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PMS-500可吸入颗粒物采样器的研制和性能测试

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辐射防护 2006年第5期26卷 257-263页

作者：刘龙波王旭辉刘蜀疆刘红杰吴艳敏常印忠殷宝辉翟涛夏兵张自禄西北核技术研究所西安710024 中国环境科学研究院北京100012

研制了用于环境中可吸入颗粒物(PM10)采样的PMS-500采样器。采样器运行流量为560 m3/h,采用变频技术控制流量稳定,用聚丙烯纤维滤材作为PM10的收集介质。设计了一种矩形喷嘴撞击器作为PM10切割器,撞击器的收集介质为容尘量较大的聚氨酯... 详细信息

研制了用于环境中可吸入颗粒物(PM10)采样的PMS-500采样器。采样器运行流量为560 m3/h,采用变频技术控制流量稳定,用聚丙烯纤维滤材作为PM10的收集介质。设计了一种矩形喷嘴撞击器作为PM10切割器,撞击器的收集介质为容尘量较大的聚氨酯泡沫。对采样器的性能测试结果为:切割器的切割粒径为9.9μm,捕集效率曲线的几何标准偏差为1.4;采样期间流量波动在±2%之内;双层滤材对0.2μm气溶胶的收集效率不小于99%。采样器可方便地拆分为三部分,机动性较好。本采样器与市售大流量PM10采样器的采样效率相当,其性能可以满足环保行业对PM10采样的要求。

关键词： PM10 气溶胶采样器研制

壳寡糖对S180荷瘤鼠Bcl-2、Bax蛋白表达的影响

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中国医药导报 2012年第13期9卷 27-28页

作者：蒋瑞雪赵宪孙艳王琪兴桂华吴艳敏官杰齐齐哈尔医学院医学技术学院黑龙江齐齐哈尔161006 齐齐哈尔第一医院介入科黑龙江齐齐哈尔161000

目的观察壳寡糖对S180小鼠Bcl-2、Bax蛋白表达情况及肿瘤细胞凋亡的影响。方法选择体内注射的方法将壳寡糖注入S180小鼠体内,用免疫组织化学法测定瘤组织Bcl-2、Bax蛋白的表达情况。结果壳寡糖能降低S180小鼠瘤组织抑凋亡基因Bcl-2的表... 详细信息

目的观察壳寡糖对S180小鼠Bcl-2、Bax蛋白表达情况及肿瘤细胞凋亡的影响。方法选择体内注射的方法将壳寡糖注入S180小鼠体内,用免疫组织化学法测定瘤组织Bcl-2、Bax蛋白的表达情况。结果壳寡糖能降低S180小鼠瘤组织抑凋亡基因Bcl-2的表达,提高促凋亡基因Bax的表达。结论通过调节Bcl-2、Bax的表达而诱使肿瘤细胞凋亡是壳寡糖抗肿瘤作用机制之一。

关键词：壳寡糖 S180小鼠 Bcl-2 Bax 凋亡

铁路隧道石墨烯纤维增强复合材料盖板的研发及应用

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中国铁路 2019年第9期 95-101页

作者：王志伟马伟斌郭小雄王晓奎武雁民石玉龙中国铁道科学研究院集团有限公司铁道建筑研究所北京100081 大秦铁路股份有限公司大同工务段山西大同037005

针对铁路隧道盖板存在易开裂渗漏、密封性差、保温性差等问题,从新材料、新结构、新工艺等方面研发出一种适用于我国铁路隧道的不淤积堵塞、不开裂破损、易疏通维护的新型石墨烯纤维增强复合材料盖板及安装工艺。从材料比选、结构设计... 详细信息

针对铁路隧道盖板存在易开裂渗漏、密封性差、保温性差等问题,从新材料、新结构、新工艺等方面研发出一种适用于我国铁路隧道的不淤积堵塞、不开裂破损、易疏通维护的新型石墨烯纤维增强复合材料盖板及安装工艺。从材料比选、结构设计、性能试验、制备试验、数值模拟及室内试验等方面,阐述该新型盖板的研发过程及适用性。通过工程应用实践,验证该新型盖板可在铁路隧道工程中广泛应用。

关键词：铁路隧道石墨烯纤维增强复合材料盖板制备试验安装工艺

Precise base editing of non-allelic acetolactate synthase genes confers sulfonylurea herbicide resistance in maize

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The Crop Journal 2020年第3期8卷 449-456页

作者： yanmin Li Jinjie Zhu Hao wu Changlin Liu Changling Huang Jinhao Lan yanming Zhao Chuanxiao Xie Institute of Crop Sciences Chinese Academy of Agricultural SciencesNational Key Facility for Crop Gene Resources and Genetic ImprovementBeijing 100081China Qingdao Agricultural University Qingdao 266109ShandongChina Anhui Agricultural University Hefei 230036AnhuiChina

Single-nucleotide polymorphisms contribute to phenotypic diversity in maize. Creation and functional annotation of point mutations has been limited by the low efficiency of conventional methods based on random mutation. An efficient tool for generating targeted single-base mutations is desirable for both functional genomics and precise genetic improvement. The objective of this study was to test the efficiency of targeted C-to-T base editing of two non-allelic acetolactate synthase(ALS) in generating sulfonylurea herbicide-resistant mutants. A CRISPR/Cas9 nickase-cytidine deaminase fused with uracil DNA glycosylase inhibitor(UGI) was employed to achieve targeted conversion of cytosine to thymine in ZmALS1 and ZmALS2. Both protoplasts and recovered mutant plants showed the activity of the cytosine base editor, with an in vivo efficiency of up to 13.8%. Transgene-free edited plants harboring a homozygous ZmALS1 mutation or a ZmALS1 and ZmALS2 double mutation were tested for their resistance at a dose of up to 15-fold the recommended limit of chlorsulfuron, a sulfonylurea herbicide widely used in agriculture. Targeted base editing of C-to-T per se and a phenotype verified in the generated mutants demonstrates the power of base editing in precise maize breeding.

关键词： Precise base editing of non-allelic acetolactate synthase genes confers sulfonylurea herbicide resistance in maize

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浅析高原红细胞增多与血尿酸的关系

西南军医 2017年第5期19卷 407-408页

作者：刘成海吕国志吴彦民杨聪杨五洪文朝远解放军第115医院内科西藏林芝860000

目的观察高原红细胞增多对血尿酸(UA)水平的影响,为高原地区研究高尿酸血症的机制奠定基础。方法选择刚进藏新兵99名,将其分为0月(对照组)和1、2、6、12个月(观察组),检测各组血红蛋白(HGB)及血尿酸水平并作比较分析。结果各观察组血红... 详细信息

目的观察高原红细胞增多对血尿酸(UA)水平的影响,为高原地区研究高尿酸血症的机制奠定基础。方法选择刚进藏新兵99名,将其分为0月(对照组)和1、2、6、12个月(观察组),检测各组血红蛋白(HGB)及血尿酸水平并作比较分析。结果各观察组血红蛋白水平明显高于正常对照组(P<0.05),各观察组血尿酸水平也明显高于正常对照组(P<0.05),且血尿酸水平变化与高原红细胞增多有明显的相关性。结论高原红细胞增多是引起高尿酸血症的因素之一。

关键词：高原红细胞增多高原地区尿酸

典型配电网网架结构的模拟及智能分布式终端在网架上的应用案例

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电力系统装备 2021年第15期 26-28页

作者：宋祺鹏王继东吴艳敏李玉凌李丽鹏天津大学电气自动化与信息工程学院天津300072 中国电力科学研究院有限公司北京100192 海军工程大学电气工程学院湖北武汉430033 郑州轻工业大学建筑环境工程学院河南郑州450000

配电网是电网和用户之间的枢纽,采用合理的组网方案和接线方式,能提高供电可靠性。从配电网常见的网架结构出发,介绍了典型配网网架的模拟设计,比较了不同网架结构的性能,并分析了智能分布式终端在典型配网网架上的应用案例。

关键词：配电网接线方式组网方案可靠性线损率分布式终端

Two-Dimension(2D) Cu-MOFs/aptamer Nanoprobe for In Situ ATP Imaging in Living Cells

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Journal of Analysis and Testing 2021年第2期5卷 165-173页

作者： Xinxin Shi Hui Xu Yanan wu yanmin Zhao Hong-Min Meng Zhaohui Li Lingbo Qu College of Chemistry Green Catalysis CenterHenan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical ApplicationsZhengzhou Key Laboratory of Functional Nanomaterial and Medical TheranosticZhengzhou UniversityZhengzhou 450001China

Monitoring the intracellular adenosine triphosphate(ATP)level is vital for elaborating its function in physiological ***,the intracellular fluorescence sensing of ATP using ATP aptamer remains difficult owing to non-target displacement and susceptibility toward enzymatic ***,by combining 2D Cu-MOF nanosheets and FAM labelled ATP aptamer,we developed a fluorescent Cu-MOFs/aptamer nanoprobe to image and sense intracellular *** nanoprobe reveals a very low fluorescence intensity because of the excellent quenching efficiency of 2D Cu-MOF *** presence of ATP was capable to dissociate the FAM-aptamer from Cu-MOF nanosheets and resulted in an intense fluorescence *** Cu-MOFs/aptamer nanoprobe enables highly sensitive and selective measurement of ATP level ranging from 10μM to 800μM with a detection limit of 4.24μ*** nanosystem also further realized in situ detection of the undulation of ATP trigged by drug stimulation,depending on the selective delivery of the nanoprobe and attractive capability of resisting nonspecific *** constructed nanoprobe may supply a potential platform in clinical diagnostics and biological studies.

关键词： Metal–organic frameworks Aptamer ATP Bio-sensing Cell imaging

血必净治疗AECOPD合并SIRS患者的临床疗效

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中国继续医学教育 2020年第29期12卷 167-170页

作者：李轲拾景海李若然杨青茹张敬浩刘媛媛武焱旻徐州市中心医院呼吸内科江苏徐州221009

目的观察血必净注射液对合并全身炎症反应综合征(SIRS)的AECOPD患者的治疗价值。方法将82例AECOPD合并SIRS患者随机分为对照组和治疗组,每组均入组41例,均予常规治疗,治疗组除常规治疗外,同时予血必净注射液静脉应用。观察两组治疗前、... 详细信息

目的观察血必净注射液对合并全身炎症反应综合征(SIRS)的AECOPD患者的治疗价值。方法将82例AECOPD合并SIRS患者随机分为对照组和治疗组,每组均入组41例,均予常规治疗,治疗组除常规治疗外,同时予血必净注射液静脉应用。观察两组治疗前、治疗后4 d、8 d的血清C反应蛋白(CRP)、内毒素水平变化,并比较临床疗效及住院时间。结果治疗后4 d、8 d,与对照组比较,血必净治疗组患者血清CRP、内毒素水平下降(P<0.05);同时治疗组患者的临床总有效率明显高于对照组(P<0.05),住院时间缩短(P<0.05)。结论血必净能有效改善AECOPD合并SIRS患者的系统性炎症反应及内毒素水平,提高临床总有效率,缩短住院时间。

关键词：血必净慢性阻塞性肺疾病急性加重全身炎症反应综合征内毒素 C-反应蛋白

Divertor detachment operation in helium plasmas with ITER-like tungsten divertor in EAST

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Plasma Science and Technology 2022年第7期24卷 112-118页

作者： Jianbin LIU Lingyi MENG Houyang GUO Kedong LI Jichan XU Huiqian WANG Guosheng XU Fang DING Ling ZHANG yanmin DUAN Bin ZHANG Lin YU Ping WANG Ang LI Donggui wu Rui DING Liang WANG Institute of Plasma Physics HFIPSChinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China School of Mechanical Engineering Anhui University of Science&TechnologyHuainan 232001People's Republic of China General Atomics San DiegoCalifornia 92186United States of America Institute of Energy Hefei Comprehensive National Science CentreHefei 230031People's Republic of China

Detachment in helium(He)discharges has been achieved in the EAST superconducting tokamak equipped with an ITER-like tungsten *** paper presents the experimental observations of divertor detachment achieved by increasing the plasma density in He *** density ramp-up,the particle flux shows a clear rollover,while the electron temperature around the outer strike point is decreasing *** divertor detachment also exhibits a significant difference from that observed in comparable deuterium(D)*** density threshold of detachment in the He plasma is higher than that in the D plasma for the same heating power,and increases with the heating ***,detachment assisted with neon(Ne)seeding was also performed in L-and H-mode plasmas,pointing to the direction for reducing the density threshold of detachment in He ***,excessive Ne seeding causes confinement degradation during the divertor detachment *** precise feedback control of impurity seeding will be performed in EAST to improve the compatibility of core plasma performance with divertor detachment for future high heating power operations.

关键词： divertor detachment helium plasma density threshold EAST