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（＊）-Serial coalgebras

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Frontiers of Mathematics in china 2012年第5期7卷 955-970页

作者： hailou yao {2. fan Yanru PING college of applied {2.s Beijing University of TechnologyBeijing 100124China

In this paper, we introduce the notion of （＊）-serial coalgebras which is a generalization of serial coalgebras. We investigate the properties of （＊）-serial coalgebras and their comodules, and obtain sufficient a... 详细信息

关键词： Coalgebra biserial comodule (,)-serial coalgebra quiver

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余代数的Krull维数

北京工业大学学报 2016年第8期42卷 1265-1269页

作者：姚海楼范维丽平艳茹北京工业大学应用数理学院北京100124

为了研究余代数的结构,基于素子余代数引进了余代数Krull维数概念,通过局部化方法对其进行了研究,得到一些有关Krull维数的等式与不等式,从而为余代数的研究提供了有用的工具.

关键词：余代数余模素余代数 Krull 维数诺特余代数

Climate and extrema of ocean waves in the East china Sea

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science china Earth sciences 2018年第7期61卷 980-994页

作者： Hailun HE Jinbao SONG Yefei BAI yao XU Juanjuan WANG fan BI State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic AdministrationHangzhou 310012China Ocean college Zhejiang UniversityZhoushan 316021China Department of Ocean and Resources Engineering University of Hawaii at ManoaHonoluluHI 96822USA School of Geographic and Oceanographic sciences Nanjing UniversityNanjing 210023China National Marine Environment Forecasting Center Beijing 100081China North china Sea Marine Forecasting Center of State Oceanic Administration Qingdao 266061China Shandong Provincial Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266061China

Wave climate plays an important role in the air-sea interaction over marginal seas. Extreme wave height provides fundamental information for various ocean engineering practices, such as hazard mitigation, coastal structure design, and risk assessment. In this paper, we implement a third generation wave model and conduct a high-resolution wave hindcast over the East china Sea to reconstruct a 15-year wave field from 1988 to 2.02.for derivation of monthly mean wave parameters and analysis of extreme wave conditions. The numerical results of the wave field are validated through comparison with satellite altimetry measurements, low-resolution reanalysis, and the ocean wave buoy record. The monthly averaged wave height and wave period show seasonal variation and refined spatial patterns of surface waves in the East china Sea. The climatological significant wave height and mean wave period decrease from the open ocean in the southeast toward the continental area in the northwest, with the pattern generally following the bathymetry. Extreme analysis on the significant wave height at the buoy station indicates the hindcast data underestimate the extreme values relative to the observations. The spatial pattern of extreme wave height shows single peak emerges at the southwest of Ryukyu Island although a wind forcing with multi-core structure at the extreme is {2..

关键词： Wave climate East china Sea Extreme value analysis WaveWatch-lll

A Time-Varying Parameter Estimation Method for Physiological Models Based on Physical Information Neural Networks

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Computer Modeling in Engineering & sciences 2023年第12期137卷 2243-2265页

作者： Jiepeng yao Zhanjia Peng Jingjing Liu Chengxiao fan Zhongyi Wang Lan Huang college of Information and Electrical Engineering China Agricultural UniversityBeijing100083China Key Laboratory of Agricultural Information Acquisition technology(beijing) Ministry of AgricultureBeijing100083China Key Laboratory of Modern Precision Agriculture System Integration Research Ministry of EducationBeijing100083China

In the establishment of differential equations,the determination of time-varying parameters is a difficult problem,especially for equations related to life ***,we propose a new framework named BioE-PINN based on a physical information neural network that successfully obtains the time-varying parameters of differential *** the proposed framework,the learnable factors and scale parameters are used to implement adaptive activation functions,and hard constraints and loss function weights are skillfully added to the neural network output to speed up the training convergence and improve the accuracy of physical information neural *** this paper,taking the electrophysiological differential equation as an example,the characteristic parameters of ion channel and pump kinetics are determined using *** results demonstrate that the numerical solution of the differential equation is calculated by the parameters predicted by BioE-PINN,the RootMean Square Error(RMSE)is between 0.01 and 0.3,and the Pearson coefficient is above 0.87,which verifies the effectiveness and accuracy of ***,realmeasuredmembrane potential data in animals and plants are employed to determine the parameters of the electrophysiological equations,with RMSE 0.02.0.2.and Pearson coefficient above *** conclusion,this framework can be applied not only for differential equation parameter determination of physiological processes but also the prediction of time-varying parameters of equations in other fields.

关键词： Physics-informed neural network differential equation bioelectrical signals inverse problems

Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia

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Journal of Genetics and Genomics 2017年第6期44卷 295-306页

作者： Jinsong Tang Yu fan Hong Li Qun Xiang Deng-Feng Zhang Zongchang Li Ying He Yanhui Liao Ya Wang fan He Fengyu Zhang Yin {2. Shugart Chunyu Liu Yanqing Tang Raymond C.K.Chan Chuan-Yue Wang Yong-Gang {2. Xiaogang Chen Institute of Mental Health National Clinical Research Center for Mental Health Disorders and National Technology Institute of Psychiatryand Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceThe Second Xiangya HospitalCentral South University Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of sciences & Yunnan Province Kunming Institute of Zoology Department of Psychiatry The First Affiliated Hospital of Zhengzhou University Kunming college of Life science University of Chinese Academy of Sciences Neuropsychology and applied Cognitive Neuroscience Laboratory and CAS Key Laboratory of Mental HealthInstitute of PsychologyChinese Academy of Sciences beijing Key Laboratory of Mental Disorders Department of PsychiatryBeijing Anding Hospitaland Center of SchizophreniaBeijing Institute for Brain Disorders and Laboratory of Brain Disorders of the Ministry of Science and TechnologyCapital Medical University Unit on Statistical Genomics Intramural Research ProgramsNational Institute of Mental HealthNIH Institute of Human Genetics University of Illinois at Chicago Department of Psychiatry The First Affiliated Hospital of China Medical University CAS Center for Excellence in Brain science and Intelligence technology Chinese Academy of Sciences

Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still *** implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations(DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs(including one splicing site) were identified and shared by twins, which were either located in previously reported schizophrenia risk genes(p.V2.689 I mutation in TTN, p.S2.06 T mutation in GCN1L1, IVS3+1G > T in DOCK1) or had a benign to damaging effect according to in silico prediction analysis. By searching the inherited rare damaging or loss-of-function(LOF) variants and common susceptible alleles from three classes of schizophrenia candidate genes, we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2. RELN and FEZ1. Four inherited copy number variations(CNVs; including a large deletion at 16p13.11) implicated for schizophrenia were identified in four families, respectively. Most of families carried both missense DNMs and inherited risk variants, which might suggest that DNMs, inherited rare damaging variants and common risk alleles together conferred to schizophrenia susceptibility. Our results support that schizophrenia is caused by a combination of multiple genetic factors, with each DNM/variant showing a relatively small effect size.

关键词： Whole-genome sequencing Schizophrenia Monozygotic twin De novo mutation Combined effect Susceptibility

Concise Total Synthesis of Dysoxylactam A and a Simplified Analog

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Chinese Journal of Chemistry 2022年第17期40卷 2027-2034页

作者： Guan-Zhou Yang Lei Wang yao-Yue fan Zeng-Wei Lai Xue-Ni Yu Li-Guang Lou Kun Gao Jian-Min Yue State Key Laboratory of applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou University222 Tianshui South RoadLanzhouGansu730000 China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai201203 China university of Chinese Academy of sciences No.19A Yuquan RoadBeijing100049 China

A total synthesis of 17-membered macrocyclolipopeptide dysoxylactam A,a potent agent reversing P-glycoprotein(P-gp)-mediated multidrug resistance(MDR)in cancer cells,was developed from the starting material(S)-2.methylbutanal in a linear sequence of 12.steps with 2..2.overall *** key steps include proline-catalyzed asymmetric aldol reaction,Evans aldol reaction and Krische allylation to construct the multiple stereocenters containing fragment,and ring-closing metathesis to furnish the *** total synthesis facilitates the preparation of large amount samples of dysoxylactam A and the side chain simplified derivatives for further biological tests and preliminary structure-activity relationship exploration.

关键词： Total synthesis Dysoxylactam A Macrocyclolipopeptide Reversing multidrug resistance Structure-activity relationship

Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere

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Research 2023年第4期2023卷 595-608页

作者： Yue Yin Yaping Yan Biao fan Wenping Huang Jie Zhang Hai-Yan Hu Xiaoqiong Li Dongbin Xiong Shu-Lei Chou yao Xiao Hai Wang School of Medical technology Beijing Institute of TechnologyBeijing 100081China college of Materials Engineering Henan University of EngineeringXinzheng 451191China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China university of Chinese Academy of sciences Beijing 100049China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Life science Beijing Institute of TechnologyBeijing 100081China Institute of Advanced Materials Hubei Normal UniversityHuangshi 415000China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong UniversityXi'anShaanxiChina

Triple-negative breast cancer(TNBC)is a subtype of breast cancer with high mortality,and the efficacy of monotherapy for TNBC is still ***,we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon *** intelligent material contains a superadsorbed silicon dioxide sphere,sufficient loading space,a nanoscale hole on its surface,a robust shell,and an outer bilayer,and it could load both programmed cell death protein 1/programmed cell death ligand 1(PD-1/PD-L1)small-molecule immune checkpoints and small-molecule photosensitizers with excellent loading contents,protect these small molecules during the systemic circulation,and achieve accumulation of them in tumor sites after systemic administration followed by the application of laser irradiation,thereby realizing dual attack of photodynamic therapy and immunotherapy on ***,we integrated the fasting-mimicking diet condition that can further enhance the cellular uptake efficiency of nanoparticles in tumor cells and amplify the immune responses,further enhancing the therapeutic ***,a novel combination therapy“PD-1/PD-L1 immune checkpoint blockade+photodynamic therapy+fasting-mimicking diet”was developed with the aid of our materials,which eventually achieved a marked therapeutic effect in 4T1-tumor-bearing *** concept can also be applied to the clinical treatment of human TNBC with guiding significance in the future.

关键词： eventually thereby dioxide

Simulation of the landform change process on a purple soil slope due to tillage erosion and water erosion using UAV technology

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Journal of Mountain science 2020年第6期17卷 1333-1344页

作者： YANG Chao SU Zheng-an fan Jian-rong fanG Hai-dong SHI Liang-tao ZHANG Jian-hui HE Zhou-{2. ZHOU Tao WANG Xiao-yi Key Laboratory of Mountain Hazards and Earth Surface Processes Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Research Center for Digital Mountain and Remote Sensing Application Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China university of Chinese Academy of science Beijing 100049China Institute of Tropical Eco-agriculture sciences Yunnan Academy of Agricultural SciencesYuanmou 651300China Forestry college Sichuan Agricultural UniversityChengdu 611130China

Both tillage erosion and water erosion are severe erosional forms that occur widely on sloping agricultural ***,previous studies have rarely considered the process of landform change due to continuous simulation experiments of alternating tillage erosion and water *** identify such changes,we applied a scouring experiment(at a 60 L min-1 water discharge rate based on precipitation data from the local meteorological station and the catchment area in the Yuanmou County,Yunnan Province,china)and a series of simulated tillage experiments where plots were consecutively tilled 5,10,and 15 times in rotation(representing 5 yr,10 yr,and 15 yr of tillage)at slope gradients of 5°,10°,and 2.°.Close-range photogrammetry(CRP)employing an unmanned aerial vehicle(UAV)and a real-time kinematic global positioning system(RTK-GPS)was used to measure landform changes,and highresolution digital elevation models(DEMs)were generated to calculate net soil loss ***,the CRP was determined to be accurate and applicable through the use of erosion *** average tillage erosion rates were 69.85,131.45,and 155.34 t·hm-2.tillage pass-1,and the average water erosion rates were 1892.52.2.61.76,and 4405.93 t·hm-2.h-1 for the 5°,10°,and 2.°sloping farmland plots,*** water erosion rates increased as tillage intensity increased,indicating that tillage erosion accelerates water *** these intensive tillage treatments,slope gradients gradually decreased,while the trend in slope gradients increased in runoff plots at the conclusion of the scouring *** to the original plots(prior to our experiments),interactions between tillage and water erosion caused no obvious change in the landform structure of the runoff plots,while the height of all the runoff plots *** findings showed that both tillage erosion and water erosion caused a pseudo-steady-state landform evolutionary mechanism and resulted in thin soil layers on cultivat

关键词： Landform change Tillage erosion Water erosion Close range photogrammetry Erosion pins Runoff plot

Three-dimensional silk fibroin microsphere-nanofiber scaffolds for vascular tissue engineering

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Medicine in Novel technology and Devices 2021年第1期9卷 52-59页

作者： Qiang Liu Guoliang Ying Nan Jiang Ali KYetisen Danyu yao Xiaoying Xie Yubo fan Haifeng Liu Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeijing Advanced Innovation Centre for Biomedical EngineeringBeihang UniversityBeijing100191People’s Republic of China Department of Chemistry Stanford UniversityCA94305USA School of Materials science and Engineering Wuhan Institute of TechnologyWuhan430205People’s Republic of China Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA02139USA School of Engineering and applied sciences Harvard UniversityCambridgeMA02138USA Department of Chemical Engineering Imperial College LondonLondonSW72AZUK School of Life Information science and Instrument Engineering Hangzhou Dianzi UniversityHangzhou310018Zhejiang ProvincePeople’s Republic of China

A significant limitation in the engineering of artificial small-diameter vascular scaffolds is that the number of endothelial cells(ECs)is not sufficient to generate a confluent coverage of the vascular scaffolds,so that the surfaces of vascular scaffolds form thrombus via platelet adhesion and *** decrease relies on three-dimensional(3D)scaffolds to mimic the natural extracellular matrix(ECM)as templates to regulate cell behavior and facilitate tissue ***,we developed 3D scaffolds consisting of silk fibroin(SF)nanofibers and homogeneous microspheres by electrospinning and *** nanofibers with diameters ranging from 2.0 to 350 nm doped with microspheres(2.10μm)formed bridge-shaped *** were seeded and maintained on the 3D microsphere-nanofiber scaffolds with a mean fiber diameter of 300 nm.A 10%higher ratio of cell proliferation on 3D microsphere-nanofiber SF scaffolds was noted as compared to that on microporous and sponge-like SF scaffolds with small surface network fabricated by ***,the gene transcript levels including CD146,VE-C and PECAM-1 were better preserved on 3D microsphere-nanofiber SF scaffolds than those on freeze-dried ***,the developed 3D microsphere-nanofiber structure may have a myriad of applications in vascular tissue engineering scaffolds and cardiovascular devices.

关键词： Microfluidics Silk fibroin Electrospinning Micro/nanostructure Tissue engineering