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Local coordination and electronic interactions of Pd/MXene via dual‐atom codoping with superior durability for efficient electrocatalytic ethanol oxidation

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Carbon Energy 2024年第8期6卷 166-177页

作者： Zhangxin chen Fan Jing Minghui Luo Xiaohui Wu Haichang Fu Shengwei Xiao Binbin Yu Dan chen Xianqiang Xiong yanxian Jin School of Pharmaceutical and Chemical Engineering Taizhou UniversityTaizhouZhejiangChina School of Sciences Zhejiang Sci‐Tech UniversityHangzhouZhejiangChina

Catalyst design relies heavily on electronic metal‐support interactions,but the metal‐support interface with an uncontrollable electronic or coordination environment makes it ***,we outline a promising approach for the rational design of catalysts involving heteroatoms as anchors for Pd nanoparticles for ethanol oxidation reaction(EOR)*** doped B and N atoms from dimethylamine borane(DB)occupy the position of the Ti_(3)C_(2)lattice to anchor the supported Pd *** electrons transfer from the support to B atoms,and then to the metal Pd to form a stable electronic center.A strong electronic interaction can be produced and the d‐band center can be shifted down,driving Pd into the dominant metallic state and making Pd nanoparticles deposit uniformly on the ***‐obtained Pd/DB–Ti_(3)C_(2)exhibits superior durability to its counterpart(∼14.6%retention)with 91.1%retention after 2000 cycles,placing it among the top single metal anodic ***,in situ Raman and density functional theory computations confirm that Pd/DB–Ti_(3)C_(2)is capable of dehydrogenating ethanol at low reaction energies.

关键词： durability electronic interactions ethanol oxidation heteroatom codoping Pd/MXene

An update of the Guangzhou Twin Eye Study

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Annals of Eye Science 2018年第1期3卷 258-262页

作者： Xiaohu Ding yanxian chen Mingguang He State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Shenzhen Key Laboratory of Ophthalmology Shenzhen Eye HospitalJinan UniversityShenzhen 518040China Centre for Eye Research Australia MelbourneAustralia Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneAustralia

The Guangzhou Twin Eye Study(GTES)is a population-based study of young twins residing in Guangzhou *** major aim of GTES is to explore the impact of genes,environmental factors and gene-environment interactions on common eye *** 2006,for more than 1,300 twin pairs,age 7-26 years old,progressive ocular phenotypes,such as refraction,ocular biometrics,weight,and height were collected annually,while non-progressive phenotypes such as parental refraction,corneal thickness,retinal fundus,intraocular pressure and DNA only collected at *** the current study,we summarize the major findings on the etiology of myopia in recent decades.

关键词： Twin study gene environment myopia prediction

Instantaneous preparation of gold-carbon dot nanocomposites for on-site SERS identification of pathogens in diverse interfaces

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Photonics Research 2024年第6期12卷 1303-1312页

作者： yanxian GUO YE LIU CHAOCAI LUO YUE ZHANG YANG LI FEI ZHOU ZHOUYI GUO ZHENGFEI ZHUANG ZHIMING LIU School of Electronic Engineering and Intelligentization Dongguan University of TechnologyDongguan 523808China Department of Physics University of Science and Technology of ChinaHefei 230026China MOE Key Laboratory of Laser Life Science&Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Rapid detection of pathogens present on contaminated surfaces is crucial for food safety and public health due to the high morbidity and mortality of bacterial ***,a sensitive and efficient method for on-site identification of foodborne pathogens on anisotropic surfaces was developed by using an in situ instantaneously prepared surface-enhanced Raman scattering(SERS)*** achieve this,molybdenum-doped gallic acidderived carbon dots(MCDs)are utilized as the reductant for synthesizing Au@MCDs nanohybrids within just 3 s at ambient *** synergistic effect of the electromagnetic enhancement and charge transfer of Au@MCDs enables excellent SERS performance 10 times stronger than bare Au *** bioassay platform requires less than 5 min to complete the quantitative detection of foodborne pathogens on various microbial-contaminated interfaces with a sensitivity of 10 CFU/m *** innovative strategy breaks the long-standing limitations of SERS substrates in practical use,such as the time-consuming process,interference of residual surfactants,poor surface stability,and few application scenarios,providing a promising tool for widespread applications in biomedical research and clinical diagnostics.

关键词： temperature molybdenum consuming

有创和无创序贯机械通气治疗肺结核并严重呼吸衰竭的临床疗效对比

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齐齐哈尔医学院学报 2017年第4期38卷 420-422页

作者：陈廷宪阳江市公共卫生医院广东529500

目的探讨有创和无创序贯机械通气治疗肺结核并严重呼吸衰竭的临床疗效。方法选择我院2014年1月至2016年1月收治的46例肺结核并严重呼吸衰竭患者实施有创机械通气,当肺部感染基本控制时,随机分为两组,每组23例。对照组患者继续行同步间... 详细信息

目的探讨有创和无创序贯机械通气治疗肺结核并严重呼吸衰竭的临床疗效。方法选择我院2014年1月至2016年1月收治的46例肺结核并严重呼吸衰竭患者实施有创机械通气,当肺部感染基本控制时,随机分为两组,每组23例。对照组患者继续行同步间歇指令通气加压力支持通气,观察组患者改无创序贯机械通气治疗。观察两组患者治疗效果,并就两组患者脱机时间进行对比。结果观察组和对照组患者治疗总有效率分别为95.65%、69.57%,两组比较差异有统计学意义(P<0.05)。观察组患者脱机时间(4.2±1.2)d显著低于对照组(5.8±1.4)d,差异有统计学意义(P<0.05)。结论肺结核并严重呼吸衰竭实施有创机械通气,当肺部感染基本控制时,改无创序贯机械通气可以缩短机械通气时间,临床疗效较好,值得临床推广。

关键词：无创序贯机械通气肺结核呼吸衰竭脱机时间

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近视的预防和治疗：从研究证据到临床实践

中华眼视光学与视觉科学杂志 2017年第1期19卷 1-3页

作者：陈燕先何明光中山大学中山眼科中心眼科学国家重点实验室广州510060

近年来，近视患病率在世界范围内不断上升，儿童近视和高度近视逐渐成为影响国民健康的公共卫生问题。关于近视防治的研究不断取得新进展，但在有效性和适用人群上仍存在一定的争议。笔者对国内外重要的研究数据和结果进行了客观的总结... 详细信息

近年来，近视患病率在世界范围内不断上升，儿童近视和高度近视逐渐成为影响国民健康的公共卫生问题。关于近视防治的研究不断取得新进展，但在有效性和适用人群上仍存在一定的争议。笔者对国内外重要的研究数据和结果进行了客观的总结，并对近视防治进入临床实践的前景作出初步的评价。

关键词：儿童屈光不正近视防治述评

屈光门诊进行儿童近视眼控制应从证据到临床实践

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中华眼科杂志 2019年第2期55卷 89-92页

作者：杨晓陈燕先曾骏文何明光中山大学中山眼科中心眼科学国家重点实验室广州510060 暨南大学附属深圳眼科医院深圳眼科学重点实验室 518040

近年来国内外有关控制近视眼进展的方法研究取得了不少突破,但未能有效解决如何将研究成果转化为临床实践。很多专科医院均开设了屈光门诊,但除了给患者配戴眼镜进行矫正外,并没有更多有效的思路和方法,尤其在如何控制儿童近视眼进展这... 详细信息

近年来国内外有关控制近视眼进展的方法研究取得了不少突破,但未能有效解决如何将研究成果转化为临床实践。很多专科医院均开设了屈光门诊,但除了给患者配戴眼镜进行矫正外,并没有更多有效的思路和方法,尤其在如何控制儿童近视眼进展这一难题方面。为了让更多临床医师了解最新的研究证据,本文结合临床实践经验,对如何在屈光门诊开展近视眼防控进行分析,并提出建议。

关键词：近视阿托品眼药水接触镜儿童

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胆道阻塞对肝脏酶的组织化学变化的研究

解剖学杂志 1989年第2期12卷 83-87页

作者：熊希凯陈艳贤董大翠赵小明方善德同济医科大学解剖学教研室同济医院外科

结扎胆总管的情况下,阻塞上端胆管内压不断增高,当胆管内压达20～25cm水柱时,胆汁即逆流到体循环。本文分别在结扎胆总管后1、2、3、4周,观察肝脏酶的组织化学变化。随着结扎时间的延长,肝脏琥珀酸脱氧酶(SDH)、葡萄糖-6-磷酸酶(G-6-Pa... 详细信息

结扎胆总管的情况下,阻塞上端胆管内压不断增高,当胆管内压达20～25cm水柱时,胆汁即逆流到体循环。本文分别在结扎胆总管后1、2、3、4周,观察肝脏酶的组织化学变化。随着结扎时间的延长,肝脏琥珀酸脱氧酶(SDH)、葡萄糖-6-磷酸酶(G-6-Paso)、三磷酸腺苷酶(ATPase)的活性明显减弱,分别由强阳性变成可疑阳性,而酸性磷酸酶(ACP)、碱性磷酸酶(AKP)的活性明显增强,由阳性变成强阳性。实验结果提示胆道阻塞时间延长,肝脏酶的功能发生明显的紊乱。

关键词：胆道阻塞肝脏酶组织化学

Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang Fu Yanyan Lin Mingzhen Bai Jia Yao Chongfei Huang Long Gao Ningning Mi Haidong Ma Liang Tian Ping Yue Yong Zhang Jinduo zhang yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo Meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal *** study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by mass spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome maintenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids

不同户外活动干预方案对中国儿童近视患病率长期影响的模拟分析

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中华实验眼科杂志 2023年第12期41卷 1203-1207页

作者：陈燕先张健韩晓彤胡音王丽丽何明光香港理工大学中国香港999077 中山大学中山眼科中心、眼科学国家重点实验室、广东省眼科视觉科学重点实验室、广东省眼部疾病临床医学研究中心广州510060

目的评估3种不同户外活动干预方案对中国学龄儿童近视患病率的长期影响。方法以儿童屈光不正研究的横断面数据作为近视原始患病率,广州双生子眼病研究的10年纵向数据作为近视原始发病率,并基于广州户外活动纵向研究数据得出户外活动干... 详细信息

目的评估3种不同户外活动干预方案对中国学龄儿童近视患病率的长期影响。方法以儿童屈光不正研究的横断面数据作为近视原始患病率,广州双生子眼病研究的10年纵向数据作为近视原始发病率,并基于广州户外活动纵向研究数据得出户外活动干预的效应量。提出3种不同的干预方案,即对1~6年级儿童进行户外活动干预(方案a)、对1~3年级儿童进行户外活动干预(方案b)和对幼儿园最后1年至小学3年级儿童进行户外活动干预(方案c),不同干预方案中户外活动干预均指每日增加40 min的户外活动时间。模拟分析假设患病率随发病率下降和儿童就读年级的升高而递减,高度近视儿童的近视程度也随着近视发病的延迟而下降。结果随着干预时间的延长,儿童整体近视患病率有明显下降趋势,其中方案a实施5年后人群近视患病率由34.67%降至25.71%,实施10年后降至24.89%,平均每年下降0.98%;方案b和方案c对儿童近视患病率的长期影响相似,实施10年后近视患病率分别降至26.00%和26.20%,平均每年下降0.87%和0.85%。方案a带来的近视度数降幅最大,实施5年后原15岁高度近视人群的平均屈光度为-5.94 D,实施10年后为-5.88 D;其次为方案b,实施第5年和第10年的屈光度分别为-6.08 D和-6.02 D。结论对小学1~6年级儿童实施强化户外活动干预可能是降低近视高发地区人群总体患病率的较佳策略。

关键词：儿童近视患病率户外活动数据模拟