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Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3244-3266页

作者： Peiran Chen Mandi Wu yaqing he Binghua Jiang Ming-Liang he Department of Biomedical Sciences City University of Hong KongHKSARHong KongChina Shenzhen Center for Disease Control and Prevention Shenzhen 518055 GuangdongChina Cell Signaling and Proteomic Center Academy of Medical SciencesZhengzhou UniversityZhengzhouHenanChina

The coronavirus disease 2019(COVID-19)caused by coronavirus SARS-CoV-2 infection has become a global pandemic due to the high viral transmissibility and pathogenesis,bringing enormous burden to our *** patients infect... 详细信息

关键词： infection alterations therapeutic

基于新能源消纳的高温电解制氢系统建模与控制方法研究

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太阳能学报 2024年第1期45卷 484-491页

作者：赫亚庆张新燕王维庆李佳蓉赵晨欢王海云新疆大学可再生能源发电与并网控制教育部工程研究中心乌鲁木齐830017 清华大学电力系统及发电设备控制和仿真国家重点实验室北京100084 电力规划设计总院北京100120

基于新能源随机波动以及低温电解制氢系统转化效率较低且无法切换到发电状态,提出一种高温电解制氢变负载情形下的高效最大产氢点多模型优化控制方法。首先构建计及辅助设备在内的高温固体氧化物电解系统整体协同运行的多能耦合优化模型... 详细信息

基于新能源随机波动以及低温电解制氢系统转化效率较低且无法切换到发电状态,提出一种高温电解制氢变负载情形下的高效最大产氢点多模型优化控制方法。首先构建计及辅助设备在内的高温固体氧化物电解系统整体协同运行的多能耦合优化模型,分析其影响系统电解的工作温度、电流强度、物料流速等诸多因素并导出高能安全产氢率;其次,在PID控制的基础上,给出一种既能实现变负荷同步准确跟踪产氢轨迹和优化电网调控需求,又能最大优化产氢效率的自适应时变线性变参数模型预测控制方法;最后,通过算例仿真验证所提方法较PID控制电解系统升温速率快,过渡时间短,电解电流、水蒸气流速、H2流速、电炉功率都能平稳过渡至稳态点,具有一定的理论和实用价值。

关键词：高温制氢固体氧化物新能源消纳多能耦合模型预测控制

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褐藻胶寡糖对绿豆芽品质的影响

中国食品添加剂 2024年第2期35卷 119-127页

作者：何雅清唐文竹李宪臻大连工业大学生物工程学院大连116034

将绿豆浸泡在浓度不同的褐藻胶寡糖溶液(浓度分别为0.001、0.01、0.1和1μg/mL)中,测定发芽后绿豆芽的产量(鲜重和芽长),并确定其主要营养成分及抗氧化成分含量、抗氧化活性以及抗氧化酶的活性。结果显示,褐藻胶寡糖对绿豆芽生长有明显... 详细信息

将绿豆浸泡在浓度不同的褐藻胶寡糖溶液(浓度分别为0.001、0.01、0.1和1μg/mL)中,测定发芽后绿豆芽的产量(鲜重和芽长),并确定其主要营养成分及抗氧化成分含量、抗氧化活性以及抗氧化酶的活性。结果显示,褐藻胶寡糖对绿豆芽生长有明显促进作用,能减少绿豆芽中植酸的含量;可提高可溶性蛋白、维生素C、总多酚及各组分多酚、总黄酮及各组分黄酮的含量;显著提高过氧化物酶(POD)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的酶活力,从而提高了绿豆芽清除DPPH、H_(2)O_(2)和羟自由基的能力。结果表明,以浓度0.01μg/mL的褐藻胶寡糖为最佳。本研究可为褐藻胶寡糖改善绿豆芽品质提供一定的理论依据。

关键词：绿豆芽褐藻胶寡糖添加剂抗氧化

2020-2022年深圳地区柯萨奇病毒A6的流行病学与分子特征分析

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病毒学报 2024年第1期40卷 106-114页

作者：黄小丽陈龙姚相杰孟君周莎刘婉秋张玉萍何雅青胡贵方南方医科大学公共卫生学院广州510515 深圳市疾病预防控制中心病原微生物检测所深圳518055 深圳市保健委员会办公室保健保障科深圳518020 南华大学公共卫生学院衡阳421001

了解COVID-19流行期间(2020-2022年)深圳地区手足口病(Hand,food and mouth disease,HFMD)优势病原体柯萨奇病毒A6(Coxackieviurs A6, CVA6)的流行情况以及其VP1区的分子特征,为有效预防HFMD提供科学依据。2020-2022年深圳市疾病预防控制中心收集手足口病哨点监测病例样本共1 733份。采用实时荧光RT-PCR方法对标本进行肠道病毒核酸检测。随机挑选分布于不同月份经RT-PCR判定为CVA6阳性的样本共108例进行VP1全长基因序列扩增和测序。使用生物信息学软件对CVA6进行分子系统发育与氨基酸变异分析。1 733份手足口病病例标本中,检出EV阳性1 627份,总检出率为94.65%(1627/1733);检出CVA6阳性1 042份,CVA6检出率为60.13%(1 042/1 733)。2020-2022年各年度HFMD主要病原体均为CVA6,各年的检出率分别为84.62%(341/403)、46.70%(382/818)和62.30%(319/512)。基于VP1序列的分子系统发育分析表明,2020-2022深圳地区测定的77株CVA6毒株均属于D3a基因型,但处在两个明显不同的进化分支,两个不同进化分支的CVA6毒株之间存在L15P和V173I两个氨基酸差异位点。77株CVA6毒株之间,核苷酸相似性和氨基酸相似性分别为91.8%~100%和97.2%~100%,其VP1氨基酸序列出现了19个(7.20%, 19/264)氨基酸多态位点。CVA6是2020-2022年深圳市引起HFMD的主要病原体,在2020年是绝对优势型别。深圳地区流行的CVA6仍然是我国内地地区主流基因亚型D3a,但是表现出了一定的遗传多样性。

关键词： HFMD CVA6 VP1基因分子流行病学

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引水隧洞不良地质段超前地质预报技术及应用

山东交通科技 2024年第4期 108-112页

作者：周杜杨遵俭刘运雄贺亚青罗泽毅湖南建工集团有限公司湖南长沙410004

针对山岭隧道开挖过程中地质探测的复杂性和局限性,结合桂林市某引水隧洞工程,综合利用高密度电法、大地电磁法、声波测井及剪切波速联合测试法对隧洞沿线地层岩性及不良地质体的分布与规模进行勘探。通过多种勘测结果,研究隧洞沿线的... 详细信息

针对山岭隧道开挖过程中地质探测的复杂性和局限性,结合桂林市某引水隧洞工程,综合利用高密度电法、大地电磁法、声波测井及剪切波速联合测试法对隧洞沿线地层岩性及不良地质体的分布与规模进行勘探。通过多种勘测结果,研究隧洞沿线的地层岩性及不良地质体的分布特征,并分析不良地质体对引水隧洞施工的影响,为隧洞安全施工提供坚实可靠的依据。

关键词：引水隧洞综合物探地层剖析不良地质体

Molecular Epidemiological Characteristics of Gastroenteritis Outbreaks Caused by Norovirus GII.4 Sydney[P31]Strains—China,October 2016–December 2020

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China CDC weekly 2021年第53期3卷 1127-1132,I0001页

作者： Xi Zhu yaqing he Xingyan Wei Xiangyu Kong Qing Zhang Jingxin Li Miao Jin Zhaojun Duan Key Laboratory of Medical Virology and Viral Diseases Ministry of Health of the People’s Republic of ChinaBeijingChinaNational Institute for Viral Disease Control and PreventionChina CDCBeijingChina Shenzhen Center for Disease Control and Prevention ShenzhenGuangdongChina.

Introduction:Human noroviruses are the leading cause of acute viral gastroenteritis(AGE)worldwide in all age ***.4 strains have been the predominant genotype circulating globally over the last 2 decades and since ***.4 Sydney viruses have emerged and caused the majority of AGE outbreaks ***:Data from norovirus outbreaks from the laboratory-based surveillance of norovirus outbreaks in China(CaliciNet China)between October 2016–December 2020 were ***:During October 2016–December 2020,1,954 norovirus outbreaks were reported,and positive fecal samples from 1,352(69.19%)outbreaks were ***.4 Sydney[P31]viruses accounted for 2.1%(October 2016–August 2017),5.5%(September 2017–August 2018),3.3%(September 2018–August 2018),26.6%(September 2019–August 2020),and and 1.1%(September 2020–December 2020)of GII outbreaks,*** to reference strains of GII.4 Sydney[P31]from 2012 to 2013,7 amino acid mutations in epitopes[A(297,372 and 373),B(333),E(414),and H(309 and 310)]and 1 in human histo-blood group antigens binding site at site II 372 were found by analyzing 9 GII.4 Sydney[P31]complete genomic ***:This report identified the genomic variation of GII.4 Sydney[P31]from CaliciNet *** surveillance with prompt genotyping and genetic analysis is necessary to monitor the emergence of novel GII.4 variants.

关键词： Sydney GII prompt

Antibody response and cross-neutralization after Omicron BA.2 infection

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Signal Transduction and Targeted Therapy 2023年第2期8卷 348-350页

作者： Yiwen Zhang Rong Li Yuzhuang Li Hong Yang Liqiong Zhou Jing Yuan Ting Pan Bingfeng Liu Hui Zhang yaqing he Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry of EducationGuangdong Engineering Research Center for Antimicrobial Agent and ImmunotechnologyZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong510080China Shenzhen Center for Disease Control and Prevention Shenzhen518055GuangdongChina Shenzhen Third People’s Hospital Second Hospital Affiliated to Southern University of Science and TechnologySouth China Hospital of Shenzhen UniversityShenzhen518011GuangdongChina

Dear Editor,The Omicron(B.1.1.529)variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first identified in November 2021,in South Africa and *** first Omicron sub-lineage that emerged was BA.1,which was supplanted by BA.2 in many *** of the most notable features of the Omicron variant is its ability to evade neutralizing antibodies(nAbs)targeting the original virus lineages.

关键词： Antibody acute respiratory

Mass transfer in heap leaching of weathered crust elution deposited rare earth ore with Al_(2)(SO_(4))_(3) solution

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Journal of Rare Earths 2024年第6期42卷 1175-1181,I0007页

作者： Jingqun Yin Dedong Zeng Jun Tian yaqing Weng Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang330096China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China

In order to increase efficiency and avoid NH^(4+)-N pollution in the leaching process of weathered crust elution-deposited rare earth ores,the mass transfer in heap leaching with Al_(2)(SO_(4))_(3) solution was simulated with column elution and experimentally *** results indicate that the leaching yield is also up to 99%for leaching with aluminum sulfate instead of ammonium *** optimal flow rate is 60 mL/h,the height equivalent to a theoretical plate(heTP)is 1.29 mm *** peak value position of RE^(3+)is 60 mL/h,Fe^(3+)is 100 mL/h,however,Al^(3+)is 150 mL/h,and the heap leaching process has kinetic separation effect.

关键词： Raree arths Mass transfer Process optimization heapleaching Weathered crust elution-deposited rare earth ore

Detecting SARS-CoV-2 BA.2,BA.4,and BA.5 Variants Utilizing a Robust RT-RPA-CRISPR/Cas12a-Based Method-China,2023

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China CDC weekly 2023年第26期5卷 584-591页

作者： Meihui Luo Yang Pan yaqing he Ruhan A Changcheng Wu Baoying Huang Roujian Lu Li Zhao Bo Peng Fei Ye Huijuan Wang Yuda Chen Zhen Li Daitao Zhang Wenling Wang Wenjie Tan MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChina CDCBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Microbiology Laboratory Shenzhen Center for Disease Control and PreventionShenzhen CityGuangdong ProvinceChina School of Public health Baotou Medical CollegeBaotou CityInner Mongolia Autonomous RegionChina Collaborative Innovation Centre for Regenerative Medicine and Medical BioResourse Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityGuangxi Zhuang Autonomous RegionChina

Introduction:Since 2019,numerous variants of concern for severe acute respiratory syndrome virus 2(SARS-CoV-2)have emerged,leading to significant *** development of novel,highly accurate,and rapid detection techniques for these new SARSCoV-2 variants remains a primary focus in the ongoing efforts to control and prevent the coronavirus disease 2019(COVID-19)***:Reverse transcription-recombinase polymerase amplification combined with the clustered regularly interspaced short palindromic repeatsassociated protein 12a(CRISPR/Cas12a)system was used to validate the detection of the Omicron BA.2,BA.4,and BA.5 variants of ***:Our results demonstrate that the CRISPR/Cas12a assay is capable of effectively detecting the SARS-CoV-2 BA.2,BA.4,and BA.5 variants with a limit of detection of 10,1,and 10 copies/μL,***,our assay successfully differentiated the three SARS-CoV-2 Omicron strains from one ***,we evaluated 46 SARS-CoV-2 positive clinical samples consisting of BA.2(n=20),BA.4(n=6),and BA.5(n=20)variants,and the sensitivity of our assay ranged from 90%to 100%,while the specificity was 100%.Discussion:This research presents a swift and reliable CRISPR-based method that may be employed to track the emergence of novel SARS-CoV-2 variants.

关键词： CRISPR/Cas limit specificity