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Intravitreal conbercept injection with panretinal photocoagulation for high-risk proliferative diabetic retinopathy with vitreous hemorrhage

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1066-1072页

作者： yao xu Qing Ye Wei Shen Department of Ophthalmology the Fourth Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedcineSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated by mild or moderate vitreous hemorrhage(VH),with or without diabetic macular edema(DME).METHODS:Patients diagnosed with VH with/without DME secondary to HR-PDR and received PRP combined with IVC injections were recruited in this retrospective *** establishing the patient’s diagnosis,an initial IVC was performed,followed by prompt administration of *** cases who significant bleeding persisted and impeded the laser operation,IVC was sustained before supplementing with *** the completion of PRP,patients were meticulously monitored for a minimum of six *** therapy and IVC injections were judiciously adjusted based on fundus fluorescein angiography(FFA)*** effect and the incidence of adverse events were ***:Out of 42 patients(74 eyes),29 were male and 13 were female,with a mean age of 59.17±12.74y(33-84y).The diabetic history was between 1wk and 26y,and the interval between the onset of visual symptoms and diagnosis of HR-PDR was *** affected eye received 2.59±1.87(1-10)IVC injections and underwent 5.5±1.02(4-8)sessions of *** these,68 eyes received PRP following 1 IVC injection,5 eyes after 2 IVC injections,and 1 eye after 3 IVC *** absorption of VH was observed in all 74 eyes 5-50wk after initial treatment,with resolution of DME in 51 eyes 3-48wk after initial treatment.A newly developed epiretinal membrane was noted in one *** acuity significantly improved in 25 *** complications such as glaucoma,retinal detachment,or endophthalmitis were ***:The study suggests that the combination of PRP with IVC injections is an effective and safe modality for treating diabetic VH in patients with HR-PDR.

关键词： conbercept panretinal photocoagulation high-risk proliferative diabetic retinopathy vitreous hemorrhage

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The temporal and spatial variations in the Pacific wind and wave fields for the period 2002–2011

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Acta Oceanologica Sinica 2017年第3期36卷 26-36页

作者： xu yao BI Fan SONG Jinbao HE Hailun Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China North China Sea Marine Forecasting Center of State Oceanic Administration Qingdao 266061China Shandong Provincial Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266061China Ocean College Zhejiang UniversityHangzhou 310058China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic AdministrationHangzhou 310012China

The temporal and spatial variations in the wind and wave fields in the Pacific Ocean between 2002 and 2011 are analyzed using a third-generation wave model（WAVEWATCH III）. The model performance for a significant wave height is validated using in situ buoy data. The results show that the wave model effectively hindcasts the significant wave height in the Pacific Ocean, but the errors are relatively large in the mid- and low-latitude regions. The spatial distributions and temporal variations in a wind speed and the significant wave height in the Pacific Ocean are then considered after dividing the Pacific Ocean into five regions, which show meridional differences and seasonal cycles. Regional mean values are used to give yearly average time series for each separate zone. The high latitude region in the Southern Hemisphere had a stronger significant wave height trend in the model results than regions at other latitudes. The sources and sinks of wave energy are then investigated. Their regional mean values are used to quantify variations in surface waves. Finally, the spectral analyses of the daily mean wind speeds and the significant wave heights are obtained. The significant wave height and the wind speed spectra are found to be connected in some ways but also show certain differences.

关键词： the Pacific Ocean wind speed significant wave height temporal and spatial variations WAVEWATCH Ⅲ

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Application of Near-Infrared Reflectance Spectroscopy to the Evaluation of D-chiro-Inositol,Vitexin,and Isovitexin Contents in Mung Bean

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Agricultural Sciences in China 2011年第12期10卷 1986-1991页

作者： yao Yang CHENG xu-zhen REN Gui-xing Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

Mung bean （Vigna radiata L.） is rich in D-chiro-inositol （DCI）, vitexin, and isovitexin, which has beneficial effects on antidiabetic and inhibits the formation of advanced glycation end-products. In this study, near-infrared reflectance spectroscopy （NIRS） was used to predict the contents of DCI, vitexin, and isovitexin in mung bean. The spectra data were linearized with those determined by high-performance liquid chromatography （HPLC）. The models for predicting the DCI, vitexin, and isovitexin contents in mung bean were developed using partial least-squares （PLS） algorithm. Cross-validation procedures indicated good correlations between HPLC data and NIRS predictions （R2=0.90 for DCI, R2=0.81 for vitexin, and R2=0.90 for isovitexin）. The predictive contents of DCI, vitexin, and isovitexin ranged from 2.082 to 3.084%, 1.277 to 1.307%, and 0.5998 to 0.6286%, respectively. The results showed that NIRS, a well-established and widely applied technique, could be applied to rapid detection of DCI, vitexin, and isovitexin contents in mung bean.

关键词： D-chiro-inositol, vitexin, isovitexin, NIRS, mung beanMun bean is an imoortant natural so

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Electrochemical studies of 1,5-dihydroxynaphthalene as substrate for voltammetric enzyme immunoassay

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Science China Chemistry 2004年第3期47卷 184-191页

作者： JIAO Kui yao Hong xu Jin ZHANG Shusheng College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China

A sensitive voltammetric enzyme immunoanalytical method is described for assay of horseradish peroxidase (HRP), labelled-HRP and antigen:antibody:labelled-HRP conjugate (Ag︰AB︰IgG-HRP) using 1,5-dihydroxynaphthalene (1,5-DHN) as substrate. 1,5-DHN is an electrochemical inactive substance, but it may be oxidized by O2 in air to 5-hydroxy-1,4-naphtho- quinone in basic solution, which produces a well-defined voltammetric reduction peak. After adding H2O2 and HRP, HRP catalyzes H2O2 oxidizing 5-hydroxy-1,4-naphthoquinone to 3-hydroxyphthalic acid, leading to the decrease of the voltammetric reduction peak, with which the activity of HRP and the labelled-HRP, further the antigen and antibody may be determined. The mechanism of this voltammetric enzyme-linked immunoassay system is different from the previous reports, in which there are no voltammetric reduction peaks before the addition of H2O2 and HRP, and the reduction peaks appear after the addition of H2O2 and HRP. The height of the voltammetric peak is directly proportional to the concentration of HRP in the previous systems, while the decrease of the voltammetric peak is linear with the concentration of HRP in this system. This new electrochemical method is combined with an indirect enzyme immunoassay using di-rect antigen-coating format for the detection of the purified tobacco mosaic virus (TMV) with a linear range from 25.0 to 340.0 ng/mL, and a detection limit 25.0 ng/mL.

关键词： 1,5-dihydroxynaphthalene, tobacco mosaic virus, horseradish peroxidase, enzyme immunoassay, voltammetry.

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Contents of D-chiro-Inositol,Vitexin,and Isovitexin in Various Varieties of Mung Bean and Its Products

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Agricultural Sciences in China 2011年第11期10卷 1710-1715页

作者： yao Yang CHENG xu-zhen REN Gui-xing Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China

Mung bean （Vigna radiata L.） is rich in bioactive compounds including D-chiro-inositol （DCI）, vitexin, and isovitexin, which have beneficial effects on patients with diabetes. To find a better source for these valuable chemicals, we have collected 110 varieties of mung bean seed samples and 8 mung bean products to determine the levels of these bioactive compounds. We also measured the DCI content in mung bean sprouts at different germination stages. Content of DCI, vitexin, and isovitexin in all mung bean varieties ranged from 0.43 to 5.79, 0.12 to 3.00, and 0.03 to 1.16 mg g-~, respectively. The varieties of C0001321, C0003522, and C0004485 have the highest DCI, vitexin, and isovitexin contents, respectively. The mung bean products in the market contained relatively lower level of these bioactive components. Contents of DCI, vitexin, and isovitexin in all mung bean products ranged from 0.119 to 0.717, 0 to 0.547, and 0 to 0.923 mg g-~, respectively. During the 112 h of germination test, DCI level steadily increased at first stage and reached the highest level at 80 h of germination （4.79 mg g-~）. These results provide useful information for the selection of suitable varieties and proper germination stages to obtain functional ingredients from mung beans.

关键词： D-chiro-inositol vitexin isovitexin mung bean

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Performance Analysis of Physical Layer Security over α-η-κ-μ Fading Channels

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China Communications 2018年第11期15卷 138-148页

作者： Shaobo Jia Jiayan Zhang Honglin Zhao yao xu Communication Research Center Harbin Institute of Technology

In this paper, we consider the secure data transmission over α-η-κ-μ fading channels, which are recently proposed to encompass nearly all the well-known statistical models adopted in the literature. In particular, we address the secrecy performance in terms of the average secrecy capacity(ASC) and the secrecy outage probability(SOP), for which novel analytical expressions are derived. Simulation results verify the analysis and demonstrate the impact of the physical parameters on the secrecy performance of this new channel fading model.

关键词： Physical layer security α-η-κ-μgeneralized fading channels average secrecycapacity secrecy outage probability

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Evaluation of the simulation capability of the Wavewatch Ⅲ model for Pacific Ocean wave

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Acta Oceanologica Sinica 2015年第9期34卷 43-57页

作者： BI Fan SONG Jinbao WU Kejian xu yao Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences College of Physical and Environmental Oceanography Ocean University of China Ocean College Zhejiang University Key Laboratory of Physical Oceanography (Ocean University of China) Ministry of Education

Wave climate analysis and other applications for the Pacific Ocean require a reliable wave hindcast. Five source and sink term packages in the Wavewatch III model （v3.14 and v4.18） are compared and assessed in this study through comprehensive observations, including altimeter significant wave height, advanced synthetic aperture radar swell, and buoy wave parameters and spectrum. In addition to the evaluation of typically used integral parameters, the spectra partitioning method contributes to the detailed wave system and wave maturity validation. The modified performance evaluation method （PS） effectively reduces attribute numbers and facilitates the overall assessment. To avoid possible misleading results in the root mean square error-based validations, another indicator called HH （indicating the two authors） is also calculated to guarantee the consistency of the results. The widely used Tolman and Chalikov （TC） package is still generally efficient in determining the integral properties of wave spectra but is physically deficient in explaining the dissipation processes. The ST4 package performs well in overall wave parameters and significantly improves the accuracy of wave systems in the open ocean. Meanwhile, the newly published ST6 package is slightly better in determining swell energy variations. The two packages （ACC350 and BIA） obtained from Wavewatch III v3.14 exhibit large scatters at different sea states. The three most ideal packages are further examined in terms of reproducing wave- induced momentum flux from the perspective of transport. Stokes transport analysis indicates that ST4 is the closest to the NDBC-buoy-spectrum-based transport values, and TC and ST6 tend to overestimate and underestimate the transport magnitude, respectively, in swell mixed areas. This difference must be considered, particularly in air-wave-current coupling research and upper ocean analysis. The assessment results provide guidance for the selection of ST4 for use in a backgrou

关键词： Wavewatch III evaluation Pacific Ocean source and sink term packages wave-induced flux Stokes transport

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One-step synthesis of carbon-supported copper nanoparticles from biomass for N-arylation of pyrazole

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Journal of Energy Chemistry 2018年第3期27卷 859-865页

作者： Wenjing Li Yongjun Gao Pei Tang yao xu Ding Ma inan 250002.Shandong China Beijing National Laboratory for Molecular Sciences.College of Chemistry and Molecular Engineering Peking University.Beijing 100871.China College of Chemistry&Environmental Science.Hebei University Baoding 071002HebeiChina

Carbon-supported copper catalyst was prepared for the first time in one-step with copper nitrate and corn stalk through calcination under different temperatures. Uniformly dispersed nanoparticles were obtained and were identified to be Cu（0） and Cu（Ⅰ） in XRD patterns. Excellent catalytic activity and selectivity were achieved in the N-arylation of pyrazole under ligand and protection gas free conditions. About90.4% of product yield was achieved with only 0.5 mol% of copper catalyst（Cu-C-300）, which was considerably more efficient than previous reports. XPS results suggested that the N-arylation of pyrazole activity was closely related to the surface Cu（Ⅰ） species.

关键词： Corn stalk Carbon-supported copper N-arylation Ligand-free

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Magnetic and electrochemical behavior of rhombohedral α-Fe_2O_3 nanoparticles with (104) dominant facets

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Particuology 2013年第3期11卷 327-333页

作者： Zhong Liu Baoliang Lv Dong Wu Yuhan Sun yao xu State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of Sciences Key Laboratory of Salt Lake Resources and Chemistry Qinghai Institute of Salt LakesChinese Academy of Sciences Low Carbon Conversion Center Shanghai Advanced Research InstituteChinese Academy of Sciences

Uniform rhombohedral α-Fe2O3 nanoparticles, -60nm in size, were synthesized via a triphenyl- phosphine-assisted hydrothermal method. Scanning electron micrograph （SEM） and transmission electron micrograph （TEM） analyses showed that the as-synthesized rhombohedral nanoparticles were enclosed by six （1 04） planes. The concentration of triphenylphosphine played an important role in morphological evolution of the α-Fe2O3 nanoparticles. The as-prepared rhombohedral nanoparticles possessed remanent magnetization Mr of 2.6 × 10^-3 emu/g and coercivity Hc of 2.05 Oe, both lower than those of other α-Fe2O3 particles with similar size, indicating their potential applications as superparamagnetic precursor materials. Furthermore, these rbombohedral α-Fe2O3 nanoparticles exhibited good sensor capability toward H2O2 with a linear response in the concentration range of 2-20 mM.

关键词： α-Fe2O3 Morphology Magnetic materials Chemical synthesis

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Preparation,characterization and combustion properties of Zr/ZrH_2 particles coated with α-FeOOH crystal grains

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Particuology 2009年第3期7卷 169-174页

作者： Baoliang Lv yao xu Bo HOU Dong Wu Yuhan Sun State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy ofSdences Taiyuan 030001 China Graduate School of the Chinese Academy of Sciences Beijing 100049. China

Zr/ZrH2 particles with irregular morphologies and broad size distribution were uniformly coated with acicular α-FeOOH crystal grains via a facile route without using polymers or surfactants. The as-synthesized material was characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, energy dispersive X-ray （EDX）, UV-vis diffusion reflection （UV-vis） and Raman spectrometry. Based on these characterizations, the synthesis mechanism was explained in terms of combined heterogeneous nucleation and solid state transformation reaction. The presence of α-FeOOH coating greatly changed the combustion behavior of Zr/ZrH2 particles： the combustion lasting time decreased from 32 s for un-coated Zr/ZrH2 particles to 0.2 s for coated particles while the maximum temperature in the combustion process increased from 1510 ℃ to 2036℃.

关键词： Composite materials Coating Zr/ZrH2 α-FeOOH Solid state transformation Combustion

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