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Modeling Drug Concentration in Blood through Caputo-Fabrizio and Caputo Fractional Derivatives

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2767-2785页

作者： Muath Awadalla Kinda Abuasbeh Yves yannick Yameni Noupoue Mohammed S.Abdo Department of Mathematics and Statistics College of ScienceKing Faisal UniversityHafufAl Ahsa31982Saudi Arabia Institute of Statistics Biostatistics and Actuarial ScienceFaculty of ScienceUniversite Catholique de LouvainLouvain-La-Neuve1348Belgium Department of Mathematics Hodeidah UniversityAl-Hudaydah3114Yemen

This study focuses on the dynamics of drug concentration in the *** general,the concentration level of a drug in the blood is evaluated by themean of an ordinary and first-order differential *** precisely,it is solved through an initial value *** proposed a newmodeling technique for studying drug concentration in blood *** technique is based on two fractional derivatives,namely,Caputo and Caputo-Fabrizio *** first provided comprehensive and detailed proof of the existence of at least one solution to the problem;we later proved the uniqueness of the existing *** proof was written using the Caputo-Fabrizio fractional derivative and some fixed-point *** via theUlam-Hyers(UH)technique was also *** application of the proposedmodel on two real data sets revealed that the Caputo derivative wasmore suitable in this ***,for the first data set,the model based on the Caputo derivative yielded a Mean Squared Error(MSE)of 0.03095 with a corresponding best value of fractional order of derivative of ***-Fabrizio-basedderivative appeared to be the second-best method for the problem,with an MSE of 0.04324 for a corresponding best fractional derivative order of *** the second experiment,Caputo derivative-based model still performed the best as it yielded an MSE of 0.04066,whereas the classical and the Caputo-Fabrizio methods were tied with the same MSE of *** interesting finding was that the MSE yielded by the Caputo-Fabrizio fractional derivative coincided with the MSE obtained from the classical approach.

关键词： Pharmacokinetics caputo fractional derivative stability study Caputo-Fabrizio fractional derivative

Research on the Economic Cooperation between China and Gabon

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Research on the Economic Cooperation between China and Gabon

作者： POPOUET STEPHAN yannick 华中师范大学

学位级别：硕士

本文主要研究中国与非洲的关系,特别关注中国与加蓬的经济合作。根据现有文献,本文考察了相关学者就中国与加蓬经济合作给出的原因。这项研究展示了中国在加蓬投资的历史,也分析了当前和正在发展中的经济形势。这项研究进一步探讨了加... 详细信息

本文主要研究中国与非洲的关系,特别关注中国与加蓬的经济合作。根据现有文献,本文考察了相关学者就中国与加蓬经济合作给出的原因。这项研究展示了中国在加蓬投资的历史,也分析了当前和正在发展中的经济形势。这项研究进一步探讨了加蓬人对中国在加蓬投资的看法。作者认为,在加蓬的大多数中国公司都是国有企业,它们在财政方面得到了本国政府的大力支持,政府也在其与加蓬的谈判中帮助它们。通过对现有文献的分析,作者认为,中国与加蓬的经济合作与中国投资对加蓬经济增长的贡献很大。此外,我们的研究得出的结论是,中国正在非洲投入大量资金,这在加蓬的经济和贸易方面尤为明显,这种经济合作不具有任何隐藏的帝国或殖民主义倾向,因为中国的投资主要是在加蓬政府的邀请下来到加蓬的。作者还认为,尽管加蓬人对中国-加蓬合作有一些不满,但总的看法是积极的。中国公司也充分意识到这些问题并正在努力解决它们。

关键词：中国-加蓬关系经济关系中国对外投资

Structure of nanocrystalline WC-10%Co powder

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中国有色金属学会会刊：英文版 2001年第4期11卷 529-534页

作者：杨志民毛昌辉杜军 Michel Daniel Champion yannick Hagège Serge Htch Martin General Research Institute for Nonferrous Metals Centre d'Etudes de Chimie Métallurgique/CNRS 94407 Vitry-sur-Seine France

Nanostructured WC Co powders obtained by mechanical milling were investigated by combination of X ray diffraction (XRD) and high resolution transmission electron microscopy (HRTEM) techniques. Rietveld analysis indicates that the experimental XRD patterns cannot be satisfactorily explained with the hexagonal WC structure. HRTEM image analysis shows that in the as milled nanostructured powder, many WC grains contain stacking faults lying on the plane {10·0}. Analysis of phase images show that these defects are nearly periodically ordered along the direction. Based on these observations, a structural model was proposed for the WC grains with ordered stacking faults, which is in fact equivalent to a superstructure of WC with space group Amm2. When this model describing the faulted fraction of WC is introduced together with the normal WC structure (space group P6-m2) into the Rietveld refinement, a much better agreement between the calculated and experimental XRD profiles was obtained. This study allows to obtain the lattice parameters, grain size, microstrain and other structural information on the as milled powders.

关键词： structural properties mechanical milling WC Co

Comparative Study of Two Materials Combining a Standard Building Material with a PCM

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Fluid Dynamics & Materials Processing 2023年第5期19卷 1283-1290页

作者： Marwa El Yassi Ikram El Abbassi Alexandre Pierre yannick Melinge Research Laboratory in Industrial Eco-innovation and Energetics(LR2E) ECAM-EPMICergy-Pontoise95000France Laboratory of Mechanic and Materials of Civil Engineering(L2MGC) University of Cergy-PontoiseCergy-Pontoise95000France Historical Monuments Research Laboratory(LRMH) Champs-sur-Marne77420France

Phase change materials(PCMs)have the ability to store thermal energy and make it available at a later stage to keep indoor temperature within a specific range and achieve better thermal comfort in *** study focuses on the performances of materials obtained by combining a standard building material with a *** particular,two different materials mixed with the same PCM are considered under the same climatic *** related thermal behavior is assessed in the framework of numerical simulations conducted with ANSYS Fluent assuming parameters representative of a city located in *** results show that the addition of PCM to concrete and bricks can improve the thermal inertia of the resulting material.

关键词： Phase change materials building material thermal comfort passive cooling

Microstructural evolution of a recycled aluminum alloy deformed by equal channel angular pressing process

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International Journal of Minerals,Metallurgy and Materials 2012年第11期19卷 1016-1022页

作者： Thabet Makhlouf Atef Rebhi Jean-Philippe Couzinié yannick Champion Nabil Njah Applied Metallurgy Laboratory Faculty of SciencesUniversity of SfaxBP.1171 (3000) Sfax Institut de Chimie et des Matériaux Paris-Est (ICMPE) CNRS 2-8 rue Henri Dunant 94320 Thiais

The microstructural evolution of a recycled aluminum alloy after equal channel angular pressing （ECAP） up to four passes was investigated using X-ray diffxaction （XRD） analysis and transmission electron microscopy （TEM）. Microhardness tests were performed to determine the associated changes in mechanical properties. An ultrafine-grained material has been obtained with a microstructure showing a mixture of highly strained crystallites. A high density of dislocations was achieved as a result of severe plastic deformation （SPD） through the die. Changes in mechanical behavior are also revealed after ECAP due to strain hardening. Thermal analysis and TEM micrographs ob- tained after annealing indicate the succession of the recovery, recrystallization, and grain growth phenomena. Moreover, the energy stored during ECAP may be related to the dislocation density introduced by SPD. We finally emphasize the role played by the precipitates in this alloy.

关键词： aluminum alloys equal channel angular pressing (ECAP) microstructural evolution precipitates

High-density single antibody electrochemical nanoarrays

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Nano Research 2023年第4期16卷 5412-5418页

作者： Khalil Chennit yannick Coffinier Shuo Li Nicolas Clément Agnès Anne Arnaud Chovin Christophe Demaille UniversitéParis Cité CNRSLaboratoire d’Electrochimie MoléculaireParis F-75013France Institute of Electronics Microelectronics and NanotechnologyCNRSUniversity of LilleAvenue PoincaréBP60069Villeneuve d’Ascq 59652France IIS LIMMS/CNRS-IIS UMI2820The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

The fabrication and electrochemical interrogation of very high density single-antibody nanoarrays is *** nanodots,15 nm in diameter,arranged in large(cm2)square arrays with a pitch of 200 nm,are used as carriers for primary antibodies(immunoglobulin G(IgG)),further recognized by secondary redox-labeled detection *** scale interrogation of the antibody array by cyclic voltammetry,and nanoscale interrogation of individual nanodots by mediator tethered atomic forcescanning electrochemical microscopy(Mt/AFM-SECM),enable the occupancy of nanodots by single antibody molecules to be *** involving the competitive adsorption of antibodies of different species onto the nanodots evidence the possibility of using single-antibody nanoarrays for digital electrochemical immunoassays.

关键词： single entity electrochemistry electrochemical digital immunoassays atomic force-scanning electrochemical microscopy(AFM-SECM)

N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography–mass spectrometry

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Journal of Pharmaceutical Analysis 2017年第1期7卷 34-47页

作者： Lieselotte Veryser Lien Taevernier Evelien Wynendaele yannick Verheust Ann Dumoulin Bart De Spiegeleer Drug Quality and Registration (DruQuaR) group Faculty of Pharmaceutical Sciences Ghent University Ottergemsesteenweg 460 B-9000 Ghent Belgium LIWET Department of Industrial Biological Sciences Ghent University Campus Kortrijk Graaf Karel de Goedelaan 5 B-8500 Kortrijk Belgium

Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are responsible for these pharmacological actions. Therefore, in the present study, the NAA content of the two plants was analytically characterised. Different extracts were prepared from the roots, the leaves, the stems and the flowers. The structures of NAAs have been assigned in ethanolic extracts of Achillea millefolium and Achillea ptarmica using high performance liquid chromatography – electrospray ionisation – mass spectrometry(HPLC–ESI–MS) and gas chromatography – electron impact – mass spectrometry(GC–EI–MS). Using both analytical techniques, the structures of 14 and 15 NAAs have been assigned in Achillea ptarmica and Achillea millefolium, respectively. Structures of two new NAAs, previously never observed in Achillea ptarmica,were assigned: deca-2E,6Z,8E-trienoic acid 2-methylbutylamide(homospilanthol) or a related isomeric compound and deca-2E,4E-dienoic acid N-methyl isobutylamide. The structure of homospilanthol or a related isomeric compound was also assigned in Achillea millefolium for the first time.

关键词： N-alkylamides Achillea millefolium Achillea ptarmica HPLC–ESI–MS GC–EI–MS

Nonlinear increase,invisibility,and sign inversion of a localized fs-laser-induced refractive index change in crystals and glasses

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Light(Science & Applications) 2020年第1期9卷 1398-1409页

作者： Jerome Lapointe Jean-Philippe Berube yannick Ledemi Albert Dupont Vincent Fortin Younes Messaddeq Real Vallee Centre d’Optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalG1V 0A6 QuebecQCCanada

Multiphoton absorption via ultrafast laser focusing is the only technology that allows a three-dimensional structural modification of transparent ***,the magnitude of the refractive index change is rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated *** propose to address this issue by employing a femtosecond-laser-induced electronic band-gap shift(FLIBGS),which has an exponential impact on the refractive index change for propagating wavelengths approaching the material electronic resonance,as predicted by the Kramers–Kronig *** by theoretical calculations,based on a modified Sellmeier equation,the Tauc law,and waveguide bend loss calculations,we experimentally show that several applications could take advantage of this ***,we demonstrate waveguide bends down to a submillimeter radius,which is of great interest for higher-density integration of fs-laser-written quantum and photonic *** also demonstrate that the refractive index contrast can be switched from negative to positive,allowing direct waveguide inscription in ***,the effect of the FLIBGS can compensate for the fs-laser-induced negative refractive index change,resulting in a zero refractive index change at specific wavelengths,paving the way for new invisibility applications.

关键词： waveguide millimeter refractive

Design of New Optogenetic Sinusoidal Probe:Optical and Mechanical Simulation

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Design of New Optogenetic Sinusoidal Probe:Optical and Mecha...

作者： Bouget Maxime yannick Joseph 上海交通大学

学位级别：硕士

经过数年对神经电极微尺寸技术的研究,研究人员期望获得对神经组织更小的侵入性伤害,但是现在微尺寸技术对降低植入‘损伤的性能改善已经触及了机械损伤的极限。最近一些新的电极形状设计（正弦型形状）为减小电极植入的侵入性伤害、提... 详细信息

经过数年对神经电极微尺寸技术的研究,研究人员期望获得对神经组织更小的侵入性伤害,但是现在微尺寸技术对降低植入‘损伤的性能改善已经触及了机械损伤的极限。最近一些新的电极形状设计（正弦型形状）为减小电极植入的侵入性伤害、提高电极记录性能开辟了新的可能性。本文旨在继续探索这种新的电极设计方法,并使其适应最新的神经组织刺激技术:光遗传学技术。本文的目标是找到导光性能良好的柔性形状。首先开展设计可行性研究:形状、材料和制作工艺。在形状和制作工艺层面主要遵循已经发表的有关正弦型电极的结论。这部分还要求必须为光学导向器找到具有良好柔韧性、生物相容性和适宜折射率的芯/包层材料。出于以上考虑,研究中放弃了将Parylene-C/Parylene-N组合作为芯/包层材料的选择。其次,使用两种不同的方法进行光学仿真:光束和光线追踪方法。结果显示了不同的形状参数对光传导的影响。由此,选择了若干组光传导性能较好的形状设计。最后,将在光学仿真软件中找到的各种形状进行力学仿真,得到表征其柔韧性的数据,将其与正弦型电极的侵入性数据进行比较。由于研究中保持了与正弦型电极相同的全局性设计,可以得出新设计电极的侵入性伤害的结论。本文最后得出了一组光学正弦型电极的形状参数、机械和光学特征,理论上可以在改善长期植入电极的植入损伤与记录性能。

关键词：神经探针正弦形光遗传学光学模拟机械模拟