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Soluble Human Leukocyte Antigen-G Expression in Pregnancy Success and Early Pregnancy Loss in Korle-Bu Teaching Hospital

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Open Journal of Immunology 2016年第1期6卷 1-6页

作者： Abdul-Rahman Mubarak Irene Sitsofe Blebu Kareem Mumuni yao tettey Richard Kwasi Gyasi Andrew Anthony Adjei Michael Ofori Department of Pathology School of Biomedical and Allied Health Sciences University of Ghana Accra Ghana Department of Obstetrics and Gynaecology School of Medicine and Dentistry University of Ghana Accra Ghana Department of Immunology Noguchi Memorial Institute of Medical Research Accra Ghana

Introduction: Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) class Ib antigen characterized by a limited polymorphism. The expression of HLA-G at immune privileged sites and its ability to inhibit the effectors functions of immune cells has set HLA-G as a molecule of immune tolerance. This expression pattern is unique among HLA genes and suggests that HLA-G may be involved in interactions that are critical in establishing and/or maintaining pregnancy. Methods: Soluble HLA-G (sHLA-G) levels were measured using a BioVendor sHLA-G ELISA kit following the manufacturer’s protocol. The study participants include women undergoing spontaneous abortion, non-pregnant women, males and an archive sample of women who had normal vaginal deliveries without any complications and any history of malaria infection from gestation to delivery. Results: Soluble HLA-G levels were higher among women undergoing spontaneous abortion as compared to women who had normal vaginal delivery and non-pregnant women. Soluble HLA-G levels were also higher in second trimester as compared to first trimester in both women who had spontaneous abortions and women who had normal delivery. Conclusion: Although sHLA-G levels were higher among women undergoing spontaneous abortion as compared to non-pregnant women and women who had normal delivery, this may be playing a role in the maintenance of maternal immune tolerance to fetal antigen, since plasma sHLA-G levels increased with increasing trimester in both women who had normal delivery and women undergoing spontaneous abortion.

关键词： Soluble Human Leukocyte Antigen G (sHLA-G) Spontaneous Abortion Maternal Immune Tolerance Implantation

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Human Immunodeficiency Virus, Syphilis Prevalence and Risk Factors among Migrant Workers in Konongo, Ghana

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Advances in Infectious Diseases 2014年第3期4卷 132-141页

作者： Andrew A. Adjei James Brandful Mark Lurie Margaret Lartey Francis Krampa Awewura Kwara Theophilus K. Adiku yao tettey Richard K. Gyasi Aaron L. Lawson Timothy Flanigan Brown University School of Medicine Rhode Island USA Noguchi Memorial Institute for Medical Research Legon Ghana University of Ghana Medical School College of Health Sciences Accra Ghana

Migrant workers, particularly gold mining workers, have been identified as a group at risk for HIV and sexually transmitted infections (STI). A cross-sectional study was undertaken on the correlates of human immunodeficiency virus (HIV) and syphilis infections in a sample of migrants (Ghanaian citizens [156] and non-Ghanaian citizens [8]) working in a gold mining centres in Konongo, Ghana. The study was conducted between the months of January 2013 to December 2013. Of a total of 600 eligible migrant workers, only 164 (27.33%;males 114, females 50) of the eligible migrants took part in the study. Subjects voluntarily completed a risk-factor questionnaire and provided blood specimen for testing for the presence of antibodies to HIV and Treponema pallidum, the causative agent of syphilis. These data were analyzed using both univariate and multivariate techniques. The median age of the participants was 29.0 years (range 18 - 62 years). Of the 164 migrant workers tested, HIV and syphilis seroprevalence were 6.7% and 3.7% respectively. On multivariate analysis, the independent determinants for HIV infection were being female [odds ratio (OR) 2.94;95% confidence interval (95% CI 0.86 - 10.0);unmarried (OR 10.13;95% CI 1.2 - 81.09);drug use (OR 3.76;95% CI 0.38 - 36.3);and blood transfusion (OR 2.45;95% CI 0.27 - 22.37). Similarly, on multivariate analysis, the independent determinants for syphilis infection were having concurrent sexual partners (OR 2.16;95% CI 0.38 - 12.12);and blood transfusion (OR 5.07;95% CI 0.51 - 50.37). Consistent with similar studies worldwide, our results suggest high prevalence of HIV and syphilis infections among migrant workers who work in gold mining centres in Ghana.

关键词： HIV Seropositivity Syphilis Seropositivity Migrant Workers Gold Mining Centres Risk Factors

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