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Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C

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World Journal of Hepatology 2015年第26期7卷 2688-2695页

作者： Satoshi Hiramine Norihiro Furusyo Eiichi Ogawa Makoto Nakamuta Eiji Kajiwara Hideyuki Nomura Kazufumi Dohmen Kazuhiro Takahashi Takeaki Satoh Koichi Azuma Akira Kawano Toshimasa Koyanagi Kazuhiro Kotoh Shinji Shimoda Jun hayashi Depart- ment of General Internal Medicine Kyushu University Hospital Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization Department of Hepatology Steel Memorial Yahata Hospital the Center for Liver Disease Shin-Kokura Hospital Department of Internal Medicine Chihaya Hospital Department of Medicine Hamanomachi Hospital Center for Liver Disease National Hospital Organization Kokura Medical Center Department of Medicine Kyushu Central Hospital Department of Medicine Kitakyushu Municipal Medical Center Department of Medicine Fukuoka City Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Kyushu General Internal Medicine Center Hara- Doi Hospital

AIM: To investigate the efficacy of virological response(VR) to telaprevir(TVR)-based triple therapy in predicting treatment outcome of hepatitis ***: This prospective, multicenter study consisted of 253 Japanese patients infected with hepatitis C virus(HCV) genotype 1b. All received 12 wk of TVR in combination with 24 wk of pegylatedinterferon-α(IFN-α) and ribavirin. Serum HCV RNA was tested at weeks 1, 2, 3, 4, 6, 8, 12, 16, 20, and 24. VR was defined as undetectable serum HCV RNA. Sustained virological response(SVR) was VR at 24 wk after the end of treatment and was regarded as a successful ***: Of 253 patients, 207(81.8%) achieved SVR. The positive predictive value of VR for SVR was 100% at week 2, after which it gradually decreased, and was over 85% to week 12. The negative predictive value(NPV) gradually increased, reaching 100% at week 12. The upslope of the NPV showed a large increase from week 4(40.6%) to week 6(82.4%). There was a moderate concordance between the SVR and VR at week 6(kappa coefficient = 0.44), although other VRs had poor concordance to SVR. Multiple logistic regression analysis extracted VR at week 6(P < 0.0001, OR = 63.8) as an independent factor contributing to SVR. In addition, the interleukin-28 B single nucleotide polymorphism and response to previous pegylated-IFN-α and ribavirin therapy were identified as independent factors for ***: VR at week 6, but not at week 4, is an efficient predictor of both SVR and non-SVR to TVRbased triple therapy.

关键词： Chronic hepatitis C Direct-acting antiviral agent

2013年第十七届上海艺术博览会——让消费爱上艺术

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中华儿女（海外版）（书画名家） 2014年第2期 40-51页

作者：吴彦婕王安桅陈九鲁虹郭斯予唐云辉吕洪良刘峰周雯雯 George hayashi Rodica Doret 上海艺博会组委会宣传部朱屺瞻艺术馆上海多伦现代美术馆《中国当代艺术30年》香港天成国际拍卖公司上海书画院上海师范大学美术学院

主持语：主题为＂让消费爱上艺术＂的第十七届上海艺术博览会在上海世贸商城圆满谢幕,来自15个国家的143家优秀画廊参加展览。艺博会自1997年创办以来,十多年每年都在进步,今年更是取得了非凡的成绩,在为期4天的展会中,观众人次和成交... 详细信息

主持语：主题为＂让消费爱上艺术＂的第十七届上海艺术博览会在上海世贸商城圆满谢幕,来自15个国家的143家优秀画廊参加展览。艺博会自1997年创办以来,十多年每年都在进步,今年更是取得了非凡的成绩,在为期4天的展会中,观众人次和成交量双双刷新历史纪录。

关键词：艺术博览会艺博会艺术装饰消费拉动艺术品市场专题展艺术评论家吕洪精神需求一幅画

Colorectal endoscopic submucosal dissection: Recent technical advances for safe and successful procedures

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World Journal of Gastrointestinal Endoscopy 2015年第14期7卷 1114-1128页

作者： Katsumi Yamamoto Tomoki Michida Tsutomu Nishida Shiro hayashi Masafumi Naito Toshifumi Ito Department of Gastroenterology Japan Community Healthcare Organization Osaka Hospital Third Department of Internal Medicine Teikyo University Medical Center Department of Gastroenterology Toyonaka Municipal Hospital

Endoscopic submucosal dissection(ESD) is very useful in en bloc resection of large superficial colorectal tumors but is a technically difficult procedure because the colonic wall is thin and endoscopic maneuverability is poor because of colonic flexure and extensibility. A high risk of perforation has been reported in colorectal ESD. To prevent complications such as perforation and unexpected bleeding, it is crucial to ensure good visualization of the submucosal layer by creating a mucosal flap, which is an exfoliated mucosa for inserting the tip of the endoscope under it. The creation of a mucosal flap is often technically difficult; however, various types of equipment, appropriate strategy, and novel procedures including our clip-flap method, appear to facilitate mucosal flap creation, improving the safety and success rate of ESD. Favorable treatment outcomes with colorectal ESD have already been reported in many advanced institutions, and appropriate understanding of techniques and development of training systems are required for world-wide standardization of colorectal ESD. Here, we describe recent technical advances for safe and successful colorectal ESD.

关键词： Endoscopic submucosal dissection Colo- rectal tumo

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活性炭过滤器在环境净化中的应用

水处理信息报导 2002年第3期 36-36页

作者： hayashi Toshiaki

基于旋转GAUSS曲面体热源模型的激光焊接热过程的数值模拟

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电焊机 2007年第5期37卷 51-54页

作者：张瑞华片山聖二内藤恭章樊丁兰州理工大学甘肃省有色金属新材料省部共建国家重点实验室甘肃兰州730050 大阪大学接合科学研究所

利用旋转GAUSS曲面体新型热源模型,忽略深熔激光焊时小孔对传热的影响,建立了移动激光热源作用下的三维数学模型。采用PHOENICS3.4软件,模拟了SUS304不锈钢深熔激光焊接热过程的温度场和熔池熔合线形状,得到了激光深熔焊接时的温度场分... 详细信息

利用旋转GAUSS曲面体新型热源模型,忽略深熔激光焊时小孔对传热的影响,建立了移动激光热源作用下的三维数学模型。采用PHOENICS3.4软件,模拟了SUS304不锈钢深熔激光焊接热过程的温度场和熔池熔合线形状,得到了激光深熔焊接时的温度场分布规律和“钉头”状的熔池形状,数值模拟结果与实验结果基本吻合。

关键词：激光焊接旋转GAUSS曲面体 PHOENICS

黄色人工晶状体与无色人工晶状体植入患者的视功能比较

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 45-45页

作者： hayashi K. hayashi H. 刘瑛 Dr. hayashi Eye Hospital 4-7-13 Hakataekimae Hakata-Ku Fukuoka 812 Japan

Aim: To compare the visual function in patients with short wavelength blue light blocking yellow tinted intraocular lenses (IOLs) with that in patients with non-tinted IOLs. Methods: 74 patients scheduled for bilateral cataract surgery underwent implantation of either yellow IOLs (HOYA YA60BB) or nontinted IOLs (VA60BB) in both eyes. Contrast visual acuity with and without a glare source was measured under photopic (100 cd/m2) and mesopic (slightly higher luminance than typically used-5 cd/m2) conditions at 2 weeks and 3 months after surgery using the contrast sensitivity accurate tester. Visual acuity and the incidence of patients who noted cyanopsia were also examined. Results: No significant differences between the yellow tinted and non-tinted IOL groups were observed in mean visual acuity or in photopic or higher luminance mesopic contrast visual acuity with and without glare source at either 2 weeks or 3 months after surgery. Furthermore, there was no significant difference in contrast visual acuity loss as a result of glare. The incidence of patients who noticed cyanopsia was significantly less in the yellow tinted IOL group than in the non-tinted IOL group at 2 weeks after surgery (p=0.0234), but no patients reported cyanopsia at 3 months. Conclusion: Visual function in patients with yellow tinted IOLs is virtually the same as that in patients with non-tinted IOLs.

关键词：视功能晶状体对比度视力患者

中国学习者的日语长音、拨音、促音之间的知觉混同

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中国语音学报 2018年第1期 99-106页

作者：张林姝林良子山田玲子日本神户大学日本国际电气通信基础技术研究所(ATR)

日语作为拍(莫拉)语言,其中包含的被称为“特殊拍”的三个音位:长音/R/、拨音/N/和促音/Q/,无论知觉还是生成上,对以音节语言为母语的日语学习者来说都很困难。过去大多数研究都主要讨论因“是否具有特殊拍”而形成最小对立体(minimalpa... 详细信息

日语作为拍(莫拉)语言,其中包含的被称为“特殊拍”的三个音位:长音/R/、拨音/N/和促音/Q/,无论知觉还是生成上,对以音节语言为母语的日语学习者来说都很困难。过去大多数研究都主要讨论因“是否具有特殊拍”而形成最小对立体(minimalpair)的两个词[如“さか/saka/(坡)”和“さっか/saQka/(作家)”]之间如何区别,却极少有研究探讨含有长音、拨音、促音(尽管它们同为特殊拍)的词之间如何区别。在本研究中,以母语是汉语的日语学习者(中国日语学习者)为对象进行了两个实验,探讨日语学习者是否会在知觉上混淆长音、拨音和促音,并且与日语母语者进行了比较。在实验一中,实验参与者听取两个含有特殊拍的非词(如“ターパカ/taRpaka/”和“タッパカ/taQpaka/”),然后判断这两个词是否相同。实验结果中对反应时间的分析显示,实验参与者在区别“特殊拍”词与“自立拍(非特殊拍)”词时的反应时间并不一定比区别“特殊拍”词与“特殊拍”词(两个特殊拍类型不同)时的反应时间更长。在实验二中,实验参与者听取句子,句中包含一个有特殊拍的非词(如“カンタパ/kaNtapa/”),然后仅从特殊拍一处不同的四个选项中选出句中那个非词。结果显示,与日语母语者不同,中国日语学习者在知觉上会有将拨音误听为长音,以及混淆长音与促音的现象。以上两个实验结果说明,三种类型的特殊拍之间也极有可能存在知觉上的混同。

关键词：莫拉语言日语特殊拍长音拨音促音汉语母语者日语学习者知觉混同

Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan

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World Journal of Gastroenterology 2016年第5期22卷 1891-1901页

作者： Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi Department of Gastroenterology and Hepatology Tokyo Medical University6-7-1 NishishinjukuShinjuku-kuTokyo 160-0023Japan First Department of Internal Medicine Gifu University HospitalGifu 501-1194Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology and Nephrology Chiba University Graduate School of MedicineChiba 260-8677Japan Department of Gastroenterology Chiba Cancer CenterFunabashi Municipal HospitalChiba 260-8717Japan Department of Gastroenterology Clinical Research InstituteNational Hospital OrganizationKyushu Medical CenterFukuoka 810-8563Japan Division of Gastroenterology Department of MedicineKurume University School of MedicineKurume 830-0011Japan Department of Gastroenterology Onomichi General HospitalOnomichi 722-8508Japan Department of Medical Oncology and Hematology Sapporo Medical University School of MedicineSapporo 060-8543Japan Department of Surgery and Oncology Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Iwate Medical UniversityMorioka 020-0023Japan Department of Gastroenterology and Hepatology Graduate School of MedicineHokkaido UniversitySapporo 060-8648Japan Division of Gastroenterology and Hepatology Omori Medical CenterToho UniversityTokyo 143-0015Japan Department of Gastroenterology Tottori University HospitalYonago 683-8504Japan Department of Internal Medicine Division of GastroenterologyJichi Medical UniversityShimotsuke 329-0498Japan Department of Gastroenterology Digestive Disease CenterShowa UniversityNorthern Yokohama HospitalYokohama 224-0032Japan Department of Gastroenterology and Hepatology Graduate School of MedicineNagoya UniversityNagoya 466-8550Japan Department of Gastroenterology Mutsu General HospitalMutsu 035-0071Japan Division of Gastroenterology Department of Internal MedicineOhashi Medical CenterToho UniversityTokyo 153-0044Japan Department of Gastroenterology Mie University

AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic ***: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two

关键词： Cholangioscopy Endoscopic retrogradecholangiopancreatography Pancreatoscopy Singleoperator SpyGlass

Acura RLX轿车用新型V6 3.5L汽油机的开发

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汽车与新动力 2014年第1期46卷 29-35页

作者： N.Suzuki Y.hayashi M.Odell T.Esaki A.Sato K.Ishiki S.Watanabe 王晓滕李研芳

本田公司应用最新的动力总成技术"地球梦科技",开发了1款3.5 L V6汽油机。该发动机的总体设计目标是降低二氧化碳排放,并向客户提供驾驶乐趣。"地球梦科技"的理念旨在降低排放的同时改善燃油经济性。为达到这一目标,并为用户提供驾驶乐... 详细信息

本田公司应用最新的动力总成技术"地球梦科技",开发了1款3.5 L V6汽油机。该发动机的总体设计目标是降低二氧化碳排放,并向客户提供驾驶乐趣。"地球梦科技"的理念旨在降低排放的同时改善燃油经济性。为达到这一目标,并为用户提供驾驶乐趣,采用了三级可变气门正时及升程电控技术和可变气缸管理系统。将这种配气机构技术与缸内直接喷射技术相结合,可提升3.3%的功率,并降低燃油耗20%。为满足中型豪华轿车对噪声及振动水平的要求,开发了新型发动机悬置系统,以改善3缸运行模式的发动机振动。阐述了带可变气缸管理系统及缸内直接喷射系统的三级可变气门正时及升程电控技术、减摩技术,以及新型发动机悬置系统的结构及优势。

关键词：车用汽油机可变气门正时及升程电控技术可变气缸管理系统燃油经济性主动控制式发动机悬置系统