检索结果-南通市图书馆

Unveiling Organic Electrode Materials in Aqueous Zinc-Ion Batteries:From Structural Design to Electrochemical Performance

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第10期16卷 47-81页

作者： Dujuan Li Yuxuan Guo Chenxing Zhang Xianhe Chen Weisheng Zhang Shilin Mei Chang-jiang yao State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081People's Republic of China

Aqueous zinc-ion batteries(AZIBs)are one of the most compelling alternatives of lithium-ion batteries due to their inherent safety and economics *** response to the growing demand for green and sustainable energy storage solutions,organic electrodes with the scalability from inexpensive starting materials and potential for biodegradation after use have become a prominent choice for *** gratifying progresses of organic molecules with electrochemical performance in AZIBs,the research is still in infancy and hampered by certain issues due to the underlying complex *** for designing organic electrode materials for AZIBs with high specific capacity and long cycling life are discussed in detail in this ***,we put emphasis on the unique electrochemistry of different redox-active structures to provide in-depth understanding of their working *** addition,we highlight the importance of molecular size/dimension regarding their profound impact on electrochemical ***,challenges and perspectives are discussed from the developing point of view for future *** hope to provide a valuable evaluation on organic electrode materials for AZIBs in our context and give inspiration for the rational design of high-performance AZIBs.

关键词： Aqueous zinc-ion batteries Organic electrodes Functional groups Molecular size/geometry Electrochemical performances

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

在线全文

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2024年第3期6卷 502-514页

作者： Jian-Yu Liu yao-yao jiang Peng-Jie Li Bo yao Yi-Jing Song Ji-Xiu Gao Gulab Said Yang Gao Jun-Yu Lai Chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan Laoshan Laboratory Qingdao 266237China Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82(IC50=0.079 and 0.081μmol/L)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model(TGI=52.63%)and prolonged the survival time(ILS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKT EGFR/ERK T-cell infiltration

Antecedent snowmelt and orographic precipitation contributions to water supply of Pakistan disastrous floods,2022

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第3期15卷 419-430页

作者： Yan WANG Peng CUI Chen-Di ZHANG Guo-Tao ZHANG Jian-Sheng HAO Xu YUAN yao-Zhi jiang Lu WANG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610299China Polar and Marine Research Institute College of Harbor and Coastal EngineeringJimei UniversityXiamen 361021China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 610054China Hebei Province Tangshan Caofeidian Meteorological Bureau Tangshan 063000China

In 2022,the Pakistan witnessed the hottest spring and wettest summer in *** devastating floods inundated a large portion of Pakistan and caused enormous ***,the primary water source and its contributions to these unprecedented floods remain *** on the reservoir inflow measurements,Multi-Source Weighted-Ensemble Precipitation(MSWEP),the fifth generation ECMWF atmospheric reanalysis(ERA5)products,this study quantified the contributions of monsoon precipitation,antecedent snow-melts,and orographic precipitation enhancement to floods in *** found that the Indus experienced at least four inflow up-rushes,which was mainly supplied by precipitation and snowmelt;In upper Indus,abnormally high temperature continued to influence the whole summer and lead to large amounts of snowmelts which not only was a key water supply to the flood but also provided favorable soil moisture conditions for the latter *** July,the snowmelt has higher contributions than the precipitation to the streamflow of Indus River,with contribution value of more than 60%.Moreover,the snowmelt could still supply 20%-40%water to the lower Indus in July and August;The leading driver of 2022 mega-floods over the southern Pakistan in July and August was dominated by the precipitation,where terrain disturbance induced precipitation account to approximately 33%over the southern *** results help to understand the mechanisms of flood formation,and to better predict future flood risks over complex terrain regions.

关键词： Extreme heavy rainfall Snowmelt Orographic precipitation Floods Pakistan

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于NIR-Ⅱ荧光成像的临床应用研究进展

激光杂志 2024年第9期45卷 244-252页

作者：江尧西南大学重庆400700

近红外荧光成像技术作为一种备受关注的术中导航技术,在生物医学领域的应用已变得愈发重要,其非侵入性、高灵敏度以及高分辨率的特性使得其成为生物医学研究的得力助手。传统的生物光学成像技术如NIR-Ⅰ虽然能够提供丰富的生理和病理信... 详细信息

近红外荧光成像技术作为一种备受关注的术中导航技术,在生物医学领域的应用已变得愈发重要,其非侵入性、高灵敏度以及高分辨率的特性使得其成为生物医学研究的得力助手。传统的生物光学成像技术如NIR-Ⅰ虽然能够提供丰富的生理和病理信息,但在某些方面仍存在局限性,如成本高、操作复杂、检测效率低等。因此,急需一种更加先进、高效、便捷的成像技术来满足需要。正是在这样的背景下,NIR-Ⅱ荧光成像技术应运而生。近红外二区(NIR-Ⅱ)荧光成像技术因其独特的组织穿透深度和极低的背景噪声,在生物医学成像领域展现了巨大的潜力和广阔的应用前景。基于此,将对NIR-Ⅱ荧光成像技术的背景原理与NIR-Ⅱ荧光探针开发面临的挑战进行展示,并介绍吲哚菁绿(ICG)作为NIR-Ⅱ荧光探针在医学领域的应用,介绍NIR-Ⅱ荧光成像在肿瘤诊断与治疗中的实际应用。

关键词：荧光成像近二外应用

在线全文

学校读者我要写书评

暂无评论

人工智能嵌入国家治理数字化的三个向度

自然辩证法研究 2024年第9期40卷 123-129页

作者：姜耀东东北大学马克思主义学院沈阳110169

数字化时代来临,人工智能已成为推进国家治理体系和治理能力现代化发展不可或缺的重要一环。人工智能嵌入国家治理具有深层次的内在逻辑,是立足马克思恩格斯技术观的理论根基,顺应技术变革推动数字化治理的时代进程,发挥中国特色社会主... 详细信息

数字化时代来临,人工智能已成为推进国家治理体系和治理能力现代化发展不可或缺的重要一环。人工智能嵌入国家治理具有深层次的内在逻辑,是立足马克思恩格斯技术观的理论根基,顺应技术变革推动数字化治理的时代进程,发挥中国特色社会主义显著优势为其嵌入提供根本保障。人工智能嵌入国家治理的存在样态是建立在机器学习和深度学习的核心维度上,从人驾驭技术的交互治理视域来看是价值耦合,从技术服务于人的交互治理视域来看是技术扩散。人工智能嵌入国家治理加持新技术,打造人机协同治理新格局,实现国家治理数字化新发展。

关键词：人工智能数字化国家治理科技哲学

Improvement and security analysis of multi-ring discrete modulation continuous variable quantum secret sharing scheme

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第7期33卷 189-197页

作者：姜欢窈聂敏杨光孙爱晶张美玲裴昌幸 School of Communications and Information Engineering&School of Artificial Intelligence Xi'an University of Posts and TelecommunicationsXi'an 710121China State Key Laboratory of Integrated Service Networks Xidian UniversityXi'an 710071China

In order to avoid the complexity of Gaussian modulation and the problem that the traditional point-to-point communication DM-CVQKD protocol cannot meet the demand for multi-user key sharing at the same time, we propose a multi-ring discrete modulation continuous variable quantum key sharing scheme(MR-DM-CVQSS). In this paper, we primarily compare single-ring and multi-ring M-symbol amplitude and phase-shift keying modulations. We analyze their asymptotic key rates against collective attacks and consider the security key rates under finite-size effects. Leveraging the characteristics of discrete modulation, we improve the quantum secret sharing scheme. Non-dealer participants only require simple phase shifters to complete quantum secret sharing. We also provide the general design of the MR-DM-CVQSS *** conduct a comprehensive analysis of the improved protocol's performance, confirming that the enhancement through multi-ring M-PSK allows for longer-distance quantum key distribution. Additionally, it reduces the deployment complexity of the system, thereby increasing the practical value.

关键词： discrete modulation continuous variable quantum secret sharing scheme

从越界走向跨界:数智技术赋能职业教育新质发展的实践理性

在线全文

学校读者我要写书评

暂无评论

中国职业技术教育 2024年第28期 63-69,77页

作者：封冰姚江南京工业职业技术大学南京工程学院

数智技术是推动人类社会思维方式、组织架构与运作模式全方位重塑的驱动器,亦是当代先进生产力的集中体现与重要标志。面向数字浪潮激荡的时代背景,职业教育新质发展在依托数智技术取得质效跃升的过程中需审慎思考数智技术工具理性和价... 详细信息

数智技术是推动人类社会思维方式、组织架构与运作模式全方位重塑的驱动器,亦是当代先进生产力的集中体现与重要标志。面向数字浪潮激荡的时代背景,职业教育新质发展在依托数智技术取得质效跃升的过程中需审慎思考数智技术工具理性和价值理性的统一。当前,数智技术的广泛渗透性与延伸性钳制职业教育发展边界,潜藏知识碎化分解、教育主客体技术工具理性博弈、思维惰化等多重异化风险,引致职业教育新质发展陷入技术负能困局。在探寻数智技术与职业教育跨界融合最佳边界的基础上,应推动知识系统化整合重构、厘清技术伦理边界以及弱化认知惰性,期冀为职业教育新质发展注入长效动能。

关键词：数智技术职业教育新质发展技术工具理性跨界融合

Rice Bran-derived Peptide KF-8 Attenuates Dexamethasone-induced Myopathy in Caenorhabditis elegans by Regulating Locomotion-related Genes

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Yixin Wu Jianqiang Wang Fang Huang Yajuan Chen Qinlu Lin Zhongxu Chen Zhigang Liu yao jiang Wenqing Xie Hengzhen Li Yusheng Li Ying Liang National Clinical Research Center for Geriatric Disorders， Xiangya Hospital， Central South University Molecular Nutrition Branch， National Engineering Research Center of Rice and By-product Deep Processing， College of Food Science and Engineering， Central South University of Forestry and Technology Laboratory of Functional Chemistry and Nutrition of Food， College of Food Science and Engineering， Northwest A&F University The Key Lab of Non-wood Forest Cultivation and Protection of Education Ministry， The Key Lab of Non-wood Forest Products of Forestry Ministry， Forestry Institute， Central South University of Forestry & Technology Department of Orthopedics， Xiangya Hospital， Central South University

Background and aims: Dexamethasone is a common glucocorticoid medication with adverse effects that can cause muscle atrophy， but no drug intervention has been approved or recommended for this condition. KF-8 is a rice bran-derived anti-oxidant peptide that extends the life span of Caenorhabditis elegans. Methods: We established a C. elegans model of dexamethasone-induced myopathy to evaluate the potential therapeutic effects of KF-8 in this model. C. elegans muscle function was assessed in terms of locomotory behaviors including crawling， swimming， burrowing， pharyngeal pumping， and head swing. Muscle actin filament integrity was evaluated using fluorescence imaging. The molecular mechanisms of KF-8 were investigated using transcriptome sequencing， qRT-PCR， RNA interference， and western blot analysis. Results: Dexamethasone disrupted actin filaments in the striated muscles of the body wall and inhibited C. elegans crawling， swimming， burrowing， pharyngeal pumping， and head swing. KF-8 reversed the actin filament disruption and locomotor dysfunction induced by dexamethasone. Transcriptome sequencing， pathway enrichment， and qRT-PCR analyses revealed that KF-8 regulated the locomotion-related genes W04G5.10， vha-12， and ddr-1， as well as age-1 (the catalytic subunit ortholog of PI3K)， and akt1. RNA interference， conducted using a genetically engineered E. coli HT115 strain as a food source， confirmed age-1 as a key regulator of locomotor function of C. elegans. Further mechanistic studies with C2C12 myotubes showed that KF-8 regulated the IRS-PI3K-Akt pathway， the master regulator of protein synthesis and degradation. Conclusion: Together， these findings suggest that KF-8 protects against dexamethasone-induced myopathy in C. elegans by regulating locomotion-related genes and the IRS-PI3K-Akt pathway.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

移情作用下节事符号感知对民俗体验的影响

包装工程 2024年第8期45卷 381-396页

作者：姚江贺晨欢南京工程学院南京211167

目的通过构建“节事符号感知-移情-民俗体验”模型,来研究节事符号感知对民俗体验的影响作用,并探讨移情的中介作用,旨在创新提升民俗体验的新路径及民俗文化的现代传承与传播的新思路。方法采用文献研究法,以心理学感知和移情理论、认... 详细信息

目的通过构建“节事符号感知-移情-民俗体验”模型,来研究节事符号感知对民俗体验的影响作用,并探讨移情的中介作用,旨在创新提升民俗体验的新路径及民俗文化的现代传承与传播的新思路。方法采用文献研究法,以心理学感知和移情理论、认知学的符号理论及经济学的感知价值理论为基础,从设计学视角出发,通过梳理节事符号感知、移情与民俗体验三者之间的关系内涵,构建以移情为中介的节事符号感知对民俗体验影响作用的数据模型;采用问卷调查法和数据分析法研究移情作用下节事符号感知对民俗体验的影响机制。结果证实了节事符号感知对民俗体验和移情的正向影响及作用,同时证实了认知移情和行为移情对现实场景民俗体验有着显著的正向影响,对虚拟场景民俗体验有非显著的正向影响,验证了移情在节事符号感知和民俗体验之间的中介效应。结论明晰了移情在提升节事符号感知和民俗体验中的重要作用,通过移情可以建立民俗节事体验的情感连接、促进民俗文化交流与认同,对丰富民俗体验的形式和打造民俗节事文化的传承、传播等方面具有一定的启示意义。

关键词：民俗节事符号感知交互体验移情