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Focal Segmental Glomerulosclerosis in Côte d’Ivoire: Epidemiological, Clinical and Pathological Aspects

Open Journal of Pathology 2022年第4期12卷 146-155页

作者： N’Dah Kouame Justin Tia Weu Melanie Akpro Sedy Louess De Randorphe Lagou Delphine Amélie Toure Ibrahiman Kobenan Atta Anne Rebecca Abouna Alain Didier Guei Monley Cyr Tuo Wonko-Tian Alice Oka Kouamé Hubert Diopo Sery Patrick Olivier Delma Samuel Cherif Ibrahima Traore Moussa Amekoudi Eyram Ouattara Belarsi Safiatou yao Kouame Hubert Ackoundou Nguessan Clément Adonis Koffi Laurence yao gnangoran victor Gnionsahie Dazé Apolinaire Mohenou Isidore Jean-Marie Diomandé Department of Anatomic Pathology University Teaching Hospital of Bouake Bouake Ivory Coast Department of Nephrology University Teaching Hospital of Bouake Bouake Ivory Coast Department of Nephrology University Teaching Hospital of Yopougon Abidjan Ivory Coast Department of Anatomic Pathology University Teaching Hospital of Cocody Abidjan Ivory Coast Department of Nephrology University Teaching Hospital of Treichville Abidjan Ivory Coast Department of Nephrology University Teaching Hospital of Blaise Compaore Ouagadougou Burkina Faso Department of Anatomic Pathology University Teaching Hospital of Donka Conakry Guinea Department of Nephrology University Teaching Hospital of Sylvanus Olympio Lome Togo Department of Nephrology University Teaching Hospital of Treichville Abidjan Ivory Coast

Focal segmental glomerulosclerosis (FSGS) is characterized histologically by hyalinosis and sclerosis of glomeruli associated or not with podocyte involvement. The objective of our work was to clarify the epidemiological aspects and histological variants of FSGS in Côte d’Ivoire. Materials and Methods: This was a descriptive retrospective study, conducted from January 2015 to December 2019 using the renal biopsy registers (RB) of the Pathological Anatomy and Cytology departments of the Teaching Hospital of Cocody and Bouake in collaboration with the Nephrology Services of Côte d'Ivoire and the sub-region. The biopsies underwent conventional histopathology and/or immunofluorescence techniques. The parameters analyzed were: frequency, age, gender, proteinuria, biopsy indications and histological aspects and the different correlations between histological aspects and socio-demographic characteristics. Results: FSGS represented 58.1% (n = 104) of glomerular nephropathies. The average age of patients was 32.1 ± 13.3 years, with extremes of 13 and 70 years. The sex ratio was equal to 1. Nephrotic syndrome (68.9%), chronic renal failure (14.3%) and acute renal failure (10.1%) were the main indications for renal biopsy (RB). The mean proteinuria at the time of diagnosis was 4 ± 3.7 g/24 h. It was massive (3.5 g/24 h) in 42.3% of patients. FSGS was primary in 29.8% (n = 31) and secondary in 70.2% (n = 73) of patients, of which 27.9% (n = 35) was due to HIV. According to the Columbia classification, 62.5% NOS type was found;23.1% collapsing type;7.7% tip lesion type;4.8% cell type and 1.9% perihilary type. Conclusion: FSGS is a complex heterogeneous entity. It affects young people in our context with a homogeneous gender distribution. Understanding its histogenesis is essential for optimal patient management.

关键词： Kidney Glomerulus Histology FSGS Côte d’Ivoire

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Sequential Analysis in the Identification of 3rd Order System Tract in the Abidjan Margin

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Open Journal of Applied Sciences 2024年第6期14卷 1474-1489页

作者： Blandine Akissi Egoran N’guessan Donald Ahoure Fori yao Paul Assalé Sylvain Mondé Loukou victor N’da UFR Marine Sciences San Pedro University San Pedro Cte dIvoire UFR of Sciences and Technologies Alassane Ouattara Bouak Laboratory of Plant Biology and Earth Sciences Bouak Cte dIvoire UFR/STRM Flix Houphout Boigny de Cocody Abidjan Cte dIvoire PETROCI Consultant at the Center for Analysis and Research Department of Sequential Stratigraphy Abidjan Cte dIvoire

The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. Consequently, identifying these mechanisms allows us to predict the hydrocarbon generation potential of source rocks. In the Ivorian offshore sedimentary basin, certain studies have contributed to understanding and characterizing the petroleum system. However, these previous works did not integrate biostratigraphic data to highlight sedimentary facies. This study, conducted on two wells in the Abidjan margin, is crucial as it helps us comprehend the geometry of fossil sediments in relation to sea level variations. It will also aid in reconstructing the basin-filling history and predicting the distribution of rocks capable of trapping oil, determining lowstand systems tracts (reservoir rocks), transgressive systems tracts, and highstand systems tracts (cap rocks). Lithological analysis revealed predominantly clayey sedimentation with sandy layers. Well log data facilitated the delineation of formation boundaries and highlighted reservoirs consisting of sands, sandstones, limestones, and occasionally intercalated shales. Integrating these analysis results with biostratigraphic interpretations based on foraminifera and palynomorphs revealed that the traversed formations were deposited in a transitional environment ranging from Coniacian to Maastrichtian ages. Applying sequential stratigraphy concept from well logging resolved dating issues encountered in microfossil-poor or microfossil-free zones. The results of the Coniacian-Maastrichtian age sequential subdivision were aligned with the chart.

关键词： Sequence Stratigraphy Systems Tracts Senonian Côte d’Ivoire

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基于深度强化学习的空天地一体化网络信息物理系统垂直切换策略

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通信学报 2024年第8期45卷 180-191页

作者：武艳潘广川姚明旿杨清海梁中明西安电子科技大学空天地一体化综合业务网全国重点实验室陕西西安710071 深圳大学计算机与软件学院物联网研究中心广东深圳518060

针对空天地一体化网络信息物理系统模型复杂、很难获得网络拓扑先验知识和模型化假设的特点,研究其基于深度强化学习的垂直切换策略。首先,综合考虑系统稳定性、切换开销和网络使用成本约束,将垂直切换策略问题建模为约束马尔可夫决策过... 详细信息

针对空天地一体化网络信息物理系统模型复杂、很难获得网络拓扑先验知识和模型化假设的特点,研究其基于深度强化学习的垂直切换策略。首先,综合考虑系统稳定性、切换开销和网络使用成本约束,将垂直切换策略问题建模为约束马尔可夫决策过程(CMDP),并给出保证可行解存在的充分条件;其次,提出约束-近端策略优化(CPPO)算法解决该问题,并在基站侧引入分布式强化学习机制加速训练收敛。相较于基准策略,仿真验证了所提垂直切换策略的优越性和有效性。

关键词：空天地一体化网络信息物理系统深度强化学习垂直切换

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A novel artificial intelligent model for predicting air overpressure using brain inspired emotional neural network

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International Journal of Mining Science and Technology 2020年第5期30卷 683-689页

作者： victor Amoako Temeng yao Yevenyo Ziggah Clement Kweku Arthur Department of Mining Engineering Faculty of Mineral Resources TechnologyUniversity of Mines and TechnologyTarkwaWestern RegionGhana Department of Geomatic Engineering Faculty of Mineral Resources TechnologyUniversity of Mines and TechnologyTarkwaWestern RegionGhana

Blasting is the live wire of mining and its operations,with air overpressure(AOp)recognised as an end product of *** is known to be one of the most important environmental hazards of *** research in this area of mining is required to help improve on safety of the working *** of previous studies has shown that many empirical and artificial intelligence(AI)methods have been proposed as a forecasting *** an alternative to the previous methods,this study proposes a new class of advanced artificial neural network known as brain inspired emotional neural network(BIENN)to predict *** proposed BI-ENN approach is compared with two classical AOp predictors(generalised predictor and McKenzie formula)and three established AI methods of backpropagation neural network(BPNN),group method of data handling(GMDH),and support vector machine(SVM).From the analysis of the results,BI-ENN is the best by achieving the least RMSE,MAPE,NRMSE and highest R,VAF and PI values of 1.0941,0.8339%,0.1243%,0.8249,68.0512%and 1.2367 respectively and thus can be used for monitoring and controlling AOp.

关键词： Air overpressure Artificial intelligence Emotional neural network Blasting Mining

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基于ISSA-XGBoost的毕赤酵母菌发酵软测量

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传感器与微系统 2024年第8期43卷 122-125页

作者：沈瑶张立刚王建扬江苏大学电气信息工程学院江苏镇江212013 扬中市威柯特生物工程设备有限公司江苏扬中212200

针对毕赤酵母菌发酵过程菌体浓度难以在线检测,离线测量又存在极易染菌导致数据集不完整等问题,提出了一种基于改进麻雀搜索算法(ISSA)优化极致梯度提升(XGBoost)的软测量建模方法。首先,利用主成分分析(PCA)算法对样本数据进行主元分析... 详细信息

针对毕赤酵母菌发酵过程菌体浓度难以在线检测,离线测量又存在极易染菌导致数据集不完整等问题,提出了一种基于改进麻雀搜索算法(ISSA)优化极致梯度提升(XGBoost)的软测量建模方法。首先,利用主成分分析(PCA)算法对样本数据进行主元分析,降低噪声和冗余度;然后,在标准麻雀算法(SSA)中引入自适应超参数和混合变异策略,增强了算法跳出局部极值和全局搜索的能力;最后,构建菌体浓度的ISSA-XGBoost软测量模型,并与XGBoost、SSA-XGBoost模型进行比较。仿真实验结果表明:ISSA-XGBoost模型的均方根误差(RMSE)、平均相对误差(MRE)均比XGBoost、SSA-XGBoost模型低,且ISSA-XGBoost的决定系数(R^(2))更接近于1,说明预测精度明显优于改进前,能够满足对毕赤酵母菌发酵过程菌体浓度的实时测量。

关键词：毕赤酵母麻雀算法极致梯度提升软测量模型

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Correlation between Reasons for Prescription and Karyotype Results in Patients Referred for Suspected Chromosomal Abnormalities

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Open Journal of Genetics 2023年第2期13卷 97-103页

作者： Zhou Patricia Deh Malika Joane Astrid Dieth Quidana Désirée Coulibaly Mimbra Olivia Annick Bouatinin Bi You Etienne Bazago Goulai Abou Joël Landry Okon Brahima Doukouré Mohenou Isidore Jean-Marie Diomandé gnangoran victor yao Laboratory of Histology-Embryology-Cytogenetics Training and Research Unit-Medical Sciences Félix Houphou&eumlt-Boigny University Abidjan C&ocircte d’Ivoire Laboratory of Pathologycal Anatomy and Cytology Training and Research Unit-Medical Sciences Félix Houphou&eumlt-Boigny University Abidjan C&ocircte d’Ivoire Laboratory of Clinical Cytology and Reproductive Biology Training and Research Unit-Medical Sciences Alassane Ouattara University Bouaké C&ocircte d’Ivoire

Karyotype prescription is based on clinical signs (or reasons for karyotype prescription) which are phenotypic manifestations associated with chromosomal abnormalities. The aim of this study was to establish a correspondence between karyotype indications and their results in patients. This was a retrospective study that was carried out in the Histology-Embryology-Cytogenetics laboratory of the University Hospital of Cocody-Abidjan from 2014 to 2019. 58 patient files were identified and included the indication or reason for prescribing a constitutional karyotype and the biological result obtained. An individual data sheet was used to collect the data. 17 reasons for prescription were identified and divided into 2 groups. Sexual ambiguity was the most frequent reason (29.3%). The first group (G1) represented the 10 reasons for which the karyotype results were normal. The second group (G2) corresponded of the 7 motives with normal or abnormal karyotype results. Several anomalies were listed according to these reasons: inversions, mosaics (anomalies of number and structure) and trisomy 21. The last was the most frequent chromosomal anomaly (69.24%). It was found in several reasons for karyotype prescription: malformations, neurological disorders, suspected trisomy and cardiac pathology. Several factors could explain these results, among which are the limits of the karyotype and the non-genetic causes that can induce these abnormal phenotypes. Complementary examinations to the karyotype are molecular cytogenetic techniques, notably fluorescence in situ hybridization (FISH) and array comparative genomic hybridization (Array-CGH).

关键词： Diagnosis Reasons for Prescription Karyotype Chromosomal Abnormalities

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Appropriate Means to Vulgarize the Human Cytogenetics

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Open Journal of Genetics 2023年第4期13卷 125-133页

作者： Zhou Patricia Deh Abou Joël Landry Okon Gnaté François Montéomo Quidana Désirée Coulibaly Mimbra Olivia Annick Bouatinin Philippe Irenée Agossou Bi You Etienne Bazago Goulai Brahima Doukouré gnangoran victor yao Mohenou Isidore Jean-Marie Diomandé Histology-Embryology-Cytogenetics Laboratory UFR-Medical Sciences Félix Houphou&#235t-Boigny University Abidjan C&#244te d’Ivoire Laboratory of Physiology Pharmacology and Pharmacopoeia UFR-Nature Sciences Nangui-Abrogoua University Abidjan C&#244te d’Ivoire Pathological Anatomy and Cytology Laboratory UFR-Medical Sciences Félix Houphou&#235t-Boigny University Abidjan C&#244te d’Ivoire Laboratory of Clinical Cytology and Biology of Reproduction UFR-Medical Sciences Alassane Ouattara University Bouaké C&#244te d’Ivoire

Purpose: Insufficient epidemiological data on the prevalence of chromosomal abnormalities may hamper investments in research and interventions for better prevention and treatment of these major threats to the population in numerous countries. The aim of this literature review is to contribute to the popularization of cytogenetics. Methodology: This literature review is a text which contains, analyzes and organizes several referenced articles in French and English which have been selected from electronic databases. It provides a documentation of various activities and progress that have an interest in the field of cytogenetics. Results: In the context of cytogenetics, it is necessary to establish partnerships to strengthen infrastructures and produce quality results. The setting up of cytogenetic services and incentives for participatory research give space to the community in the production of knowledge and innovation, alongside researchers. It’s important to create biobanks, where samples of substances from the human body are collected for use in research into the causes and mechanisms of many diseases and their treatments. To carry out clinical trials aims at assessing the effectiveness of a therapeutic strategy, as is currently the case with the use of cytogenetic tests (karyotype, FISH, etc.) as tool of therapeutic decision and prognostic in cancer biology. The monitoring of the ethic of cytogenetic research projects allows protecting rights, security and welfare of subjects. To solve issues of data management and analysis such as the obstacle to the acquisition of tools and the insufficiency in the training of researchers. Furthermore, dissemination of research results will lead to better understanding of research results, greater public engagement in science and greater social respect for research. Conclusion: Cytogenetics can benefit from these actions such as the development of its research infrastructures and training programs for its workforce as well as t

关键词： Human Cytogenetics Vulgarization Actions

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五种蕨类植物气体交换作用的节律响应

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植物生理学报 2023年第11期59卷 2107-2116页

作者：曾云鸿蒋海港杨霏 victor RESCO DE DIOS 姚银安西南科技大学生命科学与工程学院四川绵阳62100 西班牙莱里达大学作物和森林科学系西班牙莱里达25198

昼夜节律对光合作用和气孔导度(G_(s))的重要调节作用已经在种子植物和藻类植物中进行了系统的研究。然而,最早进化的维管束植物-蕨类植物的相关作用还尚未研究。本研究中以5种蕨类植物为材料进行正常的光周期驯化处理,然后转移至全光... 详细信息

昼夜节律对光合作用和气孔导度(G_(s))的重要调节作用已经在种子植物和藻类植物中进行了系统的研究。然而,最早进化的维管束植物-蕨类植物的相关作用还尚未研究。本研究中以5种蕨类植物为材料进行正常的光周期驯化处理,然后转移至全光照条件下生长,测量正常和全光照下的气体交换和光化学指标,在排除光照影响条件下分析这5种蕨类植物节律响应特点及种间差异,以明确其节律响应特点。结果发现:全光照下,大多数蕨类植物如肾蕨、夏雪银线蕨和鸟巢蕨净光合速率(P_(n))表现出了昼夜节律,节律驱动的P_(n)昼夜变化占15.8%~42.7%,并且肾蕨的光电子传递效率(Φ_(PSII))、阿波银线蕨的非光化学猝灭系数(NPQ)和夏雪银线蕨的光下最大荧光(F’m)也呈现出了昼夜节律;鸟巢蕨和阿波银线蕨的G_(s)表现出了昼夜节律;夏雪银线蕨、阿波银线蕨和鸟巢蕨的P_(n)/胞间二氧化碳浓度(C_(i))上也表现出昼夜节律;还有4种蕨类植物在蒸腾速率(T_(r))表现出昼夜节律。对其中一种具有较强节律响应的绿地珊瑚蕨进行光合色素、非结构性碳(NSC)含量和光合作用、气孔运动相关基因表达分析发现:蕨类植物的光合作用和水分运输相关基因的表达表现出明显的昼夜节律,如捕光色素复合体蛋白基因(SaLHCB2、SaLHCB5)、碳酰酐酶基因(SaSA2)、玉米黄素环氧酶基因(SaZEP)和水通道蛋白基因(SaPIP1s)等;P_(n)的变化与淀粉负反馈调节作用和光合作用相关蛋白转录调节相关,而与气孔与叶肉导度无关。蕨类植物的光合作用的节律调节具有较强的保守性,其水分运输消耗与气孔运动具有相对独立的调节作用。本研究结果对于蕨类植物的多样性保护和利用具有重要意义。

关键词：蕨类植物昼夜节律气体交换光化学作用光合色素

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A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study

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Neural Regeneration Research 2022年第12期17卷 2743-2749页

作者： Xiao-Jun Guan Tao Guo Cheng Zhou Ting Gao Jing-Jing Wu victor Han Steven Cao Hong-Jiang Wei Yu-yao Zhang Min Xuan Quan-Quan Gu Pei-Yu Huang Chun-Lei Liu Jia-Li Pu Bao-Rong Zhang Feng Cui Xiao-Jun Xu Min-Ming Zhang Department of Radiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Neurology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCAUSA Institute for Medical Imaging Technology School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Information Science and Technology ShanghaiTech UniversityShanghaiChina Helen Wills Neuroscience Institute University of CaliforniaBerkeleyCAUSA Department of Radiology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang ProvinceChina

Brain radiomics can reflect the characteristics of brain ***,the value of T1-weighted images,quantitative susceptibility mapping,and R2*mapping in the diagnosis of Parkinson’s disease(PD)was underestimated in previous *** this prospective study to establish a model for PD diagnosis based on brain imaging information,we collected high-resolution T1-weighted images,R2*mapping,and quantitative susceptibility imaging data from 171 patients with PD and 179 healthy controls recruited from August 2014 to August *** to the inclusion time,123 PD patients and 121 healthy controls were assigned to train the diagnostic model,while the remaining 106 subjects were assigned to the external validation *** extracted 1408 radiomics features,and then used data-driven feature selection to identify informative features that were significant for discriminating patients with PD from normal controls on the training *** informative features so identified were then used to construct a diagnostic model for *** constructed model contained 36 informative radiomics features,mainly representing abnormal subcortical iron distribution(especially in the substantia nigra),structural disorganization(e.g.,in the inferior temporal,paracentral,precuneus,insula,and precentral gyri),and texture misalignment in the subcortical nuclei(e.g.,caudate,globus pallidus,and thalamus).The predictive accuracy of the established model was 81.1±8.0%in the training *** the external validation dataset,the established model showed predictive accuracy of 78.5±2.1%.In the tests of identifying early and drug-naïve PD patients from healthy controls,the accuracies of the model constructed on the same 36 informative features were 80.3±7.1%and 79.1±6.5%,respectively,while the accuracies were 80.4±6.3%and 82.9±5.8%for diagnosing middle-to-late PD and those receiving drug management,*** accuracies for predicting tremor-dominant and non-tremor-dominant PD w

关键词： diagnosis imaging biomarker iron magnetic resonance imaging neuroimaging Parkinson’s disease quantitative susceptibility mapping R2*mapping radiomics T1-weighted imaging

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三种藓类植物固碳耗水节律调节作用

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植物生态学报 2023年第7期47卷 988-997页

作者：蒋海港曾云鸿唐华欣刘伟李杰林何国华秦海燕王丽超 victor RESCO de DIOS 姚银安西南科技大学生命科学与工程学院四川绵阳621002 Department of Crop and Forest Sciences University of LleidaLleidaSpain

藓类植物作为缺乏维管组织的非等水植物,其光合作用和耗水量主要受到光照、温度和水分供应状况的影响;这些环境条件随昼夜交替改变,是否使得藓类植物形成了类似维管植物的内在昼夜节律调节机制,目前还所知甚少;理解其节律响应特点对于... 详细信息

藓类植物作为缺乏维管组织的非等水植物,其光合作用和耗水量主要受到光照、温度和水分供应状况的影响;这些环境条件随昼夜交替改变,是否使得藓类植物形成了类似维管植物的内在昼夜节律调节机制,目前还所知甚少;理解其节律响应特点对于藓类植物的保育与利用具有重要意义。该研究对脆枝青藓(Brachythecium thraustum)、大灰藓(Hypnum plumaeforme)和长叶提灯藓(Mnium lycopodioides)进行12 h/12 h的昼夜光周期驯化后进行24 h/0 h的持续光照处理,分别测定3种藓类在12 h/12 h和24 h/0 h光周期条件下的净光合速率(Pn)和蒸腾速率(Tr),结果表明:排除光照和叶-气水汽压差(VPD)等环境影响之后,3种藓类的这两个指标均观察到明显的节律变化,节律调节作用能够解释其Pn和Tr日变化的23.4%和30.2%;且维管植物中少见的Tr节律作用出现在所有受试的藓类植物上;Pn和Tr的节律响应存在明显的种间差异,该研究中节律性最强的物种为脆枝青藓。以脆枝青藓为例进一步分析其全光照下非结构性碳水化合物(NSC)的节律响应时序转录组,结果表明:35.1%的淀粉、糖类合成代谢相关基因的表达具有节律性,且与NSC含量的昼夜节律变化相关;脱落酸信号和气孔调节相关基因的表达变化与Tr的节律调节相关;光合电子传递和暗反应相关蛋白的转录水平变化与光合作用节律保持一致。藓类植物虽然丢失了生物钟核心反馈环CCA1/LHY基因,但是核心生物钟功能集中于PRRs家族,通过级联调节使得光合作用生物学过程和保卫细胞水分/离子运输过程等相关基因表达呈现显著的节律性,最终导致固碳耗水的节律响应高度保守。

关键词：昼夜节律转录组光合作用蒸腾作用气孔脆枝青藓大灰藓长叶提灯藓

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