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Modeling gut neuro-epithelial connections in a novel microfluidic device

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Microsystems & Nanoengineering 2023年第6期9卷 235-246页

作者： Jose M.de Hoyos-Vega Xi yu Alan M.Gonzalez-Suarez Sisi Chen Arnaldo Mercado-Perez Eugene Krueger Jeric Hernandez yaroslav Fedyshyn Brooke R.Druliner David R.Linden Arthur Beyder Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUSA Enteric Neuroscience Program(ENSP) Mayo ClinicRochesterMNUSA Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMNUSA

The intestinal lumen is filled with diverse chemical and physical *** epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract ***,the neuro-epithelial connections remain poorly resolved,in part because the tools for orchestrating interactions between these cellular compartments are *** describe the development of a two-compartment microfluidic device for co-culturing enteric neurons with intestinal epithelial *** device contains epithelial and neuronal compartments connected by *** epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal *** demonstrated that organoids planarized effectively and retained epithelial phenotype for over a *** the second chamber we dissociated and cultured intestinal myenteric neurons including intrinsic primary afferent neurons(IPANs)from transgenic mice that expressed the fluorescent protein *** extended projections into microgrooves,surrounded and frequently made contacts with epithelial *** density and directionality of neuronal projections were enhanced by the presence of epithelial cells in the adjacent *** microfluidic device represents a platform that may,in the future,be used to dissect structure and function of neuro-epithelial connections in the gut and other organs(skin,lung,bladder,and others)in health and disease.

关键词： fluid bladder organs

Subsolidus Conceptual Design of CaO-AI_2O_3-TiO_2-SiO_2 System and Its Significance for Manufacturing Advanced Ceramics

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China's Refractories 2016年第1期25卷 44-52页

作者： Michail I. RYSCHENKO yaroslav N. PITAK Elena yu. FEDORENKO Maria yu. LISyuTKINA Alexey V. SHEVTSOV National Technical University "Kharkiv Polytechnic Institute" Kharkov 61002 Ukraine

The article deals the structure of the CaO -Al2O3 - TiO2 -SiO2 system as a basis for obtaining advanced ce- ramics with a complex of high-operational characteris- tics. As a result o[＇investigations the phase charctcteristics are represented trod the graph of the relationship of the elementaory tetrahedra has been plotted. The most techno- logical system area ,for the production of heat resistant advanced ceramics has been determined. The batches for producing heat and chemical resistant dense advanced ceramics made of natural, technical and technogenic raw materials have been developed.

关键词： geometric - topological characteristics thermodynamic analysis resource conservation ceramic eomprising tialite sintering processes phase formation

Self-organization of various“phase-separated”nanostructures in a single chemical vapor deposition

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Nano Research 2020年第6期13卷 1723-1732页

作者： Jinmei Wang Dongyue Xie Zhen Li Xiaohang Zhang Xing Sun Amanda L.Coughlin Thomas Ruch Qiang Chen yaroslav Losovyj Seunghun Lee Heshan yu Haidong Zhou Haiyan Wang Jian Wang Shixiong Zhang Department of Physics Indiana UniversityBloomingtonIndiana47405USA Department of Mechanical&Materials Engineering University of Nebraska-LincolnLincolnNE68588USA Department of Materials Science and Engineering University of MarylandCollege ParkMaryland20742USA School of Materials Engineering Purdue UniversityWest LafayetteIndiana47907USA Department of Physics and Astronomy University of TennesseeKnoxvilleTennessee37996USA Department of Chemistry Indiana UniversityBloomingtonIndiana47408USA College of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China Department of Materials Science and NanoEngineering Rice UniversityHoustonTexas77005USA

Chemical vapor deposition(CVD)is one of the most versatile techniques for the controlled synthesis of functional *** multiple precursors are induced,the CVD process often gives rise to the growth of doped or alloy *** this work,we demonstrate the self-assembly of a variety of‘phase-separated’functional nanostructures from a single CVD in the presence of various *** specific,with silicon substrate and powder of Mn and SnTe as precursors,we achieved self-organized nanostructures including Si/SiOx core-shell nanowire heterostructures both with and without embedded manganese silicide particles,Mn11Si19 nanowires,and SnTe *** Si/SiOx core-shell nanowires embedded with manganese silicide particles were grown along thedirection of the crystalline Si via an Au-catalyzed vapor-liquid-solid process,in which the Si and Mn vapors were supplied from the heated silicon substrates and Mn powder,*** contrast,direct vapor-solid deposition led to particle-free-oriented Si/SiOx core-shell nanowires and-oriented Mn11Si19 nanowires,a promising thermoelectric *** Sn or Te impurities were detected in these nanostructures down to the experimental *** crystalline insulator SnTe nanoplates with dominant{100}and{111}facets were found to be free of Mn(and Si)impurities,although nanoparticles and nanowires containing Mn were found in the vicinity of the *** multiple-channel transport was observed in the SnTe nanoplates,it may not be related to the topological surface states due to surface ***,we carried out thermodynamic analysis and density functional theory calculations to understand the‘phase-separation’phenomenon and further discuss general approaches to grow phase-pure samples when the precursors contain residual impurities.

关键词： nanomaterials synthesis silicon nanowires topological crystalline insulators phase separation chemical vapor deposition

Effect of Anterior Capsule Polishing on the Need for Laser Capsulotomy

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Open Journal of Ophthalmology 2017年第4期7卷 319-331页

作者： Hamad Elzarrug Kevin M. Miller yu Fei Shahriar Farzad yaroslav O. Grusha Department of Ophthalmology Faculty of Medicine Benghazi University Benghazi Libya Department of Ophthalmology Jules Stein Eye Institute David Geffen School of Medicine at UCLA Los Angeles CA USA

Purpose: To determine the effect of anterior capsule polishing (APC) on the rate of posterior capsule opacification (PCO) as assessed by the need for laser posterior capsulotomy. Setting: University-based clinical practice, Jules Stein Eye Institute, Los Angles, California, USA. Methods: This study involved a retrospective review of eyes that underwent phacoemulsification and intraocular lens implantation between September 1991 and June 1999. Lens epithelial cells in the 763 study eyes were mechanically debrided or polished from the inside surface of the anterior capsules using a pair of Shepherd-Rentsch (Morning STAAR Inc.) capsule polishers. The 484 control eyes that had surgery earlier in the series were not polished. The rate of laser capsulotomy in the ACP and the non-ACP groups was compared using a Kaplan-Meier survival analysis. Multivariate regression was performed to determine if variables other than ACP influenced the need for laser posterior capsulotomy. Results: We identified 763 eyes that had ACP and 484 that did not. At the 24-month follow-up interval, 26.6% of the eyes in the ACP group had received a capsulotomy versus 19.50% in the non-APC. Next, a separate study was done using only one eye per patient, taking the patient as the unit of analysis. Again the capsulotomy rate was higher in the ACP group compared to the non-ACP (1.02 per 100 person-months of follow-up vs. 0.74 per 100 person-months of follow-up). Finally, a third Kaplan-Meier analysis was done on 52 patients that had one eye treated with the ACP procedure and the other eye with the non-ACP procedure. Although the log-rank test showed the statistical significant of this analysis to be borderline, the results again favored the non-ACP group with a lower capsulotomy rate. Multivariate analysis showed very similar results to the above univariate studies. The mean time to capsulotomy was 46 months for the polished group and 70 months for the unpolished group. The severity of cataract (p = 0.4

关键词： Anterior Capsule Polishing Posterior Capsule Opacification Laser Posterior Capsulotomy

Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

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Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Evgeniya V.Dolgova Oleg M.Andrushkevich Polina E.Kisaretova Anastasia S.Proskurina Genrikh S.Ritter Tatyana D.Dubatolova Margarita V.Romanenko Oleg S.Taranov yaroslav R.Efremov Evgeniy L.Zavyalov Alexandr V.Romaschenko Sergey V.Mishinov Svetlana S.Kirikovich Evgeniy V.Levites Ekaterina A.Potter Alexandr A.Ostanin Elena R.Chernykh Stanislav yu.Roshchin Anatoliy V.Bervitskiy Galina I.Moysak Jamil A.Rzaev Sergey S.Bogachev Institute of Cytology and Genetics SB RAS Novosibirsk 630090Russia A.I.Evdokimov Moscow State University of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia The State Research Center of Virology and Biotechnology"Vector" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia Sklifosovsky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objective:Glioma is a highly invasive tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuvant therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CSCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CSCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in vitro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** SCID mice with developed subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(P<0.05).In the experiment with intracerebral transplantation of U87 cells followed by surgical excision of the developed graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median survival of the mice twofold relative to the ***:The effectiveness of the Karanahan approach has been demonstrated both in vitro and in vivo in treating developed subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

The Modern Development of New Promising Fields in Forensic Examinations

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Journal of Forensic Science and Medicine 2021年第4期7卷 137-144页

作者： Igor V.Borysenko Oleg yu.Bululukov Valeriy D.Pcholkin Vasyl V.Baranchuk Vladlena O.Prykhodko Department of Criminalistics Yaroslav Mudryi National Law UniversityKharkivUkraine Department of Criminal Procedure Criminalistics and ExpertologyKharkiv National University of Internal AffairsKharkivUkraine Organizational and Analytical Department of the Organizational and Analytical Support and Rapid Response Main Department of the National Police in KyivKyivUkraine

The relevance of the study is forensic expert activity in terms of forensic examinations have been so transformed that existing theoretical provisions do not already solve traditional problems in some fields;their solvation requires new approaches of both theoretical and practical *** this regard,the purpose of this study is to analyze the content of new innovative directions in forensic examinations,including criminalistic ones,and the possibility of their effective application in forensic expert *** methodological basis of the study is the dialectical method of scientific knowledge,which allowed the authors to consider the theoretical and scientific,and practical foundations of modem trends in forensic examinations,including criminalistic *** also helped to identify promising fields of examinations necessary for crime ***,authors singled out the following advanced fields:biometric and computer forensic analyses,polygraph,and odor and trace evidence *** materials of the article are of practical value for forensic experts and criminologists,law enforcement agencies.

关键词： Analysis of digital evidence odor evidence analysis polygraph psychophysiological examinations trace evidence analysis