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Chinese journal of Natural Medicines 2017年第4期15卷 271-280页

作者： Saba Khanam Ambreen Fatima Rahul Smita jyoti Fahad Ali Falaq Naz Barkha Shakya yasir Hasan Siddique Drosophila Transgenic Laboratory Section of GeneticsDepartment of ZoologyFaculty of Life SciencesAligarh Muslim UniversityAligarhUttar Pradesh 202002India

Capsaicin(trans-8-methyl-N-vanillyl-6-nonenamide) is the main component in hot peppers, including red chili peppers, alapenos, and habanero, belonging to the genus Capsicum. Capsaicin is a potent antioxidant that interferes with free radical activities. In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate(MMS) induced toxicity in third instar larvae of transgenic Drosophila melanogaster(hsp70-lacZ)Bg^9. The third instar was allowed to feed on the diet having different doses of capsaicin and MMS separately and in combination. The results suggested that the exposure of third instar larvae to the diet having MMS alone showed significant hsp70 expression as well as tissue DNA and oxidative damage, whereas the larvae feed on the diet having MMS and capsaicin showed a decrease in the toxic effects for 48-h of exposure. In conclusion, capsaicin showed a dose-dependent decrease in the toxic effects induced by MMS in the third instar larvae of transgenic Drosophila melanogaster.

关键词： Capsaicin Methyl methanesulphonate Drosophila melanogaster Toxicity

巴基斯坦山达克矿区ASTER遥感数据蚀变信息提取及找矿预测

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地质论评 2022年第6期68卷 2381-2395页

作者：刘磊蒲小楠洪俊张辉善 yasir Shaheen Khalil 长安大学地球科学与资源学院西安710054 自然资源部岩浆作用成矿与找矿重点实验室中国地质调查局西安地质调查中心西安710054 巴基斯坦地质调查局巴基斯坦白沙瓦25100

巴基斯坦查盖火山岩浆岩带属于特提斯成矿域的重要组成部分之一,是巴基斯坦境内最重要的斑岩型铜矿带,但目前其相关的遥感研究还较少,制约了对该成矿带的找矿潜力分析。笔者等以山达克矿床及其周边为研究区,对先进星载热辐射与反射辐射... 详细信息

巴基斯坦查盖火山岩浆岩带属于特提斯成矿域的重要组成部分之一,是巴基斯坦境内最重要的斑岩型铜矿带,但目前其相关的遥感研究还较少,制约了对该成矿带的找矿潜力分析。笔者等以山达克矿床及其周边为研究区,对先进星载热辐射与反射辐射计(Advanced Spaceborne Thermal Emission and Reflection Radiometer, ASTER)数据进行RBD (Relative absorption band depth)比值假彩色合成、主成分分析、光谱角制图等处理,获得蚀变遥感异常信息分布特征,通过对蚀变特征和主要控矿要素进行遥感研究,建立了山达克矿床遥感找矿模型并开展成矿预测,为该成矿带矿产勘查提供借鉴。根据建立的遥感找矿模型,圈定了找矿预测靶区10处。对矿区东矿体和矿区北部的2个靶区进行野外验证,证实了提取结果与实际地质事实吻合较好,对矿区岩石样品进行光谱实测,表明样品实测光谱曲线与标准矿物光谱曲线的吸收特征位置高度相似,证实了研究区绢云母化、青磐岩化等蚀变较强且分布较广。结果表明本次研究提取的矿化蚀变结果可信度较高,可为后续找矿勘查工作提供参考。

关键词：巴基斯坦山达克铜矿 ASTER 矿化蚀变遥感找矿模型

Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population

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Chinese Medical journal 2011年第9期124卷 1333-1337页

作者： Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza javaid Irfan yasir Waheed Iram Bilal Abida Raza Nuclear Medicine Oncology and Radiotherapy Institute Islamabad Punjab University Lahore Pakistan Institute of Biochemistry & Biotechnology Punjab University Lahore Pakistan NUST Center of Virology and Immunology National University of Sciences and Technology Islamabad Pakistan COMSATS Institute Islamabad Pakistan

Background Hepatitis C virus （HCV） constitutes a major public health issue around the world, especially in developing countries like Pakistan. In this study, we assessed outcome of interferon （INF） treatment in chronic hepatitis C patients categorized by gender, age, and viral *** In this study, 750 HCV positive patients with genotype 3 were selected, out of which 616 completed the entire treatment. Their personal history, pro-treatment HCV RNA and serum alanine transaminase （ALT） was *** were treated with combination therapy of INF-α 2b three million units （thrice a week） plus ribavirin （1000-1200mg per day） for 24 weeks. After 24 weeks their HCV RNA and serum ALT level was *** Out of the 616 patients, 391 （63.5%） responded to therapeutic regimen （INF-α 2b plus ribavirin）. Among the responders, 27.1% were men and 36.4% were women. Best treatment response was observed in patients having Iow viral load ＜8×105 IU/ml and age ≤40 years than patients having Iow viral load and age ＞40 years （73.2% vs. 60.3%, P=0.05）.Conclusions Better response to IFN-α 2b plus ribavirin was observed in patients with lower viral RNA and younger *** suggests that all patients considered for treatment should have quantification of serum HCV RNA level. The result can be used to counsel patients on the likelihood of response and may influence the patient＇s decision on treatment.

关键词： hepatitis C interferon ribavirin

应用SNP精准鉴定大豆种质及构建可扫描身份证

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作物学报 2018年第3期44卷 315-323页

作者：魏中艳李慧慧李骏 yasir A.Gamar 马岩松邱丽娟国家农作物基因资源与遗传改良重大科学工程/农业部种质资源利用重点实验室/中国农业科学院作物科学研究所北京100081 广西大学农学院广西南宁530004 黑龙江省农业科学院大豆研究所黑龙江哈尔滨150086

为加强大豆种质资源管理及品种保护,本研究构建了一套基于单核苷酸多态性(SNP)标记的快速鉴定体系。选用分布于13个基因的23个SNP标记对599份大豆表型精准鉴定种质进行基因型分析。结果表明,SNP标记的遗传多样性指数范围0~0.722,其中3个... 详细信息

为加强大豆种质资源管理及品种保护,本研究构建了一套基于单核苷酸多态性(SNP)标记的快速鉴定体系。选用分布于13个基因的23个SNP标记对599份大豆表型精准鉴定种质进行基因型分析。结果表明,SNP标记的遗传多样性指数范围0~0.722,其中3个SNP在供试材料中不存在碱基差异,2个SNP为特异等位变异。从具有多态性的20个SNP中选出14个(Gly SNP14)用于种质鉴定,其中12个为高多态性SNP,2个为特异性SNP。模拟结果表明,Gly SNP14的种质鉴别能力(750份种质)高于任意相同数目标记构成的SNP随机组合(最多361份种质)。Gly SNP14在599份种质中共形成了176个单倍型,其中100份种质具有独特的单倍型。结合这些种质的其他属性,构建了100份种质由38个数字组成的身份证,前10位数字为种质属性信息码,包括品种类别、来源地等;11~38位数字为品种分子指纹码,代表品种的特异分子信息,并最终以一维码和二维码的形式表示,为种质资源简易管理与保护利用提供了有效途径。

关键词：大豆 SNP 遗传多样性 DNA指纹图谱品种ID

Civil-GIS incorporated approach for water resource management in a developed catchment for urban-geomorphic sustainability:Tallowa Dam,southeastern Australia

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International Soil and Water Conservation Research 2016年第4期4卷 304-313页

作者： Ali K.M.Al-Nasrawi Brian G.jones yasir M.Alyazichi Sarah M.Hamylton Mohammed T.jameel Ali Faraj Hammadi School of Earth and Environmental Sciences University of WollongongNSW 2522Australia School of Civil Mining&Environmental EngineeringUniversity of WollongongNSW 2522Australia School of Mechanical Materials and Mechatronics EngineeringUniversity of WollongongNSW 2522Australia

Damming rivers causes two main problems affecting a river's geomorphic ecosystem and its water *** Tallowa Dam on the Shoalhaven River in southeastern NSW,Australia,provides a case study to find the best sustainable solutions to avoid these *** project uses a civil-infrastructure idea to design a grid of collector pipes from the reservoir bottom *** data analysis using ArcGIS 10.2 is used to determine the best grid location for the pipes in the *** and sediment samples have been analysed for grain size,heavy metal and organic matter *** dam has led to a significant decline in sediment transport and water discharge to the lower reaches of the river which has resulted in greater erosion of sediment and higher salinity rates within the lower river and coastal *** quality in the reservoir has been affected by increased sediment accumulation,particularly mud,which has increased the amount of heavy metal and nutrient pollution that could eventually affect the water users.A proposed solution is to use over-storage water to remove accumulated sediment from the base of the dam through a net of collector pipes controlled by automechanical gates,instead of flowing over the top of the *** would maximize the volume of upstream sediment and contained pollutants that can be released from the reservoir into the downstream river ecosystems as well as providing better water quality and a longer water storage time.

关键词： Water quality Geomorphology Pollutants Civil-infrastructure GIS-detection

NS1 antigen: A new beam of light in the early diagnosis of dengue infection

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Asian Pacific journal of Tropical Medicine 2016年第12期9卷 1187-1189页

作者： Muhammad Suleman Rani Faryal Muhammad Masroor Alam Salmaan Sharif Shahzad Shaukat Uzma Bashir Aamir Adnan Khurshid Mehar Angez Massab Umair Mian Muhammad Sufian yasir Arshad Ghulam Mujtaba Syed Sohail Zahoor Zaidi Department of Microbiology Quaid-i-Azam University Department of Virology National Institute of Health

Objective: To evaluate NS1 antigen detection ELISA for the early laboratory diagnosis of dengue virus infection. Methods: The present study was conducted to evaluate the overall positivity of NS1 antigen detection ELISA and its comparison with viral RNA detection via real time PCR and Ig M antibodies detection by ELISA. Results: A total of 1 270 serum samples were tested 86%(1 097/1 270) were detected positive by one or more than one diagnostic test. Out of 1 270, 64%(807/1 270) were positive by NS1 ELISA and 52%(662/1 270), 51%(646/1 270) were positive by real-time RT-PCR and Ig M ELISA ***: NS1 antigen detection ELISA is highly suitable diagnostic tools and it also has great value for use in outbreak and epidemic situation.

关键词： Dengue Pakistan Epidemiology ELISA NS1 Antigen

不同肥料对退化茶园根际土壤微生物代谢活性和群落结构的影响

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生态学杂志 2017年第10期36卷 2894-2902页

作者：蒋宇航林生林伟伟陈婷 yasir Arafat 位小丫林文雄福建省农业生态过程与安全监控重点实验室福建农林大学生命科学学院福州350002 作物生态与分子生理学福建省高校重点实验室福建农林大学福州350002

于福建省安溪县桃舟乡,选择宿根连作20年茶园进行田间试验。以未施肥(CK)、氮肥(NF)、羊粪(GM)及豆科绿肥(LF)等处理后的茶树根际土壤作为供试土样,分析不同肥料对茶树根际土壤理化特性、微生物代谢活性及其不同类型磷脂脂肪酸含量变化... 详细信息

于福建省安溪县桃舟乡,选择宿根连作20年茶园进行田间试验。以未施肥(CK)、氮肥(NF)、羊粪(GM)及豆科绿肥(LF)等处理后的茶树根际土壤作为供试土样,分析不同肥料对茶树根际土壤理化特性、微生物代谢活性及其不同类型磷脂脂肪酸含量变化等影响。结果表明:NF、GM和LF均能够提高茶园土壤pH值和有机质(OM)及速效钾(AK)等含量,其pH分别提高0.47%、2.36%和2.13%;OM分别提高17.56%、27.48%和54.96%;AK分别提高56.10%、63.41%和73.17%;碱解氮(AN)和速效磷(AP)在NF处理下分别下降了9.10%和335.00%;在GM处理下分别提高了17.06%和2.11倍;在LF处理下分别提高了16.70%和3.88倍;同时,施肥能提高土壤脲酶、蔗糖酶、多酚氧化酶和过氧化物酶等活性,且提高效果由高到底依次为LF、GM、NF;酸性磷酸酶活性(ACP)和微生物对磷素利用率(UTP)在NF处理下分别降低70.04%和249.00%;在GM处理下分别提高了24.74%和1.80倍;在LF处理下分别提高34.28%和2.51倍;与此同时,GM和LF还能够提高根际土壤微生物群落丰度以及菌群多样性。综上所述,豆科绿肥和羊粪能够有效改善茶园土壤肥力,促进根际微生物对养分的代谢活性,对提升茶园经济效益和生态效益具有现实意义。

关键词：羊粪氮肥豆科绿肥茶树根际土壤微生物群落

Insight into the phytochemical, biological, and in silico studies of Erythrina suberosa roxb.: A source of novel therapeutic bioactive products from a medicinal plant

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Food Bioscience 2023年第2期52卷 1421-1432页

作者： Abdulhakeem S.Alamri Hammad Saleem Irfan Pervaiz Umair Khurshid juwairiya Butt Tahir Ali Chohan Majid Alhomrani Marcello Locatelli Syafiq Asnawi Zainal Abidin yasir Nasser H Alqahtani Kannan RRRengasamy Mohamad Fawzi Mahomoodally Department of Clinical Laboratory Sciences The Faculty of Applied Medical SciencesTaif UniversityTaifSaudi Arabia Centre of Biomedical Sciences Research(CBSR) Deanship of Scientific ResearchTaif UniversitySaudi Arabia Institute of Pharmaceutical Sciences(IPS) University of Veterinary&Animal Sciences(UVAS)LahorePakistan KITAAS Khaldunia College of PharmacyLahorePakistan Department of Pharmaceutical Chemistry Faculty of PharmacyThe Islamia University of Bahawalpur63100Pakistan School of Life Sciences University of Westminster115 New Cavendish StreetLondonW1W 6UWUK Department of Pharmacy University‘G.d’Annunzio of Chieti-Pescara66100ChietiItaly jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon Selatan47500Bandar SunwaySelangor Darul EhsanMalaysia MOI Clinics Security Forces HospitalRiyadhSaudi Arabia Laboratory of Natural Products and Medicinal Chemistry(LNPMC) Department of PharmacologySaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai600077India Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusR´eduit80837Mauritius Centre of Excellence for Pharmaceutical Sciences North-West UniversityPrivate Bag X6001Potchefstroom2520South Africa

Background:Erythrina suberosa(***)*** known as corky coral tree is used as a folklore medicine to treat ulcers and *** study explored the phytochemical profiles of methanol and dichloromethane(DCM)extracts from the aerial,root,and flower parts of ***:Total bioactive contents,high-performance liquid chromatography array(HPLC-PDA)polyphenolic quantification,and ultra-high performance liquid chromatography-mass spectrometry(UHPLC-MS)analysis were used to evaluate the phytochemical *** potential was evaluated by determining their antioxidant(DPPH,ABTS,FRAP,CUPRAC,Phosphomolybdenum,and metal chelating)and enzyme inhibitory(cholinesterase,amylase,glucosidase,and tyrosinase)***:The phenolic(46.26 mg GAE/g extract)and flavonoid(32.46 mg QE/g extract)contents were found to be highest in the methanolic extract of roots(EsR-M).HPLC-PDA analysis determined the presence of numerous bioactive compounds,including catechin,syringic acid,p-hydroxy benzoic acid,gallic acid,vanillic acid,epicatechin,rutin,chlorogenic acid,carvacrol,sinapinic acid,and naringenin in considerable amounts.A total of 143 phytochemicals,belonging to phenolic,flavonoid,coumarin,terpenoid,chalcone,saponin,and glycoside classes,were tentatively identified by UHPLC-MS *** methanolic extract(EsA-M)exhibited highest radical scavenging(DPPH 86.81 mgTE/g extract,ABTS 245.17 mgTE/g extract)as well as reducing potential(FRAP 177.12 mgTE/g extract,CUPRAC 177.12 mgTE/g extract).Likewise,it was also noted to be most active for BChE(5.70 mg GALAE/g extract)and tyrosinase inhibition(148.35 mg KAE/g extract).While,roots-DCM extract(EsR-D)presented considerable inhibition for AChE(4.69 mg GALAE/g extract)and amylase(0.81 mmol ACAE/g extract)***,davallioside A,and isovitexin were docked to tyrosinase to depict possible ***:This study has established baseline data on the biological and phytochemical profile of ***

关键词： Erythrina suberosa HPLC-PDA UHPLC-MS Antioxidant Enzyme inhibition Natural products

巴基斯坦新特提斯构造–岩浆演化与重要金属成矿作用

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西北地质 2024年第3期57卷 154-176页

作者：洪俊张辉善吕鹏瑞 Tahseenullah Khan yasir Shaheen Khalil 王志华张海迪自然资源部岩浆作用成矿与找矿重点实验室中国地质调查局西安地质调查中心陕西西安710119 巴基斯坦巴利亚大学地球科学与环境学院巴基斯坦伊斯兰堡44000 巴基斯坦地质调查局巴基斯坦伊斯兰堡44000 长安大学资源学院陕西西安710054

巴基斯坦在大地构造位置上处于印度、欧亚和阿拉伯三大板块的汇聚带,正同时发生着大陆碰撞和大洋俯冲作用,是研究地球系统深部圈层相互作用与成矿效应的绝佳天然实验室。但是,目前对于巴基斯坦构造演化与成矿作用的研究还不系统,对于巴... 详细信息

巴基斯坦在大地构造位置上处于印度、欧亚和阿拉伯三大板块的汇聚带,正同时发生着大陆碰撞和大洋俯冲作用,是研究地球系统深部圈层相互作用与成矿效应的绝佳天然实验室。但是,目前对于巴基斯坦构造演化与成矿作用的研究还不系统,对于巴基斯坦的大型–超大型矿床形成的背景和机制仍不清楚。笔者针对巴基斯坦不同类型的优势矿种开展了深入解剖和对比研究,系统梳理最新研究进展,围绕巴基斯坦新特提斯构造–岩浆演化与成矿作用响应的关键科学问题,分析铜矿、铬铁矿、铅锌矿以及碳酸岩有关的稀土矿床等重要金属成矿类型形成的构造环境以及与区域重大地质事件的耦合关系,总结巴基斯坦区域成矿规律,为资源潜力分析和境内外找矿勘查提供依据。

关键词：新特提斯岩浆作用铬铁矿斑岩铜矿碳酸岩巴基斯坦

Dengue outbreak in Swat and Mansehra,Pakistan 2013;an epidemiological and diagnostic perspective

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Asian Pacific journal of Tropical Medicine 2016年第4期9卷 371-375页

作者： Muhammad Suleman Rani Faryal Uzma Bashir Aamir Muhammad Masroor Alam Nadia Nisar Salmaan Sharif Shahzad Shaukat Adnan Khurshid Mehar Angez Massab Umair Ghulam Mujtaba Mian Muhammad Sufian yasir Arshad Lubna Rehman Syed Sohail Zahoor Zaidi Department of Microbiology.Quaid-i-Azam University Department of Virology National Institute of Health

Objective:To High light some epidemiological,clinical and diagnostic features of dengue fever during an outbreak and the role of different diagnostic techniques to achieve the highest level of accuracy in ***:Blood samples(n=323) were collected along with epidemiological and clinical data from suspected dengue patients who visited different hospitals in Swat and Mansehra district of Pakistan between May-November 2013 during a dengue *** were tested for the detection of viral nucleic acid by real-lime *** structural protein-1(NS1antigen and IgM antibodies by ***:Out of 323 cases with clinical dengue infection,304 were positive by one or more diagnostic parameter:201 samples were positive by real-time PCR,209 were positive by NS1 ELISA and 190 were positive by IgM *** of real-time PCR and NS1 *** were comparable for early diagnosis of dengue virus *** antibody detection assay was found useful for the diagnosis in the samples collected later than day 5 of ***:The use of real-lime PCR or detection of non stnictural protein NS 1 by ELISA followed by IgM antibodies detection can be recommended for early diagnosis of dengue virus infection with a high level of accuracy.

关键词： Dengue virus NS1 Antigen Pakistan Diagnosis Epidemiology Khyber Pakhtunkhwa