the nido-decaborane anchor should play a significant role in suppressing aggregation-caused quenching followed by presenting solid-state emission with stimuli responsiveness.

关键词： carborane helicene mechanochromism aggregation-induced emission