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Successful treatment of an enormous rectal mucosa-associated lymphoid tissue lymphoma by endoscopic full-thickness resection:A case report

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World Journal of Gastroenterology 2022年第10期28卷 1078-1084页

作者： Fang-Yuan Li Xiao-Long Zhang Qi-De Zhang yao-hui wang Digestive Endoscopy Center Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of TCMNanjing 210046Jiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of TCMNanjing 210046Jiangsu ProvinceChina

BACKGROUND Colorectal mucosa-associated lymphoid tissue lymphoma(MALToma),a rare kind of nongastric MALToma,lacks consensus on its endoscopic features and standard *** to previous studies on the clinical characteristics and outcomes of colorectal MALToma,endoscopic resection remains a good therapeutic *** SUMMARY A 71-year-old woman suffered intermittent hematochezia for 1 mo,accompanied with abdominal pains but without weight loss,fever,chills or *** showed a massive hemispheric mass with rough and hyperemic mucosa in the lower ***-band imaging magnifying endoscopy detected some branching abnormal blood vessels and disappearance of glandular structure,which was similar with the tree-like appearance sign in gastric *** ultrasonography revealed the lesion to be hypoechoic,boundary-defined,and echo uniform inside,originating from the muscularis *** enhanced computed tomography(CT)demonstrated a soft tissue mass with defined *** enlarged superficial lymph nodes were detected by B-mode ultrasound.C13-urea breath test and serum Helicobacter pylori antibody were both *** patient underwent endoscopic full-thickness *** pathological analysis indicated colorectal *** patient remained asymptomatic after discharge,and follow-up positron emission tomography–CT and colonoscopy showed no residual lesion,remnants or lymph node *** This case provides new information on the specific endoscopic features of colorectal MALToma and an alternative treatment for patients.

关键词： Mucosa-associated lymphoid tissue lymphoma Endoscopic full-thickness resection Endoscopic minimally invasive surgery Endoscopy Case report

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Disruption of egg-specific protein causes female sterility in Bombyx mori

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Insect Science 2022年第1期29卷 128-138页

作者： Xia Xu yao-hui wang Zu-Lian Liu Yong-Qiang wang Lin He Kai Li Yong-Ping Huang Institute of Sericulture and Tea Research Zhejiang Academy of Agricultural SciencesHangzhou310021China Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai200032China School of Life Science East China Normal UniversityShanghai200062China

Yolk proteins are the main source of nutrients during embryonic and early larval development in oviparous animals. Therefore, vitellogenesis is crucial for reproduction. The silkworm, Bombyx mori, is a model lepidopteran insect in which there are three yolk proteins: vitellin, 30-kDa protein, and egg-specific protein (Esp). In this study, we explored the gene function of Esp through transgenic clustered regularly interspaced palindromic repeats (CRISPR) / CRISPR-associated protein 9 technology-mediated mutations in the silkworm. We found that Esp mutation resulted in female sterility but had no effect on male fertility. Female mutants could lay eggs after mating, but the eggs were smaller and lighter colored than those laid by wild-type females. The most important finding is that the eggs laid by female mutants did not hatch. Furthermore, we observed stable inheritance of female sterility caused by Esp mutation through successive generations. Thus, Esp encodes a yolk protein that is crucial for female reproductive success and is a potential target for pest control.

关键词： Bombyx mori CRISPR/Cas9 Esp female sterility

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Exploring the Cation Regulation Mechanism for Interfacial Water Involved in the Hydrogen Evolution Reaction by In Situ Raman Spectroscopy

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Nano-Micro Letters 2024年第3期16卷 303-312页

作者： Xueqiu You Dongao Zhang Xia‑Guang Zhang Xiangyu Li Jing‑Hua Tian yao‑hui wang Jian‑Feng Li School of Ocean Information Engineering Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent ProcessingJimei UniversityXiamen 361021People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005People’s Republic of China Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsCollege of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007People’s Republic of China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005People’s Republic of China

Interfacial water molecules are the most important participants in the hydrogen evolution reaction(HER).Hence,understanding the behavior and role that interfacial water plays will ultimately reveal the HER ***,investigating interfacial water is extremely challenging owing to the interference caused by bulk water molecules and complexity of the interfacial ***,the behaviors of interfacial water in different cationic electrolytes on Pd surfaces were investigated by the electrochemistry,in situ core-shell nanostructure enhanced Raman spectroscopy and theoretical simulation *** spectral evidence reveals a red shift in the frequency and a decrease in the intensity of interfacial water as the potential is shifted in the positively *** comparing the different cation electrolyte systems at a given potential,the frequency of the interfacial water peak increases in the specified order:Li+

关键词： In situ Raman Interfacial water Hydrogen evolution reaction Cations

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CRISPR/Cas9-based mutation reveals Argonaute 1 is essential for pigmentation in Ostrinia fumacalis

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Insect Science 2019年第6期26卷 1020-1028页

作者： Lang You Hong-Lun Bi yao-hui wang Xiao-Wei Li Xi-En Chen Zhi-Qian Li CAS Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai China

Ostrinia fumacalis (Lepidoptera: Pyralidae) is one of the most destructive agricultural pests in Asia. Traditional pest-management methods include sex pheromone capture, transgenic crops that produce Bacillus thuringiensis toxin, and pesticides. Although these strategies control pest populations effectively, they also cause negative side effects, including dramatically increased pesticide resistance, severe pollution, and hazards for human health. Recently developed genome editing tools provide new prospects for pest management and have been successfully used in several species. However, few examples have been reported in the agricultural pest O. fumacalis due to a lack in genomic information. In this report, we identified only one transcript of O. fumacalis Argonaute 1 (OfAgo 1) gene from the genome and cloned the open reading frame. OfAgol presented the maximum expression at the embryo stage or in the fat body during the larval stages. To understand its function, an OfAgol mutant was constructed using the Clustered Regularly Interspaced Short Palindromic Repeat/RNA-guided Cas9 nuclease (CRISPR/Cas9). Mutagenesis of OfAgol disrupted cuticle pigmentation by dowregulating micro RNAs and pigmentation-related genes. This is the first report for the cloning and functional analysis of OfAgol, revealing a role of OfAgol in cuticle pigmentation. The current report also established a CRISPR/Cas9 system in O. fumacalisy providing a new insight for pest management.

关键词： Agol CRISPR/Cas9 cuticle pigmentation Ostrinia fumacalis pest management

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CRISPR/Cas9-mediated Tyrosine hydroxylase knockout resulting in larval lethality in Agrotis ipsilon

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Insect Science 2018年第6期25卷 1017-1024页

作者： Yang Yang yao-hui wang Xi-En Chen Di Tian Xia Xu Kai Li Yong-Ping Huang Lin He School of Life Science East China Normal UniversityShanghaiChina Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control College of Plant Science &TechnologyHuazhong Agricultural UniversityWuhanChina

Tyrosine hydroxylase (TH)is involved in insect melanin and the catecholamine biosynthesis *** as an enzyme catalyzing the conversion of tyrosine to 3,4- dihydroxyphenylalanine is the first step reaction in the *** TH has been proven to affect the pigmentation of the epidermis and development in many insects,there is no report about physiological function of the THgene inAgrotis *** we cloned the TH gene from ***-quantitative real-time polymerase chain reaction (PCR) analysis showed that AiTH was expressed at all development ***,its high expression levels in the head and epidermis suggest that it is mainly related to pigment deposition and insect ***,we used the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9system to target the AiTH gene:deletion events were detected at the target *** with the control group,a few mutants with the phenomenon of narrowing in the egg shell and embryos can develop but cannot hatch;the other hatched embryos were seriously dehydrated after hatching and died within the first *** real-time PCR analysis revealed that THwas down-regulated ***,our work demonstrated thatAiTHplays an important role in growth and development of newly hatched larvae;meanwhile,it would be a promising target to explore a control strategy for ***.

关键词： Agrotis ipsilon CRISPR/Cas9system larvae lethal Tyrosine hydroxylase

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The Masc gene product controls masculinization in the black cutworm, Agrotis ipsilon

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Insect Science 2019年第6期26卷 1037-1044页

作者： yao-hui wang Xi-En Chen Yang Yang Jun Xu Gang-Qi Fang Chang-Ying Niu Yong-Ping Huang Shuai Zhan CAS Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology ShanghaiChina Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control College of Plant Science & Technology Huazhong Agricultural University Wuhan China School of Life Science East China Normal UniversityShanghaiChina

Sex determination has been studied in the model lepidopteran species Bombyx mori, but it remains poorly understood in lepidopteran pests. In the present study, we identified and characterized the Masculinizer (Masc) gene in a Noctuidae pest species, Agrotis ipsilon. Sequence analysis revealed that AiMasc encodes a protein of 658 amino acids that has two CCCH-type zinc finger domains and two conserved cysteine residues (Cys-277 and Cys-280). We assessed the masculinizing activity AiMasc in BmN cells and found that/z'Masc induced expression of the male-specific doublesex isoform. Disruption of Masc via clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) in A. ipsilon caused abnormalities in abdominal segments and external genitalia, resulting in male-specific sterility. These results suggest that Masc participates in the process of sex determination in A. ipsilon. Successful identification of sex-determination gene in a pest species may enable the development of novel genetic approaches for pest control.

关键词： Agrotis ipsilon CRISPR/Cas9 Masc sex determination

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Core-shell nanoparticle enhanced Raman spectroscopy in situ probing the composition and evolution of interfacial species on PtCo surfaces

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Nano Research 2024年第6期17卷 4687-4692页

作者： Jing Liu Han-Liang Zhong Xiangyu Li Mu-Fei Yue Wei-Min Yang Xueqiu You Jing-Hua Tian yao-hui wang Jian-Feng Li Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing School of Ocean Information EngineeringJimei UniversityXiamen 361021China College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China

The composition and evolution of interfacial species play a key role during electrocatalytic *** the structural evolution and intermediate during catalytic process by in situ characterization can shed new light on the electrocatalytic reaction mechanism and develop highly efficient ***,directly probing the interfacial species is extremely difficult for most spectroscopic techniques due to complicated interfacial environment and ultra-low surface ***,electrochemical core-shell nanoparticle enhanced Raman spectroscopy is utilized to probe the composition and evolution processes of interfacial species on Au@Pt,Au@Co,and Au@PtCo core-shell nanoparticle *** spectral evidences of interfacial intermediates including hydroxide radical(OH*),superoxide ion(O_(2)^(−)),as well as metal oxide species are directly captured by in situ Raman spectroscopy,which are further confirmed by the both isotopic experiment and density functional theory *** results provide a mechanistic guideline for the rational design of highly efficient electrocatalysts.

关键词： in situ Raman core-shell nanoparticle PtCo interfacial species composition and evolution

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In situ tracking of the lithiation and sodiation process of disodium terephthalate as anodes for rechargeable batteries by Raman spectroscopy

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Nano Research 2024年第1期17卷 245-252页

作者： Xiu-Mei Lin Chong Han Xin-Tao Yang Jia-Sheng Lin Wei-Qiang Yang Hong-Xu Guo yao-hui wang Jin-Chao Dong Jian-Feng Li Department of Chemistry and Environment Science Fujian Province University Key Laboratory of Analytical ScienceMinnan Normal UniversityZhangzhou 363000China College of Energy College of Chemistry and Chemical EngineeringCollege of MaterialsState Key Laboratory of Physical Chemistry of Solid SurfacesiChEMXiamen UniversityXiamen 361005China Institute of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China

Organic compounds represent an appealing group of electrode materials for rechargeable batteries due to their merits of biomass,sustainability,environmental friendliness,and *** terephthalate(Na_(2)C_(8)H_(4)O_(4),Na_(2)TP),an organic salt with a theoretical capacity of 255 mAh·g^(-1),is electroactive towards both lithium and ***,its electrochemical energy storage(EES)process has not been directly observed via in situ characterization techniques and the underlying mechanisms are still under ***,in situ Raman spectroscopy was employed to track the de/lithiation and de/sodiation processes of *** appearance and then disappearance of the–COOLi Raman band at 1625 cm^(-1) during the de/lithiation,and the increase and then decrease of the–COONa Raman band at 1615 cm^(-1) during the de/sodiation processes of Na2TP elucidate the one-step with the 2Li+or 2Na+transfer *** also found that the inferior cycling stability of Na2TP as an anode for sodium-ion batteries(SIBs)than lithium-ion batteries(LIBs)could be due to the larger ion radium of Na+than Li+,which results in larger steric resistance and polarization during *** Na2TP,therefore,shows greater changes in spectra during de/sodiation than de/*** expect that our findings could provide a reference for the rational design of organic compounds for EES.

关键词： disodium terephthalate(Na_(2)C_(8)H_(4)O_(4) Na2TP) in situ Raman spectroscopy de/lithiation de/sodiation mechanisms

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang wang hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-nave patients with schizophrenia

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Neuroscience Bulletin 2015年第1期31卷 31-42页

作者： Ming-Li Li Bo Xiang Yin-Fei Li Xun Hu Qiang wang Wan-Jun Guo Wei Lei Chao-Hua Huang Lian-Sheng Zhao Na Li Hong-Yan Ren hui-yao wang Xiao-Hong Ma Wei Deng Tao Li The Mental Health Center and the Psychiatric Laboratory West China HospitalSichuan University State Key Laboratory of Biotherapy West China HospitalSichuan University Huaxi Biobank West China HospitalSichuan University

The catechol-O-methyltransferase（COMT） gene is a schizophrenia susceptibility gene. A common functional polymorphism of this gene,Val158/158 Met,has been proposed to influence gray matter volume（GMV）. However,the effects of this polymorphism on cortical thickness/surface area in schizophrenic patients are less clear. In this study,we explored the relationship between the Val158 Met polymorphism of the COMT gene and the GMV/ cortical thickness/cortical surface area in 150 firstepisode treatment-nave patients with schizophrenia and 100 healthy controls. Main effects of diagnosis were found for GMV in the cerebellum and the visual,medial temporal,parietal,and middle frontal cortex. Patients with schizophrenia showed reduced GMVs in these regions. And main effects of genotype were detected for GMV in the left superior frontal gyrus. Moreover,a diagnosis × genotype interaction was found for the GMV of the left precuneus,and the effect of the COMT gene on GMV was due mainly to cortical thickness rather than cortical surface area. In addition,a pattern ofincreased GMV in the precuneus with increasing Met dose found in healthy controls was lost in patients with schizophrenia. These findings suggest that the COMTMet variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia,and the effect of the COMT gene on GMV in schizophrenia is mainly due to changes in cortical thickness rather than in cortical surface area.

关键词： schizophrenia COMT gray matter imaging genetics

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