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Copper-based nanomaterials as peroxidase candidates for intelligent colorimetric detection and antibacterial applications

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Particuology 2024年第1期84卷 126-135页

作者： yanyan huang Huimin Zhong Cong Jiang Jiahui Yang Jingwen Zhang Fei Zhao Chaoqun Liu College of Light Industry and Food Engineering Nanjing Forestry UniversityNanjing210037China College of Pharmacy Institutes of Environment and MedicineHenan UniversityKaifeng475004China

With natural polyphenol compound tannic acid(TA)as the ingredient,copper tannate(CuTA)nanolayer material was formed by self-assembly under the conditions of heating and copper *** ion and tannic acid could coordinate to form Cu-O-C structure which was similar to the Fe-N-C structure of natural heme *** addition,the obtained CuTA nanomaterial possessed excellent peroxidase-like catalytic activity and *** on this excellent enzymatic activity,CuTA nanomaterials could be used for colorimetric detection of hydrogen peroxide with a smartphone and decomposition of organic *** on the structural characteristics and catalytic activity,the copper tannate nanozymes could also serve as potential antibacterial reagents to effectively inhibit the growth of gram-negative and positive bacteria in a low hydrogen peroxide *** work may promote the exploration of novel peroxidase mimetics and broaden the applications of nanozymes.

关键词： Nanozyme Colorimetric detection Smartphone Antibacteria

Facilitated Prediction of Micropollutant Degradation via UV-AOPs in Various Waters by Combining Model Simulation and Portable Measurement

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Engineering 2024年第6期37卷 87-95页

作者： yanyan huang Mengkai Li Zhe Sun Wentao Li James R.Bolton Zhimin Qiang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Civil and Environmental Engineering University of AlbertaEdmontonAB T6G 1H9Canada State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

The degradation of micropollutants in water via ultraviolet(UV)-based advanced oxidation processes(AOPs)is strongly dependent on the water *** reactive radicals(RRs)formed in UV-AOPs have different reaction selectivities toward water matrices and degradation efficiencies for target ***,process selection and optimization are *** study developed a facilitated prediction method for the photon fluence-based rate constant for micropollutant degradation(K′_(p,MP))in various UV-AOPs by combining model simulation with portable *** methods for measuring the scavenging capacities of the principal RRs(RRSCs)involved in UV-AOPs(i.e.,HO^(·),SO_(4)^(·-),and Cl^(·))using a mini-fluidic photoreaction system were *** simulation models consisted of photochemical,quantitative structure–activity relationship,and radical concentration steady-state approximation *** RRSCs were determined in eight test waters,and a higher RRSC was found to be associated with a more complex water ***,by taking sulfamethazine,caffeine,and carbamazepine as model micropollutants,the k′_(p,MP) values in various UV-AOPs were predicted and further verified experimentally.A lower k′_(p,MP) was found to be associated with a higher RRSC for a stronger RR competition;for example,k′_(p,MP) values of 130.9 and 332.5 m^(2) einstein^(–1),respectively,were obtained for carbamazepine degradation by UV/H_(2)O_(2) in the raw water(RRSC=9.47×10^(4) s^(-1))and sand-filtered effluent(RRSC=2.87×10^(4) s^(-1))of a drinking water treatment *** developed method facilitates process selection and optimization for UV-AOPs,which is essential for increasing the efficiency and cost-effectiveness of water treatment.

关键词： UV-AOPs Micropollutant degradation Reactive radicals Water matrix Model simulation

Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 707-721页

作者： Binlong Chen Yanzhong Zhao Zichang Lin Jiahao Liang Jialong Fan yanyan huang Leye He Bin Liu Health Management Center The Third Xiangya HospitalCentral South UniversityChangsha410013China Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha410013China Department of Laboratory Medicine The Third Xiangya HospitalCentral South UniversityChangsha410013China College of Biology Hunan UniversityChangsha410082China

Due to the non-targeted release and low solubility of anti-gastric cancer agent,apatinib(Apa),a first-line drug with long-term usage in a high dosage often induces multi-drug resistance and causes serious side *** order to avoid these drawbacks,lipid-film-coated Prussian blue nanoparticles(PB NPs)with hyaluronan(HA)modification was used for Apa loading to improve its solubility and targeting ***,anti-tumor compound of gamabufotalin(CS-6)was selected as a partner of Apawith reducing dosage for combinational gastric ***,HA-Apa-Lip@PB-CS-6 NPs were constructed to synchronously transport the two drugs into tumor *** vitro assay indicated that HA-Apa-Lip@PB-CS-6 NPs can synergistically inhibit proliferation and invasion/metastasis of BGC-823 cells via downregulating vascular endothelial growth factor receptor(VEGFR)and matrix metalloproteinase-9(MMP-9).In vivo assay demonstrated strongest anti-tumor growth and liver metastasis of HA-Apa-Lip@PB-CS-6 NPs administration in BGC-823 cells-bearing mice compared with other groups due to the excellent penetration in tumor tissues and outstanding synergistic *** summary,we have successfully developed a new nanocomplexes for synchronous Apa/CS-6 delivery and synergistic gastric cancer(GC)therapy.

关键词： Apatinib Gamabufotalin Lipid/Prussian blue nanoparticles Gastric cancer

Development of Mg-Al LDH and LDO as novel protective materials for deacidification of paper-based relics

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Chinese Chemical Letters 2024年第9期35卷 475-480页

作者： Sinong Wang Shanshan Jin Xue Yang yanyan huang Peng Liu Yi Tang Yuliang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai 200433China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Centre of Chemistry for Energy MaterialsFudan UniversityShanghai 200433China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Key Laboratory of Pulp and Paper Science&Technology of Ministry of Education Qilu University of Technology(Shandong Academy of Sciences)Ji’nan 250353China

Acidification of paper-based relics is a common problem,leading to their degradation and eventual *** deacidification is highly dependent on a limited variety of alkaline materials,and the development of new materials that are safe,efficient and easy-to-prepare is highly demanded to ensure a high level of safety and effective protection of paper-based *** study proposes the introduction of layered double hydroxide(LDH)and its calcined product,mixed metal oxide(layered double oxide(LDO)),as innovative protective materials for the deacidification of paper with varying levels of *** results demonstrate that treatment with Mg-Al LDH/LDO can effectively modify the p H of acidic paper(e.g.,pH~4.0–6.4)to a neutral or weakly basic state,maintaining this desirable p H range even under long-term accelerated aging ***,LDH proves to be well-suited for the protection of slightly acidified paper(e.g.,pH>5.5),while LDO serves as an especially option for the deacidification of severely acidified paper(e.g.,pH≤5.5).During aqueous deacidification,due to the memory effect of the LDH-based materials,LDO is converted to rehydrated LDH,which creates a mild and appropriate alkaline retention in the paper,avoiding damage caused by strong alkalinity such as cellulose degradation and pigment fading during subsequent long-term natural preservation of the ***,Mg-Al LDH/LDO materials also exhibit flame-retardant and bacteriostatic *** opens up opportunities for the safe,efficient and multifunctional protection of acidified paper-based relics.

关键词： Layered double hydroxide Layered double oxide Structural memory effect Paper protection Deacidification

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中国南方冬季最低温延伸期预报方法尝试

地球物理学报 2024年第6期67卷 2096-2109页

作者：戴金黄艳艳钱伊恬南京信息工程大学气象灾害教育部重点实验室/气候与环境变化国际合作联合实验室/气象灾害预报预警与评估协同创新中心南京210044 南方海洋科学与工程广东省实验室(珠海) 广东珠海519080

未来10~30天的延伸期预报一直是当前的难点问题.本文针对对极端低温事件异常敏感的中国南方地区,构建了预报时效为25天的冬季最低温的有效延伸期预报模型.利用1979/1980—2019/2020年冬季日平均再分析资料,本文研究发现,在季节内尺度,... 详细信息

未来10~30天的延伸期预报一直是当前的难点问题.本文针对对极端低温事件异常敏感的中国南方地区,构建了预报时效为25天的冬季最低温的有效延伸期预报模型.利用1979/1980—2019/2020年冬季日平均再分析资料,本文研究发现,在季节内尺度,相比于原始变量,利用当候值减去其5候前值的增量方法可以放大和延长预测信号.中国南方地区的土壤温度和平流层50 hPa位势高度作为影响南方冬季最低温的关键因子,它们通过影响西伯利亚地区环流异常、北大西洋涛动以及欧亚遥相关型,对中国南方冬季最低温进行调制.由于两个增量形式的关键因子具有50天的准周期性,存在超前5候的显著自相关,超前5候增量形式的土壤温度和平流层极涡异常可以有效预报我国南方最低温增量.将预报的最低温增量,加上5候前的观测,得到的独立试报时段(2009/2010—2019/2020年冬季)的最低温与观测的时间相关系数为0.45,极端低温日命中率为57%.本研究使用的增量方法可以为当前极端天气事件的延伸期预报提供新思路.

关键词：冬季最低温增量方法延伸期预报

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基于势场增强烟花算法的二维全局路径规划

兵工学报 2024年第10期45卷 3499-3518页

作者：孙鹏耀黄炎焱王凯生南京理工大学自动化学院江苏南京210094

高质量路径是未来无人自主作战的重要前提,针对复杂障碍环境下路径规划问题,提出基于势场增强烟花算法(Potential-field Enhanced Fireworks Algorithm,PEFWA)的路径规划方法。建立规划空间模型与动态维数路径描述模型,设立包含可行性... 详细信息

高质量路径是未来无人自主作战的重要前提,针对复杂障碍环境下路径规划问题,提出基于势场增强烟花算法(Potential-field Enhanced Fireworks Algorithm,PEFWA)的路径规划方法。建立规划空间模型与动态维数路径描述模型,设立包含可行性因素与长度因素的目标函数,将路径规划问题转化为最优化问题;设计动态维数烟花初始化与维度增删操作,使相邻维度个体满足距离约束;提出基于障碍空间信息的爆炸幅度计算方法和连续维度选择方法,生成改进爆炸火花,提高全局搜索能力;引入势场引导策略,生成势场增强爆炸火花,让所选维度在合力方向上多次搜索,提高局部优化能力;采用交叉组合策略生成变异火花,并对超出规划空间的维度个体进行删减操作,提高多样性烟花高效产生能力;提出基于余弦相似度的双层锦标赛选择策略,提高烟花特征延续能力。采用相同基准函数,将PEFWA与烟花算法(Fireworks Algorithm,FWA)、粒子群优化(Particle Swarm Optimization,PSO)算法、遗传算法(Genetic Algorithm,GA)进行对比。研究结果表明:PEFWA的优化性能更强;在相同复杂障碍环境下进行多次路径规划仿真实验,验证了PEFWA中各个模块的有效性,与PSO算法、GA、A*算法相比,PEFWA在规划成功率、路径长度、路径光滑度、结果鲁棒性等方面均有优势;PEFWA在二维全局路径规划问题上具有有效性与优越性。

关键词：全局路径规划烟花算法势函数动态维数交叉组合

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基于深度Q网络的无人车侦察路径规划

系统工程与电子技术 2024年第9期46卷 3070-3081页

作者：夏雨奇黄炎焱陈恰南京理工大学自动化学院江苏南京210094

在城市战场环境下,无人侦察车有助于指挥部更好地了解目标地区情况,提升决策准确性,降低军事行动的威胁。目前,无人侦察车多采用阿克曼转向结构,传统算法规划的路径不符合无人侦察车的运动学模型。对此,将自行车运动模型和深度Q网络相结... 详细信息

在城市战场环境下,无人侦察车有助于指挥部更好地了解目标地区情况,提升决策准确性,降低军事行动的威胁。目前,无人侦察车多采用阿克曼转向结构,传统算法规划的路径不符合无人侦察车的运动学模型。对此,将自行车运动模型和深度Q网络相结合,通过端到端的方式生成无人侦察车的运动轨迹。针对深度Q网络学习速度慢、泛化能力差的问题,根据神经网络的训练特点提出基于经验分类的深度Q网络,并提出具有一定泛化能力的状态空间。仿真实验结果表明,相较于传统路径规划算法,所提算法规划出的路径更符合无人侦察车的运动轨迹并提升无人侦察车的学习效率和泛化能力。

关键词：深度强化学习无人侦察车路径规划深度Q网络

开封地区砂岩孔隙热储回灌化学堵塞数值模拟研究

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太阳能学报 2024年第2期45卷 225-235页

作者：黄艳艳那金雷宏武长江大学资源与环境学院武汉430100 岩土力学和工程国家重点实验室中国科学院武汉岩土力学研究所武汉430071

以开封圳宇花园的地热开发过程为研究对象,利用TOUGHREACT程序构建三维砂岩孔隙热储层的温度场-化学场-渗流场多场耦合模型,并对主要影响因素进行敏感性分析,探究地热回灌过程对热储层化学堵塞过程的影响。热储层中方解石、石英、伊利... 详细信息

以开封圳宇花园的地热开发过程为研究对象,利用TOUGHREACT程序构建三维砂岩孔隙热储层的温度场-化学场-渗流场多场耦合模型,并对主要影响因素进行敏感性分析,探究地热回灌过程对热储层化学堵塞过程的影响。热储层中方解石、石英、伊利石、钙-蒙脱石、二氧化硅矿物沉淀,钾长石、钠长石和白云石矿物溶解,其中方解石矿物为主要沉淀矿物,堵塞回灌井热储层,导致孔隙度降低约10%。回灌过程中回灌水注入流速、温度、井间距的改变影响地热水回灌过程中方解石沉淀,从而导致热储层孔隙度变化。

关键词：地热井方解石孔隙度化学堵塞 THC耦合 TOUGHREACT程序

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超网络体系作战下的打击目标优选模型

系统工程与电子技术 2024年第1期46卷 182-189页

作者：高泽伦郑少秋梁汝鹏黄炎焱南京理工大学自动化学院江苏南京210094 中国电子科技集团第二十八研究所江苏南京210007

针对当前进行海上作战体系目标优选分析与决策时对打击代价考虑不足的问题,提出综合考虑目标节点重要度和打击费效度的网络节点分析模型。利用超网络构建海上作战体系网络模型,通过度和介数等指标评估网络中节点的重要度;利用打击费效... 详细信息

针对当前进行海上作战体系目标优选分析与决策时对打击代价考虑不足的问题,提出综合考虑目标节点重要度和打击费效度的网络节点分析模型。利用超网络构建海上作战体系网络模型,通过度和介数等指标评估网络中节点的重要度;利用打击费效比为指标评估网络中节点的打击代价,进而将目标分析与选择问题转化为多目标优化问题,建立寻优模型,并通过人工鱼群算法进行寻优求解。最后对模型进行案例仿真应用,通过专家Delphi法评估检验,结果表明所建立的模型方法可行,对水面舰队体系的目标分析与选择具有借鉴作用。

关键词：目标选择超网络打击代价人工鱼群算法多目标优化