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Amblyopia screening for first and second-grade children in Jordan

International Journal of Ophthalmology(English edition) 2022年第2期15卷 352-356页

作者： Khalil m.Al-Salem mohammad S.Saleem Ismat Ereifej Hamzeh m.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-momani Layal mohammed Hammad Omar Ahmad al-Habahbeh yaqeen m.assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al maaitah Deya'-Aldin muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah mahmoud mohammad murad Amany Jehad Faleh AL-Zurqan Enas Jamal mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.matar Department of Ophthalmology and Visual Sciences Mutah UniversityAl-Karak 11183Jordan Royal medical Services Department of Ophthalmology Amman 11855Jordan Department of Ophthalmology and Visual Sciences Al-Sharif Eye CenterAmman 11194Jordan Jordanian menistrery of Health IrbidAmman 11855Jordan National Woman's Health Care Center(NWHCC) Amman 11855Jordan

AIm:To share the results of a national screening program for amblyopia in school children in the north of ***:This is a prospective national screening study for *** program rolls first and second-grade children(6 to 7 years old) in the north of *** eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic *** visual acuity was tested using an ETDRS visual acuity chart without ***,children were tested with full cycloplegic refraction when the test criteria were *** amblyopia was defined as a best-corrected visual acuity difference of 2 or more *** comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best ***:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with *** their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population.

关键词： amblyopia screening Jordan community ophthalmology pediatric ophthalmology population-based study screening program

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Expression and regulation of aldehyde dehydrogenases in prostate cancer

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Journal of Cancer metastasis and Treatment 2018年第1期4卷 515-531页

作者： Ali I.m.Ibrahim maria Sadiq Fiona m.Frame Norman J.maitland Klaus Pors Institute of Cancer Therapeutics School of Pharmacy and Medical SciencesFaculty of Life SciencesUniversity of BradfordWest Yorkshire BD71DPUK Department of Pharmacy Al-Zaytoonah University of JordanAmman 11733Jordan Cancer Research Unit Department of BiologyUniversity of YorkHeslingtonNorth Yorkshire YO105DDUK

The functional role of aldehyde dehydrogenases(ALDHs)in prostate cancer remains an area of some *** studies have used high ALDH functional activity to isolate putative cancer stem cells with tumour-initiating and propagating properties,while evidence is also emerging about the involvement of specific isoforms in migration,invasiveness and *** of specific ALDH isoforms,which contribute to both drug resistance and aggressiveness of the disease remains a challenge within the complex heterogeneity of prostate *** purpose of this perspective is to dissect functional roles for ALDH in the tumour microenvironment and to evaluate the potential of the ALDH gene family as biomarkers and/or targets for therapeutic intervention.

关键词： Aldehyde dehydrogenase retinoic acid prostate cancer castration-resistant prostate cancer cancer stem cells multidrug resistance

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