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Analysis and Optimization of a Spatial Parallel Mechanism for a New 5-DOF Hybrid Serial-Parallel Manipulator

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Chinese Journal of Mechanical Engineering 2018年第3期31卷 60-68页

作者： dong-sheng Zhang Yun-Dou Xu Jian-Tao yao Yong-sheng Zhao Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan University Key Laboratory of Advanced Forging & Stamping Technology and Science of Ministry of National Education Yanshan University

Hybrid manipulators have potentially application in machining industries and attract extensive attention from many researchers on the basis of high sti ness and high dexterity. Therefore,in order to expand the application prospects of hybrid manipulator,a novel 5?degree?of?freedom(DOF) hybrid serial?parallel manipulator(HSPM) is proposed. Firstly,the design plan of this manipulator is introduced. Secondly,the analysis of this manipulator is carried out in detail,including kinematics analysis,statics analysis,and workspace analysis. Especially,an amplitude equivalent method of disposing the over?constrained force/couple to the non?overconstrained force/couple is used in the statics analysis. Then,three performance indices are used to optimize the PM. Two of them have been widely used,and the third one is a new index which considers the characteristics of the actuated force. Based on the performance indices,the performance atlas is drawn and the optimal design of the PM is investigated. In order to satisfy the anticipant kinetic characteristics of the PM,the verification of the optimized physical dimension is done and the workspace based on the optimized physical dimension is carried out. This paper will lay good theoretical foundations for application of this novel HSPM and also can be applied to other hybrid manipulators.

关键词： Parallel mechanism Performance indices Optimal design Performance atlas

子宫内膜癌中血管内皮生长因子和微血管密度的表达

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现代生物医学进展 2006年第10期6卷 60-61页

作者：宋印利王艳丽姚东升哈尔滨医科大学大庆校区哈尔滨医科大学附属第五医院大庆163319 哈尔滨医科大学附属四院

目的：探讨子宫内膜癌血管内皮生长因子(Vascular Endometrial Growth Factor,VEGF)的表达,及其与临床病理参数的关系。方法：采用S-P免疫组化法,应用VEGF多克隆抗体检测50例子宫内膜腺癌及20例正常子宫内膜中VEGF的表达,计数微血管密度... 详细信息

目的：探讨子宫内膜癌血管内皮生长因子(Vascular Endometrial Growth Factor,VEGF)的表达,及其与临床病理参数的关系。方法：采用S-P免疫组化法,应用VEGF多克隆抗体检测50例子宫内膜腺癌及20例正常子宫内膜中VEGF的表达,计数微血管密度(Microvessel Density,MVD)。结果：子宫内膜癌中VFGF表达阳性率明显高于正常子宫内膜,分别为92％和30％,P＜0．01。子宫内膜癌中的MVD明显高于正常子宫内膜,分别为：46．0±4．5和14．0±1．7,P＜0．05。MVD在深肌层浸润组中显著高于浅肌层浸润组,分别为：69．9±16．8和42．8±4．4,P＜0．05。结论：VEGF、MVD与子宫内膜癌的发生有关。子宫内膜癌发生发展依赖血管生成。MVD可作为子宫内膜癌的预后因素。

关键词：血管内皮生长因子子宫内膜癌免疫组化

Armillariella tabescens发酵生产菌丝体复合多糖的条件

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暨南大学学报（自然科学与医学版） 2006年第5期27卷 746-753页

作者：刘大岭罗林波陈子明谢春芳姚冬生梁郁强暨南大学生命科技学院微生物生物技术研究所广东广州510632

试验研究了5L发酵罐上液体深层培养假密环菌，生产菌丝体复合多糖的发酵条件，同时比较用酵母泥作培养基和用马铃薯作培养基发酵过程中假密环菌的生长情况、产多糖量和菌丝体生长形态．结果表明：接种量为5％，温度（26．0±0．5）℃，p... 详细信息

试验研究了5L发酵罐上液体深层培养假密环菌，生产菌丝体复合多糖的发酵条件，同时比较用酵母泥作培养基和用马铃薯作培养基发酵过程中假密环菌的生长情况、产多糖量和菌丝体生长形态．结果表明：接种量为5％，温度（26．0±0．5）℃，pH为6．00±0．2，溶氧保持在20％以上；从培养开始到收罐的0～85h，搅拌速度从80r／min到160r／min分阶段递增；补料分批发酵，上罐培养3—4d为最适发酵条件．使用马铃薯复合培养基发酵的发酵液中菌密度最高可达11．541g（干质量）·L^-1，而使用酵母泥复合培养基菌密度最高达9．657g（干质量）·L^-1，前者比后者高出19．51％．而酵母泥培养基的多糖质量浓度则最高达1．27g·L^-1，比马铃薯培养基高出22．83％．且平均培养时间比马铃薯培养基缩短12h．

关键词：假蜜环菌发酵多糖啤酒酵母泥

双进气道结构下带凹腔补燃室燃烧特性数值研究

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大连理工大学学报 2025年第1期65卷 38-47页

作者：王彦红姚弘悦东明东北电力大学能源与动力工程学院吉林吉林132012 大连理工大学能源与动力学院辽宁大连116024

针对导弹应用固体冲压发动机补燃室的掺混燃烧问题,通过一次燃气的气相燃烧模型和硼燃料的KING燃烧模型,探究了双侧90°和双侧180°进气条件下带凹腔补燃室(后倾角范围为90°~150°)的温度场和流场分布情况.阐述了凹腔旋流效应及其对燃... 详细信息

针对导弹应用固体冲压发动机补燃室的掺混燃烧问题,通过一次燃气的气相燃烧模型和硼燃料的KING燃烧模型,探究了双侧90°和双侧180°进气条件下带凹腔补燃室(后倾角范围为90°~150°)的温度场和流场分布情况.阐述了凹腔旋流效应及其对燃烧过程和燃烧产物的影响,进行了燃烧性能量化分析.数值结果表明:双侧180°进气条件下凹腔增大了燃料和空气的掺混空间,凹腔截面出现4个大对冲旋涡,掺混更加均匀,有利于燃烧组织,有效燃烧空间更大,补燃室出口总燃烧效率达到85%.双侧90°进气条件下凹腔截面形成逆时针单向旋涡,燃烧集中在狭小空间,对燃烧过程不利,补燃室出口总燃烧效率仅为55%.凹腔后倾角由90°提高到120°时,燃料和空气的掺混空间增大,促进了燃烧过程.凹腔后倾角继续提高到150°,凹腔空间增大改善燃烧的作用微弱.

关键词：双进气道结构凹腔补燃室硼颗粒燃烧过程

Wear and corrosion resistance of laser-cladded Fe-based composite coatings on AISI 4130 steel

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International Journal of Minerals,Metallurgy and Materials 2018年第6期25卷 716-728页

作者： Li Fan Hai-yan Chen yao-hua dong Li-hua dong Yan-sheng Yin College of Ocean Science and Engineering Shanghai Maritime University Department of Marine Engineering Nantong Shipping College School of Mechanical Engineering Shanghai Jiaotong University

The wear and corrosion resistance of Fe_（72.2）Cr_（16.8）Ni_（7.3）Mo_（1.6）Mn_（0.7）C_（0.2）Si_（1.2） and Fe_（77.3）Cr_（15.8）Ni_（3.9）Mo_（1.1）Mn_（0.5）C_（0.2）Si_（1.2） coatings laser-cladded on AISI 4130 steel were *** coatings possess excellent wear and corrosion resistance despite the absence of expensive yttrium,tungsten,and cobalt and very little *** microstructure mainly consists of dendrites and eutectic phases,such as duplex（γ＋α）-Fe and the Fe–Cr（Ni）solid solution,confirmed via energy dispersive spectrometry and X-ray *** cladded Fe-based coatings have lower coefficients of friction,and narrower and shallower wear tracks than the substrate without the cladding,and the main wear mechanism is mild abrasive *** test results suggest that the soft Fe_（72.2）Cr_（16.8）Ni_（7.3）Mo_（1.6）Mn_（0.7）C_（0.2）Si_（1.2） coating with high Cr and Ni concentrations has high passivation resistance,low corrosion current,and positive corrosion potential,providing a better protective barrier layer to the AISI 4130 steel against corrosion.

关键词： Fe-based coating laser cladding AISI 4130 steel wear resistance corrosion resistance

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古建筑防雷设计的探讨

陕西气象 2019年第4期 53-55页

作者：姚东升高超刘通胡旻李晓磊陕西省防雷中心西安710014 西安北方光电科技防务有限公司西安710043

对于古建筑防雷,只有有效防止其受到直击雷的损害,才能最大程度保护古建筑,减少遭受雷击的可能性。结合实际工作经验,分析总结了古建筑防雷的基本原则,并结合某古建筑防雷设计案例,详细分析古建筑防雷综合设计,对加强古建筑的防雷工作... 详细信息

对于古建筑防雷,只有有效防止其受到直击雷的损害,才能最大程度保护古建筑,减少遭受雷击的可能性。结合实际工作经验,分析总结了古建筑防雷的基本原则,并结合某古建筑防雷设计案例,详细分析古建筑防雷综合设计,对加强古建筑的防雷工作有一定参考价值。

关键词：古建筑防雷电涌

High production of β-glucosidase from a marine Aspergillus niger immobilized on towel gourd vegetable sponges

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Chinese Chemical Letters 2015年第8期26卷 1011-1015页

作者： dong-sheng Xue Jiang-Bo Wang Shan-Jing yao Ministry of Education of Fermentation Key Laboratory and Collaboration Innovation Centre of Industrial Fermentation Hubei University of Technology Department of Chemical and Biological Engineering Zhejiang University

To produce β-glucosidase by consecutive batch fermentation, a marine Aspergillus niger was immobilized on a natural carrier, towel gourd vegetable sponges. The immobilized mycelia were 0.15 g/g carrier with the immobilized biomass percentage of over 95%. The immobilized mycelia possessed the long durability（22.5 days）. The maximum production occurred 1.5 day earlier by the immobilized mycelia than by the free mycelia. β-Glucosidase production of five consecutive batches was over 110 U/m L. At high salinity,the activity and stability of β-glucosidase from the marine A. niger increased remarkable. Immobilizing the marine A. niger on the novel natural carrier achieved the efficient production of β-glucosidase.

关键词： glucosidase niger vegetable batch durability earlier salinity biomass reserved producing

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假蜜环菌深层发酵补料分批培养工艺研究

江西农业学报 2006年第2期18卷 115-117页

作者：刘大岭罗林波陈子明姚冬生暨南大学生命科技学院生物技术室广东广州510632

研究了5L发酵罐上用酵母泥复合培养基,液体深层培养假蜜环菌的补料分批工艺。优化的补料流加方式(根据还原糖浓度补料并添加微量钴离子)相对于分批培养,培养过程中最大菌体干重平均提高了6.284g/L,即产量提高了77.3%。

关键词：假蜜环菌补料分批培养啤酒酵母泥

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang dong-sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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