A core-shell structural composite was synthesized with lithium terephthalate（Li2C8H4O4） coated on spinel Li4Ti5O12（LTO）. The composite displays a capacity of about 200 mA h g-1and a good rate capability with two c...
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A core-shell structural composite was synthesized with lithium terephthalate（Li2C8H4O4） coated on spinel Li4Ti5O12（LTO）. The composite displays a capacity of about 200 mA h g-1and a good rate capability with two charge/discharge platforms at ~ 1.55 and ~ 0.8 V. The excellent cycling performance of the composite is attributed to the successful combination of high cycling stability of LTO and high specific capacity of Li2C8H4O4. In addition, an interesting phenomena is observed for the first time for this composite which is that lithium ions transfer between LTO and Li2C8H4O4at a fast speed. This is investigated in details via the asymmetric charge/discharge measurement and cyclic voltammogram（CV）.The LTO/Li2C8H4O4composite may have potential applications to be used as an anode material for the electric vehicle batteries, which is shallowly charged/discharged at ordinary times using the charge/discharge platform of LTO and fully charged/discharged at emergency to release the extra high capacity from Li2C8H4O4.
The specific interaction between sense and antisense peptides was studied by high-performance affinity chromatography (HPAC) and quartz crystal microbalance (QCM) biosensor. Fragment 1-14 of human interferon-β (hIFN-...
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The specific interaction between sense and antisense peptides was studied by high-performance affinity chromatography (HPAC) and quartz crystal microbalance (QCM) biosensor. Fragment 1-14 of human interferon-β (hIFN-β) was chosen as sense peptide and its three antisense peptides (AS-IFN 1, AS-IFN 2, and AS-IFN 3) were designed according to the degeneracy of genetic codes. The affinity column was prepared with sense peptide as ligand and the affinity chromatographic behavior was evaluated. Glu-substituted antisense peptide (AS-IFN 3) showed the strongest binding to immobilized sense peptide at pH 7.5. A quartz crystal microbalance-flow injection analysis (QCM-FIA) system was introduced to investigate the recognition process in real-time. The equilibrium dissociation constants between sense peptide and AS-IFN 1, AS-IFN 2 and AS-IFN 3 measured 2.08×10-4, 1.31×10-4 and 2.22× 10-5 mol/L, respectively. The mechanism study indicated that the specific recognition between sense peptide and AS-IFN 3 was due to sequence-dependent and multi-modal affinity interaction.
The interaction of nanoparticles with proteins is extremely complex, important for understanding the biological properties of nanomaterials, but is very poorly understood. We have employed a combinatorial library of s...
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The interaction of nanoparticles with proteins is extremely complex, important for understanding the biological properties of nanomaterials, but is very poorly understood. We have employed a combinatorial library of surface modified gold nanoparticles to interrogate the relationships between the nanoparticle surface chemistry and the specific and nonspecific binding to a common, important, and representative enzyme, acetylcholinesterase （ACHE）. We also used Bayesian neural networks to generate robust quantitative structure-property relationship （QSPR） models relating the nanoparticle surface to the AChE binding that also provided significant understanding into the molecular basis for these interactions. The results illustrate the insights that result from a synergistic blending of experimental combinatorial synthesis and biological testing of nanoparticles with quantitative computational methods and molecular modeling.
HYD-PEP06,an endostatin-modified polypeptide,has been shown to produce effective anticolorectal carcinoma effects through inhibiting epithelial-mesenchymal transition(EMT).However,whether HYD-PEP06 has similar suppres...
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HYD-PEP06,an endostatin-modified polypeptide,has been shown to produce effective anticolorectal carcinoma effects through inhibiting epithelial-mesenchymal transition(EMT).However,whether HYD-PEP06 has similar suppressive effect on hepatocellular carcinoma(HCC) remained *** this study,HYD-PEP06 inhibited metastasis and EMT but not proliferation in *** finder pathway reporter array and Western blot analysis revealed that HYD-PEP06 suppressed HCCLM3 cell metastasis and EMT by inhibiting the PI3 K/AKT ***,HYD-PEP06 exerted antimetastasis effects in HepG2 cancer stem-like cells(CSCs) via suppressing the WNT/β-catenin signaling ***,in HCCLM3 tumor-bearing BALB/c nu/nu nude mice,HYD-PEP06 substantially suppressed tumor growth,lung metastasis and HCC *** results suggest that HYD-PEP06 inhibits the metastasis and EMT of HCC and CSCs as well,and thus has the potential as an agent for HCC treatment.
Enzymatic hydrolysis has been widely used to produce bioactive hydrolysates from sea cucumber body ***,inspired by the clarification of Apostichopus japonicus genome,we investigated the enzymatic hydrolysis of sea cuc...
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Enzymatic hydrolysis has been widely used to produce bioactive hydrolysates from sea cucumber body ***,inspired by the clarification of Apostichopus japonicus genome,we investigated the enzymatic hydrolysis of sea cucumber body wall by using the omics *** proteins,including major yolk proteins,collagens,extracellular matrix glycoproteins and muscle proteins,were released from the body wall by different hydrolysis condition.A portfolio of 216 shared peptides were detected in the peptidome by papain with different hydrolysis time,while 32 shared peptides were detected in the peptidome by differing *** peptides and the relative abundance distribution profiles of shared peptides changed depending on hydrolysis approaches,indicating dynamic changes of peptidome during ***,release of sulfated fucan and fucosylated chondroitin sulfate changed with the hydrolysis *** monitoring of dynamic enzymatic hydrolysis process at a molecular scale would contribute to production and quality control of sea cucumber hydrolysates.
Aqueous rechargeable batteries are the promising energy storge technology due to their safety,low cost,and environmental *** ion(NH_(4)^(+))is an ideal charge carrier for such batteries because of its small hydration ...
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Aqueous rechargeable batteries are the promising energy storge technology due to their safety,low cost,and environmental *** ion(NH_(4)^(+))is an ideal charge carrier for such batteries because of its small hydration radius and low molar *** this study,VO_(2)·xH_(2)O with rich oxygen defects(d-HVO)is designed and synthesized,and it exhibits unique nanoarray structure and good electrochemical performances for NH_(4)^(+)*** and calculation results indicate that oxygen defects in d-HVO can enhance the conductivity and diffusion rate of NH_(4)^(+),leading to improved electrochemical *** most significant improvement is observed in d-HVO with 2 mmol thiourea(d-HVO-2)(220 mAh·g^(-1) at 0.1 A·g^(-1)),which has a moderate defect content.A full cell is assembled using d-HVO-2 as the anode and polyaniline(PANI)as the cathode,which shows excellent cycling stability with a capacity retention rate of 80%after 1000 cycles and outstanding power density up to 4540 W·kg^(-1).Moreover,the flexible d-HVO-2||PANI battery,based on quasi-solid electrolyte,shows excellent flexibility under different bending *** study provides a new approach for designing and developing high-performance NH_(4)^(+)storage electrode materials.
The dissociation of water is the rate-determining step of several energy-relating reactions due to high energy barrier in homolysis of H-O ***,engineering vacancy-atom ensembles via injecting oxygen vacancy(V O)into s...
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The dissociation of water is the rate-determining step of several energy-relating reactions due to high energy barrier in homolysis of H-O ***,engineering vacancy-atom ensembles via injecting oxygen vacancy(V O)into single facet-exposed TiO_(2)-Pd catalyst to form V_(O)-Pd ensemble is proposed and *** outstanding activity of as-prepared catalyst,1.5-PdTV_(O),toward water dissociation is established with a turnover frequency of 240 min^(−1) in ammonia borane hydrolysis at 298 *** functional theory simulation suggests that the V_(O)-Pd ensemble is responsible for the high intrinsic catalytic *** molecules tend to be dissociated on V_(O) sites and ammonia borane molecules on Pd *** H atoms from water dissociation on V_(O) combine with H atoms from ammonia borane on Pd atoms to generate H_(2).This insights into engineering vacancy-atom ensembles catalysis provide a new avenue to design catalytic materials for important energy chemical reactions.
Rechargeable aqueous zinc-ion batteries(ZIBs)are regarded as a promising competition to lithium-ion batteries as energy storage devices,owing to their high safety and low ***,the development of high-performance ZIBs i...
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Rechargeable aqueous zinc-ion batteries(ZIBs)are regarded as a promising competition to lithium-ion batteries as energy storage devices,owing to their high safety and low ***,the development of high-performance ZIBs is largely hindered by the shortage of ideal cathode materials with high-rate capability and long-cycle ***,we address this bottleneck issue by the quenching-tailored surface chemistry of V_(2)O_(5) cathode *** rapid quenching from high temperatures,Al ions are doped into V_(2)O_(5) lattice(Al-V_(2)O_(5))and abundant oxygen vacancies are formed on the surface/nearsurface,which facilitate the desired rapid electron *** density functional theory(DFT)simulations elucidate that the doping of Al ions into V_(2)O_(5) remarkably reduces the Zn^(2+)-diffusion barriers and improves the electrical conductivity of V_(2)O_(5).As a proof-of-concept application,the thus-optimized AlV_(2)O_(5) cathode delivers a superior specific capacity of 532 m Ah g^(-1) at 0.1 A g^(-1) and a long-cycling life with76%capacity retention after 5000 cycles,as well as a good rate *** work provides not only a novel strategy for tuning the surface chemistry of V_(2)O_(5) to boost the Zn^(2+)storage but also a general pathway of modifying metal oxides with improved electrochemical performance.
Natural fish scales demonstrate outstanding mechanical efficiency owing to their elaborate architectures and thereby may serve as ideal prototypes for the architectural design of man-made *** bioinspired magnesium com...
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Natural fish scales demonstrate outstanding mechanical efficiency owing to their elaborate architectures and thereby may serve as ideal prototypes for the architectural design of man-made *** bioinspired magnesium composites with fish-scale-like orthogonal plywood and double-Bouligand architectures were developed by pressureless infiltration of a magnesium melt into the woven contextures of continuous titanium *** composites exhibit enhanced strength and work-hardening ability compared to those estimated from a simple mixture of their constituents at ambient to elevated *** particular,the double-Bouligand architecture can effectively deflect cracking paths,alleviate strain localization,and adaptively reorient titanium fibers within the magnesium matrix during the deformation of the composite,representing a successful implementation of the property-optimizing mechanisms in fish *** strength of the composites,specifically the effect of their bioinspired architectures,was interpreted based on the adaptation of classical laminate *** study may offer a feasible approach for developing new bioinspired metal-matrix composites with improved performance and provide theoretical guidance for their architectural designs.
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