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Journal of China University of Mining and Technology 2008年第1期18卷 64-66,81页

作者： WANG Qi-sheng LI Xi-bing ZhAO Guo-yan SHAO Peng yao jin-rui College of Resourcesand Safety Engineering Central South University Changsha Hunan 410083 China Henan Polytechnic University Jiaozuo Henan 454000 China Guizhou Kaiyang Phosphor Mine Group Co. Guiyang Guizhou 532000 China

Specimens of steel fiber reinforced concrete （SFRC） in volume ratios of 0%, 0.5%, 1% and 1.5% were prepared to study the supporting effect of SFRC at these diffterent volume ratios in a deep soft rock tunnel. Experiments with mechanical properties of compressive strength in cubic specimens, cleave strength in cylindrical specimens and four-point flexure strength of sheet metal specimens were carded out. The experimental results indicate that SFRC in a volume ratio of 1% is superior in ranking to other volume ratios in terms of technique and economics. By means of a numerical simulation, given the characteristics of soft rock deformation and damage at great depth, a new support substitution scheme of SFRC to replace plain concrete is proposed. The results of an industrial trial show that the support provided by SFRC can withstand large deformations of the surrounding rock. Good resuits have been obtained in a practical anplication.

关键词： volume ratio steel fiber concrete mechanical performance experiment great depth soft rock tunnel

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硬岩金属矿山深部开采中的动力学问题

中国有色金属学报 2011年第10期21卷 2551-2563页

作者：李夕兵姚金蕊宫凤强中南大学资源与安全工程学院深部金属矿产开发与灾害控制湖南省重点实验室

从深部开采环境阐述了金属矿硬岩在高地应力作用下的储能特征,并从深部开采工艺方面分析了随着金属矿山开采深度的不断增加,连续采矿方法已经成为未来深部开采的必然趋势。通过分析,认为处于高应力下的硬岩矿体在承受连续采矿法带来的... 详细信息

从深部开采环境阐述了金属矿硬岩在高地应力作用下的储能特征,并从深部开采工艺方面分析了随着金属矿山开采深度的不断增加,连续采矿方法已经成为未来深部开采的必然趋势。通过分析,认为处于高应力下的硬岩矿体在承受连续采矿法带来的动力扰动时,可以认为是岩石动静组合的受力问题。在此基础上,利用岩石动静组合加载理论分析了硬岩矿山在深部开采中的几个关键动力学问题,主要包括:硬岩矿山深部开采中的系统扰动和岩爆、深部开采中爆破引发的矿震及巷道失稳现象、深部硬岩开采中的能量释放与有序调控。理论分析和工程实践证明,硬岩金属矿山深部开采中存在的很多动力学问题可以利用岩石动静组合加载理论进行科学论证和分析,这对深部采矿的工程实践有较好的指导意义。

关键词：硬岩金属矿山深部开采动力学问题岩爆诱导崩落非爆开采

The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi jin Suyu Wang Yujia yao Qin Jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

Numerical simulation of optimum mining design for high stress hard-rock deposit based on inducing fracturing mechanism

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Transactions of Nonferrous Metals Society of China 2012年第9期22卷 2241-2247页

作者：姚金蕊马春德李夕兵杨金林中南大学资源与安全工程学院长沙410083 贵州开磷集团贵阳550302

The 3D numerical simulation model of deep hard-rock deposit in Kaiyang Phosphate Mine of Guiyang was established based on the practical engineering using 3DEC numerical simulation software. The distribution characteristics of displacement fields and plastic zones of the orebody were simulated in three different excavation cases, including the case of excavation artificial inducted roadway in the orebody, the case of horizontal or vertical excavation direction and the case of the upward or downward excavation order. The simulation results indicate that the plastic zone and displacement field of surrounding rock around the inducted roadway are continuously increasing with the increase of the exposure time after digging an artificial inducted roadway in the orebody. Thus the raw rock ore becomes easier to be fragmented, which provides advantageous conditions for roadheader to cut high stress hard-rock. It is worthy noting that there is a large difference in effective utilization of deep ground pressure between horizontal and vertical excavation directions. The later can produce larger deformation and fracture zone than the former on the rock mass around the deduced roadway, which means that the later may utilize the high ground pressure more effectively to break hard-rock. And the obtained results also show that upward excavation order is more helpful for ground pressure to break rock than downward excavation order.

关键词： inducted fracturing high stress hard-rock deposit excavation case roadheader excavation numerical simulation

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微震监测传感器布设方案评价模型及应用

东北大学学报(自然科学版) 2016年第4期37卷 594-598+608页

作者：张楚旋李夕兵董陇军姚金蕊中南大学资源与安全工程学院贵州开磷集团

为了弥补微震监测传感器布设方案仅依靠经验进行比选的不足,基于逼近理想解的排序法(TOPSIS)的基本思想建立了传感器布设方案评价模型.首先,从技术条件、经济条件、工程条件三方面选取对传感器布设方案影响最大的指标构建评价指标体系.... 详细信息

为了弥补微震监测传感器布设方案仅依靠经验进行比选的不足,基于逼近理想解的排序法(TOPSIS)的基本思想建立了传感器布设方案评价模型.首先,从技术条件、经济条件、工程条件三方面选取对传感器布设方案影响最大的指标构建评价指标体系.其次,考虑指标处于边缘状态时对权重的影响采用变权计算得到各方案的指标权重.最后,利用逼近理想解的排序法计算各方案综合优劣度.用该评价方法评估用沙坝矿微震监测传感器布设方案,得出各方案优劣程度,为微震监测传感器布设多方案比选提供了一个较好的途径.

关键词：微震监测传感器布设方案评价逼近理想解的排序法变权重理论

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深部硬岩截割特性及可截割性改善方法

中国有色金属学报 2022年第3期32卷 895-907页

作者：王少锋李夕兵王善勇姚金蕊中南大学资源与安全工程学院长沙410083 澳大利亚纽卡斯尔大学土木工程系澳大利亚纽卡斯尔NSW 2308 贵州磷化(集团)有限责任公司贵阳550081

深部硬岩的截割特性受到岩石特性、截割参数、应力环境等众多因素影响。利用TRW−3000型岩石真三轴电液伺服诱变(扰动)试验系统研究了受限应力条件、截齿加载方式、岩石力学特性、人为诱导缺陷等对硬岩截割特性的影响。研究发现:在单轴... 详细信息

深部硬岩的截割特性受到岩石特性、截割参数、应力环境等众多因素影响。利用TRW−3000型岩石真三轴电液伺服诱变(扰动)试验系统研究了受限应力条件、截齿加载方式、岩石力学特性、人为诱导缺陷等对硬岩截割特性的影响。研究发现:在单轴受限应力下,随受限应力增大岩石截割由易变难再变易,高单轴受限应力反倒有利于截齿破岩,但当单轴受限应力过高时,截齿破岩扰动易引发岩爆;动静组合破岩时,截齿预静载越大破岩能力越强;随着岩石脆性指数的增大,岩石可截割性先降低后升高;诱导加卸荷损伤、临空面切槽、临空面钻孔等人为诱导缺陷可提高硬岩的可截割性。同时,获得了深部硬岩可截割性改善方法,提出了深部硬岩矿体非爆机械化开采模式。采矿试验证明,开挖诱导巷道致裂矿体形成松动区后利用掘进机破岩和在矿柱底部开挖预切槽后利用高频破碎锤破岩,可将非爆机械化采矿效率从32.6 t/h分别提高到107.7 t/h和158.2 t/h。

关键词：硬岩截割动静组合破岩人为诱导缺陷可截割性改善非爆机械化开采

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen jin He jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu jin Zhang Yagang yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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深井软岩巷道破坏原因及矿压显现规律

中国矿业 2007年第11期16卷 72-74,78页

作者：王其胜李夕兵姚金蕊中南大学资源与安全工程学院贵州开磷集团矿业总公司贵州贵阳532000

根据现场调查和实测结果,分析了马路坪矿软岩巷道围岩变形和破坏的主要原因。通过数值模拟计算,分析了巷道围岩破碎区、塑性区范围和应力位移分布规律,为巷道合理支护形式的选择提供理论依据。

关键词：深井软岩巷道变形破坏原因应力位移分布数值模拟

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells