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Comprehensive Analysis of Estrogen Receptor 1 Dysregulation in Liver Hepatocellular Carcinoma: Implications for Prognosis and Therapeutic Targeting - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 51-59页

作者： Syed Hussain Raza yasir Hameed Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study investigates the expression pattern and regulatory mechanisms of estrogen receptor 1 (ESR1) in liver hepatocellular carcinoma (LIHC) through comprehensive bioinformatics analysis. Utilizing UALCAN and GEPIA2 databases, significant down-regulation of ESR1 expression is observed in LIHC samples compared to normal controls, indicating its potential role in tumor progression. Further analysis reveals consistent down-regulation across different clinical variables including patient age, gender, race, and various stages of LIHC, affirming the regulatory role of ESR1 in tumor development and progression. Additionally, promoter methylation analysis demonstrates hypermethylation of ESR1 in LIHC samples, negatively correlating with its expression. This association persists across different clinical parameters, emphasizing the inverse relationship between ESR1 methylation and expression levels. Survival analysis indicates that up- regulation of ESR1 is associated with better overall survival, suggesting its potential as a prognostic biomarker in LIHC. Furthermore, genetic mutation analysis using cBioPortal reveals a spectrum of alterations in ESR1, including amplification, missense mutation, deep deletion, splice mutation, and truncating mutation, highlighting the genetic complexity of ESR1 in LIHC. These findings collectively contribute to a deeper understanding of ESR1 dysregulation in LIHC and its clinical implications as a potential therapeutic target and prognostic marker.

关键词： Estrogen receptor 1 Liver hepatocellular carcinoma Biomarker Prognosis

Thermal analysis and Joule-Thomson expansion of black hole exhibiting metric-affine gravity

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Chinese Physics C 2024年第1期48卷 173-183页

作者： Muhammad yasir 夏铁成 Faisal Javed G.Mustafa Department of Mathematics Shanghai UniversityShanghai 200444China Department of Physics Zhejiang Normal UniversityJinhua 321004China Zhejiang Institute of Photoelectronics and Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua 321004China New Uzbekistan University Mustaqillik Ave.54Tashkent 100007Uzbekistan

This study examines a recently hypothesized black hole,which is a perfect solution of metric-affine gravity with a positive cosmological constant,and its thermodynamic features as well as the Joule-Thomson *** develop some thermodynamical quantities,such as volume,Gibbs free energy,and heat capacity,using the entropy and Hawking *** also examine the first law of thermodynamics and thermal fluctuations,which might eliminate certain black hole *** this regard,a phase transition from unstable to stable is conceivable when the first law order corrections are *** addition,we study the efficiency of this system as a heat engine and the effect of metric-affine gravity for the physical parameters q_(e),q_(m),κ_(s),κ_(d),and κ_(sh).Further,we study the Joule-Thomson coefficient and inversion temperature,and observe the isenthalpic curves in the Ti−Pi *** metric-affine gravity,a comparison is made between a van der Waals fluid and a black hole to study their similarities and differences.

关键词： black hole in metric-affine gravity thermodynamics Joule-Thomson expansion

反相乳液聚合法制备缔合型耐盐聚合物及其流变性能

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精细化工 2024年第1期41卷 195-205页

作者：刘雅梦赖小娟杨振福 yasir MFMukhtar 文新卢丽娟陕西科技大学化学与化工学院轻化工助剂化学与技术教育部重点实验室陕西西安710021 中国石油集团川庆钻探工程有限公司长庆石油工程监督公司陕西西安710021 苏丹科技大学工程学院苏丹喀土穆47500

以丙烯酰胺(AM)、2-丙烯酰胺-十二烷基磺酸钠(AMC_(12)S)、疏水单体29-(4-辛基苯氧基)-3,6,9,12,15,18,21,24,27-壬氧烷酮基甲基丙烯酸酯(GTE-10)为原料,通过反相乳液聚合法制备了一种缔合型耐盐聚合物p(AM/AMC_(12)S/GTE-10)。通过FTIR、~1HNMR、SEM、TEM及激光粒度分析仪对其结构和形貌进行了表征,并对其流变性能、触变性能和黏弹性进行了评价。结果表明,疏水单体GTE-10成功引入聚合物中,聚合完成后的乳液粒径分布集中且均一,盐(NaCl、CaCl_(2))的加入使p(AM/AMC_(12)S/GTE-10)分子聚集态更紧密,形成的空间网络结构更稳定。质量分数为0.7%的p(AM/AMC12S/GTE-10)聚合物水溶液在140℃时表现出较好的耐温性能;在120℃、170s^(–1)条件下剪切1 h,在质量浓度为20000 mg/L的NaCl和CaCl_(2)水溶液中分别配制质量分数0.7%的聚合物溶液,其表观黏度分别为64.8和54.1m Pa·s;聚合物具有较好的剪切恢复性能;盐水条件下储能模量大于损耗模量,金属离子与苯氧乙烯基发生络合反应,使分子间作用力增强,形成的空间结构更稳定且难被破坏,黏弹性更高。

关键词：反相乳液聚合耐盐流变性能黏弹性触变性油田化学品

Analysis of cerium substitution in Co-Sr based spinel ferrites for high frequency application

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Journal of Rare Earths 2024年第9期42卷 1755-1763,I0005页

作者： Laura Khudaysh Inas A.Ahmed Syeda Rabia Ejaz Sajjad Ahmad Khan yasir A.Haleem Mohamed M.Ibrahim Mahmood Ali Hafiz Muhammad Tahir Farid Zeinhom M.El-Bahy Department of Physics Faculty of ScienceJazan UniversityJazan45142Saudi Arabia Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha62224Saudi Arabia Department of Physics The Government Sadiq College Women UniversityBahawalpur63100Pakistan Institute of Physics Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Centre of Excellence in Solid State Physics University of the PunjabLahorePakistan Department of Physics Government CollegeTaunsa Sharif32200Pakistan Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City11884CairoEgypt

Spinel ferrites exhibit exceptional magnetic properties,making them a distinctive class of magnetic *** sol-gel technique was utilized for the synthesis of spinel ferrites with the chemical formula Co_(0.6)Sr_(0.4)Ce_(x)Fe_(2-x)O_(4). Following that,a comprehensive X-ray diffraction analysis unveiled the crystalline cubic structure of the synthesized *** the utilization of the M-H loop approach,the ferromagnetic attributes of ferrites were assessed,and the assimilation of rare earth elements led to substantial enhancements in saturation magnetization,remanence,and *** ferrites with a high concentration of rare earth elements have improved direct current resistivity and activation *** logarithm of a material's resistance increased from 5.29 to 8.12 Ω·cm as cerium is *** a change in the amount of cerium,the activation energy goes up from 0.19 to *** changing the frequency from 5.5 to 9.5 GHz,the dielectric characteristics were *** the frequency goes up,the dielectric constant goes *** ferrites that have been made better in every way can be used in high-frequency applications.

关键词： Activation energy DC electrical resistance Remanence magnetization Cobalt strontium spinel ferrites High frequency application Rare earths

弹力带抗阻训练对巴基斯坦大学生板球运动员投掷球速度的影响研究

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弹力带抗阻训练对巴基斯坦大学生板球运动员投掷球速度的影响研究

作者： IQBAL yasir(尹贺) 首都体育学院

学位级别：硕士

带混合连接的装配式混凝土剪力墙抗震性能研究

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振动与冲击 2024年第19期43卷 306-318页

作者：韩启浩 yasir Naeem 汪大洋何建鑫江西理工大学土木与测绘工程学院江西赣州341000 广州大学土木工程学院广州510006

基于完成的带水平连接的装配式混凝土剪力墙(precast concrete shear walls with horizontal connection,PCSW-HC)试验研究,提出了一种带混合连接的装配式混凝土剪力墙(precast concrete shear walls with hybrid connection,PCSW-HVC),其中,水平连接采用高强螺栓的“强”连接方式,竖向连接采用钢剪切键(steel shear key,SSK)的“弱”连接方式。首先,结合已完成的试验,建立带水平连接的装配式混凝土剪力墙的数值模型,通过对比试验与数值分析结果,验证了材料本构关系的选取、各部件相互作用关系设置的正确性。进一步,采用同样的建模方法,建立带混合连接的装配式混凝土剪力墙的数值模型。分析了不同竖缝型式和增设钢剪切键对带混合连接的装配式混凝土剪力墙抗震性能的影响,揭示了其损伤失效模式。结果表明:单片剪力墙模块分割成较小尺寸模块拼装后,抗侧刚度有一定程度的减小,但刚度退化更缓慢,剪力墙墙板损伤更小,具有更好的变形能力;在剪力墙模块之间的竖缝中增设钢剪切键后,提高抗侧刚度的同时还可以改善其刚度退化行为,与不带钢剪切键模型相比,单片剪力墙(Single模型)和竖向滑动双片剪力墙(Sliding模型)峰值割线刚度分别提高了14.9%和11.4%;带混合连接的装配式混凝土剪力墙的损伤失效模式为“钢剪切键塑性屈服-墙板模块底部损伤-墙板模块破坏”,实现了钢剪切键塑性屈服耗能与墙板塑性损伤转移的“双功能”控制。

关键词：装配式混凝土剪力墙混合连接数值分析耗能失效模式

Plant Nitrogen Metabolism: Balancing Resilience to Nutritional Stress andAbiotic Challenges

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 581-609页

作者： Muhammad Farhan Manda Sathish Rafia Kiran Aroosa Mushtaq Alaa Baazeem Ammarah Hasnain Fahad Hakim Syed Atif Hasan Naqvi Mustansar Mubeen yasir Iftikhar Aqleem Abbas Muhammad Zeeshan Hassan Mahmoud Moustafa Department of Plant Pathology Faculty of Agricultural Sciences&TechnologyBahauddin Zakariya UniversityMultan60800Pakistan Centro de Investigación de Estudios Avanzados del Maule(CIEAM) Vicerrectoría de Investigación y PostgradoUniversidad Católica del MauleTalca3460000Chile College of Food Science and Nutritional Engineering China Agricultural UniversityBeijingChina Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Biotechnology Faculty of Biological SciencesLahore University of Biological and Applied SciencesLahorePakistan Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan Department of Agriculture and Food Technology Karakorum International UniversityGilgitPakistan Department of Biology Faculty of ScienceKing Khalid UniversityAbhaSaudi Arabia

Plant growth and resilience to abiotic stresses,such as soil salinity and drought,depend intricately on nitrogen *** review explores nitrogen’s regulatory role in plant responses to these challenges,unveiling a dynamic interplay between nitrogen availability and abiotic *** the context of soil salinity,a nuanced rela-tionship emerges,featuring both antagonistic and synergistic interactions between salinity and nitrogen ***-induced chlorophyll depletion in plants can be alleviated by optimal nitrogen supplementation;however,excessive nitrogen can exacerbate salinity *** delve into the complexities of this interaction and its agri-cultural ***,a vital element within essential plant structures like chloroplasts,elicits diverse responses based on its *** review comprehensively examines manifestations of nitrogen deﬁciency and toxicity across various crop types,including cereals,vegetables,legumes,and ***,we explore the broader consequences of nitrogen products,such as N_(2)O,NO_(2),and ammonia,on human ***-ing the intricate relationship between nitrogen and salinity,especially chloride accumulation in nitrate-fed plants and sodium buildup in ammonium-fed plants,is pivotal for optimizing crop nitrogen ***,prudent nitrogen use is essential,as overapplication can exacerbate nitrogen-related *** Use Efﬁ-ciency(NUE)is of paramount importance in addressing salinity challenges and enhancing sustainable crop *** this goal requires advancements in crop varieties with efﬁcient nitrogen utilization,pre-cise timing and placement of nitrogen fertilizer application,and thoughtful nitrogen source selection to mitigate losses,particularly urea-based fertilizer *** review article delves into the multifaceted world of plant nitrogen metabolism and its pivotal role in enabling plant resilience to nutritional stress and abiotic chall

关键词： Synthetic nitrogen nitrogen signaling sustainable agriculture eutrophication ammonium nitrate

Parallel Technologies with Image Processing Using Inverse Filter

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Journal of Computer and Communications 2024年第1期12卷 110-119页

作者： Rahaf Alsharhan Areej Muheef Yasmin Al Ibrahim Afnan Rayyani yasir Alguwaifli College of Computer Science and Information Technology (CCSIT) Imam Abdulrahman Bin Faisal University (IAU) Dammam Saudi Arabia

Real-time capabilities and computational efficiency are provided by parallel image processing utilizing OpenMP. However, race conditions can affect the accuracy and reliability of the outcomes. This paper highlights the importance of addressing race conditions in parallel image processing, specifically focusing on color inverse filtering using OpenMP. We considered three solutions to solve race conditions, each with distinct characteristics: #pragma omp atomic: Protects individual memory operations for fine-grained control. #pragma omp critical: Protects entire code blocks for exclusive access. #pragma omp parallel sections reduction: Employs a reduction clause for safe aggregation of values across threads. Our findings show that the produced images were unaffected by race condition. However, it becomes evident that solving the race conditions in the code makes it significantly faster, especially when it is executed on multiple cores.

关键词： Parallel Parallelization Image Processing Inverse Filtering OpenMP Race Conditions

Accelerating Large-Scale Sorting through Parallel Algorithms

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Journal of Computer and Communications 2024年第1期12卷 131-138页

作者： Yahya Alhabboub Fares Almutairi Mohammed Safhi Yazan Alqahtani Adam Almeedani yasir Alguwaifli College of Computer Science and Information Technology Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia

This study explores the application of parallel algorithms to enhance large-scale sorting, focusing on the QuickSort method. Implemented in both sequential and parallel forms, the paper provides a detailed comparison of their performance. This study investigates the efficacy of both techniques through the lens of array generation and pivot selection to manage datasets of varying sizes. This study meticulously documents the performance metrics, recording 16,499.2 milliseconds for the serial implementation and 16,339 milliseconds for the parallel implementation when sorting an array by using C++ chrono library. These results suggest that while the performance gains of the parallel approach over its serial counterpart are not immediately pronounced for smaller datasets, the benefits are expected to be more substantial as the dataset size increases.

关键词： Sorting Algorithm Quick Sort QuickSort Parallel Parallel Algorithms