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Nano Research 2017年第1期10卷 344-353页

作者： yaping hou Hongzhi Mao Liqiang Xu Key Laboratory of Colloid & Interface Chemistry (Shandong University) Ministry of Education and School of Chemistry and ChemicalEngineering Shandong University Jinan 250100 China

MIL-100（V） is an inorganic-organic hybrid material composed of trimesic acid ligands and vanadium trimer supertetrahedra. MIL-100（V） is expected to be a good host for sulfur impregnation and an excellent sulfur cathode host for Li-S batteries, not only because of its unique mesoporous structure, but also owing to the presence of vanadium ions with various valence states, which can offer different Lewis acid sites and allow for strong interactions with sulfur and lithium polysulfides. In this study, mesoporous M1L-100（V） and MIL-100（V）/ reduced graphene oxide （rGO） composites have been applied as novel hosts for Li-S batteries for the first time. When tested as cathodes for Li-S batteries, both S@MIL-100（V） and S@MIL-100（V）/rGO exhibit excellent electrochemical performance. The S@MIL-100（V） cathode has been demonstrated to have a reversible capacity of -550 mAh/g at 0.1 C （1 C = 1,675 mAh/g） after 200 cycles with low capacity fading of 0.17% per cycle. Moreover, S@MIL-100（V）/rGO maintains a capacity of 650 mAh/g at 0.1 C after 75 cycles, whereas at 0.5 C, the capacity is maintained at 500 mAh/g after 200 cycles and 450 mAh/g after 300 cycles. The above results reveal that the use of MIL-100（V） and MIL-100（V）/rGO as hosts for Li-S batteries can effectively enhance the cycling stability and improve the electrochemical performance of Li-S batteries.

关键词： metal-organic framework MIL-100(V) MIL-100(V)/reducedgraphene oxide (rGO) lithium-sulfur batteries

Multi-Sinusoidal Waveform Shaping for Integrated Data and Energy Transfer in Aging Channels

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China Communications 2023年第4期20卷 243-258页

作者： Jie Hu yaping hou Kun Yang Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Integrated data and energy transfer(IDET)is capable of simultaneously delivering on-demand data and energy to low-power Internet of Everything(Io E)*** propose a multi-carrier IDET transceiver relying on superposition waveforms consisting of multi-sinusoidal signals for wireless energy transfer(WET)and orthogonal-frequency-divisionmultiplexing(OFDM)signals for wireless data transfer(WDT).The outdated channel state information(CSI)in aging channels is employed by the transmitter to shape IDET *** the constraints of transmission power and WDT requirement,the amplitudes and phases of the IDET waveform at the transmitter and the power splitter at the receiver are jointly optimised for maximising the average directcurrent(DC)among a limited number of transmission frames with the existence of carrier-frequencyoffset(CFO).For the amplitude optimisation,the original non-convex problem can be transformed into a reversed geometric programming problem,then it can be effectively solved with existing *** for the phase optimisation,the artificial bee colony(ABC)algorithm is invoked in order to deal with the *** between the amplitude optimisation and phase optimisation yields our joint *** results demonstrate the advantage of our joint design for the IDET waveform shaping with the existence of the CFO and the outdated CSI.

关键词： integrated data and energy transfer(IDET) wireless energy transfer(WET) simultaneous wireless information and power transfer(SWIPT) carrier-frequency-offset(CFO) waveform aging channels outdated channel state information(CSI) orthogonal frequency division multiplexing(OFDM)

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基于物联网视角下智慧医院建设要点分析

中国卫生产业 2024年第2期21卷 128-131页

作者：陈硕杨阳侯亚萍联勤保障部队第九八八医院河南郑州450000

随着物联网技术及其产业链的成熟,物联网应用已逐渐渗透到业务极为繁杂的医疗行业。智慧医院是指利用物联网技术将医疗设备、医疗资源和医疗服务进行互联互通,实现医院管理和医疗服务的智能化和高效化。物联网技术在智慧医院建设中发挥... 详细信息

随着物联网技术及其产业链的成熟,物联网应用已逐渐渗透到业务极为繁杂的医疗行业。智慧医院是指利用物联网技术将医疗设备、医疗资源和医疗服务进行互联互通,实现医院管理和医疗服务的智能化和高效化。物联网技术在智慧医院建设中发挥着重要的作用,可以提升医疗效率,优化资源配置,提升患者体验,实现个性化健康管理,并提高医疗安全性。本文旨在基于物联网视角,分析物联网技术在智慧医院建设中的应用。

关键词：物联网智慧医院应用

Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents

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Neuroscience Bulletin 2016年第5期32卷 455-462页

作者： yaping hou Fanghua Wang Linping Cheng Tao Luo Jie Xu Huaqiao Wang Medical Genetic Centre Guangdong Women and Children Hospital Guangzhou 510010 China Maternal and Children Metabolic-Genetic Key Laboratory Guangdong Women and Children HospitalGuangzhou 510010 China School of Food Science and Engineering South China University of Technology Guangzhou 510640 China Dongsheng Hospital of Guangzhou 375 People's RoadGuangzhou 510120 China Department of Anatomy and Neurobiology Zhongshan School of Medicine Sun Yat-sen University 74 Zhongshan Second Road Guangzhou 510080 China

In our previous studies, significant hypermethylation of the sirtuin 1（SIRT1） gene and demethylation of the b-amyloid precursor protein（APP） gene were found in patients with Alzheimer＇s disease（AD） compared with the normal population. Moreover, the expression of SIRT1 was significantly decreased while that of APP was increased in AD patients. These results indicated a correlation of DNA methylation with gene expression levels in AD patients. To further investigate the epigenetic mechanism of gene modulation in AD, we used two epigenetic drugs, the DNA methylation inhibitor 5-aza-20-deoxycytidine（DAC） and the histone deacetylase inhibitor trichostatin A（TSA）, to treat human neuroblastoma SK-N-SH cells in the presence of amyloid b-peptide Ab25-35（Ab25-35）. We found that DAC and TSA had different effects on the expression trends of SIRT1 and APP in the cell model of amyloid toxicity. Although other genes, such as microtubule-associated protein s, presenilin 1, presenilin 2, and apolipoprotein E, were up-regulated after Ab25-35treatment, no significant differences were found after DAC and/or TSA treatment. These results support the evidence in AD patients and reveal a strong correlation of SIRT1/APP expression with DNA methylation and/or histone modification, which may help understand the pathogenesis of AD.

关键词： Sirtuin 1 DNA methylation Histone modification Alzheimer's disease Trichostatin A

Neuroprotection of a cocktail therapy involving anti-intercellular adhesion molecule 1 antibody and insulin-like growth factor 1 in treatment of cerebral ischemia/reperfusion injury in cats Nuclear magnetic resonance examination and pathological validatio

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Neural Regeneration Research 2008年第12期3卷 1332-1337页

作者： Huaijun Liu Liqun Yan yaping hou Shuochun Wu Dan He Linfang Li Yankai Wu BoyuanHuang Fei Yang Department of Medical Imaging Second Hospital Hebei Medical University Shijiazhuang 050000 Hebei Province China

BACKGROUND： The pathophysiological mechanisms of ischemia are extremely complicated. It is difficult to confirm and maintain the therapeutic effects if only one neuroprotective agent is used. It is hypothesized that a cocktail therapy involving a combined application of neuroprotective agents is feasible and offers excellent therapeutic potential. OBJECTIVE： To evaluate the neuroprotective effects of a cocktail therapy of insulin-like growth factor 1 （IGF1） combined with anti-intercellular adhesion molecule 1 （ICAM1） antibody in the treatment of cerebral ischemia/reperfusion injury using medical imaging, pathology, and functional neurological deficit scoring techniques. DESIGN, TIME AND SETTING： This randomized, controlled, neuroimaging analysis of function and pathological observation was performed at the Laboratory of Molecular Imaging, Second Hospital, Hebei Medical University between September 2006 and December 2007. MATERIALS： Transient middle cerebral artery occlusion （MCAO） was induced in 24 healthy adult cats. Anti-ICAM1 antibody and IGF1 were sourced from the Shanghai Kangcheng Biological Product Co., Ltd., China. Stereotaxic apparatus was purchased from the Center for Medical Apparatus and Instruments, Shandong Liaocheng People＇s Hospital, China. The in situ apoptosis kit was provided by the Beijing Zhongshan Biotechnique Co., Ltd., China. METHODS： Twenty-four cat models of MCAO were randomly divided into four groups （n = 6）： control, IGF1, anti-ICAM 1 antibody and cocktail therapy. Following a 2-hour ischemia and subsequent lateral cerebral ventricular puncture, 100 μg IGFl（cerebral ventricular）, 100 μg anti-ICAM1 antibody （i.v.）, 50 μg IGFl（lateral cerebral ventricular）＋ 50 μg anti-ICAM1 antibody （i.v.）, and 100 μg physiological saline （i.v.） were administered to the IGF1, anti-ICAM1 antibody, cocktail therapy and control groups, respectively. On the following day, the same administration was performed again. MAIN OUTCOME MEASURES： Pathological observat

关键词： neuroprotection cocktail therapy ischemia/reperfusion magnetic resonance imaging

Distribution of Borehole Temperature at Four High-altitude Alpine Glaciers in Central Asia

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Journal of Mountain Science 2009年第3期6卷 221-227页

作者： LIU yaping hou Shugui WANG Yetang SONG Linlin State Key Laboratory of Cryospheric Sciences Cold andArid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences China Graduate University of Chinese Academy of Sciences Beijing 100049 China

The distribution of borehole temperature at four high-altitude alpine glaciers was investigated. The result shows that the temperature ranges from -13.4℃ to -1.84℃, indicating the glaciers are cold throughout the boreholes. The negative gradient （i.e., the temperature decreasing with the increasing of depth） due to the advection of ice and climate warming, and the negative gradient moving downwards relates to climate warming, are probably responsible for the observed minimum temperature moving to lower depth in boreholes of the Gyabrag glacier and Miaoergou glacier compared to the previously investigated continental ice core borehole temperature in West China. The borehole temperature at 10m depth ranges from -8.0℃ in the Gyabrag glacier in the central Himalayas to -12.9℃ in the Tsabagarav glacier in the Altai range. The borehole temperature at 10 m depth is 3-4 degrees higher than the calculated mean annual air temperature on the surface of the glaciers and the higher 10 m depth temperature is mainly caused by the production of latent heat due to melt-water percolation and refreezing. The basal temperature is far below the melting point, indicating that the glaciers are frozen to bedrock. The very low temperature gradients near the bedrock suggest that the influence of geothermal flux and ice flow on basal temperature is very weak. The low temperature and small velocity of ice flow of glaciers are beneficial for preservation of the chemical and isotopic information in ice cores.

关键词： Borehole temperature Glacier CentralAsia Climate warming

激光定向能量沉积Ti-6Al合金的组织与性能研究

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铸造技术 2024年第9期45卷 838-846页

作者：袁晓慧李瑞迪柯林达候亚平肖鹏中南大学冶金国家重点实验室湖南长沙410083 上海航天精密机械研究所上海201600 湖南省计量检测研究院湖南长沙410000 湖南云箭集团有限公司湖南长沙410100

激光定向能量沉积成形钛合金具有高效快速、材料利用率高等优势,但其较大的冷却速率及温度梯度等固有特性使得成形的钛合金容易出现各向异性,因此有必要对激光定向能量沉积钛合金不同平面及不同方向上的组织与性能进行研究。选定Ti-6Al... 详细信息

激光定向能量沉积成形钛合金具有高效快速、材料利用率高等优势,但其较大的冷却速率及温度梯度等固有特性使得成形的钛合金容易出现各向异性,因此有必要对激光定向能量沉积钛合金不同平面及不同方向上的组织与性能进行研究。选定Ti-6Al合金作为研究对象,采用光学显微镜、X射线衍射仪、扫描电镜和电子背散射衍射对激光定向能量沉积Ti-6Al合金物相、微观组织形貌和晶粒特征进行研究。结果表明,合金中只存在单一的α相,该物相为HCP结构;Ti-6Al合金不同成形高度表现出不同的微观组织特征,即沿着构建方向,底部为细小的等轴晶,中间为柱状晶,顶部为等轴晶/近等轴晶。在XOY面的平均晶粒尺寸最小,为22.2519μm;YOZ面存在最大的晶粒尺寸,为38.9408μm。在3个不同平面中,XOY面的小角度晶界体积分数最高,为19.5%;YOZ面小角度晶界体积分数最低,为12.2%。沿Z方向上,即与建造方向平行时抗拉强度最高,为669.94 MPa,相应的伸长率为13.9%;沿X方向上抗拉强度为560.55 MPa,其相应的伸长率最低,为11.4%。

关键词： Ti-6Al合金激光定向能量沉积各向异性微观组织力学性能

In situ autophagy regulation in synergy with phototherapy for breast cancer treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2317-2332页

作者： Huijuan Zhang Xiangyang Xuan yaping Wang Zijun Qi Kexuan Cao Yingmei Tian Chaoqun Wang Junbiao Chang Zhenzhong Zhang Lin hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China School of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Autophagy is an important factor in reducing the efficacy of tumor phototherapy(including PTT and PDT).Accurate regulation of autophagy in tumor cells is a new strategy to improve the anti-tumor efficiency of PTT/*** project intended to construct a tumor-activated autophagy regulator to efficiently block PTT/PDT-induced autophagy and realize synergistic sensitization to tumor *** achieve this goal,we first synthesized TRANSFERRIN(Tf)biomimetic mineralized nano-tellurium(Tf-Te)as photosensitizer and then used disulfide bond reconstruction technology to induce Tf-Te *** autophagy inhibitor hydroxychloroquine(HCQ)and iron ions carried by Tf were simultaneously loaded to prepare a tumor-responsive drug reservoir Tf-Te/*** entering breast cancer cells through the“self-guidance system”,Tf-Te/HCQ can generate hyperpyrexia and ROS under NIR laser irradiation,to efficiently induce PTT/PDT ***,the disulfide bond broke down in response to GSH,and the nanoparticles disintegrated to release Fe2+and HCQ at fixed *** simultaneously induce lysosomal alkalinization and increased osmotic pressure,effectively inhibit autophagy,and synergistically enhance the therapeutic effect of *** vivo anti-tumor results have proved that the tumor inhibition rate of Tf-Te/HCQ can be as high as 88.6%on 4T1 tumor-bearing *** multifunctional drug delivery system might provide a new alternative for more precise and effective tumor phototherapy.

关键词： Autophagy Tumor phototherapy Synergistic sensitization HCQ TRANSFERRIN Disulfide bond reconstruction GSH Biomimetic mineralized nano-tellurium

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静电除尘器的粉尘非稳态收集过程

环境科学学报 2008年第10期28卷 2059-2063页

作者：郝文阁侯亚平东北大学资源与土木工程学院沈阳110004

为了全面揭示电除尘器粉尘非稳态收集过程,建立完整的非稳态静电收尘理论,根据静电学基本原理,研究了极板粉尘层电荷导入、积累、释放的过程,推导出随粉尘层厚度增长而改变的动态收尘电场强度计算公式,进而得到荷电粒子动态驱进速度公式... 详细信息

为了全面揭示电除尘器粉尘非稳态收集过程,建立完整的非稳态静电收尘理论,根据静电学基本原理,研究了极板粉尘层电荷导入、积累、释放的过程,推导出随粉尘层厚度增长而改变的动态收尘电场强度计算公式,进而得到荷电粒子动态驱进速度公式,最终形成静电除尘非稳态收集理论.研究结果表明,在静电收尘过程中,粒子驱进速度与粉尘比电阻、工作电压、粉尘层厚度等多种因素有关;随粉尘比电阻的升高,收尘效率下降,当供电电压为最佳工作电压时收尘效率最高.针对不同比电阻粉尘进行了多项实验研究,实验结果与理论研究结果吻合.非稳态静电收尘理论成功地解释了实际静电收尘过程中与传统静电收尘理论相矛盾的地方,为静电除尘器的设计及其运行参数的选取提供了更为科学的理论基础.

关键词：静电除尘器极板沉积粉尘层积累电荷驱进速度收尘效率

Bazi Bushen alleviates reproductive aging in aged male mice

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Chinese Journal of Natural Medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing ZHANG Shaolan ZHANG yaping JIANG Yuning JI Chuanyuan NIU Kunxu LI Hongrong hou Yunlong WEI Cong Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of Traditional Chinese Medicine·College of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional Chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2)mouse *** study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural ***,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive *** was achieved by assessing sex hormone production,testicular histomorphology,and *** to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged ***,spermatogenesis was *** analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory *** these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular *** contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid ***,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： Traditional Chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis