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Reducing porcine corneal graft rejection, with an emphasis on porcine endogenous retrovirus transmission safety: a review

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 324-332页

作者： yao-wen song Zhi-Qiang Pan Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Science Key Laboratory

Donor cornea shortage is a primary hurdle in the development of corneal transplantation. Of all species, porcine corneas are the ideal transplantation material for humans. However, the xenoimmune rejection induced by porcine corneal xenotransplantation compromises surgical efficacy. Although the binding of IgM/IgG in human serum to a genetically modified porcine cornea is significantly weaker than that of the wild type(WT), genetically modified porcine corneas do not display a prolonged graft survival time in vivo. Conversely, costimulatory blockade drugs, such as anti-CD40 antibodies, can reduce the xenoimmune response and prolong graft survival time in animal experiments. Moreover, porcine endothelial grafts can survive for more than 6mo with only the subconjunctival injection of a steroid-based immunosuppressants regime; therefore, they show great value for treating corneal endothelial disease. In addition, zoonotic transmission is a primary concern of xenotransplantation. Porcine endogenous retrovirus(PERV) is the most significant virus assessed by ophthalmologists. PERV integrates into the porcine genome and infects human cells in vitro. Fortunately, no evidence from in vivo studies has yet shown that PERV can be transmitted to hosts.

关键词： corneal xenotransplantation genetically modified pigs wild type pigs costimulatory blockade drugs porcine endothelial grafts porcine endogenous retrovirus safety

Neighbor Sum Distinguishing Total Coloring of Triangle Free IC-planar Graphs

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Acta Mathematica Sinica,English Series 2020年第3期36卷 292-304页

作者： wen yao song Yuan Yuan DUAN Lian Ying MIAO School of Mathematics and Statistics Zaozhuang UniversityZaozhuang 277160P.R.C hina School of Mathematics China University of Mining and TechnologyXuzhou 221116P.R.C hina

A graph is IC-planar if it admits a drawing in the plane such that each edge is crossed at most once and two crossed edges share no common end-vertex.A proper total-k-coloring of G is called neighbor sum distinguishing if∑_c(u)≠∑_c(v)for each edge uv∈E(G),where∑_c(v)denote the sum of the color of a vertex v and the colors of edges incident with *** least number k needed for such a total coloring of G,denoted byχ∑"is the neighbor sum distinguishing total chromatic *** and Wozniak conjecturedχ∑"(G)≤Δ(G)+3 for any simple graph with maximum degreeΔ(G).By using the famous Combinatorial Nullstellensatz,we prove that above conjecture holds for any triangle free IC-planar graph with△(G)≥***,it holds for any triangle free planar graph withΔ(G)≥6.

关键词： Neighbor sum distinguishing total coloring Combinatorial Nullstellensatz triangle free IC-planar graph maximum degree

Acyclic Edge Coloring of IC-planar Graphs

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Acta Mathematicae Applicatae Sinica 2020年第3期36卷 581-589页

作者： wen-yao song Yuan-yuan DUAN Juan WANG Lian-ying MIAO School of Mathematics and Statistics Zaozhuang UniversityZaozhuang 277160China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A proper edge coloring of a graph G is acyclic if there is no 2-colored cycle in *** acyclic chromatic index of G is the least number of colors such that G has an acyclic edge coloring and denoted byχ′a(G).An IC-plane graph is a topological graph where every edge is crossed at most once and no two crossed edges share a *** this paper,it is proved thatχ′a(G)≤Δ(G)+10,if G is an IC-planar graph without adjacent triangles andχ′a(G)≤Δ(G)+8,if G is a triangle-free IC-planar graph.

关键词： Acyclic chromatic index acyclic edge coloring IC-planar graph

Therapeutic potential of Rho-associated kinase inhibitor Y27632 in corneal endothelial dysfunction:an in vitro and in vivo study

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 19-25页

作者： yao-wen song Jun-Yu Chen Xu Li Li Wang Zhi-Qiang Pan Shanxi Eye Hospital Taiyuan 030002Shanxi ProvinceChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science Key LaboratoryBeijing 100730China

AIM:To investigate the effects of a selective inhibitor of Rho-associated kinase(ROCK),Y-27632,on inbred Wuzhishan porcine corneal endothelial cells(PCECs)in vitro and in vivo ***:Primary PCECs were trypsinized from Wuzhishan miniature porcine corneal *** optimal concentration of Y-27632 on PCECs was determined through MTT and 5-ethynyl-2'-deoxyuridine(EdU)-labeling *** New Zealand rabbits were used as a corneal endothelial dysfunction model,and a PCECs suspension supplemented with Y-27632 was injected into the anterior chamber of the *** progression of rabbit corneal opacity and edema were observed by slit lamp *** rabbits were sacrificed,and rabbit globes were enucleated for trypan blue-alizarin red staining,hematoxylineosin staining,and immunofluorescence ***:Administration of 100μmol/L Y-27632 facilitated PCECs'proliferation *** rabbit corneas injected with PCECs suspension and 100μmol/L Y-27632 were restored to transparency significantly after ***:The 100μmol/L Y-27632 treatment improves PCECs'proliferation *** our results suggest that Y-27632 and PCECs can be used to treat corneal endothelial dysfunction.

关键词： corneal endothelial dysfunction Rho kinase inhibitor Y-27632 porcine corneal endothelial cells cell proliferation

Comparative study of functional optical zone:small incision lenticule extraction versus femtosecond laser assisted excimer laser keratomileusis

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 238-244页

作者： yao-wen song Meng-Fan Cui Yi Feng Min Qu Yan Gao Rui He Department of Excimer Laser Shanxi Eye HospitalTaiyuan 030002Shanxi ProvinceChina The First Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

AIM:To investigate the size of functional optical zone(FOZ)after small incision lenticule extraction(SMILE)versus femtosecond laser assisted excimer laser keratomileusis(FS-LASIK)for myopia correction and potential associated factors for ***:A total of 133 patients who received corneal refractive surgery in our hospital between November 2018 and July 2021 were retrospectively *** were 63 patients(123 eyes)in SMILE group and 70patients(139 eyes)in FS-LASIK *** size of FOZ was measured using Pentacam 3-dementional anterior segment analyzer before and 3mo after surgery,so as to analyze postoperative achieved functional optical zone(AFOZ)and its contributing ***:When planned functional optical zone(PFOZ)was 6.5 mm for both groups,AFOZ was 1.45±0.27 and 1.67±0.25 mm smaller than preoperative FOZ in SMILE group and FS-LASIK group 3mo after *** in SMILE group was significantly larger than that in FS-LASIK group(P<0.001).Variation of FOZ was negatively correlated with preoperative spherical equivalent(SE)and positively correlated with variation of mean keratometry value(△Km),variation of spherical aberration(△SA),and variation of Q-value(△Q,all P<0.001)in both *** variable linear regression equations were△FOZ=1.354-0.1×pre-SE+0.336×△Q+1.462×△SA in SMILE group and△FOZ=1.512+0.137×△Q+0.468×△SA in FS-LASIK ***:AFOZ is significantly smaller than preoperative FOZ in both SMILE and FS-LASIK *** the same PFOZ,larger AFOZ is achieved in SMILE group than in FS-LASIK group.

关键词： functional optical zone small incision lenticule extraction femtosecondlaser assisted excimer laser keratomileusis spherical equivalent spherical aberration

Long-term safety of laser in situ keratomileusis in eyes with thin corneas： 5-year follow-up

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1227-1233页

作者： yao-wen song Rui He Jack X.Ma Douglas D.Koch Li Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology and VisualScience Key Laboratory Beijing 100730 China Shanxi Eye Hospital Taiyuan 030002 Shanxi ProvinceChina Mc Govern Medical School University of Texas Health Science Center at Houston TX 75835 USA Cullen Eye Institute Department of Ophthalmology Baylor College of Medicine Houston TX 75844 USA

AIM： To investigate the long term（≥5 y） efficacy, predictability, and safety of laser in situ keratomileusis（LASIK） in eyes with thin corneas [central corneal thickness（CCT）〈500 μm]. METHODS： A total of 339 patients met the criteria of this study. Finally, 175 eyes of 89 patients who had thin corneas and underwent LASIK≥5 y ago returned to our clinic and included in this study. Preoperative parameters recorded included uncorrected visual acuity（UCVA）, corrected distance visual acuity（CDVA）, manifest refraction, CCT and corneal topography. At returning visits, in addition to visual acuity and manifest refraction, ultrasound CCT and corneal topography were performed. Optical coherence tomography was used to measure the CCT, LASIK flap thickness, and residual stromal bed thickness（RSBT）. Safety index, efficacy index, percentage of eyes within ±0.5 D and ±1.0 D of refraction, percent tissue altered（PTA）, and percentage stromal bed thickness（PSBT） were calculated. RESULTS： The safety index was 1.09 and efficacy index was 0.99. The percentages of eyes within ±0.5 D and ±1.0 D were 71.2% and 87.7%, respectively. The mean PTA was 40%±6%（range 20% to 55%）; 76 eyes（43.4%） had PTA 〈40% and 99 eyes（56.6%） had PTA≥40%. The mean RSBT was 303±27 μm（range 240 to 390 μm）, and 2 eyes had RSBT〈250 μm. The mean PSBT was 61%±9%（range 51% to 85%）. No eyes developed ectasia. CONCLUSION： In this cohort with the PSBT of 50% or more, LASIK is safe with follow-up for at least 5 y.

关键词： LASIK thin cornea long-term safety percent tissue altered percentage stromal bed thickness

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大雷诺数下方柱绕流PIV试验及数值模拟

工程热物理学报 2018年第8期39卷 1731-1737页

作者：秦浩肖姚宋文武孙延国流体及动力机械教育部重点试验室成都610039 西华大学能源与动力工程学院成都610039 西南交通大学风工程研究中心成都610031

基于风洞试验利用粒子图像测速技术(PIV)研究了大雷诺数(Re=3.42×10~4)下方柱绕流流场,并应用本征正交分解(POD)法分解PIV瞬态速度场,获得了方柱尾流的低阶模态和重构流场结果,研究方柱绕流的流动机理.采用γ-Re_θ和k-ωSST两种湍流... 详细信息

基于风洞试验利用粒子图像测速技术(PIV)研究了大雷诺数(Re=3.42×10~4)下方柱绕流流场,并应用本征正交分解(POD)法分解PIV瞬态速度场,获得了方柱尾流的低阶模态和重构流场结果,研究方柱绕流的流动机理.采用γ-Re_θ和k-ωSST两种湍流模型研究了大雷诺数下方柱尾流的速度分布以及湍动能变化。风洞PIV试验可准确的观测方柱尾流脉动流场,基于POD方法得到的前6阶模态占总能量的78.7%,前6阶模态即可较准确重构流场并捕获流场的主要特征。通过对比,γ-Re_θ模型是较优的湍流模型,可较好地得到尾流的湍动能及其变化规律。

关键词：方柱绕流粒子测速仪 POD 数值模拟风洞试验

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li Yanqi song Sujuan Qin Qiaoyan wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing yao Yuan Li Xi Liu wenping Liang Yu Li Liyong Wu Zhe Wang Weihong song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor