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Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus

Science China(Life Sciences) 2023年第11期66卷 2614-2628页

作者： Siyu Yang Dong Chen Lei Xie xiaoxiao Zou yanyuan xiao Lin Rao Tianxiong Yao Qing Zhang Liping Cai Fei Huang Bin Yang Lusheng Huang State Key Laboratory of Pig Genetic Improvement and Production Technology Jiangxi Agricultural UniversityNanchang 330045China

The hippocampus is a brain region associated with memory,learning and spatial navigation,its aging-related dysfunction is a common sign of Alzheimer’s *** is a good model for human neurodegenerative disease,but our understanding of the regulatory program of the pig hippocampus and its cross-species conservation in humans remains ***,we profiled chromatin accessibility in 33,409 high-quality nuclei and gene expression in 8,122 high-quality nuclei of the pig hippocampus at four postnatal *** identified 510,908 accessible chromatin regions(ACRs)in 12 major cell types,among which progenitor cells such as neuroblasts and oligodendrocyte progenitor cells showed a dynamic decrease from early to later developmental *** revealed significant enrichment of transposable elements in cell type-specific ACRs,particularly in *** identified oligodendrocytes as the most prominent cell type with the greatest number of genes that showed significant changes during the *** identified ACRs and key transcription factors underlying the trajectory of neurogenesis(such as POU3F3 and EGR1)and oligodendrocyte differentiation(RXRA and FOXO6).We examined 27 Alzheimer’s disease-related genes in our data and found that 15 showed cell type-specific activity(TREM2,RIN3 and CLU),and 15 genes displayed age-associated dynamic activity(BIN1,RABEP1 and APOE).We intersected our data with human genome-wide association study results to detect neurological disease-associated cell *** present study provides a single nucleusaccessible chromatin landscape of the pig hippocampus at different developmental stages and is helpful for the exploration of pigs as a biomedical model in human neurodegenerative diseases.

关键词： hippocampus pig chromatin accessibility gene expression nuclei accessible chromatin regions development

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Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs

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Science China(Life Sciences) 2022年第8期65卷 1517-1534页

作者： Yaling Zhu Zhimin Zhou Tao Huang Zhen Zhang Wanbo Li Ziqi Ling Tao Jiang Jiawen Yang Siyu Yang yanyuan xiao Carole Charlier Michel Georges Bin Yang Lusheng Huang State Key Laboratory of Pig Genetic Improvement and Production Technology Jiangxi Agricultural UniversityNanchang 330045China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefei 230032China Unit of Animal Genomics GIGA-Institute and Faculty of Veterinary MedicineUniversity of Liege4000 LiegeBelgium

The limited knowledge of genomic noncoding and regulatory regions has restricted our ability to decipher the genetic mechanisms underlying complex traits in pigs. In this study, we characterized the spatiotemporal landscape of putative enhancers and promoters and their target genes by combining H3K27ac-targeted Ch IP-Seq and RNA-Seq in fetal(prenatal days 74–75) and adult(postnatal days 132–150) tissues(brain, liver, heart, muscle and small intestine) sampled from Asian aboriginal Bama Xiang and European highly selected Large White pigs of both sexes. We identified 101,290 H3K27ac peaks, marking 18,521promoters and 82,769 enhancers, including peaks that were active across all tissues and developmental stages(which could indicate safe harbor locus for exogenous gene insertion) and tissue-and developmental stage-specific peaks(which regulate gene pathways matching tissue-and developmental stage-specific physiological functions). We found that H3K27ac and DNA methylation in the promoter region of the XIST gene may be involved in X chromosome inactivation and demonstrated the utility of the present resource for revealing the regulatory patterns of known causal genes and prioritizing candidate causal variants for complex traits in pigs. In addition, we identified an average of 1,124 super-enhancers per sample and found that they were more likely to show tissue-specific activity than ordinary peaks. We have developed a web browser to improve the accessibility of the results(http://***/pencode/?genome=sus Scr11).

关键词： H3K27ac ChIP-Seq RNA-Seq pig XIST complex traits

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Kaiser Criterion in Factor Models

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Acta Mathematica Sinica,English Series 2025年第2期41卷 547-552页

作者： Changhu Wang Jianhua Guo yanyuan Ma Shurong Zheng School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China School of Mathematics and Statistics Beijing Technology and Business UniversityBeijing 100048P.R.China Department of Statistics Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA KLAS and School of Mathematics and Statistics Northeast Normal UniversityChangchun 130024P.R.China

Despite of the wide use of the factor models, the issue of determining the number of factors has not been resolved in the statistics literature. An ad hoc approach is to set the number of factors to be the number of eigenvalues of the data correlation matrix that are larger than one, and subsequent statistical analysis proceeds assuming the resulting factor number is correct. In this work, we study the relation between the number of such eigenvalues and the number of factors, and provide the if and only if conditions under which the two numbers are equal. We show that the equality only relies on the properties of the loading matrix of the factor model. Guided by the newly discovered condition, we further reveal how the model error affects the estimation of the number of factors.

关键词： Factor model Kaiser criterion positive definite

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Li,Na,and Cs-based metal-organic frameworks for room temperature phosphorescence applications

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Science China Chemistry 2025年

作者： Jiaqi Ma Rui Feng yanyuan Jia Mingshi Zhang Shuo Guo College of Chemistry and Chemical Engineering Inner Mongolia University School of Materials Science and Engineering Smart Sensing Interdisciplinary Science Center Nankai University & TKL of Metal and Molecule Based Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Department of Chemistry and Biochemistry University of California San Diego

The conventional design of metal-organic frameworks (MOFs) with room-temperature phosphorescence (RTP) mostly relies on using heavy metals,as the heavy atom effect can effectively increase the efficiency of intersystem crossing (ISC) to get a better phosphorescence *** the first time,we reported the highly efficient RTP of a lithium-based MOF IMU-101 with a lifetime (τ) of 299 ms and a quantum yield (QY) of 4.91%.In addition,MOFs IMU-102 and IMU-103,with sodium and cesium as metal nodes,were successfully *** phosphorescence properties of this series of alkali metal MOFs were systematically studied and *** crystallography and computational calculation show that the mechanism for achieving RTP for this material lies in the ultrashort coordination bond of Li,which enables the reduction of non-radiative ***-101,as a cheap and environmentally friendly room-temperature phosphorescent material,has been further developed into composite polymer inks and bulk *** makes them promising for applications in anti-counterfeiting and information encryption.

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Current progress of information fusion in China

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Chinese Science Bulletin 2013年第36期58卷 4533-4540页

作者： JING ZhongLiang PAN Han QIN yanyuan School of Aeronautics and Astronautics Shanghai Jiao Tong University

Information fusion is a challenging task to extract the required information for high-level applications from various homogeneous or heterogeneous *** paper summarizes some improvements in recent five years in the presented structure of information fusion,including estimation fusion,image fusion and *** technologies of information fusion and their variants are *** the state-of-the-art of the algorithms for information fusion have been proposed,there still remains some fundamental challenges with regard to exploiting the emerging multi-sensors’characteristics and their special ***,some potential prospects of estimation fusion and image fusion are discussed.

关键词：信息融合进度中国图像融合多传感器发展前景挑战性结构

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护理本科生学业自我效能感在医学教育环境与跨专业合作学习准备度间的中介效应分析

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中华护理教育 2025年第1期22卷 72-77页

作者：雷延源崔香淑陆军军医大学士官学校军事护理系石家庄市050011 延边大学护理学院吉林省延吉市133002

目的探讨学业自我效能感在医学教育环境与跨专业合作学习准备度之间的中介作用。方法采用便利抽样法,自2022年3月—4月选取吉林省5所高校的344名护理本科生为研究对象,采用一般资料调查问卷、学业自我效能感量表、医学教育环境评定量表... 详细信息

目的探讨学业自我效能感在医学教育环境与跨专业合作学习准备度之间的中介作用。方法采用便利抽样法,自2022年3月—4月选取吉林省5所高校的344名护理本科生为研究对象,采用一般资料调查问卷、学业自我效能感量表、医学教育环境评定量表及跨专业合作学习准备量表对其进行问卷调查。结果344名护理本科生的学业自我效能感得分为(74.78±10.71)分,医学教育环境得分为(136.17±25.38)分,跨专业合作学习准备度得分为(71.50±9.57)分。Pearson相关性分析结果显示,护理本科生学业自我效能感与医学教育环境得分呈正相关(r=0.561,P<0.05),学业自我效能感与跨专业合作学习准备度得分呈正相关(r=0.476,P<0.05),医学教育环境与跨专业合作学习准备度得分呈正相关(r=0.620,P<0.05)。学业自我效能感在医学教育环境与跨专业合作学习准备度之间具有部分中介作用,中介效应占总效应的28.34%。结论医学教育环境可通过学业自我效能间接影响跨专业合作学习准备度,护理教育者可以通过改善医学教育环境,提升护理本科生的学业自我效能感来提高其跨专业合作学习准备度。

关键词：护理本科生学业自我效能感医学教育环境跨专业合作学习准备度

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Programmable Adaptive Security Scanning for Networked Microgrids

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Engineering 2021年第8期7卷 1087-1100页

作者： Zimin Jiang Zefan Tang Peng Zhang yanyuan Qin Department of Electrical and Computer Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Computer Science and Engineering University of ConnecticutStorrsCT 06269USA

Communication-dependent and software-based distributed energy resources(DERs)are extensively integrated into modern microgrids,providing extensive benefits such as increased distributed controllability,scalability,and ***,malicious cyber-attackers can exploit various potential *** this study,a programmable adaptive security scanning(PASS)approach is presented to protect DER inverters against various power-bot ***,three different types of attacks,namely controller manipulation,replay,and injection attacks,are *** approach employs both software-defined networking technique and a novel coordinated detection method capable of enabling programmable and scalable networked microgrids(NMs)in an ultra-resilient,time-saving,and autonomous *** coordinated detection method efficiently identifies the location and type of power-bot attacks without disrupting normal NM *** simulation results validate the efficacy and practicality of the PASS for securing NMs.

关键词： Networked microgrids Programmable adaptive security scanning Coordinated detection Software defined networking

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A note on statistical analysis of factor models of high dimension

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Science China Mathematics 2021年第8期64卷 1905-1916页

作者： Zhigen Gao Jianhua Guo yanyuan Ma KLAS and School of Mathematics and Statistics Northeast Normal UniversityChangchun 130024China Department of Statistics Pennsylvania State UniversityUniversity ParkPA 16802USA

Linear factor models are familiar tools used in many *** pioneering literatures established foundational theoretical results of the quasi-maximum likelihood estimator for high-dimensional linear factor *** results are based on a critical assumption:The error variance estimators are uniformly bounded in *** of making such an assumption,we provide a rigorous proof of this result under some mild conditions.

关键词： bounded in probability heteroscedasticity high-dimensional linear factor model

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3D Interconnected MoO_2 Nanocrystals on Nickel Foam as Binder-free Anode for Li-ion Batteries

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Journal of Wuhan University of Technology(Materials Science) 2018年第6期33卷 1315-1322页

作者： QI yanyuan Center for Materials Research and Analysis Wuhan University of Technology School of Materials Science and Engineering Wuhan University of Technology

MoO_2 nanocrystals(NCs) on Ni foam were simply synthesized via a facile hydrothermal method and a dip-coating method. It was worth noting that ultrafine interconnected MoO_2 nanocrystals(about 10 nm) were uniformly anchored on Ni foam to fabricate a particular three-dimensional architecture, which may provide more active sites and shorter transmission pathways for lithium ions. As binder-free anode, MoO_2 NCs on Ni foam deliver a high initial discharge capacity of 990 mAh·g^(-1) and retain a reversible capacity of 924 mAh· g(-1) after 100 cycles at a current density of 0.1 C. More importantly, when the current density returns from 2 C to 0.1 C, the capacity recovers to 910 mAh·g(-1)(about 92% of the original high capacity), suggesting excellent cycling stability and rate capability. The particular 3 D electrode as binder-free anode makes it a promising anode candidate for high-performance lithium-ion batteries.

关键词： MoO2 nanocrystals 3D architecture binder-free anode lithium-ion batteries

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Carbide Precipitation in Austenite of a Titanium-Tungsten-Bearing Low-Carbon Steel

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Acta Metallurgica Sinica(English Letters) 2022年第7期35卷 1090-1102页

作者： yanyuan Zhou Zhenqiang Wang Haokai Dong Fengchun Jiang Key Laboratory of Superlight Materials and SurfaceTechnology Ministry of Education College of MaterialScience and Chemical EngineeringHarbin EngineeringUniversityHarbin150001China National Engineering Research Center of Near-Net-ShapeForming for Metallic Materials South China Universityof TechnologyGuangzhou510641China

In this study,the carbide precipitation at 925 ℃ in austenite(γ)of a 0.04C–1.5Mn–0.10Ti–0.39 W(wt%)low-carbon steel was investigated by stress relaxation(SR)high-resolution transmission electron microscopy and atom probe ***-principles calculations were employed to reveal the precipitation *** indicate that a high dispersion of W-and Fe-rich M C-type ultrafi ne carbides(<10 nm)forms during the very early stage prior to the onset of precipitation determined by *** ultrafi ne carbides possess a B1-crystal structure with a lattice parameter of 3.696Å,which is quite close to that ofγ(3.56Å).It can signifi cantly decrease the misfi t of carbide/γinterface with a cube-on-cube relationship,thus assisting the carbide *** the time prolongs,a few spherical or polygonal Ti-rich(Ti,W)C particles(18–60 nm)are formed at the expense of the ultrafi ne carbides by nucleation and growth on ***(Ti,W)C particles are identifi ed with a“core–shell”structure(Ti-rich core and Ti,W-rich shell),which leads to a better-coarsening resistance compared with pure TiC in Ti *** results show that the composition and structure of carbides at certain stage are closely related to a combined eff ect of W,Fe,and Ti atoms together with interstitial vacancies.

关键词： Alloy carbide Precipitation (Ti,W)C Aging hardening Stability Microalloyed steel

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