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In vivo bioluminescence imaging of hyperglycemia exacerbating stem cells on choroidal neovascularization in mice

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 519-527页

作者： Xiang Gao Yu Wang Hui-Yuan Hou Yang Lyu Hai-Yan Wang Li-bo yao Jian Zhang Feng Cao Yu-Sheng Wang Department of Ophthalmology Xijing Hospital Eye Institute of Chinese PLA Fourth Military Medical University State Key Laboratory of Cancer Biology Department of Biochemistry and Molecular Biology Fourth Military Medical University Department of Cardiology Xijing Hospital Fourth Military Medical University

AIM： To investigate the influence of hyperglycemia on the severity of choroidal neovascularization（CNV）,especially the involvement of bone marrow-derived cells（BMCs） and underlying mechanisms.·METHODS： BMCs from firefly luciferase（Fluc）/green fluorescent protein（GFP） double transgenic mice were transplanted into C57BL/6J wide-type mice. The recipient mice were injected intraperitoneally with streptozotocin（STZ） daily for 5 consecutive days to induce diabetes mellitus（DM）, followed by CNV laser *** BMCs recruitment in CNV exposed to hyperglycemia was firstly examined in Fluc/GFP chimeric mice by in vivo optical bioluminescence imaging（BLI） and in vitro Fluc assays. The CNV severity was evaluated by H＆E staining and choroidal flatmount. The expression of vascular endothelial growth factor（VEGF） and stromal cell derived factor-1（SDF-1） was detected by Western blot.·RESULTS： BLI showed that the BMCs exerted dynamic effects in CNV model in Fluc/GFP chimeric mice exposed to hyperglycemia. The signal intensity of transplanted Fluc＋GFP＋BMCs in the DM chimeric mice was significantly higher than that in the control chimeric mice with CNV induction at days 5, 7, 14 and 21（121861.67 ±9948.81 vs 144998.33 ±13787.13 photons/second/cm2/sr for control and DM mice, P5d〈0.05; 178791.67±30350.8 vs240166.67 ±22605.3, P7d〈0.05; 124176.67 ±16253.52 vs196376.67 ±18556.79, P14d〈0.05; 97951.60 ±10343.09 vs119510.00 ±14383.76, P21d〈0.05）, which was consistent with in vitro Fluc assay at day 7 [relative light units of Fluc（RLU1）], 215.00±52.05 vs 707.33±88.65, P 〈0.05; RLU1/relative light units of renilla luciferase（RLU2）, 0.90 ±0.17 vs 1.83 ±0.17, P 〈0.05]. The CNVs in the DM mice were wider than those in the control group at days 5, 7, 14 and21（147.83±17.36 vs 220.33±20.17 μm, P5d〈0.05; 212.17 ±24.63 vs 326.83 ±19.49, P7d〈0.05; 163.17 ±18.24 vs265.17 ±20.55, P14d〈0.05; 132.00 ±10.88 vs 205.33 ±12.98,P21d〈0.05）. The average area of CNV in the DM group was larger at 7d（20688.

关键词： hyperglycemia choroidal neovascularization bone marrow-derived cells molecular imaging in vivo optical bioluminescence imaging

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产权政策强度、贸易结构与国民收入提升

经济与管理研究 2014年第3期35卷 36-46页

作者：姚博西安交通大学经济与金融学院

本文通过把产权政策强度引入到贸易结构对国民收入提升的影响架构中,从理论上分析了产权政策强度对多样化结构贸易形式与专业化结构贸易形式的外部性,以及由该外部性所包含的要素优化积累作用与技术创新推动作用两方面的影响效果,并以... 详细信息

本文通过把产权政策强度引入到贸易结构对国民收入提升的影响架构中,从理论上分析了产权政策强度对多样化结构贸易形式与专业化结构贸易形式的外部性,以及由该外部性所包含的要素优化积累作用与技术创新推动作用两方面的影响效果,并以中国和经合组织成员国数据对其进行实证检验。结果表明:产权政策强度与高技术密集度贸易行业的匹配性大于低技术密集度贸易行业,同时这种匹配性也更容易增强要素优化积累作用与技术创新推动作用的外部性,适宜合理的产权政策强度有助于贸易行业的要素优化积累作用和技术创新推动作用发挥,但实施强度过高的产权政策则会起到阻碍作用。

关键词：产权政策强度专业化贸易多元化贸易国民收入

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外资管制放宽与城市劳动力收入变化

南开经济研究 2022年第8期 22-41页

作者：姚博中国社会科学院财经战略研究院 100006

本文研究1997—2011年外资管制放宽如何影响城市劳动力收入变化,从城市层面考察了外商投资自由化引起的收入分配效应。研究发现,受外资管制放宽影响较大的城市劳动力收入增长缓慢,这在生产加工型部门表现更为明显。城市低人力资本劳动... 详细信息

本文研究1997—2011年外资管制放宽如何影响城市劳动力收入变化,从城市层面考察了外商投资自由化引起的收入分配效应。研究发现,受外资管制放宽影响较大的城市劳动力收入增长缓慢,这在生产加工型部门表现更为明显。城市低人力资本劳动力的收入增长遭受冲击较大,技能溢价在外资管制放宽程度较大的城市提高更快,外资管制放宽导致国内企业的市场竞争环境更为激烈,低人力资本劳动力的就业质量和工作性质会变得更加不稳定。在未来继续加大对外资开放的过程中,需要重视受外资管制放宽冲击较大城市的人力资本要素禀赋提升和人力资本跨区域流动。

关键词：外资管制放宽劳动力收入增长人力资本人口流动

Characterization of Avian Influenza A(H7N9) Virus Prevalence in Humans and Poultry in Huai′an,China：Molecular Epidemiology,Phylogenetic,and Dynamics Analyses

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Biomedical and Environmental Sciences 2016年第10期29卷 742-753页

作者： YANG Peng Fei YAN Qing Li LIU Chun Cheng XING Ya Dong ZHANG Min Hui GAO Qiang YU Hao yao Hai bo HE Nan Jiang Huai'an Center for Disease Control and Prevention Huai'an 223001 Jiangsu China Hongzhe County Disease Control and Prevention Huai'an 223199 Jiangsu China

Objective To trace the source of human H7N9 cases in Huai＇an and elucidate the genetic characterization of Huai＇an strains associated with both humans and birds in live poultry *** An enhanced surveillance was implemented when the first human H7N9 case was confirmed in Huai＇*** specimens,cloacal swabs,and fecal samples were collected and screened by real-time reverse transcription-polymerase chain reaction（RT-PCR） for H7N9 *** positive samples were subjected to further RT-PCR and genome *** phylodynamic patterns of H7N9 virus within and separated from Huai＇an and evolutionary dynamics of the virus were *** Six patients with H7N9 infection were previously exposed to live poultry market and presented symptoms such as fever（〉38.0 °C） and *** of this study support the hypothesis that live poultry markets were the source of human H7N9 *** analysis revealed that all novel H7N9 viruses,including Huai＇an strains,could be classified into two distinct clades,A and ***,the diversified H7N9 virus circulated in live poultry markets in Huai＇***,the common ancestors of the Huai＇an H7N9 virus existed in January *** mean nucleotide substitution rates for each gene segment of the H7N9 virus were（3.09-7.26）×10-3 substitutions/site per year（95% HPD：1.72×10-3 to 1.16×10-2）.Conclusion Overall,the source of exposure of human H7N9 cases in Huai＇an was live poultry market,and our study highlights the presence of divergent genetic lineage of H7N9 virus in both humans and poultry specimens in Huai＇an.

关键词： Molecular epidemiology H7N9 Virus Phylogenetic tree Phylodynamic analysis

Atomically flat surface preparation for surface-sensitive technologies

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Chinese Physics B 2020年第2期29卷 438-441页

作者： Cen-yao Tang Zhi-Cheng Rao Qian-Qian Yuan Shang-Jie Tian Hang Li yao-bo Huang He-Chang Lei Shao-Chun Li Tian Qian Yu-Jie Sun Hong Ding Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Songshan Lake Materials Laboratory Dongguan 250100China

Surface-sensitive measurements are crucial to many types of researches in condensed matter ***,it is difficult to obtain atomically flat surfaces of many single crystals by the commonly used mechanical *** demonstrate that the grind-polish-sputter-anneal method can be used to obtain atomically flat surfaces on topological *** types of surface-sensitive measurements are performed on CoSi(001)surface with dramatically improved quality of *** method extends the research area of surface-sensitive measurements to hard-to-cleave alloys,and can be applied to irregular single crystals with selective crystalline *** may become a routine process of preparing atomically flat surfaces for surface-sensitive technologies.

关键词： grind-polish-sputter-anneal atomically flat single crystal surface topological materials

Fault Diagnosis and Reliable Configuration of Uncertain Strip Area Based on MPSO-SVM

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Fault Diagnosis and Reliable Configuration of Uncertain Stri...

激光微熔覆沉积成形工艺参数对TC4钛合金沉积组织的影响

第40届中国控制会议

作者： Mochen Li bo yao Fuzhong Wang College of Mathematics and System Science Shenyang Normal University Department of Basic Education Shenyang Institute of Engineering

For a class of linear uncertain flight control systems,in terms of the strip region,the problem of actuator continuous gain fault and reliable control is *** the same time,in order to solve the difficulty of selecting parameters of support vector machine,a parameter optimization algorithm based on improved Particle Swarm Optimization（MPSO） is *** with grid search method,particle swarm optimization and genetic algorithm,this method has the advantages of fast convergence,short time consuming and high *** the problem that the pole information is difficult to obtain,the algorithm theory of pole observer is given to realize the real-time observation of unknown ***,the effectiveness of reliable controller design is further proved by numerical simulation.

关键词： reliable control support vector machine pole observer particle swarm optimization algorithm grid search method genetic algorithm

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稀有金属材料与工程 2016年第2期45卷 439-444页

作者：姚波林峰马旭龙清华大学先进成形制造教育部重点实验室北京100084 陆军航空兵学院北京101123

通过改变激光微熔覆沉积制造过程中的激光功率和扫描速度,研究了成形工艺参数对TC4合金组织和显微硬度的影响。结果表明:激光微熔覆沉积组织可以为贯穿整个熔覆层的外延生长的柱状晶,也可能下部晶粒延续着前一层的柱状晶生长,最上部为... 详细信息

通过改变激光微熔覆沉积制造过程中的激光功率和扫描速度,研究了成形工艺参数对TC4合金组织和显微硬度的影响。结果表明:激光微熔覆沉积组织可以为贯穿整个熔覆层的外延生长的柱状晶,也可能下部晶粒延续着前一层的柱状晶生长,最上部为快速凝固的枝晶薄层。宏观上存在明暗2个组织区域,当P/V值小于40 W·s·mm^(-1)时,成形试样的显微组织顶部区域为明区,下部为暗区。2个区域的组织都为细长针状马氏体,明区组织更细密。同时,明区的硬度要比暗区高,并且随着激光功率的增加或扫描速度的减小,顶部明区的宽度增加,而明区和暗区的硬度都呈下降趋势。反之为暗区在上,明区在下。此时,明区的组织仍然是细针状的马氏体组织。暗区是由于发生了固溶时效处理,细针状马氏体组织粗化,同时暗区的硬度要高于明区的硬度。

关键词：激光微熔覆 TC4 工艺参数显微组织显微硬度

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动力敏感性结构风荷载全阶概率分析方法

建筑结构学报 2016年第2期37卷 100-105页

作者：姚博全涌顾明同济大学土木工程防灾国家重点实验室上海200092

高层建筑主体结构设计风荷载受来流风速的方向性影响较为明显,传统风荷载估算方法偏于保守。为此,提出一种考虑风向的风荷载全阶概率分析方法,基于可靠度理论将单风向的风荷载概率分布表达成风荷载效应系数极值和来流风速极值的概率分... 详细信息

高层建筑主体结构设计风荷载受来流风速的方向性影响较为明显,传统风荷载估算方法偏于保守。为此,提出一种考虑风向的风荷载全阶概率分析方法,基于可靠度理论将单风向的风荷载概率分布表达成风荷载效应系数极值和来流风速极值的概率分布函数。为了计入结构动力敏感性的影响,基于风洞试验获得的结构气动力数据,通过对结构动力响应分析,将风荷载效应系数极值的概率分布参数表达成来流风速的函数,进而结合各个风向的风荷载概率分布数据,给出了动力敏感性结构具有一定保证率的风荷载。最后,将所提方法的计算结果与蒙特卡洛模拟方法和传统方法的计算结果进行了详细对比。结果表明,本文方法计算结果与蒙特卡洛方法模拟结果吻合较好,传统的最不利荷载法和风向折减方法计算结果过于保守。

关键词：动力敏感性结构风荷载风向全阶概率方法动力响应分析

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黄海海域地质构造特征及其油气资源潜力

海洋地质与第四纪地质 2006年第2期26卷 85-93页

作者：姚伯初国土资源部广州海洋地质调查局广州510075

综合前人的研究成果,利用2000年以来在黄海采集的综合地球物理资料,结合我国及邻国在该海域的钻井成果,分析和讨论了黄海地区从古生代至新生代的构造演化历史;对南、北黄海沉积盆地形成的构造背景和盆地的构造类型进行了研究,认为在古... 详细信息

综合前人的研究成果,利用2000年以来在黄海采集的综合地球物理资料,结合我国及邻国在该海域的钻井成果,分析和讨论了黄海地区从古生代至新生代的构造演化历史;对南、北黄海沉积盆地形成的构造背景和盆地的构造类型进行了研究,认为在古生代它们是台地相沉积,中生代和新生代是张裂盆地;通过对我们采集的地震剖面之分析和研究,认为盆地中的中生界和古近系发育了良好的烃源岩,新近系发育了良好的区域盖层,储层在盆地中普遍发育。因此,在南、北黄海沉积盆地中可以找到中、小型油气田。另外,对盆地中的古生界应加强研究,在保存较好并且中新生代沉积较薄的地方做探查工作,应该有一定的油气前景。

关键词：区域构造构造演化史沉积盆地烃源岩黄海