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Journal of Innovative Optical Health Sciences 2024年第2期17卷 59-66页

作者： Dongmin Zhang Guang Yang yao tan Chong Chen Jie Zhang Hui Li School of Biomedical Engineering(Suzhou)Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230041 P.R.China Suzhou Institute of Biomedical Engineering and Technology Chinese A cademy of Sciences Suzhou Jiangsu 215163P.R.China

Light-sheet fluorescence microscopy(LSFM)has been widely used to image the three-dimensional(3D)structures and functions of various millimeter-size bio-specimen such as zebrafish.However,the sample adsorption and scattering cause shading of the light-sheet illumination,preventing the even 3D image of thick samples.Herein,we report a continuous-rotational light-sheet microscope(CR-LSM)that enables simultaneous 3D bright-field and fluorescence imaging.With a high-accuracy rotational stage,CR-LSM records the outline projections and the fluorescent images of the sample at multiple rotation angles.Then,3D morphology and fluorescent structure were reconstructed with a developed algorithm.Using CR-LSM,zebrafish’s whole-fish contour and blood vessel structures were obtained simultaneously.

关键词： Light-sheet microscope zebrafish blood vessels morphology

Gas diffusion in catalyst layer of flow cell for CO_(2) electroreduction toward C_(2+) products

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Nano Research 2024年第3期17卷 1101-1106页

作者： Xiqing Wang Qin Chen Yajiao Zhou yao tan Ye Wang Hongmei Li Yu Chen Mahmoud Sayed Ramadan A.Geioushy Nageh K.Allam Junwei Fu Yifei Sun Min Liu Hunan Joint International Research Center for Carbon Dioxide Resource Utilization School of Physics and ElectronicsCentral South UniversityChangsha 410083China School of Energy and Power Engineering Beihang UniversityBeijing 100191China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China Central Metallurgical Research and Development Institute(CMRDI) P.O.Box 87Helwan 11421CairoEgypt Energy Materials Laboratory School of Sciences and EngineeringThe American University in CairoNew Cairo 11835Egypt Research Center for Advanced Energy and Carbon Neutrality Beihang UniversityBeijing 100191China

The use of gas diffusion electrode(GDE)based flow cell can realize industrial-scale CO_(2) reduction reactions(CO_(2)RRs).Controlling local CO_(2) and CO intermediate diffusion plays a key role in CO_(2)RR toward multi-carbon(C_(2+))products.In this work,local CO_(2) and CO intermediate diffusion through the catalyst layer(CL)was investigated for improving CO_(2)RR toward C_(2+)products.The gas permeability tests and finite element simulation results indicated CL can balance the CO_(2) gas diffusion and residence time of the CO intermediate,leading to a sufficient CO concentration with a suitable CO_(2)/H_(2)O supply for high C_(2+)products.As a result,an excellent selectivity of C_(2+)products~79%at a high current density of 400 mA·cm^(-2) could be obtained on the optimal 500 nm Cu CL(Cu500).This work provides a new insight into the optimization of CO_(2)/H_(2)O supply and local CO concentration by controlling CL for C_(2+)products in CO_(2)RR flow cell.

关键词： gas diffusion electrode CO_(2)reduction Cu mass transfer C_(2)product

Copper(Ⅰ) complexes with planar chirality realize efficient circularly polarized electroluminescence

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Science China Chemistry 2023年第8期66卷 2274-2282页

作者： Ao Ying Lisi Zhan yao tan Xiaosong Cao Chuluo Yang Shaolong Gong Department of Chemistry Hubei Key Lab on Organic and Polymeric Optoelectronic MaterialsWuhan UniversityWuhan430072China Shenzhen Key Laboratory of New Display and Storage Materials College of Materials Science and EngineeringShenzhen UniversityShenzhen518060China

Chiral organometallic emitters hold great promise in potential and practical applications of circularly polarized organic lightemitting diodes(CP-OLEDs).However,developing luminescent earth-abundant organometallic complexes concurrently exhibiting circularly polarized luminescence(CPL)and high quantum efficiency remains a formidable challenge.In this study,we introduced a typical planar chiral skeleton of a[2.2]paracyclophane moiety into earth-abundant copper(I)complexes with the goal of realizing efficient CPL and thermally activated delayed fluorescence(TADF)simultaneously.Two pairs of proof-of-theconcept copper(I)enantiomers,R_(p)/S_(p)-MAC^(*)-Cu-CzP and R_(p)/S_(p)-MAC^(*)-Cu-CNCzP,were developed using planar chiral[2.2]paracyclophane-based donor ligands in a carbene-metal-amide(CMA)motif.Both panels of enantiomers not only exhibited significant mirror-image CPL signals but also displayed distinct TADF nature with fast reverse intersystem crossing rates of up to 10^(8)s^(-1).The resultant OLEDs based on the MAC^(*)-Cu-Cz P enantiomers manifested efficient circularly polarized electroluminescence with excellent external quantum efficiencies of 13.2%and ultraslow efficiency roll-off(7.7%at 10,000 nits).This article not only demonstrates one of the best performances for CP-OLEDs based on earth-abundant organometallic complexes but also represents the first example of CP-OLEDs from CMA complexes to our knowledge.

关键词： circularly polarized luminescence(CPL) organic light-emitting diode(OLED) copper(Ⅰ)complex carbene-metal-amide(CMA) thermally activated delayed fluorescence(TADF)

Improved Cohen-Sutherland algorithm for TGS transmission imaging

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Nuclear Science and Techniques 2023年第6期34卷 91-102页

作者： Yu-Cheng Yan Ming-Zhe Liu Xing-Yu Li Yu-Ting Xiong yao tan Zhuo Zuo Lan Chang Cui Li State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China The Engineering and Technical College of Chengdu University of Technology Leshan614000China Southwestern Institute of Physics Chengdu610225China Sichuan University of Science and Engineering Zigong643000China

Tomographic gamma scanner(TGS),an advancedγ-ray nondestructive analysis technique,can locate and analyze nuclides in radioactive nuclear waste,and TGS can be categorized into two processes:e.g.,transmission measurement and emission measurement.Specifically,transmission measurements provide the basis for accurate measurement of nonuniform radionuclide content in TGS scanning.The scan data were obtained using the Monte Carlo tool Geant4 simulation,and 25 voxels were divided into five lengths and five widths in a square barrel.In this study,an encoding cropping algorithm based on draped foot vector judgment was adopted to rapidly calculate the voxel trace matrix within a square bucket of nuclear waste,and the transmission images were reconstructed using ordered subset expectation maximization.The results indicated that the cropping speed of the improved coding algorithm was significantly higher than that of the original algorithm,and the relative mean deviation and root-mean-square error between the reconstructed attenuation coefficient and the reference standard value tended to decrease with an increase in the cropped line segments in the voxel;the Pearson correlation coefficient tended to converge to 1.0.The image quality evaluation parameters of the high media-density materials were better than those of the low media-density materials in the above three indexes.The reconstruction effect was relatively poor for more complex filling materials.When there were more than 10 cropped line segments in the voxel,the reconstruction data generally tended to be stable.The graphical trimming algorithm can rapidly calculate the trace matrix of the scanned voxels;it exhibits the advantages of speed and efficiency and can serve as a novel method to solve the trace matrix of TGS nuclear waste transmission scans.

关键词： TGS Cohen-Sutherland Transmission scanning Trace matrix

Protective effects of piperine on the retina of mice with streptozotocin-induced diabetes by suppressing HIF-1/VEGFA pathway and promoting PEDF expression

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International Journal of Ophthalmology(English edition) 2021年第5期14卷 656-665页

作者： Pu Zhang Yan-Dan Zhou yao tan Ling Gao Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Changsha Aier Eye Hospital Changsha 410015Hunan ProvinceChina

AIM:To evaluate the protective mechanisms of piperine in the retina of mice with streptozotocin-induced diabetes.METHODS:In experiments in vitro,stimulation by chemical hypoxia was established in ARPE-19 cells.Then,the expression of hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor A(VEGFA),and pigment epithelium-derived factor(PEDF)was assessed at the m RNA and protein levels.In experiments in vivo,diabetes mellitus was established by intraperitoneally injecting 150 mg/kg streptozotocin once.After 3 wk of the onset of diabetes,15 mg/kg piperine was intraperitoneally injected once daily for 1 or 3 wk.Then,the retinal morphology and m RNA and protein expression were assessed.RESULTS:In hypoxia,1-100μmol/L piperine significantly decreased the expression of VEGFA m RNA and increased the expression of PEDF m RNA without affecting HIF-1αm RNA.Meanwhile,100μmol/L piperine substantially decreased the protein level of VEGFA and increased the protein level of PEDF.The HIF-1αprotein level was also hampered by piperine.In the diabetic retina of mice,the morphological damage was alleviated by piperine.Likewise,the retinal vascular leakage was substantially decreased by piperine.Further,the protein levels of HIF-1αand VEGFA were significantly reduced by piperine.Moreover,the level of the antiangiogenic factor of PEDF dramatically increased by piperine.CONCLUSION:Piperine may exert protective effects on the retina of mice with diabetes via regulating the pro-antiangiogenic homeostasis composed of HIF-1/VEGFA and PEDF.

关键词： diabetes diabetic retinopathy hypoxiainducible factor-1α/vascular endothelial growth factor A pathway pigment epithelium-derived factor piperine mice

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飞机生保系统氧气导管接头腐蚀原因分析

电镀与涂饰 2024年第4期43卷 113-121页

作者：陈黎谭瑶高深远杜娟航空工业成都飞机工业(集团)有限责任公司四川成都610091

[目的]飞机生保系统氧气导管接头装机后多次发生腐蚀问题,为保证飞机质量安全,亟需明确其腐蚀原因。[方法]针对小平管嘴与外套螺母配合面及附近区域均出现腐蚀的现象进行了形貌、组织及成分分析,并通过模拟实验来验证腐蚀成因。[结果]... 详细信息

[目的]飞机生保系统氧气导管接头装机后多次发生腐蚀问题,为保证飞机质量安全,亟需明确其腐蚀原因。[方法]针对小平管嘴与外套螺母配合面及附近区域均出现腐蚀的现象进行了形貌、组织及成分分析,并通过模拟实验来验证腐蚀成因。[结果]确定了表面腐蚀产物为不规则及泥纹花样的Cu、Zn氧化物,且存在较高含量的K、Ca、Na异常元素。氧气导管小平管嘴沟槽处容易残留中性钾皂液,在表面浸润的情况下形成了大片不规则的钾皂残留物;其余开放表面接触过中性钾皂后,在未洗净的情况下易产生不规则及泥纹花样的Cu、Zn氧化物颗粒。另外,由于焊接后小平管嘴表层脱锌形成了疏松多孔组织,因此其表面更容易吸附钾皂成分,从而加速腐蚀。[结论]氧气导管在气密试验后表面残留中性钾皂成分是导致其腐蚀的根本原因。建议气密试验后将导管彻底洗净或更换气密试验检测剂。

关键词：铅黄铜导管接头焊接气密试验中性钾皂脱锌腐蚀

安罗替尼联合放疗三线治疗广泛期小细胞肺癌真实世界研究

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中华放射肿瘤学杂志 2024年第1期33卷 13-18页

作者：宗玉峰张鑫谭遥王海峰新疆医科大学附属肿瘤医院胸腹放疗科乌鲁木齐830011

目的探索真实世界中安罗替尼联合放疗三线治疗广泛期小细胞肺癌(ES-SCLC)的临床疗效和安全性。方法收集2018年11月—2021年7月新疆医科大学附属肿瘤医院收治的采用三线治疗(安罗替尼靶向治疗)联合放疗的ES-SCLC患者40例,所有患者的治疗... 详细信息

目的探索真实世界中安罗替尼联合放疗三线治疗广泛期小细胞肺癌(ES-SCLC)的临床疗效和安全性。方法收集2018年11月—2021年7月新疆医科大学附属肿瘤医院收治的采用三线治疗(安罗替尼靶向治疗)联合放疗的ES-SCLC患者40例,所有患者的治疗方案均为在口服安罗替尼胶囊的基础上针对部分病灶行放疗。分析总生存(OS)期、无进展生存(PFS)期、安全性、生活质量。采用Kaplan-Meier法进行生存情况的统计分析。结果 40例患者中,部分缓解7例,疾病稳定24例,疾病进展9例,客观缓解率为18%,疾病控制率为78%。中位PFS期为4.5个月,中位OS期为9个月。常见的不良反应包括乏力(28%)、各类出血(合计20%)、食欲减退(13%)、手足综合征(8%)。多数不良反应为1-2级,≥3级不良反应为4例,未记录到5级不良反应。结论在真实世界中,安罗替尼联合放疗可延长ES-SCLC患者的PFS、OS期,不良反应可耐受,是一种值得进一步探索的联合治疗方案。

关键词：小细胞肺癌三线治疗安罗替尼放射疗法安全性

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基于三维数字地形图的测绘技术研究

智能建筑与智慧城市 2024年第1期 33-35页

作者：谭尧力山西省测绘地理信息院第三测绘院

通过采用计算机技术来开展测绘工作,不仅能够提高测绘效率同时也能够降低成本投入。因此本文针对当前三维数字化测绘技术展开深入分析,首先阐述了三维数字地形图的概念及特点;随后重点介绍了该种测绘技术的具体内容以及实施流程;最后探... 详细信息

通过采用计算机技术来开展测绘工作,不仅能够提高测绘效率同时也能够降低成本投入。因此本文针对当前三维数字化测绘技术展开深入分析,首先阐述了三维数字地形图的概念及特点;随后重点介绍了该种测绘技术的具体内容以及实施流程;最后探讨了如何才能切实有效地实现这一目的,以此来保证测绘结果具有较强实用价值。

关键词：三维图像数字地形图测绘技术

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龄期相关的混凝土尺寸效应断裂模型

工程力学 2024年第3期41卷 26-38页

作者：高小峰杨程李庆斌胡昱谭尧升周欣竹浙江工业大学土木工程学院杭州310023 清华大学水沙科学与水利水电工程国家重点实验室北京100084 中国三峡建工(集团)有限公司成都610041 中国长江三峡集团有限公司北京100038

该文提出了一种龄期相关的混凝土尺寸效应断裂模型。基于现有模型建立可用于确定试件尺寸和缝高比变化时混凝土断裂破坏的尺寸效应模型演化形式;结合模型参数的时变规律,提出一种考虑龄期影响的尺寸效应断裂模型;采用文献中试件龄期、... 详细信息

该文提出了一种龄期相关的混凝土尺寸效应断裂模型。基于现有模型建立可用于确定试件尺寸和缝高比变化时混凝土断裂破坏的尺寸效应模型演化形式;结合模型参数的时变规律,提出一种考虑龄期影响的尺寸效应断裂模型;采用文献中试件龄期、尺寸和缝高比变化的混凝土断裂试验结果验证模型的适用性。研究发现:为保证模型对于特定龄期混凝土断裂破坏预测的精度,建议模型所用材料常数至少由3组且最大与最小等效裂缝长度之比不小于4的混凝土试件断裂试验结果确定。指数函数形式可较好地描述混凝土材料常数的时变特性。龄期相关的尺寸效应模型可准确预测试件龄期、尺寸和缝高比变化时混凝土构件的断裂破坏。

关键词：混凝土结构断裂参数尺寸效应时变特性断裂破坏

龙门山冲断带盆山体系地下水循环特征分析——以石亭江流域绵竹段为例

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人民长江 2024年第5期55卷 128-135页

作者：郑童心漆继红许模谭谣谢杭成都理工大学地质灾害防治与地质环境保护国家重点实验室四川成都610059

山区与平原区水资源联系密切,探究山区-盆地地下水循环可为水资源开发和合理利用提供科学依据。龙门山冲断带及川西前陆盆地是中国典型的盆山系统代表,结合现场采样及前人研究结果,采用水文地质调查、水化学特征、氢氧同位素和聚类分析... 详细信息

山区与平原区水资源联系密切,探究山区-盆地地下水循环可为水资源开发和合理利用提供科学依据。龙门山冲断带及川西前陆盆地是中国典型的盆山系统代表,结合现场采样及前人研究结果,采用水文地质调查、水化学特征、氢氧同位素和聚类分析等技术方法,阐明了绵竹市境内石亭江流域龙门山冲断推覆体与前陆盆地形成的盆山体系的地下水循环特征。研究认为:大气降水为山区及平原区浅层地下水的主要补给来源,其中J_3l~3地层还接受石亭江水的侧向补给;地形对山区浅层地下水径流具有主控作用,主要沿北西、南东方向发生径流,对近平原区的浅层地下水给予少量补给;平原区浅层还接受地表水、河渠水补给,地下水自北西向南东发生运移,在玉泉镇至板桥镇附近以泉的形式进行排泄。NW向断裂构造沟通盆山体系,来源于研究区北西侧更高山区的地下水沿断裂带形成深部径流带,形成具有较高矿化度的热水。研究成果可为类似山区-盆地地下水循环系统研究提供参考。

关键词：地下水循环水化学特征氢氧同位素盆山系统石亭江流域龙门山冲断带