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The next decade of SET:from an oncoprotein to beyond

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Journal of Molecular Cell Biology 2024年第1期16卷 1-14页

作者： Han yao Meng Zhang Donglai Wang State Key laboratory of Common Mechanism Research for Major Diseases&Department of Medical Genetics Institute of Basic Medical Sciences&School of Basic MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

This year marks the fourth decade of research into the protein SET,which was discovered in *** was initially identified as an oncoprotein but later shown to be a multifaceted protein involved in regulating numerous biological processes under both physiological and pathophysiological *** dysfunction is closely associated with diseases,such as cancer and Alzheimer's *** the increasing understanding of how SET works and how it is regulated in cells,targeting aberrant SET has emerged as a potential strategy for disease *** this review,we present a comprehensive overview of the advancements in SET studies,encompassing its biological functions,regulatory networks,clinical implications,and pharmacological ***,we provide insights into the future prospects of SET research,with a particular emphasis on its promising potential in the realm of immune modulation.

关键词： SET biological process regulatory mechanism disease therapy

Narrative review of latest research progress about robotic percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第8期21卷 816-825页

作者： Zhen-Yu lIU Guang-yao ZHAI Department of Clinical Medicine Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina

Robotic percutaneous coronary intervention(R-PCI)is a novel technology in which operators can manipulate guidewires and catheter devices in interventional *** approach provides great benefits to interventional cardiologists in terms of reducing both radiation exposure and orthopedic *** large,high-quality cohort studies have confirmed the short-term safety and high technical success rate of ***,randomized long-term data are still needed before adopting them as part of standard coronary ***,tele-stenting for complex coronary lesions has significant potential for *** need to overcome the present relevant challenges for its application such as inherent delays,bedside care for unstable patients from R-PCIs to manual PCIs(M-PCIs),incompatibility for a thrombus aspiration catheter and heavily calcified *** is a great future in laboratory workflow teams,3D-printed anatomical models and multiple joint collaborative control *** narrative review summarizes the latest developments in R-PCI,with a focus on developments in robotic technology,and discusses the current and future potential use of R-PCI in clinical practice globally.

关键词： coronary injuries unstable

A Novel ISSA–DElM Model for Predicting Rock Mass Permeability

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2825-2848页

作者： Chen Xing leihua yao Yingdong Wang School of Engineering and Technology China University of Geosciences(Beijing)Beijing100083China Beijing Engineering Corporation limited Beijing100024China

In pumped storage projects,the permeability of rock masses is a crucial parameter in engineering design and *** rock mass permeability coefficient(K)is influenced by various geological parameters,and previous studies aimed to establish an accurate relationship between K and geological *** study uses the improved sparrow search algorithm(ISSA)to optimize the parameter settings of the deep extreme learning machine(DElM),constructing a prediction model with flexible parameter selection and high ***,the Spearman method is applied to analyze the correlation between geological parameters.A sample database is built by comprehensively selecting four geological indexes:burial depth,rock quality designation(RQD),fracture density characteristic index(FD),and rock mass integrity designation(RID).Hence,the defects of the sparrow search algorithm(SSA)are enhanced using the improved strategy,and the initial input weights of the DElM are ***,the proposed ISSA–DElM model is employed to predict the permeability coefficient of rock mass in the entire study *** results showed that the predictive performance of the model is superior to that of the DElM and SSA–***,this model successfully provides insights into the distribution characteristics of rock mass permeability at engineering sites.

关键词： ISSA DElM rock mass permeability coefficient geological parameter correlation analysis

Restoring cosmological concordance with axion-like early dark energy and dark matter characterized by a constant equation of state?

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Communications in Theoretical Physics 2024年第7期76卷 74-82页

作者： Yan-Hong yao Xin-He Meng School of Physics and Astronomy Sun Yatsen University 2 Daxue RoadTangjiaZhuhaiChina School of Physics Nankai University 94 Weijin RoadNankaiTianjinChina

The Hubble tension persists as a challenge in *** early dark energy(EDE)models,initially considered the most promising for alleviating the Hubble tension,fall short of addressing the issue without exacerbating other tensions,such as the S_(8)*** that a negative dark matter(DM)equation of state(EoS)parameter is conducive to reduce the value of the σ_(8)parameter,we extend the axion-like EDE model in this paper by replacing the cold dark matter(CDM)with DM characterized by a constant EoS w_(dm)(referred to as WDM hereafter).We then impose constraints on this axion-like EDE extension model,along with three other models:the axion-like EDE model,ΛWDM,and Λ*** constraints are derived from a comprehensive analysis incorporating data from the Planck 2018 cosmic microwave background,baryon acoustic oscillations,and the Pantheon compilation,as well as a prior on H_(0)(i.e.H_(0)=73.04±1.04,based on the latest local measurement by Riess et al)and a Gaussianized prior on S_(8)(i.e.S_(8)=0.766±0.017,determined through the joint analysis of KID1000+BOSS+2dlenS).We find that although the new model maintains the ability to alleviate the Hubble tension to~1.4σ,it still exacerbates the S_(8)tension to a level similar to that of the axion-like EDE model.

关键词： Hubble tension early dark energy noncold dark matter S8 tension

Exponential Synchronization of Delayed Stochastic Complex Dynamical Networks via Hybrid Impulsive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 785-787页

作者： yao Cui Pei Cheng Xiaohua Ge the School of Mathematic Science Anhui UniversityHefei 230601China IEEE the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia

Dear Editor,This letter addresses the synchronization problem of a class of delayed stochastic complex dynamical networks consisting of multiple drive and response *** aim is to achieve mean square exponential synchronization for the drive-response nodes despite the simultaneous presence of time delays and stochastic noises in node dynamics.

关键词： dynamics stochastic letter

Traditional Chinese medicine for the treatment of immune-related nephropathy:A review

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Acta Pharmaceutica Sinica B 2024年第1期14卷 38-66页

作者： Pu Jiang Changliang yao De-an Guo School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Immune-related nephropathy(IRN)refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal *** pathogenesis of IRN is not fully understood;therefore,treatment is *** Chinese medicines(TCMs)have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy,lupus nephropathy,and diabetic *** underlying mechanisms mainly include its inhibition of inflammation;improvements to renal interstitial fibrosis,oxidative stress,autophagy,apoptosis;and regulation of *** this review,we summarize the clinical symptoms of the three IRN subtypes and the use of TCM prescriptions,herbs,and bioactive compounds in treating IRN,as well as the potential mechanisms,intending to provide a reference for the future study of TCM as IRN treatments.

关键词： IgA nephropathy Diabetic nephropathy lupus nephritis Traditional Chinese medicine Immunity Pathogenesis Mechanism Pathophysiology

Crystallization management of CsPbI2Br perovskites by PbAc2-incorporated twice spin-coating process for efficient and stable CsPbI2Br perovskite solar cells

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Journal of Energy Chemistry 2024年第10期97卷 419-428页

作者： Yu liu Kun lang Huifang Han Huijing liu yao Fu Pengchen Zou Yinhui lyu Jia Xu Jianxi yao State Key laboratory of Alternate Electrical Power System with Renewable Energy Sources Beijing Key Laboratory of Energy Safety and Clean Utilization North China Electric Power University

CsPbI2Br perovskite solar cell has been extensively studied due to its exceptional thermal stability and relatively stable perovskite phase ***,the presence of bromine leads to a rapid crystallization rate of CsPbI2Br films,resulting in small grain size and high defect ***,CsPbI2Br demonstrates poor light absorption due to its wide ***,it is crucial to control the crystallization rate and increase the film thickness to reduce defect density,enhance light absorption,and improve photovoltaic *** this study,we utilized a PbAc2-incorporated twice spincoating（PTS） process to address these ***,PbAc2was added to the CsPbI2Br precursor solution to form a CsPbI2Br film,which was then coated with the CsPbI2Br precursor solution to produce the PTS film,Ac-can delay the perovskite crystallization,leading to the formation of thicker and denser CsPbI2Br ***,lone-pair electrons of the oxygen atom provided by Ac-formed coordination bonds with under-coordinated Pb2+ions to fill halogen ion vacancies,thereby reducing the defect ***,the PTS CsPbI2Br device achieved a peak power conversion efficiency（PCE） of 16.19% and maintained 96.7% of its initial PCE over 1500 h at room temperature under 25% relative humidity without any encapsulation.

关键词： Crystallization management CsPbI2Br PbAc2 Perovskite solar cells Twice spin-coating process

Co-pyrolysis of Sewage Sludge with Paint Sludge: Kinetics and Thermodynamic Analysis via Iso-conversional Methods

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 716-727页

作者：周尚群赵青林 YU Tian yao Xiaojie State Key laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China School of Mate-rials Science and Engineering Wuhan University of TechnologyWuhan 430070China

This study explored the synergistic interaction of sewage sludge(SS)and automotive paint sludge(PS)during co-pyrolysis for the optimized treatment of sewage sludge in cement kiln systems,utilizing thermogravimetric analysis(TGA)and thermogravimetric-mass spectrometry(TGA-MS).The result reveals the coexisting synergistic and antagonistic effects in the co-pyrolysis of SS/*** synergistic effect arises from hydrogen free radicals in SS and catalytic components in PS,while the main source of the antagonistic effect is that,during the mechanical mixing process,the SS/PS is converted from the particulate form into a dough-like rubbery which contributes to the film-forming effect,hindering the volatilization of volatile ***/PS co-pyrolysis reduces the yielding of tar production while increasing coke and *** study will provide some in-depth insights into the co-pyrolysis of SS/PS,and offer theoretical support for the subsequent research on the collaborative disposal processes in cement kilns.

关键词： sewage sludge co-pyrolysis automotive paint sludge evolved gas analysis

Synergistic silver-mediated and palladium-catalyzed nondirected olefination of aryl C–H bond: quick access to multi-substituted aryl olefins

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Science China Chemistry 2024年第3期67卷 882-889页

作者： Jian yao lili Shao Xiaohong Huo Xiaoming Wang Shanghai Key laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key laboratory of Organometallic Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 20032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Transition metal-catalyzed olefination of aryl C-H bond is a powerful tool for the synthesis of alkenes. While the Pd-catalyzed oxidative C-H olefination of arenes, also known as Fujiwara-Moritani reaction, has been established as one of the most efficient methods, the substrates are largely limited to terminal olefins with electron-withdrawing group(s). Herein, we report a synergistic silver-mediated and palladium-catalyzed non-directed C-H olefination of arenes with vinyl(pseudo)halides, which offers a complementary strategy to the typical Fujiwara-Moritani reaction. The reactions proceeded well for a variety of halogenated arenes, heteroarenes, and olefin substrates, providing an efficient access to various multi-substituted aryl olefins, including trisubstituted/tetrasubstituted olefins and several complex olefins derived from medicines or natural products. Mechanistic studies indicated a bimetallic Pd/Ag cooperation is operative in the catalysis, i.e., the reaction is initiated by aryl C-H bond cleavage via ligation with phosphine/Ag species, followed by transferring of the aryl moiety to a vinyl palladium intermediate,which is in turn formed by oxidative addition of vinyl(pseudo)halide to a Pd complex. This method enables the synthesis of a wide range of challenging multi-substituted vinyl products from simple arenes(directing-group free) in a streamlined and controllable fashion.

关键词： direct C–H olefination multi-substituted aryl alkenes bimetallic Pd/Ag cooperation C–H functionalization