检索结果-南通市图书馆

Regulation of TH17 cell differentiation by innate immune signals

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2012年第4期9卷 287-295页

作者： Gonghua huang yanyan Wang Hongbo Chi Department of Immunology St Jude Children's Research Hospital Memphis TN USA

Upon antigen stimulation, naive T helper cells differentiate into distinct lineages to attain specialized properties and effector functions. TH17 cells, a recently identified lineage of CD4＋ effector T cells, play a key role in the immune defense against fungi and extracellular bacteria, but also contribute to the pathogenesis of many autoimmune conditions. The differentiation of TH 17 cells is orchestrated by an intricate network of signaling pathways and transcriptional regulators in T cells. While the involvement of T cell-intrinsic pathways has been described extensively, we are just beginning to appreciate how TH17 cell development is shaped by extrinsic pathways, espec- ially the innate immune signals. Dendritic cells （DCs）, the most important cell type to bridge innate and adaptive immunity, drive TH17 cell differentiation by providing antigenic, costimulatory and cytokine signals. This is mediated by the recognition of innate and inflam- matory signals by DCs via pattern recognition receptors, cytokine receptors and other immunomodulatory receptors that in turn activate the intracellular signaling network. In particular, p38a MAP kinase has emerged as a critical pathway to program DC-dependent TH17 cell differentiation by integrating multiple instructive signals in DCs. Here, we summarize the current knowledge on the mechanisms by which DC-derived innate immune signals drive TH17 cell differentiation.

关键词： dendritic cells innate immunity MAPK T-cell differentiation TH17 cells

Nanocomposites composed of modified natural polymer and inorganic nanomaterial for safe,high-efficiency,multifunctional protection of paper-based relics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2023年第8期66卷 2225-2236页

作者： ZHAO HaiBo LIU Peng huang yanyan ZHANG HongBin Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353China

Paper-based relics as important carriers of human history and civilization have been facing severe damage problems,and their protection is a major project for cultural heritage *** far,safe,high-efficiency,and multifunctional protection materials are still urgent to be ***,through screening a series of alkaline nano-oxides and cleverly combining the advantages of modified natural polymer(quaternized chitosan)and inorganic nanomaterials(Zn O),we successfully prepared their functional nanocomposites with multiple properties and pioneered their smart application for multifunctional protection of paper *** spraying loads,this kind of nanocomposites can effectively and safely inhibit the acid degradation of paper relics and long-term maintain a natural or weak basic state even under harsh accelerated aging ***,the coating of nanocomposites does not change the chromatic aberration but partially improves the ***,the mechanical properties of paper relics are reinforced up to more than one time for all-around tensile strength,folding endurance,and tearing *** is worth noting that the usage of nanocomposites can avoid the discoloration or fading of p H-sensitive pigments/dyes and prevent the blue/red inks from *** integrating the anti-microorganism effects of the two components,the nanocomposites have exhibited a broad antimicrobial capacity for both fungi(e.g.,Plectosphaerella cucumerina and Aspergillus unguis)and bacteria(e.g.,Staphylococcus aureus).The acquired knowledge not only represents an advanced step for designing functionalized inorganic/polymer nanocomposite but also sheds light on the multi-functional integrated protection of paperbased relics.

关键词： composite material cultural relics protection multifunctional application safe deacidification anti-microorganism

在线全文

学校读者我要写书评

暂无评论

生物学视角下贝叶文献的研究进展

复旦学报（自然科学版） 2024年第5期63卷 658-666页

作者：张静语玉罕为李燕刘鹏黄艳燕复旦大学中华古籍保护研究院上海200433 云南省贝叶经保护院士工作站云南西双版纳666199 西双版纳傣族自治州图书馆云南西双版纳666199

贝叶文献是珍贵的历史遗存,随着时间的流逝,贝叶文献破损严重,亟待保护。然而,贝叶文献保护面临着系统性研究基础不足的困难。对此,本综述回顾了目前已经开展的贝叶文献生物学研究,其方向包括贝叶文献原料植物、贝叶文献表面微生物和抑... 详细信息

贝叶文献是珍贵的历史遗存,随着时间的流逝,贝叶文献破损严重,亟待保护。然而,贝叶文献保护面临着系统性研究基础不足的困难。对此,本综述回顾了目前已经开展的贝叶文献生物学研究,其方向包括贝叶文献原料植物、贝叶文献表面微生物和抑菌防虫植物提取物、贝叶文献特色植物信息挖掘等。同时,展望它未来的发展方向,包括生物学检测方法、原料植物系统发育研究与溯源、优良品种培育与筛选、抗菌防虫等。

关键词：贝叶文献贝叶棕糖棕生物学

Homomeric Inclusion and Hydrogen-Bonding Cooperatively Directed Crystalline Assembly of a Cyclotriguaiacylene Derivative with Different Aromatic Acids

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2015年第7期33卷 765-770页

作者： Jingru Song yanyan Shi Zhitang huang Qiyu Zheng Beijing National Laboratory for Molecular Science CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Five organic complexes are prepared by cocrystallization of tri-[（N-methyl-2-imidazoly）methoxy]cyclotriguiacylene （TMIM-CTG） with corresponding acids. While hydrogen bonds are the basic interactions in the five complexes, the homo-included motifs with C--H…π interactions also control the molecular arrangement except for complex 5. In complex 1, the two dimensional networks contain 1D zigzag chains formed by hydrogen bonding and 1D chains of homo-included CTG motifs. Complex 2 has 2D 4.82 hydrogen bonding networks, and the chains of homomeric inclusion extend the 2D structure to a 3D framework. Complex 3 contains four-membered rings through hydrogen bonds, and the chains of homo-inclusion link the rings to a novel 2D network. In complex 4, hydrogen bonds construct a novel double-layer 2D network, which is extended to a 3D framework by ＂hand-shake＂ dimeric homomeric inclusion interactions. Interestingly, there is no homomeric inclusion phenomenon in complex 5 and hydrogen bonds solely connect two components to a chiral （6,3） 2D network.

关键词： cyclotriveratrylene hydrogen bonds C--H…π interactions inclusion compounds crystal engineering

食品功能因子靶向运载体系及其在食品中的应用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国食品学报 2024年第6期24卷 445-454页

作者：姚庆博梁艳彤吴佳敏刘欣桐廖兰汪浪红曾新安黄燕燕佛山科学技术学院食品科学与工程学院广东佛山528225 佛山科学技术学院广东省食品智能制造重点实验室广东佛山528225 华南理工大学食品科学与工程学院广州510640

随着对功能食品中最重要的成分——功能因子研究的深入,大量的功能因子被开发应用到功能食品中。例如不饱和脂肪酸、多酚及类胡萝卜素等,因其特殊的理化性质,使自身的生物利用率低下,从而制约了其在食品中的应用。开发食品功能因子运载... 详细信息

随着对功能食品中最重要的成分——功能因子研究的深入,大量的功能因子被开发应用到功能食品中。例如不饱和脂肪酸、多酚及类胡萝卜素等,因其特殊的理化性质,使自身的生物利用率低下,从而制约了其在食品中的应用。开发食品功能因子运载系统,提高其在生物体中的利用率便成为亟需解决的问题。本文以近几年食品功能因子运载体系研究为基础,系统归纳纳米乳状液、多层乳状液、固相脂质颗粒与凝胶颗粒的理化特性,阐述多种输送体系的作用机理和应用领域,提出针对功能因子易氧化、稳定性差和生物利用率低等问题,应建立靶向运送体系,改善功能因子,实现体内的靶向作用位点控制释放。

关键词：功能因子运载体系靶向运送缓控释放

A skillful method for precipitation prediction over eastern China

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2022年第1期15卷 27-34页

作者： yanyan huang Huijun Wang Peiyi Zhang Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of EducationNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina Nansen−Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Climate change research center Chinese academy of SciencesBeijingChina

Precipitation prediction is essential for disaster prevention,yet it still remains a challenging issue in weather and climate *** paper proposes an effective prediction method for summer precipitation over eastern China(PEC) by combining empirical orthogonal function(EOF) analysis with the interannual increment *** statistical prediction models are individually developed for respective predictions of the three principal components(PCs) corresponding to the three leading EOF modes for the interannual increment of PEC(hereafter DY;EC).Each model is run for the month of March with two previous predictors derived from sea-ice concentration/soil moisture/sea surface temperature/snow depth/sea level pressure over specific *** predicted PCs are projected to the EOF modes derived from observations of DY;EC to produce a new DY;*** new DY;EC is then added to the observed PEC of the previous year to obtain the final predicted *** spatial features of the predicted PEC are highly consistent with observations,with the anomaly correlation coefficient skill ranging from 0.32 to 0.64 during *** method is applied for real-time prediction of PEC in *** the results indicate two rain belts located over northeastern China and the Yangtze-Huaihe River valley,respectively,although the chance for the occurrence of a "super" mei-yu with a similar intensity to that in 2020 would be rare in 2021.

关键词： Precipitation prediction Interannual increment approach EOF

植物Phytocyanin蛋白家族研究进展

在线全文

学校读者我要写书评

暂无评论

植物科学学报 2024年第5期42卷 644-653页

作者：贾雁茹靳雨璠焦元周映旭石杨陈稷陈雅妮黄衍焱黄进成都理工大学生态环境学院成都610059 四川农业大学农学院成都611130 四川农业大学西南作物基因资源发掘与利用国家重点实验室成都611130

质体蓝素(Phytocyanin,PC)是植物特有的一类Ⅰ型小分子蓝铜蛋白,可在植物生长发育及应对逆境胁迫过程中发挥调控作用。但目前对PC蛋白的功能研究较为有限,其分子作用机制尚不清楚。本文综述了PC蛋白的结构特征、分类及其基因的表达模式... 详细信息

质体蓝素(Phytocyanin,PC)是植物特有的一类Ⅰ型小分子蓝铜蛋白,可在植物生长发育及应对逆境胁迫过程中发挥调控作用。但目前对PC蛋白的功能研究较为有限,其分子作用机制尚不清楚。本文综述了PC蛋白的结构特征、分类及其基因的表达模式,并对近年来PC蛋白调控植物生长发育、应对生物及非生物胁迫方面的研究进展进行了总结。此外,对未来研究方向及面临的挑战进行了讨论,旨在为进一步理解PC蛋白的分子作用机制及植物抗逆品种的选育提供参考。

关键词：质体蓝素基因功能分子机制逆境胁迫

水稻Pik位点五个等位基因特异分子标记的开发及应用

在线全文

学校读者我要写书评

暂无评论

植物病理学报 2024年第3期54卷 571-581页

作者：杨好黄衍焱易春霖谭楮湉任文芮黄富石军李小艳王文明四川农业大学西南作物基因资源发掘与利用国家重点实验室成都611130 四川农业大学农学院成都611130 绵阳市农业科学研究院/厅市共建作物特色资源创制及应用四川省重点实验室绵阳621023 内江市农业科学研究院农业新技术研究所内江641000

由于绝大多数水稻亲本的稻瘟病抗性基因组成不清楚,等位基因间的高度同源,导致分子标记辅助选择技术在水稻抗病育种中的应用受到限制。本研究首先分析了稻瘟病抗性基因Pik位点11个等位基因编码区的核苷酸序列,筛选出Pikp-1、Pikh-1、Pi... 详细信息

由于绝大多数水稻亲本的稻瘟病抗性基因组成不清楚,等位基因间的高度同源,导致分子标记辅助选择技术在水稻抗病育种中的应用受到限制。本研究首先分析了稻瘟病抗性基因Pik位点11个等位基因编码区的核苷酸序列,筛选出Pikp-1、Pikh-1、Pik-1、Pikm-1和Pi1-1特异的多态性位点,再与水稻资源中心(Rice Resource Center)中155个水稻基因组进行比对分析,在序列特异性最强的位置设计引物,成功地为这5个等位基因开发出了特性的分子标记。以24个抗稻瘟病单基因系为对照,应用这些分子标记,明确了109个水稻亲本中含有Pik-1、Pikh-1、Pikp-1、Pi1-1和Pikm-1基因的材料分别有0、1、5、14和20个。对‘绵恢365’中的Pi1基因测序,验证了分子标记的有效性及准确性。本研究为Pik位点在水稻抗稻瘟病育种中的应用提供了明确的亲本资源和可靠的分子标记。

关键词：水稻稻瘟病 Pik基因位点等位基因分子标记

Problems and Solutions of China’s Real Estate Market Based on International Comparison

在线全文

学校读者我要写书评

暂无评论

China Finance and Economic Review 2018年第4期7卷 3-26页

作者： Kesha Guo yanyan huang Academy of Economic Development and Reform Huaqiao UniversityChina

On the basis of determining the international comparison method and framework of the real estate market, this paper makes a comparative analysis on the development of China’s real estate market and those of some comparable countries (or regions). The prominent problem of the real estate market in our country is the rapid rise of urban house price and the high ratio of house price to income. The direct reason is that the social funds, especially the excessive credit funds flow into the real estate market. The indirect reason is that the land supply mode makes the land price increase too fast and account for high proportion in house price, which leads to the result that the development of real estate industry is beyond the stage of economic development. These problems are not isolated, but related to each other. The rapid rise of house prices in most of the cities, especially in the first-tier cities, is the comprehensive reflection of a large amount of credit funds promoting and the drawbacks of the land supply system in essence. The main ideas to solve the problem are correctly understanding the status, role and influence of the real estate market, stabilizing and improving the short-term control policy of the real estate market, and accelerating the establishment of a long-term mechanism for the healthy development of the real estate market.

关键词： real estate market international comparison ratio of housing price to income long-term mechanism