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Chinese Journal of Chemistry 2020年第12期38卷 1681-1685页

作者： Li Gong yao xu Guizhen Liu Mengmeng Zheng xuepei Zhang Ying Hang Jingwu Kang State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China School of Physical Science and Technology ShanghoiTech UniversityHaike Rood 100Shanghai 200120China School of Life Science and Technology ShanghaiTech UniversityHaike Road 100Shanghai 200120China

of main observation and conclusion We developed a method for comprehensively profiling drug-protein interactions using micro-column affinity purification(AP)combined with label-free quantitative(LFQ)proteomics as well as the statistical and bioinformatics ***506 was used as the experimental model for proof of *** true interacting proteins were distinguished from the background proteins by their fold changes of FLQ intensities combined with *** 116 FK506 interacting proteins including 5 known target proteins were *** method was validated by using the LFQ intensity of the endogenous known drug targets together with statistical *** demonstrated that the micro-column-based affinity purification in combination with LFQ proteomics provides a highly reproducible and robust approach for profiling drug-protein interactions.

关键词： proof analysis. conclusion

Gravity and Magnetic Evidence for the Geological Setting of Major Mineral Systems of the Main Metallogenic Belts in South China: A Qualitative Analysis

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 91-93页

作者： YAN Jiayong LV Qingtian LUO Fan ZHANG Yongqian xu yao CHEN Changxin WANG xu LIU Jiahao Chinese Academy of Geological Sciences Beijing 100037China China Deep Exploration Center-SinoProbe Center China Geological Survey&Chinese Academy of Geological SciencesBeijing 100037China School of Geophysics and Measurement-control Technology East China University of TechnologyNanchang 330013China

South China is characterized by large-area multistage *** boasts a huge number of polymetallic deposits such as W-Sn,Cu-Au,rare earth deposits,thus serving as a"giant granary"of metal mineral resources in China(Lüet ... 详细信息

关键词： Bouguer gravity anomalies mineral system metallogenic belt South China

Clinical application of plasma shock wave lithotripsy in treating impacted stones in the bile duct system

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World Journal of Gastroenterology 2006年第1期12卷 130-133页

作者： Zhi xu Li-Xin Wang Neng-Wei Zhang Chun-Sheng Hou Xiao-Feng Ling yao xu Xiao-Si Zhou Department of Surgery ThirdHospital of Peking University 49 North Garden Road HaidianDistrict Beijing 100083 China Institute of Physics Chinese Academy of SciencesBeijing 100037 China

AIM： To verify the safety and efficacy of plasma shock wave lithotripsy （PSWL） in fragmenting impacted stones in the bile duct system. METHODS： From September 1988 to April 2005, 67 patients （26 men and 41 women） with impacted stones underwent various biliary operations with tube （or T-tube） drainage. Remnant and impacted stones in the bile duct system found by cholangiography after the operation were fragmented by PSWL and choledochofiberscopy. A total of 201 impacted stones were fragmented by PSWL setting the voltage at 2.5-3.5 kV, and the energy output at 2-3.1 for each pulse of PSWL. Then the fragmented stones were extracted by choledochofiberscopy. The safety and efficacy of PSWL were observed during and after the procedure. RESULTS： One hundred and ninety-nine of 201 impacted stones （99.0%） in the bile duct system were successfully fragmented using PSWL and extracted by choledochofiberscopy. The stone clearance rate for patients was 97% （65/67）. Ten patients felt mild pain in the right upper quadrant of the abdomen, and could tolerate it well. Eleven patients had a small amount of bleeding from the mucosa of the bile duct. The bleeding was transient and stopped spontaneously within 2 min of normal saline irrigation. There were no significant complications during and after the procedure. CONCLUSION：PSWL is a safe and effective method for fragmenting impacted stones in the bile duct system.

关键词： Impacted stone Plasma shock wave lithotripsy Choledochofiberscopy

Divergent topological networks in Alzheimer’s disease:a diffusion kurtosis imaging analysis

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Translational Neurodegeneration 2018年第1期7卷 91-102页

作者： Jia-Xing Cheng Hong-Ying Zhang Zheng-Kun Peng yao xu Hui Tang Jing-Tao Wu Jun xu Department of Neurology Northern Jiangsu People’s HospitalYangzhou UniversityYangzhou 225001China Department of Radiology Northern Jiangsu People’s HospitalYangzhou UniversityYangzhou 225001China Medical Experimental Center Northern Jiangsu People’s HospitalYangzhou UniversityYangzhou 225001China Department of Neurology Beijing TianTan HospitalCapital Medical UniversityBeijing 100050China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases School of MedicineYangzhou UniversityYangzhou 225001JiangsuChina

Background:Brain consists of plenty of complicated ***-model based diffusion tensor imaging(DTI)is far from satisfactory interpretation of the structural *** kurtosis imaging(DKI)is a tool to determine brain non-Gaussian diffusion *** investigated the network properties of DKI parameters in the whole brain using graph theory and further detected the alterations of the DKI networks in Alzheimer’s disease(AD).Methods:Magnetic resonance DKI scanning was performed on 21 AD patients and 19 *** networks were constructed by the correlation matrices of 90 regions and analyzed through graph theoretical ***:We found small world characteristics of DKI networks not only in the normal subjects but also in the AD patients;Grey matter networks of AD patients tended to be a less optimized ***,the divergent small world network features were shown in the AD white matter networks,which demonstrated increased shortest paths and decreased global efficiency with fiber tractography but decreased shortest paths and increased global efficiency with other DKI *** addition,AD patients showed reduced nodal centrality predominantly in the default mode network ***,the DKI networks were more closely associated with cognitive impairment than the DTI ***:Our results suggest that DKImight be superior to DTI and could serve as a novel approach to understand the pathogenic mechanisms in neurodegenerative diseases.

关键词： Small world Alzheimer’s disease Diffusion kurtosis imaging Brain networks

Conducting qi and regulating the spirit needling method for insomnia: A randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 254-258页

作者： xu yao Jia Du Ke-ping Tan Department of Acu-moxibustion and Tuina Tongde Hospital of Zhejiang ProvinceHangzhou 310012China

Objective:To evaluate the clinical effect differences between conducting qi and regulating the spirit needling method and regular needling ***:Sixty-nine patients of insomnia were randomly divided into an observation group(35 cases)and a control group(34 cases).Bǎihuì(百会GV20),Sìshéncōng(四神聪EX-HN1),Hégǔ(合谷LI4),Tàichōng(太冲LR3),Zúsānlǐ(足三里ST36)and Sānyīnjiāo(三阴交SP6)were selected in the two *** patients in the observation group were treated with needling method for conducting qi and regulating the *** patients in the control group were treated with the regular needling *** treatment was given once every other day,both groups were treated for 12 *** Sleep Quality Index(PSQI)and Epworth Sleepiness Scale(ESS)were observed before and after the treatment and the clinical effect was ***:After treatment,the total score and the score of each item of PSQI as well as the result of ESS were all improved after the treatment in the two groups(all P<0.05).The improvements in the total score of PSQI and the result of ESS in the observation group were better than the control group(both P<0.05).The total effective rate was 88.57%(31/35)in the observation group,significantly superior to 76.47%(26/34)in the control group(P<0.05).Conclusion:The conducting qi and regulating the spirit needling method achieves a better effect on insomnia as compared with the regular needling *** method achieves a remarkable improvement in sleep latency,sleep quality and daytime sleepiness.

关键词： Insomnia Conducting-qi needling method Acupuncture Randomized controlled trial(RCT)

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

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Regenerative Biomaterials 2022年第1期9卷 844-857页

作者： Pei-yao xu Ranjith Kumar Kankala Yue-Wei Li Shi-Bin Wang Ai-Zheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) XiamenFujian 361021PR China

Despite the success,it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic ***,we report a near-infrared(NIR)/acid-induced nanoplatform based on chitosan(CS)-coated indocyanine green(ICG,photosensitizer)/luteolin(LUT,a natural quorum sensing inhibitor)nanocomposites(ICG/LUT-CS)as antibacterial and antibiofilm agents for skin wound ***,the ICG/LUT nanoplatforms are prepared by the supercritical antisolvent technology and coated with the CS *** obtained ICG/LUT-CS with ultra-high encapsulation efficiency exhibited more favorable photothermal conversion effects and improved NIR laser/acid dual-induced drug release behavior than individual modalities,achieving exceptional bacteria-killing and biofilm elimination ***,the ICG/LUT-CS realized the synergetic effects of chemotherapy and photothermal therapy outcomes for wound ***,our findings provided an appealing strategy for the rapid preparation and future translational application of ICG/LUT-CS as an ideal agent for fighting against biofilm infections.

关键词： photothermal therapy supercritical carbon dioxide antibacterial antibiofilm wound healing

Recent developments on anode materials for magnesium-ion batteries:a review

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Rare Metals 2021年第2期40卷 290-308页

作者： Qi Guo Wen Zeng Shi-Lin Liu Yan-Qiong Li Jun-yao xu Jin-Xing Wang Yu Wang College of Materials Science and Engineering Chongqing UniversityChongqing400030China School of Electronic and Electrical Engineering Chongqing University of Arts and SciencesChongqing400030China Shanghai Urban Construction Vocational College Shanghai200438China

In recent years,there has been significant growth in the demand for secondary batteries,and researchers are increasingly taking an interest in the development of nextgeneration battery ***-ion batteries(MIBs)have been recognized as the optimal alternative to lithium-ion batteries(LIBs)due to their low cost,superior safety,and ***,research and development on rechargeable MIBs are still underway as some serious problems need to be *** of the most serious obstacles is the generation of an irreversible passivation layer on the surface of the Mg anode during *** addition to exploring new electrolytes for MIBs,alternative anode materials for MIBs might be an effective solution to this *** this review,the composition and working principle of MIBs have been *** addition,recent advances in the area of anode materials(metals and their alloys,metal oxides,and two-dimensional materials)available for MIBs and the corresponding Mg-storage mechanisms have also been ***,feasible strategies,including structural design,dimension reduction,and introduction of the second phase,have been employed to design high-performance MIB anodes.

关键词： Magnesium-ion batteries Energy storage systems Anode materials Metal oxides Two-dimensional materials

Interaction models of CYP1A1, GSTMl polymorphisms and tobacco smoking in intestinal gastric cancer

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World Journal of Gastroenterology 2005年第38期11卷 6056-6060页

作者： Jing Shen Run-Tian Wang yao-Chu xu Li-Wei Wang Xin-Ru Wang Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Environmental Health Sciences Mailman School of Public Health Columbia University New York NY 10032USA Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100083China Yang Zhong Cancer Research Institute Yang Zhong City Municipal Hospital Yang Zhong 212200 China

AIM： To explore the interaction models of the cytochrome P-450 （CYP） 1A1 Valvariant and glutathione S-transferase （GST） M1 null polymorphisms with tobacco smoking in the occurrence of intestinal gastric cancer. METHODS： A community-based case-control study was conducted in Yangzhong. Subjects included 114 intestinal types of gastric cancer with endoscopic and pathological diagnosis during January 1997 and December 1998, and 693 controls selected from their spouse, siblings or siblingsin-law who had no history of digestive system cancer. Logistic regression was used to estimate the interaction models. RESULTS： The frequency of the CYPIA1 Valvariant allele in cases did not differ from that in controls. The OR of GSTM1 null genotype was 2.0 （95% confidence interval [95%CI]： 1.2-3.1, P〈0.01）. It showed a significant type 2 form of interaction model when both CYPIA1 Valvariant allele and former tobacco smoking existed （i.e., among the multiplicative effects, the disease risk is increased by the tobacco exposure alone but not by the CYPIA1 variant alone）. The interaction index y was 2.8, and OReg （95%CI） was 5.0 （1.9-13.4）. GSTM1 null genctype and former tobacco smoking were significant in a type 4 interaction model （i.e., the disease risk is increased by GSTM1 null genotype or tobacco exposure alone among the multiplicative effects）. The interaction index y and OReg （95%CI） were 3.4 and 8.4 （3.4-20.9）, respectively.CONCLUSION： Different interaction models of CYPIA1 Valvariant allele and GSTM1 null genotype with tobacco smoking will contribute to understanding carcinogenic mechanism, but there is a need to further investigate in larger scale studies.

关键词： Interaction models CYP1A1 GSTM1 Tobacco smoking Intestinal gastric cancer

Preparation and Nonlinear Optical Property of Azobenzene Substituted Polyacetylene

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Chinese Chemical Letters 2005年第12期16卷 1603-1606页

作者： Shou Chun YIN Gang LI Hong yao xu Ya Chen GAO Yin Lin SONG Faculty of Chemistry and Chemical Engineering Anhui University Hefei 230039 Department of Physics Harbin Institute of Technology Harbin 150001

Two new functional polyacetylenes bearing different azobenzene group, -{ HC=C[azo-N （CH3）CH2CH2OH] } n-, [poly（EHAB）; azo = 4,4＇-azobenzene] and - { HC=C[azo-N（CH3）CH2CH2O COC3H7]},-, [poly（EEAB）]} were prepared by [Rh（nbd）Cl]2-Et3N catalysts. Poly（EHAB） has poor solubility while poly（EEAB） can be dissolved in common solvent. The polymers were characterized by FHR, ^1H NMR, UV and GPC. The nonlinear optical property of the soluble poly（EEAB） was investigated with 8 ns width pulse at 532 nm by Z-scan technique. The results show that poly（EEAB） is endowed with the larger third-order nonlinear optical property.

关键词： Substituted polyacetylene nonlinear optics azobenzene

Fe_(3)O_(4)磁性纳米材料在医学领域中的研究进展

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西南医科大学学报 2025年第1期48卷 105-110页

作者：严肖徐姚张静袁茜(综述) 柯发敏(审校) 西南医科大学药学院泸州646000

随着纳米科技的发展,磁性纳米材料尤其是四氧化三铁(Fe_(3)O_(4))纳米材料在医学领域的应用日益凸显其重要价值。Fe_(3)O_(4)磁性纳米材料(magnetic nanoparticles,MNPs)因具备独特的磁学性质、优良的生物相容性以及便捷的表面功能化能... 详细信息

随着纳米科技的发展,磁性纳米材料尤其是四氧化三铁(Fe_(3)O_(4))纳米材料在医学领域的应用日益凸显其重要价值。Fe_(3)O_(4)磁性纳米材料(magnetic nanoparticles,MNPs)因具备独特的磁学性质、优良的生物相容性以及便捷的表面功能化能力而备受科研人员青睐。该材料在外加磁场作用下能够迅速定向移动,且由于其纳米级尺寸带来的高比表面积和表面能,有利于药物分子、生物分子的高效吸附和偶联。此外,Fe_(3)O_(4)MNPs稳定的化学性质和低生物毒性使得其在医疗应用上表现出巨大潜力。在医学研究中,Fe_(3)O_(4)MNPs被广泛应用于多个领域并取得显著成果。本文就Fe_(3)O_(4)MNPs在药物载体、肿瘤热疗、血液净化、酶催化治疗、核磁共振成像、蛋白质与核酸的分离提纯、细胞分离以及免疫分析等方面的研究进展进行综述,并展望未来可能的发展路径与技术创新点。

关键词： Fe_(3)O_(4)磁性纳米材料药物载体肿瘤热疗血液净化酶催化治疗核磁共振成像蛋白质与核酸的分离提纯细胞分离免疫分析