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The Journal of Biomedical Research 2024年第1期38卷 66-75页

作者： Mingfeng He Chanjuan Gong Yinan Chen Rongting Chen yanning qian Department of Anesthesiology and Perioperative Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The current study aimed to compare the effects between remimazolam and propofol on hemodynamic stability during the induction of general anesthesia in elderly patients.We used propofol at a rate of 60 mg/(kg·h)in the propofol group(group P)or remimazolam at a rate of 6 mg/(kg·h)in the remimazolam group(group R)for the induction.A processed electroencephalogram was used to determine whether the induction was successful and when to stop the infusion of the study drug.We measured when patients entered the operating room(T_(0)),when the induction was successful(T_(1)),and when before(T_(2))and 5 min after successful endotracheal intubation(T_(3)).We found that mean arterial pressure(MAP)was lower at T_(1–3),compared with T_(0) in both groups,but higher at T_(2) in the group R,whileΔMAP_(T0–T2) andΔMAP_(max) were smaller in the group R(ΔMAP_(T0–T2):the difference between MAP at time point T_(0) and T_(2),ΔMAP_(max):the difference between MAP at time point T_(0) and the lowest value from T_(0) to T_(3)).Cardiac index and stroke volume index did not differ between groups,whereas systemic vascular resistance index was higher at T_(1–3) in the group R.These findings show that remimazolam,compared with propofol,better maintains hemodynamic stability during the induction,which may be attributed to its ability to better maintain systemic vascular resistance levels.

关键词： remimazolam propofol elderly patients hypotension left ventricular systolic function systematic vascular resistance

Oxygenation,inflammatory response and lung injury during one lung ventilation in rabbits using inspired oxygen fraction of 0.6 vs.1.0

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The Journal of Biomedical Research 2017年第1期31卷 56-64页

作者： Zeping Xu Lianbing Gu Qingming Bian Pengyi Li Lijun Wang Jingyuan Zhang yanning qian Department of Anesthesiology FirstAffiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Departments of Anesthesiology Nanjing Medical UniversityNanjingJiangsu 210009China Pathology Jiangsu Cancer HospitalNanjing Medical UniversityNanjingJiangsu 210009China

Maintaining adequate oxygenation during one-lung ventilation（OLV） requires high inspired oxygen fraction（FiO_2）.However,high FiO_2 also causes inflammatory response and lung injury.Therefore,it remains a great interest to clinicians and scientists to optimize the care of patients undergoing OLV.The aim of this study was to determine and compare oxygenation,inflammatory response and lung injury during OLV in rabbits using FiO_2 of 0.6 vs.1.0.After 30 minutes of two-lung ventilation（TLV） as baseline,30 rabbits were randomly assigned to three groups receiving mechanical ventilation for 3 hours：the sham group,receiving TLV with 0.6 FiO_2;the 1.0 FiO_2 group,receiving OLV with 1.0 FiO_2;the 0.6 FiO_2 group,receiving OLV with 0.6 FiO_2.Pulse oximetry was continuously monitored and arterial blood gas analysis was intermittently conducted.Histopathologic study of lung tissues was performed and inflammatory cytokines and the mRNA and protein of nuclear factor kappa B（NF-κB） p65 were determined.Three of the 10 rabbits in the 0.6 FiO_2 group suffered hypoxemia,defined by pulse oximetric saturation（SpO_2） less than 90%.Partial pressure of oxygen（PaO_2）,acute lung injury（ALI） score,myeloperoxidase（MPO）,tumor necrosis factor-a（TNF-α）,interleukin-6（IL-6）,mRNA and protein of NF-kB p65 were lower in the 0.6 FiO_2group than in the 1.0 FiO_2 group.In conclusion,during OLV,if FiO_2 of 0.6 can be tolerated,lung injury associated with high FiO_2 can be minimized.Further study is needed to validate this finding in human subjects.

关键词： one-lung ventilation oxygen acute lung injury rabbits

ICP-MS法检测种植中药材中的无机溴化物含量

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保鲜与加工 2024年第1期24卷 58-63页

作者：武晓剑姜悦马艳宁辛振强殷红钱勇上海诗丹德标准技术服务有限公司上海201314 国家中药现代化工程技术研究中心中药标准分中心上海201314 宁波立华制药有限公司浙江宁波315174

为建立电感耦合等离子体质谱仪(ICP-MS)检测人工种植中药中无机溴化物的分析方法,根据溴的特性确认ICP-MS测量质量数并考察了中药样品的提取方式、提取溶剂、提取时间对无机溴化物测试结果的影响。结果表明,中药样品中无机溴化物适宜的... 详细信息

为建立电感耦合等离子体质谱仪(ICP-MS)检测人工种植中药中无机溴化物的分析方法,根据溴的特性确认ICP-MS测量质量数并考察了中药样品的提取方式、提取溶剂、提取时间对无机溴化物测试结果的影响。结果表明,中药样品中无机溴化物适宜的测试条件为:样品经粉碎后采用蒸馏水为提取溶剂超声提取溴化物,并用ICP-MS进行检测,内标法定量。此条件下无机溴化物质量浓度在0~0.20μg/mL范围内具有良好的线性(R2>0.999),加标回收率为109.9%~121.3%,相对标准偏差为1.8%(n=6),中间精密度为2.7%(n=12),方法检出限为1μg/g,定量限为2μg/g。该方法可用于中药无机溴化物的检测,其操作简单、灵敏度高。

关键词：中药无机溴化物电感耦合等离子体质谱仪检测

Comparisons of different methods of anesthesia and analgesia on the levels of glycometabolism rate-limiting enzymes in erythrocytes and plasma glucose and stress hormones in patients undergoing esophagus surgery

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Journal of Nanjing Medical University 2008年第6期22卷 382-386页

作者： Xiaokun Zhang Xiongxiong Pan Yinbin Pan Jie Sun yanning qian Department of Anesthesiology Drum Tower Hospital Medical Department of Nanjing University Nanjing 210008 Jiangsu Province China Department of anesthesiology The first Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

Objective： To compare the effects of different methods of anesthesia and analgesia on the activities of phosphofructokinase（PFK）, glucose-6-phosphate dehydrogenase（G-6PD） and aldose reductase（AR） in erythrocytes and levels of plasma glucose and stress hormones in patients undergoing esophagus surgery. Methods： Sixty-two patients scheduled for esophagus surgery were randomly divided into three groups： group Ⅰ （n = 20） receiving only general anesthesia（GA） followed by intravenous patient controlled analgesia（PCA） with fentanyl 15 μg/kg. The other two groups receiving both general anesthesia combined with thoracic epidural anesthesia （GEA） and either intravenous PCA with fentanyl 15 μg/kg （group Ⅱ, n = 21） or thoracic epidural analgesia（TEA） with 0.125% ropivacaine and 0.0002% fentanyl mixture（group Ⅲ, n = 21） after the operation. Venous blood samples were collected for measurements of PFK, G-rPD and AR activities in erythrocytes and plasma glucose, cortisol, epinephrine and norepinephrine before induction （T1）, 60 min following the incision （T2）, 60 min（T3） after operation, on the lst（T4） and 2nd postoperative day（T5）. Results： The activities of PFK decreased（P 〈 0.01 or P = 0.004） and the activities of G-6PD and AR increased（P 〈 0.01） in groups Ⅰ and Ⅱ on T4 compared with those on T1 Between the two groups, the activities of these enzymes in group Ⅱ changed less than those of group Ⅰ （P 〈 0.01 or P 〈 0.05）. These enzymes activities changed slightly in group Ⅲ on T4（P 〉 0.05）. There were significant differences between group Ⅲand the other two groups（P 〈 0.0l or P 〈 0.05）. The levels of plasma glucose increased significantly on T2（P 〈 0.01）, reached peak values on Ta（P 〈 0.01） and fell on T5 in the three groups. Compared to those of groups Ⅰ and Ⅱ, the values of plasma glucose in group Ⅲwere lower on T4 and T5（P 〈 0.05 or P 〈 0.01）. The cortisol concentration in each group increased significantly at T2（P 〈 0.01 or P 〈 0.05）, and remained elevated on T5（P 〈 0.01 or P 〈 0.05）, while on T2 and T3 the cortisol levels＇

关键词： Anesthesia Analgesia Phosphofructokinases Aldose reductase Glucose-6-phasephate dehydrogenase Cortisol epinephrine norepinephrine

Treatment of herniated lumbar disc by percutaneous laser disc decompression combined with synchronous suction technique through syringe

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Journal of Nanjing Medical University 2007年第2期21卷 68-71页

作者： Dhir B. Gurung Gaojian Tao Hongyi Lin yanning qian Jian Lin Department of Anesthesia the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Department of Pain management Drum Tower Hospital Nanjing 210008 China

Objective： To compare the outcomes of percutaneous laser disc decompression （PLDD） and PLDD with synchronous suction through syringe in the patients with herniated lumbar disc（HLD）. Methods： Forty-two patients with HLD on MRI and those who did not respond to conservative treatment for 6 weeks were randomly divided into group A and group B. In group A, the patients were treated with PLDD and those in group B with PLDD and synchronous suction through syringe. GaAIAS diode laser at 810 nm was used for the ablation in both groups. The treatment effect was evaluated by modified MacNab＇s criteria on the 7^th, 30^th and 90^th day. Results： Evaluated by modified MacNab＇s criteria, the percentages of the excellent and good cases in total patients treated for group B and A were 80.95% and 57.14% on the 7^th follow-up day, 85.71% and 66.67% on the 30^th follow-up day, and 95.24% and 71.43% on the 90^th follow-up day, respectively. Conclusion： Synchronous suction technique through syringe during PLDD improves the overall outcome in the treatment of herniated lumbar disc.

关键词： percutaneous laser disc decompression herniated lumbar disc synchronous suction

老年食管癌患者围术期T淋巴细胞亚群的变化(英文)

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The Chinese-German Journal of Clinical Oncology 2010年第4期9卷 204-207页

作者： Lairong Sun Lianbing Gu Zongli Shen Yueqing Zhu yanning qian Department of Anesthesiology Jiangsu Province Tumor Hospital Nanjing 210009 China Department of Anesthesiology The 1st Affiliated Hospital Nanjing Medical Univesity Nanjing 210029 China

Objective:The aim of the study was to observe and compare the trend of T-lymphocyte subsets in the elder and adult esophageal carcinoma patients postoperatively. Methods: Forty-four esophageal carcinoma patients, classified as ASA physical status I-II, were divided into two groups. Twenty-two patients aged than 65 years were grouped as elder patient group, and the rest twenty-two patients, served as adult patient group, were younger than 60 years old. The jugular venous blood samples were collected before induction of anesthesia (T1) as baseline, after completion of surgery (T2), on the first, second and fifth postoperative days (T3, T4 and T5), respectively. The blood counts of CD3+, CD4+ and CD8+T-lymphocyte were measured by flow cytometer. Results: Compared with the baseline level, the blood CD3+, CD4+ and CD4/CD8 levels were significantly decreased immediately after surgery, on the first and second postoperative days in the two groups (P0.05). On the fifth postoperative day, CD3+, CD4+ and CD4/CD8 levels in adult group were significantly higher than those in elder group (P<0.05). Conclusion: The postoperative immune function in elder patients recovered more slowly than that in adult.

关键词： T淋巴细胞亚群围手术期老年人食管癌患者血液样本流式细胞仪 CD3

Effect of pretreatment with different concertrations of morphine, fentanyl and tramadol on the differentiation of human helper T cells in vitro

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Journal of Nanjing Medical University 2005年第6期19卷 313-315页

作者： yanning qian Wenjie Jin Ping Chen Ling Wang Huijuan Wang Yuke Tian Xuejun Zhou Department of Anesthesiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Department of Anesthesiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective： To investigate and compare the .effects of different concentrations of morphine, fentanyl and tramadol on the differentiation of human adult helper T cells in vitro. Methods： Twenty out-patients without immune disease were selected and their peripheral blood was collected. Then the Whole blood of peripheral blood mononuclear cells （PBMCs） were pretreated with different concentration of morphine, fentanyl and tramadol for 24 h. The level of CD4^＋ IFN-γ^＋ IL-2^＋/CD4^＋ IL-4^＋ IL-10^＋ was analyzed by three-color flow cytometry, and the CD4^＋ CCR5^＋ and CD4^＋ CCR3 ^＋ cells were counted to observe the imbalance of Th2/Th2. Results： The number of Th2 increased significantly and the ratio of Th2/Th2 decreased dramatically compared with the control group, and there was a dose-dependent fashion in all drugs. Conclusion： Morphine, fentanyl and tramadol can direct Th0 cells toward Th2 differentiation, especially morphine and fentanyl.

关键词： morphine fentanyl tramadol helper T cells cytokines

Boosting efficiency and stability of 2D alternating cation perovskite solar cells via rational surface-modification: Marked passivation efficacy of anion

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Journal of Energy Chemistry 2023年第9期84卷 354-362页

作者： Hualin Zheng Xuefeng Peng Tingxi Chen Ting Zhang Shihao Yuan Lei Wang Feng qian Jiang Huang Xiaodong Liu Zhi David Chen yanning Zhang Shibin Li State Key Laboratory of Electronic Thin Films and Integrated Devices and School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengdu 610054SichuanChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China(UESTC)Chengdu 610054SichuanChina Department of Electrical&Computer Engineering and Center for Nanoscale Science&EngineeringUniversity of KentuckyLexingtonKY 40506USA Institute of Electronic and Information Engineering of UESTC in Guangdong Dongguan 523808GuangdongChina

Two-dimensional(2D) alternating cation(ACI) perovskite surface defects,especially dominant iodine vacancies(V_Ⅰ) and undercoordinated Pb^(2+),limit the performance of perovskite solar cells(PVSCs).To address the issue,1-butyl-3-methylimidazolium trifluoro-methane-sulfonate(BMIMOTF) and its iodide counterpart(BMIMI) are utilized to modify the perovskite surface respectively.We find that BMIMI can change the perovskite surface,whereas BMIMOTF shows a nondestructive and more effective defect passivation,giving significantly reduced defect density and suppressed charge-carrier nonradiative recombination.This mainly attributes to the marked passivation efficacy of OTF-anion on V_Ⅰ and undercoordinated Pb^(2+),rather than BMIMI^(+) cation.Benefiting from the rational surface-modification of BMMIMOTF,the films exhibit an optimized energy level alignment,enhanced hydrophobicity and suppressed ion migration.Consequently,the BMIMOTF-modified devices achieve an impressive efficiency of 21.38% with a record open-circuit voltage of 1.195 V,which is among the best efficiencies reported for 2D PVSCs,and display greatly enhanced humidity and thermal stability.

关键词： 2D ACI perovskite solar cells Charge-carrier nonradiative recombination Surface defects passivation Energy level alignment Ionic migration Stability

中枢神经系统炎性脱髓鞘专病临床科研数据库设计与构建

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医学信息学杂志 2024年第5期45卷 83-88页

作者：武雷王冰余倩孙慧赵赫高赛郭荷娜黄燕宁孟召友肖连臣许海珍黄德晖中国人民解放军总医院第一医学中心神经内科医学部北京100853 浙江省数字医学诊断技术重点实验室杭州310030 陕西省人民医院神经内二科西安710068 陆军军医大学第二附属医院神经内科重庆400038 湖北文理学院附属医院神经内科襄阳441000 中国人民解放军联勤保障部队第900医院神经内科福州350005

目的/意义构建中枢神经系统(central nervous system,CNS)炎性脱髓鞘专病数据库,为临床科研服务,提高基层医疗水平。方法/过程利用互联网收集病历数据,经过处理和分析后,构建CNS炎性脱髓鞘专病数据库。运用统计分析、自然语言处理、人... 详细信息

目的/意义构建中枢神经系统(central nervous system,CNS)炎性脱髓鞘专病数据库,为临床科研服务,提高基层医疗水平。方法/过程利用互联网收集病历数据,经过处理和分析后,构建CNS炎性脱髓鞘专病数据库。运用统计分析、自然语言处理、人工智能影像识别和数据可视化等技术,整合分析数据库信息。结果/结论形成标准化的CNS炎性脱髓鞘专病数据库大数据信息池,将临床科研数据可视化,兼顾患者宣教、专科医生培训、多中心远程会诊功能,促进医疗科研成果转化,为未来真实世界的临床研究提供参考依据,优化诊疗路径,赋能基层医院。

关键词：炎性脱髓鞘疾病数据库大数据平台

Perioperative Changes of Plasma TNF-

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Journal of Nanjing Medical University 2000年第1期14卷 24-26页

作者： qian yanning Department of Anesthesiology Department of Nuclear Medicine Central Laboratory the First Affiliated HospitalNanjing Medical UniversityNanjing 210029P. R. China

Objective\ To investigate the perioperative chaneges of plasma levels of necrosis factor α(TNF α) and interleukin 6 (IL 6). Methods\ Thirty patients undergoing upper abdominal operations were randomly divied into epidural blockade (EB) group and intravenous procaine balanced anesthesia (IPBA) group. The plasma levels of TNF α and IL 6 were monitored perioperatively. Results\ There were no significant changes in TNF α in both groups during or after operation. But plasma IL 6 levels on the first postoperative day were significantly higher than that before induction of anesthesia in both groups [EB:(0 39±0 07) vs (0 28±0 07) ng/ml, P<0.05; IPBA:(0 42±0 07) vs (0.27±0.08) ng/ml, P<0.05]. Conclusion\ The results suggest that IL 6 is a cytokine more active than TNF α after upper abdominal operation. Surgical stress might be a more important stimulator for IL 6 release.

关键词： cytokine TNF α IL 6 stress anesthesia surgery