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Decadal and Interannual Variability of Persistent Heavy Rainfall Events over the Middle and Lower Reaches of the Yangtze River Valley

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Journal of Meteorological Research 2019年第6期33卷 1031-1043页

作者： ruan yao Xuejuan REN China Meteorological Administration–Nanjing University Joint Laboratory for Climate Prediction Studies School of Atmospheric SciencesNanjing UniversityNanjing 210023

This study investigates the relationship between the anomalous atmospheric circulation pattern and summertime persistent heavy rainfall(PHR)over the middle and lower reaches of the Yangtze River valley(MLYRV)on the decadal and interannual *** on the gridded daily rainfall data of the US Climate Prediction Center,the PHR events on grid-point and the regional PHR events considering both the area of PHR and regionally averaged rainfall intensity are identified over the MLYRV during the summers of 1979–2017.A PHR index(PHRI)is defined,to describe the variability of summertime PHR event number over the *** PHRI is then divided into the decadal and interannual *** analysis reveals that the decadal PHR events are closely related to anomalous precipitation,intensified vertical motion,and strengthened upper-level divergence over southern China,as well as an anomalous anticyclone over the western Pacific transporting more water vapor from the South China Sea(SCS)to southern *** for the interannual component,the above pattern still co-exists but over a narrow region around the *** choosing the years in which the decadal and interannual components of the PHRI are simultaneously positive(SP)or negative(SN),the features of regional PHR events in SP and SN years are analyzed,*** results show that there are more regional PHR events in SP years with enhanced intensity and larger affected areas compared with those in SN ***,the zonal oscillations of the South Asian high(SAH)and the western Pacific subtropical high(WPSH)during the regional PHR events demonstrate a better regularity in SP years than those in SN years.

关键词： middle and lower reaches of the Yangtze River valley(MLYRV) persistent heavy rainfall(PHR) decadal variability interannual variability

Action mechanisms and research methods of tRNA-derived small RNAs

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1505-1513页

作者： yaoyao Xie Lipeng yao Xiuchong Yu yao ruan Zhe Li Junming Guo Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of PathophysiologyMedical School of Ningbo University315211 NingboChina Ningbo College of Health Sciences Ningbo 315000 ZhejiangChina

tRNA-derived small RNAs(tsRNAs),including tRNA-derived fragments(tRFs)and tRNA halves(tiRNAs),are small regulatory RNAs processed from mature tRNAs or precursor *** and tiRNAs play biological roles through a variety of mechanisms by interacting with proteins or mRNA,inhibiting translation,and regulating gene expression,the cell cycle,and chromatin and epigenetic *** establishment and application of research technologies are important in understanding the biological roles of tRFs and *** study the molecular mechanisms of tRFs and tiRNAs,researchers have used a variety of bioinformatics and molecular biology methods,such as microarray analysis,real-time quantitative reverse transcription-polymerase chain reaction(qRT-PCR);Northern blotting;RNA sequencing(RNA-seq);cross-linking,ligation and sequencing of hybrids(CLASH);and photoactivatable-ribonucleoside-enhanced cross-linking and immunoprecipitation(PAR-CLIP).This paper summarizes the classification,action mechanisms,and roles of tRFs and tiRNAs in human diseases and the related signal transduction pathways,targeted therapies,databases,and research methods associated with them.

关键词： mechanisms linking inhibiting

An analysis of the mechanism underlying photocatalytic disinfection based on integrated metabolic networks and transcriptional data

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Journal of Environmental Sciences 2020年第6期32卷 28-37页

作者： Xiao-Long Liang Zhan-Min Liang Shuo Wang Xiao-Hui Chen yao ruan Qing-Ye Zhang Hong-Yu Zhang Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan430070PR China

Photocatalytic disinfection has long been used to combat pathogenic ***,the specific mechanism underlying photocatalytic disinfection and its corresponding targets remain *** this study,an analysis of the potential mechanism underlying photocatalytic disinfection was performed based on integrated metabolic networks and transcriptional *** sets of RNA-seq data(wild type and a photocatalysis-resistant mutant mediated by titanium dioxide(TiO2))were processed to constrain the genome scale metabolic models(GSMM)of *** analyzing the metabolic network,the differential metabolic flux of every reaction was computed in constrained GSMM,and several significantly differential metabolic fluxes in reactions were extracted and *** of these reactions were involved in the transmembrane transport of substances and occurred on the inner membrane or were an important component of the cell *** results,which are consistent with the reported information,validated our analysis *** addition,our work also identified other new and valuable metabolic pathways,such as the reaction ALCD2x,which has a great effect on the energy production process under bacterial anaerobic *** DHAK reaction is also related to the metabolic process of *** reactions with large differential metabolic fluxes merit further ***,to provide a strategy to address photocatalysis-resistant mutant bacteria,a metabolic compensation analysis was also *** metabolic compensation analysis results provided suggestions for a combined method that can effectively combat resistant *** method could also be used to explore the mechanisms of drug resistance in other microorganisms.

关键词： Photocatalytic disinfection Genome scale metabolic models(GSMM) RNA-seq analysis Mechanism Metabolic compensation

南京市日最高气温对支气管和心血管类疾病就诊人数的影响

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气象科学 2024年第3期44卷 593-602页

作者：单婵王子昕王雁君桑小卓姚阮艾文文江苏省气象服务中心南京210041

融合应用分布滞后非线性模型(Distributed Lag Mon-linear Model,DLNM)与广义相加模型(Generalized Additive Model,GAM),在控制新冠疫情影响、节假日效应、星期效应、长期趋势以及大气污染因子等因素基础上,探究了2018—2020年南京市... 详细信息

融合应用分布滞后非线性模型(Distributed Lag Mon-linear Model,DLNM)与广义相加模型(Generalized Additive Model,GAM),在控制新冠疫情影响、节假日效应、星期效应、长期趋势以及大气污染因子等因素基础上,探究了2018—2020年南京市日最高气温与当地支气管类、心血管类疾病就诊人数的暴露反应关系,包括滞后效应和累积效应。结果表明:对于支气管类疾病,冬季为高风险期,低温的即时效应和累积效应显著;中短期累积作用下,气温越低危险性越大;长期累积作用下,10℃左右的危险性最大;高温累积效应不显著,30℃左右滞后效应显著。对于心血管类疾病,低温的即时效应和累积效应显著,11~12℃左右影响的累积效应和持续性最强;高温的滞后效应显著,温度越高,滞后效应越明显;长期暴露于高温环境的患病风险会快速增加,日最高气温32℃左右的暴露累积风险最大。针对这两类疾病,当日最高气温在22~24℃范围内,属于人体最舒适温度。

关键词：日最高气温心血管类疾病支气管类疾病滞后效应累积效应

Double-layered skeleton of Li alloy anchored on 3D metal foam enabling ultralong lifespan of Li anode under high rate

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Chinese Chemical Letters 2024年第3期35卷 479-485页

作者： Chaohui Wei Zeyu yao Jin ruan Zhicui Song Aijun Zhou Yingze Song Donghuang Wang Jicheng Jiang Xin Wang Jingze Li Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313000China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Environmental-Friendly Energy Materials Tianfu Institute of Research and InnovationSchool of Materials and ChemistrySouthwest University of Science and TechnologyMianyang 621010China

The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed ***,the existing detrimental issues,such as dendritic growth and volume expansion,have hindered the practical implementation of *** three-dimensional frameworks(e.g.,copper and nickel foam),have been regarded as one of the fundamental strategies to reduce the local current density,aiming to extend the Sand'***,the local environment far from the skeleton is almost the same as the typical plane Li,due to macroporous space of metal ***,we built a double-layered 3D current collector of Li alloy anchored on the metal foam,with micropores interconnected macropores,via a viable thermal infiltration and cooling *** to the excellent electronic and ionic conductivity coupled with favorable lithiophilicity,the Li alloy can effectively reduce the nucleation barrier and enhance the Li^(+)transportation rate,while the metal foam can role as the primary promotor to enlarge the surface area and buffer the dimensional ***,the Li composite anode with hierarchical structure of primary and secondary scaffolds realized the even deposition behavior and minimum volume expansion,outputting preeminent prolonged cycling performances under high rate.

关键词： Double-layered skeleton Li alloy 3D Metal foam Ultralong lifespan Lithium metal batteries High rate

COMPLEX RAY EXPANSION OF PLANE WAVE

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Journal of Electronics(China) 1994年第2期11卷 176-179页

作者：尧德中阮颖铮 University of Electronic Science and Technology of China Chengdu 610054

Based on the high frequency approximation theory, the complex ray expansion of plane wave is derived. The results obtained may be regarded as the basis of the numerical expansion of plane wave, which has been used suc... 详细信息

关键词： Wave propagation Plane wave Complex ray

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旋转机械智能故障诊断系统的设计

自动化仪表 2000年第10期21卷 14-16页

作者：阮跃华北电力科学研究院英华达公司北京100045

分析了目前旋转机械智能故障诊断系统存在的问题，根据故障诊断反问题的研究成果，提出了智能故障诊断系统的设计方法，最后给出了诊断实例。

关键词：故障诊断旋转机械软件设计知识处理智能诊断

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贝那普利对环孢素A慢性肾毒性的防护作用

免疫学杂志 2007年第3期23卷 302-305页

作者：阮翘阮耀谢新立郑州大学第一附属医院核医学科河南省高等学校临床医学重点学科开放实验室郑州450052 南阳医学高等专科学校药理学教研室河南南阳473058

目的探讨贝那普利对环孢素A(CsA)慢性肾毒性的防护机理。方法选雄性大鼠30只,随机分为3组,3组均给予低盐饮食。A组为CsA溶剂(橄榄油)对照组;B组为CsA组;C组为CsA加贝那普利。观察给药28 d后各组大鼠血浆肾素活性(PRA)、血管紧张素Ⅱ(Ang... 详细信息

目的探讨贝那普利对环孢素A(CsA)慢性肾毒性的防护机理。方法选雄性大鼠30只,随机分为3组,3组均给予低盐饮食。A组为CsA溶剂(橄榄油)对照组;B组为CsA组;C组为CsA加贝那普利。观察给药28 d后各组大鼠血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)及醛固酮(ALD)水平的变化,并对肾组织进行组织学观察和免疫组织化学检测,观察贝那普利对上述改变的防护作用。结果①CsA可引起大鼠血浆PRA、AngⅡ水平明显升高,而贝那普利对大鼠PRA、AngⅡ水平的升高有明显的抑制作用;血浆醛固酮水平,A组和B组之间差异无显著性(P>0.05),而贝那普利组醛固酮水平明显下降。②CsA能导致肾间质纤维化和小动脉病变,诱导大鼠肾内转化生长因子-β1(TGF-β1)的高表达,贝那普利能减轻上述改变。结论CsA能激活肾素-血管紧张素系统(RAS),使大鼠肾内TGF-β1高表达;贝那普利能阻断RAS系统,尤其是能降低AngⅡ水平,减轻CsA引起的肾间质纤维化,使大鼠肾内TGF-β1表达下降。

关键词：环孢菌素类药物毒性血管紧张素转换酶抑制药

数字PCR定量检测血浆中环状RNA方法的建立

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生物化学与生物物理进展 2021年第6期48卷 721-726页

作者：阮垚郭俊明肖丙秀宁波大学医学院、浙江省病理生理学技术研究重点实验室宁波315211

生物标志物一直是医学领域的研究热点.目前主要以实时荧光定量PCR技术作为分子诊断的检测手段,用于大样本的核酸检测,但该技术具有限制性,会导致假阴性.作为第三代PCR的数字PCR技术,优化并提高了检测灵敏度,无需标准曲线实现绝对定量检... 详细信息

生物标志物一直是医学领域的研究热点.目前主要以实时荧光定量PCR技术作为分子诊断的检测手段,用于大样本的核酸检测,但该技术具有限制性,会导致假阴性.作为第三代PCR的数字PCR技术,优化并提高了检测灵敏度,无需标准曲线实现绝对定量检测,大大提高了检测的精准度,尤其是对于低表达RNA的检测,显得更为出色.本研究以hsacirc0061276为例,利用微滴式数字PCR EvaGreen染料法对血浆中hsacirc0061276的拷贝数进行绝对定量地检测,成功检测出胃炎和胃癌患者血浆中hsacirc0061276的具体拷贝数.因此,数字PCR作为新型检测技术在临床实际应用中有较大推广价值.

关键词：数字PCR 环状RNA 生物标志物